Sean P. Pitroda & Ralph R. Weichselbaum provide a Commentary on Iowis Zhu et al.: https://doi.org/10.1172/JCI195652
Address correspondence to: Ralph Weichselbaum, Department of Radiation and Cellular Oncology, The University of Chicago, 5,758 S. Maryland Ave., Chicago, Illinois 60,637, USA.
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Department of radiation and cellular oncology, the university of chicago, chicago, illinois, USA.
Satapathy et al. demonstrate that prostaglandin E2 promotes YAP-dependent nuclear translocation of PD-L1 via importin-α3. In the nucleus, PD-L1 cooperates with YAP-TEAD to enhance transcriptional activity, revealing a noncanonical role for PD-L1 in regulating oncogenic gene expression beyond immune evasion.
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: Intensity-modulated radiation therapy (IMRT) is increasingly used for total body irradiation (TBI) due to its ability to deliver myeloablative doses while sparing radiosensitive organs. To enable consistent evaluation in future National Clinical Trials Network (NCTN) studies, the xxx Hematologic Malignancies Working Group (HMWG) convened IMRT-TBI experts and NCTN leaders to develop consensus recommendations for standardized multi-institutional implementation.
Think about the last time you told a story to a friend. You probably adjusted it halfway through. You saw their eyebrows lift. You noticed them lean in, or glance away. You clarified a detail. You sped up the ending. That constant fine-tuning is not a bonus feature of communication: it is communication. And you can read all about this real-time coordination process in a new review by Judith Holler and Anna K. Kuhlen (Max Planck Institute for Psycholinguistics), published in Nature Reviews Psychology.
Holler and Kuhlen argue that conversation is not simply one person speaking while another listens. It is a process in which both participants continuously monitor, predict, and shape each other’s behavior. “Conversation is not a linear exchange of words,” Holler writes. “It is a jointly managed activity in which meaning emerges through coordination.”
For the first time, researchers in France and Israel have observed how an emulsified liquid droplet can transform from a hexagon into a six-pointed star shape in response to rising temperature. Publishing their results in Physical Review Letters, a team led by Eli Sloutskin at Bar-Ilan University has shed new light on the mechanisms underlying this striking behavior, revealing a previously unseen form of “nano-origami,” that could inspire future generations of self-assembling nanostructures.
When tiny amounts of liquid are isolated, surface tension usually drives them to adopt a spherical shape—but over the past decade, researchers have uncovered far more complex behavior in emulsions of oil and water. In these systems, droplets are stabilized by surfactant molecules, which reduce the surface tension between the two liquids.
Under carefully controlled temperature changes, these droplets can undergo dramatic shape transformations. Previous studies have shown spheres turning into icosahedra, and then flattening into triangular, parallelogram or hexagonal, lens-like shapes with exclusively convex edges.
Noise in bacterial stress responses is often dismissed as mere randomness. While true stochasticity exists, much variation reflects hidden variables—cell state, history, and microenvironment—that are only now becoming measurable. Choudhary and Vincent review emerging tools that disentangle chance from determinism, moving microbiology toward more mechanistic and predictive frameworks.
