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Two interconnected brain areas — the hippocampus and the entorhinal cortex — help us to know where we are and to remember it later. By studying these brain areas, researchers at Baylor College of Medicine, Rice University, The University of Texas MD Anderson Cancer Center and the National Cancer Institute have uncovered new information about how dysfunction of this circuit may contribute to memory loss in Alzheimer’s disease. Their results appear in Cell Reports.

“We created a new mouse model in which we showed that spatial memory decays when the entorhinal cortex is not functioning properly,” said co-corresponding author Dr. Joanna Jankowsky, associate professor of neuroscience at Baylor. “I think of the entorhinal area as a funnel. It takes information from other sensory cortices — the parts of the brain responsible for vision, hearing, smell, touch, and taste — and funnels it into the hippocampus. The hippocampus then binds this disparate information into a cohesive memory that can be reactivated in full by recalling only one part. But the hippocampus also plays a role in spatial navigation by telling us where we are in the world. These two functions converge in the same cells, and our study set out to examine this duality.”

The new mouse model was genetically engineered to carry a particular surface receptor on the cells of the entorhinal cortex. When this receptor was activated by administering the drug ivermectin to the mice, the cells of the entorhinal cortex silenced their activity. They stopped funnelling information to the hippocampus. This system allowed the scientists to turn off the entorhinal cortex, and to determine how this affected hippocampal function.

A drink containing liquid aspirin could extend the lives of thousands of brain cancer patients, according to breakthrough research.

British experts have found that the simple drug can cross the ‘blood-brain barrier’ — a hurdle which has so far stopped cancer drugs attacking brain tumours.

Scientists will today announce the results of early tests which show liquid aspirin is ten times more effective than any existing chemotherapy at killing brain cancer cells.

Continue reading “How liquid aspirin could help fight brain cancer: Special version of the drug found to be ten times more effective at killing cancer cells than chemotherapy” »

BMI technology is like anything else; you have an evolution process to finally reach a level of maturity. The good news is that at least at this point of time BMI is at least in that cycle where we are no longer crawling and trying to stand up. We’re in that stage of the cycle where we are standing up and taking a couple of steps at a time. In the next 3 to 5 years, things should be extremely interesting in the BMI space especially as we begin to introduce more sophisticated technology to our connected infrastructure.

Will future soldiers be able to use a direct brain interface to control their hardware?

Imagine if the brain could tell a machine what to do without having to type, speak or use other standard interfaces. That’s the aim of the US Defense Advanced Research Projects Agency (DARPA), which has committed US$60 million to a Neural Engineering System Design (NESD) project to do just that.

Continue reading “Futures: Interfacing with DARPA’s cyborg soldiers” »

Excellent start in using GPU for mapping and predictive analysis on brain functioning and reactions; definitely should prove interesting to medical & tech researchers and engineers across the board should find this interesting.

MIS Asia offers Information Technology strategy insight for senior IT management — resources to understand and leverage information technology from a business leadership perspective.

Results from quantitative MRI and neuropsychological testing show unprecedented improvements in ten patients with early Alzheimer’s disease (AD) or its precursors following treatment with a programmatic and personalized therapy. Results from an approach dubbed metabolic enhancement for neurodegeneration are now available online in the journal Aging.

The study, which comes jointly from the Buck Institute for Research on Aging and the UCLA Easton Laboratories for Neurodegenerative Disease Research, is the first to objectively show that memory loss in patients can be reversed, and improvement sustained, using a complex, 36-point therapeutic personalized program that involves comprehensive changes in diet, brain stimulation, exercise, optimization of sleep, specific pharmaceuticals and vitamins, and multiple additional steps that affect brain chemistry.

“All of these patients had either well-defined mild cognitive impairment (MCI), subjective cognitive impairment (SCI) or had been diagnosed with AD before beginning the program,” said author Dale Bredesen, MD, a professor at the Buck Institute and professor at the Easton Laboratories for Neurodegenerative Disease Research at UCLA, who noted that patients who had had to discontinue work were able to return to work and those struggling at their jobs were able to improve their performance. “Follow up testing showed some of the patients going from abnormal to normal.”

Continue reading “Pre and post testing show reversal of memory loss from Alzheimer’s disease in 10 patients” »

Definitely been seeing great research and success in Biocomputing; why I have been looking more and more in this area of the industry. Bio/ medical technology is our ultimate future state for singularity. It is the key that will help improve the enhancements we need to defeat cancer, aging, intelligence enhance, etc. as we have already seen the early hints already of what it can do for people, machines and data, the environment and resources. However, a word of caution, DNA ownership and security. We will need proper governance and oversight in this space.

© iStock/ Getty Images undefined How much storage do you have around the house? A few terabyte hard drives? What about USB sticks and old SATA drives? Humanity uses a staggering amount of storage, and our needs are only expanding as we build data centers, better cameras, and all sorts of other data-heavy gizmos. It’s a problem scientists from companies like IBM, Intel, and Microsoft are trying to solve, and the solution might be in our DNA.

A recent Spectrum article takes a look at the quest to unlock the storage potential of human DNA. DNA molecules are the building blocks of life, piecing our genetic information into living forms. The theory is that we can convert digital files into biological material by translating it from binary code into genetic code. That’s right: the future of storage could be test tubes.

Continue reading “The future of storage may be in DNA” »

A small clinical trial of 10 patients with early Alzheimer’s disease has shown that the memory loss and cognitive impairment caused by the disease can be reversed.

Scientists at the University of California, Los Angeles found a new treatment that could potentially reverse memory loss and cognitive impairment among patients with early Alzheimer’s disease.

In a small clinical trial, 10 individuals underwent a treatment called “metabolic enhancement for neurodegeneration,” or MEND. The treatment is based on 36 different factors, including changes in diet, exercise, and sleeping habits. It also includes the integration of certain drugs, vitamins, and brain stimulation therapy to a patient’s regular routine.

Continue reading “New Alzheimer’s Treatment Could Reverse Memory Loss” »

A new study helps explain how brain structure and chemistry relate to “fluid intelligence” — the ability to adapt to new situations and solve problems one has never encountered before.

The study, reported in an open-access paper in the journal NeuroImage, observed two facets of fluid intelligence*:

Continue reading “Brain markers of numeric, verbal, and spatial reasoning abilities found” »

If you think your mind is the only safe place left for all your secrets, think again, because scientists are making real steps towards reading your thoughts and putting them on a screen for everyone to see.

A team from the University of Oregon has built a system that can read people’s thoughts via brain scans, and reconstruct the faces they were visualising in their heads. As you’ll soon see, the results were pretty damn creepy.

“We can take someone’s memory — which is typically something internal and private — and we can pull it out from their brains,” one of the team, neuroscientist Brice Kuhl, told Brian Resnick at Vox.

Continue reading “Scientists have invented a mind-reading machine that visualises your thoughts” »