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Category: engineering

Biomolecular condensates are shifting blobs in our cells that organize cellular matter. They are distinct molecular communities made of DNA, RNA and proteins that “condense” molecules to key locations, yet they frequently defy description. Partly this is because they are so small, they cannot be measured using traditional microscopes.

“These blobs were once described as being ‘liquid-like’ because some of them were observed to kiss, fuse, drip and flow like raindrops on windshields,” said Rohit Pappu, Gene K. Beare Distinguished Professor of biomedical engineering the McKelvey School of Engineering at Washington University in St. Louis.

However, while the blobs may look like raindrops, computations have suggested otherwise. The molecular organization within condensates is more like that of a network that rearranges on different timescales, giving condensates more of a shifting, silly putty-like character.

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Wayne State University researchers are using photoacoustic imaging to observe brain activity and, in the process, discovering more about how it responds to different types of learning and experiences.

The team’s findings were recently published in the journal Photoacoustics.

The study, “Use of pattern recognition in to identify neuronal ensembles in the prefrontal cortex of rats undergoing conditioned fear learning,” stemmed from a project by Wayne State University School of Medicine alumnus, James Matchynski, M.D., Ph.D., and was led by School of Medicine faculty members Shane Perrine, Ph.D., associate professor of psychiatry and behavioral neurosciences, and Alana Conti, Ph.D., professor of psychiatry and and director of the Translational Neuroscience Program. The team collaborated with colleagues in the Department of Biomedical Engineering at the University of Illinois Chicago.

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Growing functional human organs outside the body is a long-sought “holy grail” of organ transplantation medicine that remains elusive. New research from the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS) and Wyss Institute for Biologically Inspired Engineering brings that quest one big step closer to completion.

A team of scientists created a new method to 3D print vascular networks that consist of interconnected blood vessels possessing a distinct “shell” of smooth muscle cells and endothelial cells surrounding a hollow “core” through which fluid can flow, embedded inside a human cardiac tissue. This vascular architecture closely mimics that of naturally occurring blood vessels and represents significant progress toward being able to manufacture implantable human organs. The achievement is published in Advanced Materials .

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Researchers at the University of Turku, Finland, have succeeded in producing sensors from single-wall carbon nanotubes that could enable major advances in health care, such as continuous health monitoring. Single-wall carbon nanotubes are nanomaterial consisting of a single atomic layer of graphene.

A long-standing challenge in developing the material has been that the nanotube manufacturing process produces a mix of conductive and semi-conductive nanotubes which differ in their chirality, i.e., in the way the graphene sheet is rolled to form the cylindrical structure of the nanotube. The electrical and chemical properties of nanotubes are largely dependent on their chirality.

Han Li, Collegium Researcher in materials engineering at the University of Turku, has developed methods to separate nanotubes with different chirality. In the current study, published in Physical Chemistry Chemical Physics, the researchers succeeded in distinguishing between two carbon nanotubes with very similar chirality and identifying their typical electrochemical properties.

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Demand for lithium is rising due to its use in batteries for mobile devices, cars and clean energy storage. Securing access to natural deposits of the mineral is now a matter of strategic importance, but lithium can be found elsewhere in nature.

As an alternative to mining, Imperial researchers have created a technology that could be used to efficiently extract it from saltwater sources such as salt-lake brines or geothermal brine solutions.

Conventional extraction from brines takes months and uses significant amounts of water and chemicals, generating greenhouse gas emissions in the process. The alternative developed by Dr. Qilei Song and his team in the Department of Chemical Engineering uses a membrane that separates lithium from by filtering it through tiny pores.

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Nickel’s role in the future of electric vehicle batteries is clear: It’s more abundant and easier to obtain than widely used cobalt, and its higher energy density means longer driving distances between charges.

However, nickel is less stable than other materials with respect to cycle life, , and safety. Researchers from the University of Texas at Austin and Argonne National Laboratory aim to change that with a new study that dives deeply into nickel-based cathodes, one of the two electrodes that facilitate in batteries.

“High-nickel cathodes have the potential to revolutionize the EV market by providing longer driving ranges,” said Arumugam Manthiram, a professor at the Walker Department of Mechanical Engineering and Texas Materials Institute and one of the leaders of the study published in Nature Energy.

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Much of cell behavior is governed by the actions of biomolecular condensates: building block molecules that glom together and scatter apart as needed. Biomolecular condensates constantly shift their phase, sometimes becoming solid, sometimes like little droplets of oil in vinegar, and other phases in between.

Understanding the electrochemical properties of such slippery molecules has been a recent focus for researchers at Washington University in St. Louis.

In research published in Nature Chemistry, Yifan Dai, assistant professor of biomedical engineering at the McKelvey School of Engineering, shares the rules involving the intracellular electrochemical properties that affect movement and chemical activities inside the cell and how that might impact cell processes as a ages. The research can inform the development of treatments for diseases like amyotrophic lateral sclerosis (ALS) or cancer.

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Density functional theory (DFT) is a cornerstone tool of modern physics, chemistry, and engineering used to explore the behavior of electrons. While essential in modeling systems with many electrons, it suffers from a well-known flaw called self-interaction error. A recent study has identified a new area where a correction for this error breaks down.

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3D integrated circuits promise smaller, faster devices with lower power consumption. Vertically stacked 3D integrated circuits also enable novel in-memory and in-sensor computing paradigms and incorporate functionally diverse materials, which can benefit many edge applications. There are several complementary approaches to 3D integration. For example, 3D heterogeneous integration involves stacking and interconnecting multiple chips, each potentially made from different materials or optimized for different functions, within a single package. On the other hand, 3D monolithic integration refers to fabricating layers of transistors sequentially on a single wafer, creating a more seamless and compact structure. This approach offers even greater density and performance benefits by reducing interlayer distances and improving signal integrity. Both techniques are crucial for advancing the next generation of high-performance, energy-efficient electronic devices and require interdisciplinary collaborations across materials science, electrical engineering, and semiconductor manufacturing.

In this Communications Engineering collection, we aim to drive research in the engineering side of 3D integration by bringing together the following topics of interest:

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A phone screen you can’t scratch no matter how many times you drop it; glasses that prevent glare; a windshield that doesn’t get dusty. These are all possibilities thanks to a new way to produce sapphire.

Researchers at The University of Texas at Austin have discovered techniques to bestow superpowers upon , a material that most of us think of as just a pretty jewel. But sapphire is seen as a critical material across many different areas, from defense to consumer electronics to next-generation windows, because it’s nearly impossible to scratch.

“Sapphire is such a high-value material because of its hardness and many other favorable properties,” said Chih-Hao Chang, associate professor in the Walker Department of Mechanical Engineering and leader of the new research. “But the same properties that make it attractive also make it difficult to manufacture at small scales.”

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