Lifeboat Foundation

In a new study published in PLOS Computational Biology, an international research team from the Max Planck Institute for Evolutionary Biology, Cardiff University, and Google has reexamined Robert Axelrod’s groundbreaking work.

By simulating more than 195 strategies in thousands of tournaments, the study revealed that success in the Iterated Prisoner’s Dilemma depends heavily on adaptation to diverse environments. Strategies that excelled in Axelrod’s controlled scenarios often failed when faced with a wider variety of opponents. Winning strategies are not only nice and reciprocal but also clever, slightly envious, and adaptable to the surrounding conditions.

The Prisoner’s Dilemma, a classic game in game theory, presents players with the choice to cooperate or defect. Mutual cooperation results in moderate rewards for both players, while unilateral defection yields a high reward for the defector and a significant loss for the cooperator. If both players defect, they receive less than they would through mutual cooperation. This tension between individual and collective benefit has made the game a model for decision-making in economics, politics, and biology.

Explore Sam Altman’s predictions on Artificial Super Intelligence (ASI), its risks, and its potential to reshape industries, economies and.

This is according to AI ethicists from the University of Cambridge, who say we are at the dawn of a “lucrative yet troubling new marketplace for digital signals of intent”, from buying movie tickets to voting for candidates. They call this the Intention Economy.

Researchers from Cambridge’s Leverhulme Centre for the Future of Intelligence (LCFI) argue that the explosion in generative AI, and our increasing familiarity with chatbots, opens a new frontier of “persuasive technologies” – one hinted at in recent corporate announcements by tech giants.

“Anthropomorphic” AI agents, from chatbot assistants to digital tutors and girlfriends, will have access to vast quantities of intimate psychological and behavioural data, often gleaned via informal, conversational spoken dialogue.

“The ultimate goal is to extend healthspan—meaning the number of years aging adults live healthy lives and enjoy overall well-being by compressing the frailty and disability that comes with aging into a shorter duration of time near the end of life,” says Andrew Brack, PhD, the PROSPR Program Manager.

The new venture will be building on some of the work that the National Institute of Aging (NIH) has been working on and will be working in collaboration with various organizations in the biotechnology industry as well as some unspecified regulators to accelerate the development, testing, and availability of new therapeutic that targets human healthspan.

It is hoped that the new initiative, along with positively impacting the healthspan of Americans, will also help to enhance the economy across the nation.

The work-related death rate fell 95% in the U.S. between 1913 & 2015.

Labor union activism is often credited with the decline, but economic expansion is what made better working conditions possible in the first place.

Read more about this trend.

Continue reading “Work Grows Safer” »

Teams designing AI should include linguistics and philosophy experts, parents, young people, everyday people with different life experiences from different socio-economic backgrounds.

Employment and production typically move from agriculture to manufacturing to services, as part of a natural progression that comes with rising income. In Asia, factories have propelled economies, but a transition to modern services could be a new source of growth and productivity. Our blog explains.

Manufacturing has been the engine of growth in Asia, but a transition to modern, tradable services could be new source of growth and productivity.

Although each condition occurs in a small number of individuals, collectively these diseases exert a staggering human and economic toll because they affect some 300 million people worldwide. Yet, with a mere 5 to 7 percent of these conditions having an FDA-approved drug, they remain largely untreated or undertreated.

Developing new medicines represents a daunting challenge, but a new artificial intelligence tool can propel the discovery of new therapies from existing medicines, offering hope for patients with rare and neglected conditions and for the clinicians who treat them.

The AI model, called TxGNN, is the first one developed specifically to identify drug candidates for rare diseases and conditions with no treatments.

Continue reading “Using AI to repurpose existing drugs for treatment of rare diseases” »

The Advanced Research Projects Agency for Health (ARPA-H), an agency within the U.S. Department of Health and Human Services (HHS) announced a new funding opportunity through the launch of the PROactive Solutions for Prolonging Resilience, or PROSPR, program. The big question that drives the program is, “What if we had therapies to extend healthspan and prevent the onset of age-related diseases?”

ARPA-H PROSPR Program Manager Andrew Brack, Ph.D., says, “the ultimate goal is to extend healthspan—meaning the number of years aging adults live healthy lives and enjoy overall well-being by compressing the frailty and disability that comes with aging, into a shorter duration of time near the end of life.” The PROSPR program builds on foundational work by the National Institute of Aging and will work with industry and regulators to accelerate the testing and availability of new therapeutics targeted at healthspan.

This commitment by ARPA-H is not only an investment in national health, but an impactful economic investment. The number of people 65 and older accounts for 18% of the U.S. population and is projected to increase to 23% by 2054. Considering their increased care needs relative to younger ages, health care costs will increase by 75% if nothing is done to prevent the progressive loss of physical functioning during aging, according to a Pew Research Center Study. It is estimated that increasing the average American healthspan would lessen health care costs due to a combination of fewer medical needs, less reliance on assistance by others, and increased potential for individuals and their family caregivers to remain in the workforce. Because of these and other factors, it is estimated that extending healthspan by one year in only 10 percent of the aging population would reduce costs of U.S.