An innovation by a collaboration of US and Chinese scientists achieved nearly 100% voltage recovery in aging lithium-ion batteries.
Category: life extension
Dr. Aubrey de Grey reveals why reversing aging may be easier than slowing it down in this mind-expanding conversation that challenges conventional wisdom about human longevity. The renowned biomedical gerontologist outlines his damage repair approach that’s gaining mainstream scientific acceptance after initial skepticism.
The financial landscape of longevity research has dramatically transformed, with billions flowing into the space. Dr. de Grey provides an insider’s assessment of major players including HEvolution (Saudi-backed), Altos Labs (Bezos-funded), Calico (Google-funded) and Retro Biosciences (Sam Altman’s venture), offering candid insights about which approaches show the most promise and why Google’s Calico has struggled despite substantial resources.
Regulatory innovation emerges as a crucial accelerator for progress. Montana’s groundbreaking expansion of Right to Try legislation now allows anyone to access treatments that have passed FDA safety trials, while special economic zones like Prospera in Honduras are creating regulatory environments specifically designed for biomedical innovation. These developments could create the competitive pressure needed to modernize traditional regulatory structures worldwide.
At the LEV Foundation, Dr. de Grey is conducting a thousand-mouse study combining four different damage repair interventions in middle-aged mice, aiming for a full year of life extension—far beyond the four months typically achieved. Unlike conventional approaches that rely on dietary modifications, this ambitious project incorporates advanced cell and gene therapies that target multiple forms of age-related damage simultaneously.
Looking forward, Dr. de Grey offers his characteristic probabilistic prediction: a 50–50 chance of reaching \.
Meditation has been linked to a slowdown in aging and reduction in stress. Biohacker Dave Asprey speaks with Fox News Digital about the health benefits of
We’re closer than ever to being able to upload our minds and become “digitally immortal.” But should we?
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What if our minds could live after our bodies have died? What if mortality became obsolete? Steven Kotler, award-winning journalist and executive director of the Flow Research Collective, has studied these seemingly sci-fi ideas, and it turns out that they’re not so fictional, after all. In fact, mind-uploading technology is expected to be available as early as 2045.
“Digital immortality” would have its upsides; we could preserve the minds of modern geniuses and have their guidance through future conflicts. Or, alternatively, things could get dark, as we have never before interfered with such complex evolutionary processes. Kotler explains that the ability to store human personalities and consciousness on computers poses profound ethical and societal questions.
By developing and using this mind-uploading technology, we are simultaneously redefining what it means to be a human being, pushing the boundary between life, death, and whatever is in between. It seems, whether we’re ready or not, that it is going to happen soon.
Driven by genetic and environmental factors, aging is a physiological process responsible for age-related degenerative changes in the body, cognitive decline, and impaired overall wellbeing. Notably, premature aging as well as the emergence of progeroid syndromes have posed concerns regarding chronic health conditions and comorbidities in the aging population. Accelerated telomere attrition is also implicated in metabolic dysfunction and the development of metabolic disorders. Impaired metabolic homeostasis arises secondary to age-related increases in the synthesis of free radicals, decreased oxidative capacity, impaired antioxidant defense, and disrupted energy metabolism. In particular, several cellular and molecular mechanisms of aging have been identified to decipher the influence of premature aging on metabolic diseases. These include defective DNA repair, telomere attrition, epigenetic alterations, and dysregulation of nutrient-sensing pathways. The role of telomere attrition premature aging in the pathogenesis of metabolic diseases has been largely attributed to pro-inflammatory states that promote telomere shortening, genetic mutations in the telomerase reverse transcriptase, epigenetic alteration, oxidative stress, and mitochondrial dysfunctions. Nonetheless, the therapeutic interventions focus on restoring the length of telomeres and may include treatment approaches to restore telomerase enzyme activity, promote alternative lengthening of telomeres, counter oxidative stress, and decrease the concentration of pro-inflammatory cytokines. Given the significance and robust potential of delaying telomere attrition in age-related metabolic diseases, this review aimed to explore the molecular and cellular mechanisms of aging underlying premature telomere attrition and metabolic diseases, assimilating evidence from both human and animal studies.
Aging is defined as a physiological phenomenon driven by genetic and biological processes, which are related to the lifespan of an individual and are associated with all age-related pathologies (Li et al., 2021). The aging process increases the susceptibility of individuals to factors leading to death as they grow older. Aging is a complex multifactorial phenomenon that involves the simultaneous interaction between various factors at different levels of functional organization. The role of genetic and environmental factors is represented by the heterogenous aging phenotype across different individuals, hence, these factors influence the lifespan of an individual via the process of aging (Jayanthi et al., 2010). With the deterioration of physiological functions critical to the survival and fertility of humans, the process of aging is known to relate to the notion of natural selection (Gilbert, 2000).
Recent advancements in in-vitro gametogenesis (IVG) suggest that lab-grown eggs and sperm could become viable within the next decade. This technology holds the promise of revolutionizing fertility treatments, particularly for individuals facing infertility and same-sex couples desiring biological children. However, it also raises significant ethical and medical considerations that must be carefully addressed.
The Human Fertilisation and Embryology Authority (HFEA), the UK’s fertility regulator, has reported that the development of lab-grown gametes, known as in-vitro gametogenesis (IVG), may become a practical option within the next decade. This technology involves creating eggs and sperm from reprogrammed skin or stem cells, potentially transforming fertility treatments by removing age-related barriers and enabling same-sex couples to have biological children.
IVG represents a significant advancement in reproductive science. By generating gametes in the laboratory, scientists can overcome challenges associated with traditional fertility treatments. This approach could provide new avenues for individuals with infertility issues and offer same-sex couples the opportunity to have children genetically related to both partners.
Cognitive Performance and Long-term Exposure to Outdoor Air Pollution: Findings from the Harmonised Cognitive Assessment Protocol Sub-Study of the English Longitudinal Study of Ageing (ELSA-HCAP)
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Although air pollution is associated with worse cognitive performance, whether these relationships differ by cognitive domain and which sources of air pollution are particularly detrimental to cognition remains understudied. This study examined associations between cognitive scores across three domains in older adults and 8–10 years of exposure to air pollutants (NO2, total PM2.5, and PM2.5 from different emission sources).
Methods.
We used data from the 2018 Harmonized Cognitive Assessment Protocol sub-study of the English Longitudinal Study of Ageing (N=1,127). Outdoor concentrations of each pollutant were estimated for 2008÷10−2017 and summarised using means and group-based trajectories. Linear regression models were used to assess long-term air pollution exposure relationships with memory, executive function, language, and global cognitive function after adjustment for key individual and neighbourhood-level confounders.
The idea of living forever has fascinated humans for centuries—but what if technology could actually make it happen? With advancements in AI and neuroscience, scientists believe that digital immortality might soon be a reality. Here’s how!
The idea of living forever has fascinated humans for centuries—but what if technology could actually make it happen? With advancements in AI and neuroscience, scientists believe that digital immortality might soon be a reality. Here’s how!
Bcl11a sustains hematopoietic stem cell functionality but contributes to dysfunction as aging progresses.