Toggle light / dark theme

Scientists in the US have created a way to 3D print materials inside the body using ultrasound. Tests in mice and rabbits suggest the technique could deliver cancer drugs directly to organs and repair injured tissue.

Dubbed deep tissue in vivo sound printing (DISP), the method involves injecting a specialized bioink. Ingredients can vary depending on their intended function in the body, but the non-negotiables are polymer chains and crosslinking agents to assemble them into a hydrogel structure.

To keep the hydrogel from forming instantly, the crosslinking agents are locked inside lipid-based particles called liposomes, with outer shells designed to leak when heated to 41.7 °C (107.1 °F) – a few degrees above body temperature.

Researchers at the Terasaki Institute for Biomedical Innovation (TIBI) have developed a technique that could help advance treatments in tissue engineering. The study, published in the journal Small, introduces a technique for producing tissues with precise cellular organization designed to mimic the natural structure of human tissue.

Using a simple light-based 3D printing method, the team created microgels with controlled internal architectures. These structures help guide how cells behave and grow, mimicking the way cells naturally behave in the body.

By adjusting properties of light as it interacts with hydrogels, the team modified the internal structure of these microgels, enabling precise control of cell organization in 3D space. This breakthrough addresses a major challenge in creating realistic, functional tissue environments critical for tissue repair and regeneration.

Researchers headed by a team at the California Institute of Technology developed an ultrasound-guided 3D printing technique that could make it possible to fabricate medical implants in vivo and deliver tailored therapies to tissues deep inside the body—all without invasive surgery. The researchers say the imaging-guided deep tissue in vivo sound printing (DISP) platform utilizes low-temperature–sensitive liposomes (LTSLs) as carriers for cross-linking agents, enabling precise, controlled in situ fabrication of biomaterials within deep tissues.

Reporting on their development in ScienceImaging-guided deep tissue in vivo sound printing”, first author Elham Davoodi, PhD, and senior, corresponding author Wei Gao, PhD, described proof of concept studies demonstrating in vivo printing within the bladders and muscles of mice, and rabbits, respectively. Gas vesicle (GV)–based ultrasound imaging integrated into the printing platform enabled real-time monitoring of the printing process and precise positioning. In their paper, the authors concluded, “DISP’s ability to print conductive, drug-loaded, cell-laden, and bioadhesive biomaterials demonstrates its versatility for diverse biomedical applications.”

Three-dimensional (3D) bioprinting technologies offer significant promise to modern medicine by enabling the creation of customized implants, intricate medical devices, and engineered tissues, tailored to individual patients, the authors wrote. “However, the implantation of these constructs often requires invasive surgeries, limiting their utility for minimally invasive treatments.”

Imagine that doctors could precisely print miniature capsules capable of delivering cells needed for tissue repair exactly where they are needed inside a beating heart.

A team of scientists led by Caltech has taken a significant step toward that ultimate goal, having developed a method for 3D-printing polymers at specific locations deep within living animals. The technique relies on sound for localization and has already been used to print capsules for selective drug delivery as well as glue-like polymers to seal internal wounds.

Previously, scientists have used to trigger polymerization, the linking of the basic units, or monomers, of polymers within living animals.

Carnegie Mellon researchers have used FRESH 3D bioprinting to create the first collagen-based microphysiologic systems, offering new hope for Type 1 diabetes treatment. Collagen is widely recognized for its role in maintaining healthy skin, but its importance extends far beyond that. As the most

Researchers at the University of Pittsburgh have created a groundbreaking tissue engineering platform using 3D-printed collagen scaffolds called CHIPS.

By mimicking natural cellular environments, they enable cells to grow, interact, and form functional tissues — a major step beyond traditional silicone-based microfluidic models. The platform not only models diseases like diabetes but could also replace animal testing in the future. Plus, their designs are freely available to fuel broader scientific innovation.

3D bioprinting: turning science fiction into science reality.

A team of Penn State researchers has used a new 3D-printing method to produce a complex metal build that was once only possible with welding: fusing two metals together into a single structure.

Using an advanced additive manufacturing process known as multi-material laser powder bed fusion—enabled by a newly acquired system in Penn State’s Center for Innovative Materials Processing Through Direct Digital Deposition (CIMP-3D)—the researchers printed a out of a blend of low-carbon stainless steel and bronze, which consists of 90% copper and 10% tin.

The researchers have published their approach in npj Advanced Manufacturing.