Gutierrez and Tyler investigate the limits of replicative lifespan in yeast. The authors show that nucleolar expansion during aging is a mortality timer. Enlargement of nucleoli beyond a defined size alters their biophysical properties; normally excluded DNA repair protein enter, causing aberrant rDNA recombination, genome instability and death.
Interesting item on biological clocks, and other things.
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Here Liz talks about her personal experience with gene therapy and the innovations, the state of the industry and what the future holds. The therapies exist why is it so difficult to make them available!?
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There are a multitude of products for sale that promise the appearance of eternal youth by erasing wrinkles or firming up jaw lines; but what if we could truly turn back time, at the cellular level? Now, researchers from Japan have found a protein that may do just that.
In a study published this month in Cellular Signaling, researchers from Osaka University have revealed that a key protein is responsible for toggling between ‘young’ and ‘old’ cell states.
As we age, older, fewer active cells, known as senescent cells, accumulate in multiple organs. These cells are noticeably larger than younger cells, and exhibit altered organization of stress fibers, the structural parts of cells that help them move and interact with their environment.
Follow one of these two diets to lower your risk of developing cancer and increase your chances of living longer, says longevity expert.
There are a multitude of products for sale that promise the appearance of eternal youth by erasing wrinkles or firming up jaw lines; but what if we could truly turn back time, at the cellular level? Now, researchers from Japan have found a protein that may do just that.
In a study published this month in Cellular Signaling, researchers from Osaka University have revealed that a key protein is responsible for toggling between “young” and “old” cell states.
As we age, older and less active cells, known as senescent cells, accumulate in multiple organs. These cells are noticeably larger than younger cells, and exhibit altered organization of stress fibers, the structural parts of cells that help them move and interact with their environment.
Based on a systematic analysis of environmental exposures associated with aging and mortality in the UK Biobank, the relative contributions of such exposures and genetic risk for mortality and a range of age-related diseases were compared, highlighting the potential beneficial effects of environment-focused interventions.
Hey everyone! Robin Hanson will be speaking on Thursday about his galaxy brain ideas on better incentive models for longevity. Plus his unique takes on prediction markets and long-term thinking. [ https://lu.ma/wzuwk1lp](https://lu.ma/wzuwk1lp)
Join us for a groundbreaking discussion with economist Robin Hanson on the future of longevity economics and city governance!
“Our findings suggest that senescent cells maintain their large size through improved adhesion to the extracellular matrix via AP2A1 and integrin β1 movement along enlarged stress fibers,” Chantachotikul said.
The link between AP2A1 and senescent cells, the researchers said, means the protein has the potential to be used as a marker for cellular aging.
The team also believes that the findings may offer a new target for future treatments of age-related diseases.
UCLA Broad Stem Cell Research Center member Ranmal Samarasinghe, MD, PhD presents his work using brain organoids to create better models of neurological disorders. An Assistant Professor in UCLA’s Neurology department, Dr. Samarasinghe splits his time between the clinic, seeing patients who have neurological conditions like epilepsy and autism, and in the lab working to create more detailed disease models using brain organoids. In this video, Dr. Samarasinghe discusses how brain organoids are becoming more sophisticated in their ability to replicate irregular brain wave patterns seen in conditions like Rett syndrome, an epilepsy primarily associated with infants. Ultimately, he hopes these stem cell-based models can be used to screen new drugs and discover new treatments for diseases like epilepsy.
Learn more about Dr. Samarasinghe’s work here:
https://stemcell.ucla.edu/member/sama… the full “The Power of Regenerative Medicine: Future Treatments for Brain Disease” webinar: • The Power of Regenerative Medicine: F…
Watch the full \.
Health, vitality and longevity through bioengineering — kevin caldwell — CEO, ossium health.
Kevin Caldwell is CEO, Co-Founder & President of Ossium Health (https://ossiumhealth.com/), a commercial stage bioengineering company that leverages its proprietary organ donor bone marrow banking platform to develop stem cell therapies for patients with life-threatening hematologic conditions, organ transplant rejection, and musculoskeletal defects.
Mr. Caldwell built Ossium from a small startup into the clinical stage bioengineering company it is today, setting the company’s mission to improve human health through bioengineering and designed its platform-based model for cellular therapeutics development. He has led the company’s successful pursuit, negotiation, and execution of more than 50 business relationships, including 5 successful fundraisings and dozens of supply partnerships, clinical partnerships, and commercial contracts with biopharmaceutical companies.
