Epigenetic reprogramming that promotes oxidative metabolism suppresses TH17 cell pathogenicity.
Category: genetics
Inside Alzheimer’s neurons, tau may set off a genetic chain reaction that ends in cell death
Alzheimer’s disease is a neurodegenerative disease characterized by a progressive decline in mental functions and memory loss. Along with frontotemporal dementia and some other neurodegenerative disorders, Alzheimer’s disease has been associated with an accumulation inside neurons of abnormal clumps of a protein called “tau.”
The tau protein is important for brain health, stabilizing structures called microtubules inside neurons. In Alzheimer’s disease and other tauopathies (i.e., diseases linked with the abnormal accumulation of tau), tau proteins aggregate into toxic and insoluble clumps that are harmful to brain cells, gradually leading to their death.
Researchers at Zhejiang University, Xiamen University and other institutes in China recently carried out a study aimed at better understanding the processes via which tau aggregation contributes to the death of neurons in patients with Alzheimer’s disease. Their findings, published in Nature Neuroscience, suggest that these tau clumps prompt the reactivation of transposable DNA elements in neurons, which can in turn lead to their death.
Legend scientific founder returns to ASCO with new ambition for high-yield, non-gene-editing CAR-T platform
Nine years after wowing the audience at the American Society of Clinical Oncology annual meeting with a CAR-T candidate that would become Carvykti—now the world’s most successful cell therapy—Legend Biotech’s scientific founder, Frank Fan, M.D., Ph.D., is returning to the spotlight with an entirely new playbook.
This time, Fan isn’t showcasing an autologous product engineered with each individual patient’s cells. Instead, with his new venture, Wondercel Therapeutics, Fan hopes an off-the-shelf universal CAR-T platform can tackle two bottlenecks of the cell therapy industry: massive production scalability and the pitfalls associated with gene editing.
“If this approach proves successful, the critical thing is that we can achieve linear scalability in CAR-T production capacity that can match traditional biologics,” Fan said in an interview with Fierce.
Lab-grown brain-spinal cord model shows ‘irreversible’ nerve damage may be reversed
Researchers at the University of Cambridge have provided the first-ever proof that human nerve regeneration after an injury can be reversed and reactivated. Using stem cell-derived brain and spinal cord organoids, scientists discovered a specific genetic network that acts like a “switch,” shutting down axon growth as neurons mature. Remarkably, by blocking key regulators within this network using an already available human drug called lynestrenol, they successfully retriggered the growth of nerve fibers. While lynestrenol itself is not an immediate cure for spinal cord injuries, this monumental discovery proves that the physiological barrier preventing nerve regeneration can be overcome — opening up incredible new possibilities for reversing paralysis and treating severe neurodegenerative diseases in the future!
Cambridge scientists have grown miniature circuits in the lab that mimic how the brain and spinal cord connect up, which underlies our movements. They used this model to show how damage to these connections previously considered ‘irreversible’ could, in fact, be reversible.
Our sophisticated organoid models help bridge the knowledge gap from animal models to what we see in patients.
Roger Penrose and Brian Cox discuss ‘remarkable new evidence’ about the origins of the universe
Roger Penrose and Brian Cox discuss how Roger got interested in physics, the Big Bang, and the role of beauty in mathematics.
Do you agree with Roger’s thoughts on string theory?
With a free trial, you can watch the full conversation NOW at https://iai.tv/video/our-future-theor… the Big Bang to the fabric of spacetime and the nature of consciousness, our core scientific assumptions frame how we understand and perceive reality. But there are many challenges to our current understanding. What if the very foundations of our theories are flawed? Should we reconsider our understanding? And how radically might our view of the universe have to change? Join Roger Penrose, Nobel Prize Laureate and winner of the Wolf prize, in collaboration with Stephen Hawking, with legendary physicist and science communicator, Brian Cox, to explore whether the flaws in our current theories are at some fundamental level insurmountable, or whether they can be extended or changed to overcome these challenges. #physics #cosmology #bigbang Awarded the 2020 Nobel Prize in Physics for his work on black holes, Roger Penrose is a world-renowned mathematician and physicist. In recent years, he has investigated the relationship between physics and the mind, famously arguing that quantum mechanics plays an essential role in solving the mysteries of human consciousness. Penrose has made numerous appearances on media such as BBC, Closer to Truth, and The Joe Rogan Experience. In 1994, he was knighted for his services to science. Famed for his poetic take on the cosmos, physicist and broadcaster Brian Cox has become one of the world’s most recognizable voices in science communication. A former musician turned particle physicist, Cox has played a key role in major experiments at CERN and the Large Hadron Collider, while also captivating millions through BBC series such as Wonders of the Universe, The Planets, and Forces of Nature. Cox has been showered with praise for his contributions, appointed Commander of the Order of the British Empire (CBE), and is the recipient of the Institute of Physics Kelvin Medal and the Michael Faraday Prize. Beyond his work as a Royal Society professor of physics at the University of Manchester, Cox advocates for public scientific literacy and political responsibility in science funding. His style blends rigorous physics with a deep sense of awe — bringing relativity, entropy, and quantum theory into living rooms around the globe. His rare ability to fuse clarity with wonder has earned global acclaim. The Institute of Art and Ideas features videos and articles from cutting edge thinkers discussing the ideas that are shaping the world, from metaphysics to string theory, technology to democracy, aesthetics to genetics. Subscribe today! https://iai.tv/subscribe?utm_source=Y… 0:00 Intro 0:44 Brian Cox on how Roger Penrose inspired him 1:39 — Beauty in mathematics 3:00 — How Roger struggled with maths at school 6:51 — How Roger got interested in physics 9:27 — What theory is best for explaining the beginning of the universe? 12:12 — A key new discovery in cosmology 18:44 — The big bang is not quantum mechanical For debates and talks: https://iai.tv For articles: https://iai.tv/articles For courses: https://iai.tv/iai-academy/courses.
From the Big Bang to the fabric of spacetime and the nature of consciousness, our core scientific assumptions frame how we understand and perceive reality. But there are many challenges to our current understanding. What if the very foundations of our theories are flawed? Should we reconsider our understanding? And how radically might our view of the universe have to change? Join Roger Penrose, Nobel Prize Laureate and winner of the Wolf prize, in collaboration with Stephen Hawking, with legendary physicist and science communicator, Brian Cox, to explore whether the flaws in our current theories are at some fundamental level insurmountable, or whether they can be extended or changed to overcome these challenges.
#physics #cosmology #bigbang.
Awarded the 2020 Nobel Prize in Physics for his work on black holes, Roger Penrose is a world-renowned mathematician and physicist. In recent years, he has investigated the relationship between physics and the mind, famously arguing that quantum mechanics plays an essential role in solving the mysteries of human consciousness.
Cyborg Tissue In the Lab! (Brainstorm Ep101)
The MSF/Doctor without Borders event will take place over the weekend of the 8th and 9th September.
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DNA ‘nicks’ make for safer, more precise genetic analysis
Researchers at Cornell University have developed a safer and more precise way to study how genes function in living tissues by refining a recently developed CRISPR-based genetic technique in fruit flies, enabling researchers to better study how genes contribute to development and disease.
Published in the Proceedings of the National Academy of Sciences, the work highlights a new method that replaces the harsh DNA cuts used in traditional CRISPR analysis with gentler cuts known as “nicks.”
According to Chun Han, associate professor in the Department of Molecular Biology and Genetics in the College of Agriculture and Life Sciences (CALS) and the Weill Institute for Cell and Molecular Biology, the approach still allows scientists to study how genes function in living tissues, but with far less unintended cellular damage and greater control over the experiment.
GD2 CAR T Cells Show Promise Against DMG
In a small clinical trial, a CAR T-cell therapy—a type of immunotherapy that uses a patient’s own immune cells to fight cancer—shrank tumors in several children and young adults with diffuse midline gliomas. This fast-growing form of brain and spinal cord cancer typically causes death within a year of diagnosis.
In the trial, several participants were still alive 2 years or more after receiving the treatment.
Patients in the trial had a type of diffuse midline gliomas known as H3K27M mutant, a genetic change that is found in about 80% of younger patients with these cancers Exit Disclaimer. Researchers at Stanford University, who led the study, designed the experimental CAR T-cell therapy to target a molecule called GD2 that is produced in large amounts by H3K27M-mutant diffuse midline gliomas.
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