Yann LeCun said:
BREAKING: Schmidhuber claims to have invented JEPA in 1992!
Is anyone surprised?
At some point, when I have nothing better to do, I’ll write a piece about what it means to invent something.
Speaking of which, one day, when I was still in high school, I wrote f(x)=0.
Every theory, every algorithm, is a special case of this (with proper definitions for f and x).
Every technology is a practical application of it.
Signaling is fundamental to how cells sense and respond to their environment—but in immune cells, those signals must be precisely amplified to mount an effective defense against invasive threats. New research by immunologists in Germany is shedding light on how that amplification occurs in T cells, revealing a key molecular mechanism that helps trigger immune responses—and may also contribute to inflammatory conditions.
Writing in Science Signaling, researchers at the University Medical Center Hamburg-Eppendorf identified a crucial step in the production of a “second messenger,” an internal signal that relays and amplifies messages received at the cell surface. Because external signaling molecules cannot enter the cell, second messengers translate those cues into powerful intracellular responses.
In T cells, that process depends on NAADP (nicotinic acid adenine dinucleotide phosphate), a molecule that drives calcium (Ca²⁺) signaling—an essential step in T cell activation. Without it, T cells cannot become the effector cells needed to fight serious threats, such as infections or cancer.
Join us as we countdown to launch of Artemis II from historic Launch Complex 39B at NASA Kennedy Space Center in Florida.
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Artemis II Moon Rocket Launch LIVE: NASA’s Artemis II Live Views from Kennedy Space Center, FL | CNBC TV18
LIVE feed from Kennedy Space Center in Florida will provide continuous views of the Artemis II Moon rocket beginning on Thursday, March 19, with rollout from the Vehicle Assembly Building to Launch Pad 39B. NASA Sends Astronauts around the Moon for the first time in 50 years.
Live view of the Artemis II Moon rocket. While the Artemis II launch window opens as early as Wednesday, April 1, the mission management team will assess flight readiness across the spacecraft, launch infrastructure, and the crew and operations teams before selecting a launch date. NASA’s Artemis II mission is scheduled to lift off from Kennedy Space Center on April 1. The two-hour launch window starts at 6:24 p.m. EDT (2224 UTC).
Four astronauts — three from NASA and one from the CSA (Canadian Space Agency) — make up the Artemis II crew:
NASA astronaut Reid Wiseman, Artemis II commander.
NASA astronaut Victor Glover, Artemis II pilot.
NASA astronaut Christina Koch, Artemis II mission specialist.
Canadian Space Agency (CSA) astronaut Jeremy Hansen, Artemis II mission specialist.
After launching into space atop NASA’s Space Launch System (SLS) rocket, the crew will journey around the Moon and back in their Orion spacecraft, named Integrity, on an approximately 10-day mission. Artemis II will be the first crewed flight test of SLS and Orion, testing the technologies we’ll need for long-term lunar exploration and human missions to Mars.
#nasa #artemislaunch #artemis2 #nasaastronauts #rocketlaunch #cnbctv18 #livestream.
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“These spaceflights will be slotted in our manifest immediately after we fly the current members of our founding astronaut community, many of whom have been anticipating their spaceflight for several years,” he said.
The company started ticket sales about two decades ago and says it currently has a backlog of more than 650 customers. In its annual report for 2024, filed in February 2025, the company said it had a backlog of about 700 customers as of the end of 2024.
Virgin Galactic reported $2 million in revenue for 2025 and a net loss of $279 million. It ended the year with $338 million in cash and equivalents on hand.
Why are some people unable to hear from birth, even though their inner ear appears intact? One possible cause lies in the so-called OTOF gene. It plays a central role in transmitting sound signals from the hair cells to the auditory nerve. Without this function, acoustic information does not reach the brain.
Researchers from the German Primate Center—Leibniz Institute for Primate Research, the University Medical Center Göttingen, and the Max Planck Institute for Multidisciplinary Sciences have now, for the first time, generated marmosets in which this gene has been knocked out precisely. The animals are healthy and develop normally, but are deaf from birth. This provides the first primate model that realistically replicates key characteristics of human deafness. The results are published in Nature Communications.
Hearing loss is one of the most common congenital sensory disorders in humans. A major cause is a defect in the OTOF gene. This gene ensures that the protein otoferlin is produced in the inner ear. This protein is necessary for sound signals to travel from the hair cells to the auditory nerve. Without it, the ear still functions externally, but the signals do not reach the brain.
In this large, international cohort, contrast-associated acute kidney injury occurred in approximately 1 in 20 endovascular thrombectomy-treated patients with acute ischemic stroke and was independently associated with poor outcomes. A simple preprocedural risk score enables early identification of high-risk individuals and may support preventive strategies.
Background and Objectives.
This debate took place in Marist College on Friday September 8th 2023. It was one of the public components of a conference on the topic of panpsychism organised by Andrei Buckareff and Philip Goff, as part of the Templeton funded project ‘Panpsychism and Pan(en)theism: Philosophy of Religion meets Philosophy of Mind.’ https://sites.google.com/view/panpsyc…
Filmed and edited by Jay Shapiro.
POEMS (Polyneuropathy, Organomegaly, Endocrinopathy, M-protein and Skin changes) syndrome is a rare multisystem disorder where early identification is essential for better long term outcomes. Yet it is often misdiagnosed. Gonçalves et al review the condition here:
https://jnnp.bmj.com/content/early/2026/01/30/jnnp-2025-…e=facebook.
And this is a related editorial: https://jnnp.bmj.com/content/early/2026/01/30/jnnp-2025-…e=facebook
Polyneuropathy, Organomegaly, Endocrinopathy, M-protein and Skin changes (POEMS) syndrome is a rare multisystemic disorder associated with plasma cell dyscrasia, most commonly presenting with peripheral neuropathy. Due to its complex and heterogeneous clinical presentation, misdiagnosis is frequent, particularly with chronic inflammatory demyelinating polyradiculoneuropathy, which often leads to delays in appropriate management. Peripheral nerve involvement in POEMS syndrome is predominantly demyelinating, typically accompanied by early axonal degeneration. Specific clinical, neurophysiological and imaging features are key to differentiating POEMS from other acquired demyelinating neuropathies.