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Ca2+-phospholipid-dependent regulation of Munc13-1 is essential for post-tetanic potentiation at mossy fiber synapses and supports working memory

LĂłpez-Murcia et al. demonstrate that Ca2+-dependent regulation of the vesicle-priming protein Munc13-1 supports synaptic short-term facilitation and post-tetanic potentiation at hippocampal mossy fiber synapses. Disruption of this regulatory mechanism is associated with impaired working memory formation.

Does Entropy Control Time?

In this episode, Neil deGrasse Tyson and Chuck Nice speak with physicist Sean Carroll about whether entropy actually creates time. Sean explains that entropy does not generate time itself, but it gives time an arrow—a direction from past to future. Even if the universe were to stop expanding and begin collapsing, entropy would still increase. The key distinction is between time (which can exist without direction) and the arrow of time, which entropy provides through statistical mechanics and phase space dynamics.

From ‘The Complex Universe, with Sean Carroll’: ‱ The Complex Universe, with Sean Carroll.

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Machine Learning–Based Sleep EEG Brain Age Index and Dementia Risk

Machine learning models using sleep EEG can generate a brain age index, and a higher BAI was validated as a prognostic marker for increased risk of future Dementia, suggesting BAI may help in early digital risk stratification.


This individual participant data meta-analysis explores the association between a machine learning–based sleep electroencephalography (EEG) brain age index and dementia risk among community-dwelling adults from 5 longitudinal cohorts.

Genius 10 Year Old’s Research Shocks Scientists Around the World

How do we evolve/survive?


At just 10 years old, Jo Nagai conducted an experiment that would surprise scientists around the world.

By raising and training swallowtail caterpillars at home, Jo demonstrated that butterflies can retain memories formed during their larval stage, even after undergoing complete metamorphosis. But what he discovered next was even more unexpected: those learned responses appeared to persist to the next generation.

This video explores Jo’s experiment, the scientific ideas behind it, and the simple question that started it all.

#research #science #nature #animals #animalbehavior #discovery #butterfly.

Caudal Granular Insular Cortex to Somatosensory Cortex I: A Critical Pathway for the Transition of Acute to Chronic Pain

Small-molecule enhancement of METTL3 S-palmitoylation as a therapeutic strategy for osteoarthritis.


METTL3 undergoes S-palmitoylation, which promotes cytoplasmic phase separation to facilitate mRNA translation and maintain its stability. We identify a small molecule that enhances this modification, providing a mechanistic basis for a potential osteoarthritis therapy.

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