Our friendly – and not so friendly – gut bacteria lie at the core of healthy ageing. Research is now revealing what it takes to maintain a youthful microbiome
Category: life extension
Nanobiotechnology Unveils the Power of Probiotics: A Comprehensive Review on the Synergistic Role of Probiotics and Advanced Nanotechnology in Enhancing Geriatric Health
The geriatric population, comprising ages 65 and above, encounters distinct health obstacles because of physiological changes and heightened vulnerability to diseases. New technologies are being investigated to tackle the intricate health requirements of this population. Recent advancements in probiotics and nanotechnology offer promising strategies to enhance geriatric health by improving nutrient absorption, modulating gut microbiota, and delivering targeted therapeutic agents. Probiotics play a crucial role in maintaining gut homeostasis, reducing inflammation, and supporting metabolic functions. However, challenges such as limited viability and efficacy in harsh gastrointestinal conditions hinder their therapeutic potential. Advanced nanotechnology can overcome these constraints by enhancing the efficacy of probiotics through nano-encapsulation, controlled delivery, and improvement of bioavailability. This review explores the synergistic potential of probiotics and advanced nanotechnology in addressing age-related health concerns. It highlights key developments in probiotic formulations, nano-based delivery systems, and their combined impact on gut health, immunity, and neuroprotection. The convergence of probiotics and nanotechnology represents a novel and transformative approach to promoting healthy aging, paving the way for innovative therapeutic interventions.
Sam Altman’s longevity startup is testing a pill for a younger brain
I’ve just hopped on a video call with the CEO of Retro Biosciences, the Sam Altman-backed longevity company, when I mention it’s quite hot.
Joe Betts-LaCroix takes my passing comment as a cue to muse on the wonders of air conditioning, and how energy and heat were once synonymous — until they weren’t.
As a multi-hyphenate scientist, entrepreneur, and once-inventor of the world’s smallest computer, Betts-LaCroix is excited by paradigm change.
At the helm of what is essentially Altman’s playground for experimenting with pushing the limits of the human lifespan, Betts-LaCroix is hoping to engineer the same shift that air conditioning brought to hot summer days for your brain and body. Ideally, one day, decouple aging from decline and disease.
The experimental memory pill works by clearing out “gunk in the cells” linked to Alzheimer’s and Parkinson’s, Betts-LaCroix said. If the pill works, it will restart stalled autophagy processes in the body, cleaning up damage, “especially in the brain cells,” he said.
In contrast, other new Alzheimer’s drugs, like Eisai’s Leqembi and Eli Lilly’s Kisunla, slow down cognitive decline by flushing out sticky amyloid plaques that are a hallmark of the disease.
Psilocybin delays aging, extends lifespan, new Emory study suggests
As revenues from the anti-aging market — riddled with hope and thousands of supplements — surged past $500 million last year, Emory University researchers identified a compound that actively delays aging in cells and organisms.
A newly published study in Nature Partner Journals’ Aging demonstrates that psilocin, a byproduct of consuming psilocybin, the active ingredient in psychedelic mushrooms, extended the cellular lifespan of human skin and lung cells by more than 50%.
In parallel, researchers also conducted the first long-term in vivo study evaluating the systemic effects of psilocybin in aged mice of 19 months, or the equivalent of 60–65 human years. Results indicated that the mice that received an initial low dose of psilocybin of 5 mg/kg, followed by a monthly high dose of 15 mg/kg for 10 months, had a 30% increase in survival compared to mice who hadn’t received any. These mice also displayed healthier physical features, such as improved fur quality, fewer white hairs and hair regrowth.
Emory University researchers identified that psilocin, a byproduct of consuming psilocybin, the active ingredient in psychedelic mushrooms, actively delays aging in cells and organisms.
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Feudal Futures: Knights & Nobles in the Space Age
Feudalism once ruled Earth—could it rule the cosmos too? We dive into the strange but plausible world of space nobles, orbital dukes, and knights of the vacuum clad in power armor or piloting mecha.
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Feudal Futures — Knights & Nobles in the Space Age.
Written, Produced & Narrated by: Isaac Arthur.
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Chapters.
0:00 Intro.
0:12 Feudalism… IN SPACE!!!? Knights, Mechs, and Space Lords.
5:04 Lords of the Vacuum – Whoever Builds the Habitat, Owns the Habitat.
9:10 Feudal Claims on Natural Resources.
14:31 Vassalage in Vacuum – How Loyalty Could Work in Space.
18:20 Breaking the Mold – Alternative Models to Feudal Ownership.
20:52 Natural Armor.
22:12 Would It Work? Or Collapse Gloriously?
23:38 The Knight Reforged – Power Armor, Mechs, and Weapons of Mass Respect.
25:12 A New Middle Ages Among the Stars?
‘Young’ immune cells reverse signs of neurodegenerative brain changes in preclinical study
“Young” immune cells created by Cedars-Sinai investigators reversed signs of aging and Alzheimer’s disease in the brains of laboratory mice, according to a study published in the journal Advanced Science.
The immune cells, which were produced from human stem cells, could be used to develop new treatments for neurological conditions in humans.
“Previous studies have shown that transfusions of blood or plasma from young mice improved cognitive decline in older mice, but that is difficult to translate into a therapy,” said Clive Svendsen, Ph.D., executive director of the Board of Governors Regenerative Medicine Institute and senior author of the study.