Archive for the ‘life extension’ category

Mar 13, 2024

9 Ways to Live to 100 And Have Fun While Doing It, According to Longevity Experts

Posted by in category: life extension

A National Geographic explorer reveals the “Power Nine” — qualities that residents of Blue Zones, regions where the average life expectancy is higher than the rest of the world, have in…

Mar 12, 2024

A cancer researcher shares 2 supplements she takes for healthy aging — and how to decide if they work for you

Posted by in categories: biotech/medical, life extension

Vitamin D and calcium supplements appear to lower cancer risk. While the combo may also lead to more heart issues, the researcher says she decided it’s worth it for her.

Mar 10, 2024

The next breakthrough for longevity obsessives: measuring organ age

Posted by in categories: biotech/medical, life extension, neuroscience

Knowing your “oldest organ” might also tell you more about your health trajectory — and the age-related diseases you could develop — than your biological age. The study found that individuals with accelerated heart aging, for example, have a 250% higher risk of heart failure. Every additional four years of age increased an individual’s risk of developing heart disease by almost 2.5-fold over 15 years, the study noted. It also found that accelerated brain and vascular aging in an individual can predict the progression of Alzheimer’s disease as strongly as the best biomarker test for the disease.

The technology to measure age organ-by-organ is far from ready to mainstream. Still, the concept has attracted the interest of those in longevity circles, according to The Wall Street Journal. Some researchers told the Journal that there may be a day when patients can test the age of their organs through a simple blood test. It’s not a far-off idea, given that there are already blood tests that can test for cancer.

However, some scientists believe there’s little merit in providing patients with these details before we devise interventions for them.

Mar 10, 2024

Uric Acid: What’s Optimal For Health?

Posted by in categories: genetics, life extension

Join us on Patreon! Links: Epigenetic, Telomere Testing:

Mar 9, 2024

Beyond Telomerase: The Quest for Chromosome Immortality

Posted by in categories: biotech/medical, life extension

Recent research challenges the long-standing understanding of the end-replication problem in DNA, revealing two distinct issues rather than one.

Half a century ago, scientists Jim Watson and Alexey Olovnikov independently realized that there was a problem with how our DNA gets copied. A quirk of linear DNA replication dictated that telomeres that protect the ends of chromosomes should have been growing shorter with each round of replication, a phenomenon known as the end-replication problem.

Continue reading “Beyond Telomerase: The Quest for Chromosome Immortality” »

Mar 9, 2024

A small-molecule TNIK inhibitor targets fibrosis in preclinical and clinical models

Posted by in categories: biotech/medical, life extension, robotics/AI

On the way to rejuvenation using AI and multidisciplinary knowledge!

An AI-generated small-molecule inhibitor treats fibrosis in vivo and in phase I clinical trials.

Mar 9, 2024

Fireside Chat with Bryan Johnson, Aubrey De Grey, and Laurence Ion | Vitalia

Posted by in categories: humor, life extension

Couple things. Mr Johnson is self aware and has a sense of humor about it. And another argument you can use against the overpopulation people is that there is currently one acre of habitable land available for every person on the planet.

Mar 9, 2024

3D Molecular Maps of the Brain: Unveiling Complexity with Spatial Omics

Posted by in categories: bioengineering, biotech/medical, chemistry, life extension, robotics/AI

“If you look at the brain chemically, it’s like a soup with a bunch of ingredients,” said Dr. Fan Lam.

Can we map the brain to show its behavior patterns when a patient is healthy and sick? This is what a recent study published in Nature Methods hopes to address as a team of researchers at the University of Illinois Urbana-Champaign used a $3 million grant obtained from the National Institute of Aging to develop a novel approach to mapping brain behavior when a patient is both healthy and sick. This study holds the potential to help researchers, medical professionals, and patients better understand how to treat diseases.

“If you look at the brain chemically, it’s like a soup with a bunch of ingredients,” said Dr. Fan Lam, who is an assistant professor of bioengineering at the University of Illinois Urbana-Champaign and a co-author on the study. “Understanding the biochemistry of the brain, how it organizes spatiotemporally, and how those chemical reactions support computing is critical to having a better idea of how the brain functions in health as well as during disease.”

Continue reading “3D Molecular Maps of the Brain: Unveiling Complexity with Spatial Omics” »

Mar 9, 2024

Striking Similarities Between Aging & Schizophrenia are Revealed

Posted by in categories: life extension, neuroscience

Scientists have revealed surprising parallels between aging and schizophrenia. There seem to be similar patterns of gene activity in the brains of people who are aging, and in those with schizophrenia. The same mechanisms may underlie the cognitive disruptions seen in older adults and people with schizophrenia. The findings have been reported in Nature.

In this work, the researchers analyzed gene expression at the single-cell level in post-mortem brain samples from 94 people with schizophrenia and 97 unaffected individuals. This gene activity was altered in two types of cells found in the brain, both neurons and astrocytes. In all, 1.2 million cells from were analyzed. This showed that in neurons, expression changed in genes that are associated with portions of synapses, the space where neurons meet and communicate; and in astrocytes, in genes that are related to synaptic function.

Mar 9, 2024

Humans aren’t overpopulated. We’re aging and shrinking

Posted by in category: life extension

Too few babies — not — is likely to be a major problem this century.

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