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Microsoft Self-Service Password Reset abused in Azure data theft attacks

A threat actor targeting Microsoft 365 and Azure production environments is stealing data in attacks that abuse legitimate applications and administration features.

Microsoft tracks the actor as Storm-2949 and says that the purpose of the attacks is “to exfiltrate as much sensitive data from a target organization’s high-value assets as possible.”

Storm-2949 used social engineering to target users with privileged roles, such as IT personnel or members of senior leadership, and obtain their Microsoft Entra ID credentials to gain access to data in Microsoft 365 applications.

Peptides as Versatile Regulators in Cancer Immunotherapy: Recent Advances, Challenges, and Future Prospects

The emergence of effective immunotherapies has revolutionized therapies for many types of cancer. However, current immunotherapy has limited efficacy in certain patient populations and displays therapeutic resistance after a period of treatment. To address these challenges, a growing number of immunotherapy drugs have been investigated in clinical and preclinical applications. The diverse functionality of peptides has made them attractive as a therapeutic modality, and the global market for peptide-based therapeutics is witnessing significant growth. Peptides can act as immunotherapeutic agents for the treatment of many malignant cancers. However, a systematic understanding of the interactions between different peptides and the host’s immune system remains unclear.

Hiring a Futurist? The Red Flag Most Leadership Teams Miss

When a leadership team hires a futurist to think about the future for them, the hire itself is the failure.

I say this as someone who gets booked to think about the future.

Executives increasingly hire futurists, consultants, and now AI tools to handle their thinking about what comes next. It feels like rigor. It looks like preparation. It is, in fact, an abdication.

Nobody can tell you what is coming with the precision your strategy deck assumes. Not a futurist. Not a consultant. Not an AI system trained on every word ever written. Plenty of people sell certainty about the future. Nobody can actually deliver it.

So how do you tell whether you are using a futurist well, or whether the booking itself is the warning sign?

I wrote a short piece arguing that the answer comes down to one question every executive should ask before signing the contract.

Full piece: [ https://www.singularityweblog.com/hiring-a-futurist/](https://www.singularityweblog.com/hiring-a-futurist/)

3D epithelial cell topology tunes signaling range to promote precise patterning

Cell behaviors in multicellular organisms are coordinated via both diffusible molecules and by signals based on direct cell–cell contacts. The mode of cell communication used influences the signaling range. In many developing epithelia, contact-based Notch-Delta lateral inhibition signaling is used to pattern cell fates. While previous work revealed that cells can use protrusions to extend the range of Notch-Delta signaling to alter these patterns, this is not a general feature of epithelia. In addition, it is not known how the complex three-dimensional (3D) shapes of epithelial cells influence cell communication. In exploring this question, we show that epithelial cells at the Drosophila wing margin, which lack basal protrusions, contact different neighbors at different heights along their apico-basal axis, effectively increasing the number of neighbors each cell touches.

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