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Roger Penrose and Brian Cox discuss ‘remarkable new evidence’ about the origins of the universe

Roger Penrose and Brian Cox discuss how Roger got interested in physics, the Big Bang, and the role of beauty in mathematics.

Do you agree with Roger’s thoughts on string theory?

With a free trial, you can watch the full conversation NOW at https://iai.tv/video/our-future-theor… the Big Bang to the fabric of spacetime and the nature of consciousness, our core scientific assumptions frame how we understand and perceive reality. But there are many challenges to our current understanding. What if the very foundations of our theories are flawed? Should we reconsider our understanding? And how radically might our view of the universe have to change? Join Roger Penrose, Nobel Prize Laureate and winner of the Wolf prize, in collaboration with Stephen Hawking, with legendary physicist and science communicator, Brian Cox, to explore whether the flaws in our current theories are at some fundamental level insurmountable, or whether they can be extended or changed to overcome these challenges. #physics #cosmology #bigbang Awarded the 2020 Nobel Prize in Physics for his work on black holes, Roger Penrose is a world-renowned mathematician and physicist. In recent years, he has investigated the relationship between physics and the mind, famously arguing that quantum mechanics plays an essential role in solving the mysteries of human consciousness. Penrose has made numerous appearances on media such as BBC, Closer to Truth, and The Joe Rogan Experience. In 1994, he was knighted for his services to science. Famed for his poetic take on the cosmos, physicist and broadcaster Brian Cox has become one of the world’s most recognizable voices in science communication. A former musician turned particle physicist, Cox has played a key role in major experiments at CERN and the Large Hadron Collider, while also captivating millions through BBC series such as Wonders of the Universe, The Planets, and Forces of Nature. Cox has been showered with praise for his contributions, appointed Commander of the Order of the British Empire (CBE), and is the recipient of the Institute of Physics Kelvin Medal and the Michael Faraday Prize. Beyond his work as a Royal Society professor of physics at the University of Manchester, Cox advocates for public scientific literacy and political responsibility in science funding. His style blends rigorous physics with a deep sense of awe — bringing relativity, entropy, and quantum theory into living rooms around the globe. His rare ability to fuse clarity with wonder has earned global acclaim. The Institute of Art and Ideas features videos and articles from cutting edge thinkers discussing the ideas that are shaping the world, from metaphysics to string theory, technology to democracy, aesthetics to genetics. Subscribe today! https://iai.tv/subscribe?utm_source=Y… 0:00 Intro 0:44 Brian Cox on how Roger Penrose inspired him 1:39 — Beauty in mathematics 3:00 — How Roger struggled with maths at school 6:51 — How Roger got interested in physics 9:27 — What theory is best for explaining the beginning of the universe? 12:12 — A key new discovery in cosmology 18:44 — The big bang is not quantum mechanical For debates and talks: https://iai.tv For articles: https://iai.tv/articles For courses: https://iai.tv/iai-academy/courses.

From the Big Bang to the fabric of spacetime and the nature of consciousness, our core scientific assumptions frame how we understand and perceive reality. But there are many challenges to our current understanding. What if the very foundations of our theories are flawed? Should we reconsider our understanding? And how radically might our view of the universe have to change? Join Roger Penrose, Nobel Prize Laureate and winner of the Wolf prize, in collaboration with Stephen Hawking, with legendary physicist and science communicator, Brian Cox, to explore whether the flaws in our current theories are at some fundamental level insurmountable, or whether they can be extended or changed to overcome these challenges.

#physics #cosmology #bigbang.

Awarded the 2020 Nobel Prize in Physics for his work on black holes, Roger Penrose is a world-renowned mathematician and physicist. In recent years, he has investigated the relationship between physics and the mind, famously arguing that quantum mechanics plays an essential role in solving the mysteries of human consciousness.

Continue reading “Roger Penrose and Brian Cox discuss ‘remarkable new evidence’ about the origins of the universe” | >

Cyborg Tissue In the Lab! (Brainstorm Ep101)

The MSF/Doctor without Borders event will take place over the weekend of the 8th and 9th September.

The show starts at 4.00pm (UK time) on 8 September. For you local start times click this link: http://www.timeanddate.com/worldclock… will be streamed here: http://www.blogtv.com/People/dprjones SCHEDULE You can find a provisional schedule here: https://spreadsheets.google.com/sprea… You can keep up with updates by following the “Announcement” page on: http://www.magicsandwichshow.com/ DONATION PAGES A link to the Firstgiving donation page is: http://www.firstgiving.com/fundraiser… The justgiving page is here: http://www.justgiving.com/DPR-Jones0 You can also use the ChipIn link on the website. EBAY ITEMS If you have anything that you can donate for auction please send an email to [email protected] Follow us on Twitter / glimpsescience Like us on Facebook / brainstormnews Biotechnology News http://tinyurl.com/8nnrnd4 Genetics News http://tinyurl.com/d4u57xe Nanotechnology http://tinyurl.com/ctyoeav Hosted by / crowbarazar Contributors / thecosmicweb / soundofscilence / julian.poultonking / adrian.ng.3591 / sogtfo.

It will be streamed here: http://www.blogtv.com/People/dprjones.

SCHEDULE You can find a provisional schedule here: https://spreadsheets.google.com/sprea…

You can keep up with updates by following the \.

DNA ‘nicks’ make for safer, more precise genetic analysis

Researchers at Cornell University have developed a safer and more precise way to study how genes function in living tissues by refining a recently developed CRISPR-based genetic technique in fruit flies, enabling researchers to better study how genes contribute to development and disease.

Published in the Proceedings of the National Academy of Sciences, the work highlights a new method that replaces the harsh DNA cuts used in traditional CRISPR analysis with gentler cuts known as “nicks.”

According to Chun Han, associate professor in the Department of Molecular Biology and Genetics in the College of Agriculture and Life Sciences (CALS) and the Weill Institute for Cell and Molecular Biology, the approach still allows scientists to study how genes function in living tissues, but with far less unintended cellular damage and greater control over the experiment.

GD2 CAR T Cells Show Promise Against DMG

In a small clinical trial, a CAR T-cell therapy—a type of immunotherapy that uses a patient’s own immune cells to fight cancer—shrank tumors in several children and young adults with diffuse midline gliomas. This fast-growing form of brain and spinal cord cancer typically causes death within a year of diagnosis.

In the trial, several participants were still alive 2 years or more after receiving the treatment.

Patients in the trial had a type of diffuse midline gliomas known as H3K27M mutant, a genetic change that is found in about 80% of younger patients with these cancers Exit Disclaimer. Researchers at Stanford University, who led the study, designed the experimental CAR T-cell therapy to target a molecule called GD2 that is produced in large amounts by H3K27M-mutant diffuse midline gliomas.

Optimize Brain Health And Longevity: Tommy Wood, MD, PhD

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Preventing uptake of alpha-synuclein to slow Parkinson’s progression

Abstract. Ribosomes are central to protein synthesis in all organisms. In mammals, the ribosome functional core is highly conserved. Remarkably, two rodent species, the naked mole-rat (NMR) and tuco-tuco, display fragmented 28S ribosomal RNA (rRNA), coupled with high translational fidelity and long lifespan. The unusual ribosomal architecture in the NMR and tuco-tuco has been speculated to be linked to high translational fidelity. Here, we show, by single-particle cryo-electron microscopy, that despite the fragmentation of their rRNA, NMR and tuco-tuco ribosomes retain their core functional architecture. Compared to ribosomes of the guinea pig, a phylogenetically related rodent without 28S rRNA fragmentation, ribosomes of NMR and tuco-tuco exhibit poorly resolved density for certain expansion segments. In contrast, the structure of the guinea pig ribosome shows high similarity to the human ribosome. Enhanced translational fidelity in the NMR and tuco-tuco may stem from subtle, allosteric effects in dynamics, linked to rRNA fragmentation.

Bed Nucleus of Stria Terminalis Enkephalin Neurons Contribute to Depletion-Induced Salt Appetite

The overconsumption of sodium contributes to a wide range of detrimental health conditions. Thus, it is imperative to gain a better understanding of the neural mechanisms driving sodium appetite. Here, we combined neuroanatomic, transgenic, behavioral, and chemogenetic approaches to investigate the role of bed nucleus of stria terminalis (BNST) enkephalin neurons (BNSTENK) in sodium appetite in male and female pENK-Cre mice. Our results demonstrate that Gi-mediated signaling onto BNSTENK neurons regulates salt consumption following sodium depletion but does not impact upon taste preference when replete. Further, Gi-mediated signaling onto BNSTENK neurons had no effect on deprivation-induced food or water intake or anxiety-like behavior.

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How schizophrenia risk may begin: Gene changes reshape signaling in developing neurons

Researchers at King’s College London have identified the biological nature and timing of changes in human cortical neurons caused by altering activity of a schizophrenia-associated gene in developing human neurons. This discovery links a genetic risk factor to cellular changes in neurons; an essential step for understanding the neurobiology of this mental illness and developing future treatments.

Schizophrenia is estimated to be one of the most heritable psychiatric conditions, with a strong developmental aspect. Large-scale human genomic studies have identified many genetic variants which are thought to increase the likelihood of schizophrenia.

However, the link between these genetic risk variants and the underlying neurobiology of schizophrenia is less well understood. Addressing this knowledge gap provides vital information that could ultimately help develop therapies for the disorder.

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