A new ring-shaped resonator for light can do a job that normally requires at least two rings.
Category: futurism
Fantastic fungi found with ability to freeze water
Can fungi influence the weather? Turns out, they just might. An international group of researchers that includes Virginia Tech’s Xiaofeng Wang and Boris A. Vinatzer discovered the identity of fungal proteins that can catalyze ice formation at high subzero temperatures. The research is published in Science Advances. One potential application of this discovery could be to engineer weather.
Dendrite-Targeting Inhibitory Interneurons Form Biased Circuits with Deep and Superficial Pyramidal Cells in Hippocampal CA1
JNeurosci: Johantges et al. used mice to study excitatory and inhibitory synaptic connections in the CA1 region, creating a circuit map with cell-type resolution that will guide future research on how the hippocampus supports learning and memory.
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In the CA1 hippocampus, pyramidal cells (PCs) can be classified as deep or superficial based on their radial position within the stratum pyramidale. Deep and superficial PCs form biased circuits with perisomatic-targeting PV+ basket cells, but it is unknown if such cell-type–specific circuit motifs extend to dendrite-targeting interneurons. Using male and female mice, we investigated synaptic connectivity and physiology in brain slices from four transgenic lines thought to capture distinct subsets of interneurons: SST-IRES-Cre, Nkx2.1-Cre, Chrna2-Cre, and Htr3a-GFP. First, we found that oriens-lacunosum moleculare (OLM) cells captured by the Chrna2-Cre line are a subset of Htr3a-GFP+ cells in the hippocampus. This novel finding is consistent with previous work showing Nkx2.1-Cre OLM cells are distinct from both Chrna2-Cre and Htr3a-GFP+ OLM cells.
Nuclear import of malaria RNA rewires splicing in host immune cells
Abou Karam et al. identify a cell communication mechanism used by the malaria parasite Plasmodium falciparum. The parasite delivers its mRNAs into monocytes and imports them into their protected nuclei, where they perturb the splicing. This extracellular RNA-based strategy disrupts host transcript processing and immune signaling, revealing another layer of host interference.
Pathogen effector disarms circadian-immune crosstalk by targeting TCP14, a dual regulator of clock and defense
Wang et al. identify the transcription factor TCP14 as a critical nexus linking the circadian clock and plant defense. The study reveals how the pathogen effector HaRxL21 hijacks this connection by recruiting TPL/TPR1 repressors to disarm TCP14, thereby providing a mechanistic understanding of how pathogens overcome circadian-gated immunity.
Serum Magnesium Levels and Intraparenchymal Hemorrhage After Mechanical Thrombectomy
In an observational cohort study, serum magnesium was not a strong predictor of hemorrhagic transformation after mechanical thrombectomy. stroke.
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Resident Macrophages Play a Role in Maintaining Murine Intraocular Pressure
Through their study, the researchers tracked fluorescently tagged resident tissue macrophages in mouse eyes. When they selectively removed these cells, the eye’s drain, or outflow, became clogged, fluid built up, and eye pressure increased.
The discovery could lead to the development of future glaucoma treatments. The next step will be research to identify these resident macrophages in human eye tissue. “This research helps us understand the role of the immune system in regulating eye pressure,” said Katy Liu, MD, PhD, assistant professor in the department of ophthalmology at Duke University School of Medicine. “Our findings show that resident macrophages are essential for maintaining healthy eye pressure,” said Liu. “Disruption of this system may contribute directly to the development of glaucoma.”
Added W. Daniel Stamer, PhD, the Joseph A.C. Wadsworth Distinguished Professor of Ophthalmology, and co-vice chair for basic science research, “Now we have a specific target for developing new therapies that can normalize the eye pressure and stop vision loss, in contrast to current medications that do not target the source of disease.”
Study shows spiral sound can shift sideways
A new University of Mississippi study shows that some sound waves don’t just move forward—they also move slightly to the side. Understanding this movement could help researchers develop more precise acoustic tools. Likun Zhang, associate professor of physics and astronomy and senior scientist at the National Center for Physical Acoustics, published his team’s study on the behavior of spiral sound waves in Physical Review Letters.
The experiment is the first measurement of the Hall Effect as it applies to acoustics. The Hall Effect occurs when something traveling forward—traditionally an electric current—is deflected slightly to the side by an external influence such as a magnetic field.
“About five years ago, our group extended the concept of the Hall Effect to acoustics, where we predicted that this would be the case,” Zhang said. “But this follow-up is the first time that we’ve been able to say, experimentally, ‘Here is that shift, and we can prove that it’s there.’”