Archive for the ‘genetics’ category

May 7, 2024

‘Whole room was in tears’: NZ scientists see major breakthrough for motor neurone disease | Newshub

Posted by in categories: biotech/medical, genetics, neuroscience

Now that’s Wonderful. It’s touching by how they were brought to tears in making progress in fighting neurogenitive disease.

Auckland scientists are celebrating an important breakthrough after zeroing in on a rare genetic mutation causing motor neuron disease. Their work is now being published in the journal Brain, and national correspondent Amanda Gillies spoke to the lead researcher. ➡️ SUBSCRIBE:

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May 7, 2024

Double sperm cloning (DSC) is a promising strategy in mammalian genetic engineering and stem cell research

Posted by in categories: bioengineering, biotech/medical, genetics

Poirier M, Smith OE, Therrien J, et al. Resiliency of equid H19 imprint to somatic cell reprogramming by oocyte nuclear transfer and genetically induced pluripotency†. Biol Reprod. 2019;102:211–9.

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May 7, 2024

First Patients Get Laboratory-Grown Vaginas

Posted by in categories: biotech/medical, genetics

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Teen girls born with a rare genetic disorder are functioning well years after successful organ implant surgeries.

May 7, 2024

Human skin cells converted into embryonic stem cells: First time human stem cells have been produced via nuclear transfer

Posted by in categories: biotech/medical, genetics, neuroscience

Year 2013 face_with_colon_three

Scientists at Oregon Health & Science University and the Oregon National Primate Research Center (ONPRC) have successfully reprogrammed human skin cells to become embryonic stem cells capable of transforming into any other cell type in the body. It is believed that stem cell therapies hold the promise of replacing cells damaged through injury or illness. Diseases or conditions that might be treated through stem cell therapy include Parkinson’s disease, multiple sclerosis, cardiac disease and spinal cord injuries.

The research breakthrough, led by Shoukhrat Mitalipov, Ph.D., a senior scientist at ONPRC, follows previous success in transforming monkey skin cells into embryonic stem cells in 2007. This latest research will be published in the journal Cell online May 15 and in print June 6.

The technique used by Drs. Mitalipov, Paula Amato, M.D., and their colleagues in OHSU’s Division of Reproductive Endocrinology and Infertility, Department of Obstetrics & Gynecology, is a variation of a commonly used method called somatic cell nuclear transfer, or SCNT. It involves transplanting the nucleus of one cell, containing an individual’s DNA, into an egg cell that has had its genetic material removed. The unfertilized egg cell then develops and eventually produces stem cells.

May 7, 2024

Researchers identify genetic factors that help some reach 100 years with sharp minds

Posted by in categories: biotech/medical, genetics, life extension, neuroscience

Researchers have discovered that individuals who live to be 100 years old and remain cognitively healthy possess genetic variations that may protect against Alzheimer’s disease. These “protective alleles” are significantly more prevalent among centenarians compared to Alzheimer’s patients and even middle-aged individuals without the disease. This finding could pave the way for new approaches in preventing and treating Alzheimer’s, particularly by focusing on enhancing these protective genetic mechanisms.

The new findings have been published in the journal Alzheimer’s & Dementia.

Alzheimer’s disease is a progressive neurological disorder that predominantly affects older adults, leading to a decline in cognitive functions such as memory and reasoning. Over time, this can result in a complete loss of independence and eventually death. The risk of developing Alzheimer’s increases significantly with age, and while it is not an inevitable part of aging, it is one of the most common causes of dementia among seniors.

May 6, 2024

Complex activity and short-term plasticity of human cerebral organoids reciprocally connected with axons

Posted by in categories: genetics, neuroscience

Connecting cerebral organoids with an axon bundle models inter-regional projections and enhances neural activity. Optogenetic stimulation induces short-term plasticity, offering insights into macroscopic circuit development and functionality.

May 6, 2024

One in 50 people ‘almost guaranteed to develop new type of Alzheimer’s disease’

Posted by in categories: biotech/medical, genetics, neuroscience

ONE in 50 people could be at risk of a new type of genetic dementia, according to a study.

Researchers found people carrying two copies of the APOE4 gene mutation are “almost guaranteed” to develop Alzheimer’s in old age.

May 6, 2024

Scientists restore brain cells impaired by a rare genetic disorder

Posted by in categories: biotech/medical, genetics, neuroscience

Scientists have found a way to restore brain cells impaired by a rare and life-threatening genetic disorder called Timothy syndrome.

A type of drug known as an antisense oligonucleotide allowed clusters of human neurons to develop normally even though they carried the mutation responsible for…

A therapy that restores brain cells impaired by a rare genetic disorder may offer a strategy for treating conditions like autism, epilepsy, and schizophrenia.

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May 5, 2024

Genetically targeted chemical assembly of functional materials in living cells, tissues, and animals

Posted by in categories: chemistry, genetics, neuroscience

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Engineered enzymes employed in neurons enable synthesis of electroactive polymers for behavior remodeling in living animals.

May 4, 2024

Metacognitive abilities may be more influenced by environment than genetics

Posted by in categories: genetics, neuroscience

A study shows that metacognition and mentalizing, complex cognitive abilities crucial for social interaction, are more influenced by environmental factors than genetics, challenging traditional views on the heritability of intelligence.

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