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Large trial shows bone healing ‘superpower’ in children

Broken wrists are among the most common injuries in children, accounting for about half of children’s fractures. Severely displaced distal radial fractures, where the bones move out of place, are often routinely treated with surgery. However—unlike adults—children have a remarkable ability to straighten broken bones, in a process called remodeling. Researchers questioned whether a plaster cast would achieve the same long-term result without exposing children to the risks of an operation.

In a major U.K. trial led by researchers at the University of Oxford, they found that most children with a severely broken wrist can be treated without surgery. The findings, published in The Lancet, suggest that a nonsurgical, cast-first approach delivers similar long-term recovery while reducing the risks associated with surgery and costs.

Professor Matt Costa, senior author and Professor, Orthopedics Trauma Surgery at the Kadoorie Institute, University of Oxford, said, “These fractures can look very severe on an X-ray, which has traditionally led to surgery to straighten the bone. But because children’s bones are still growing, they have a remarkable capacity to heal. Until now, there has been limited high-quality evidence on whether surgery was always necessary.”

Ancient viruses serve as gene delivery couriers to help bacteria resist antibiotics

Research has shed important new light on the enemies-turned-allies that allow bacteria to exchange genes, including those linked to antimicrobial resistance (AMR). The insights, which expand our understanding of the major global health threat of AMR, came as John Innes Center researchers investigated the curious phenomena of gene transfer agents (GTAs).

These gene-carrying particles look like bacteriophages (viruses that infect bacteria), but they have been domesticated from ancient viruses and put to beneficial use under the control of the bacterial host cell.

Acting as couriers, they take up parcels of host bacterial DNA and deliver them to neighboring bacteria. This “selfless” sharing, known as horizontal gene transfer, can rapidly spread useful traits including genes that confer resistance to antibiotic drugs used to treat infections.

A student-led experiment sets new limits in the search for axions

In the era of precision cosmology, research often means big science: large observatories, highly complex instruments, international collaborations and substantial funding. Yet even in such an advanced field, progress is still possible—including in the search for elusive dark matter—through more agile approaches, driven by small teams and young researchers, supported by institutions and a good dose of ingenuity.

In a paper titled “A New Limit for Axion Dark Matter with SPACE” published in the Journal of Cosmology and Astroparticle Physics, a group of then-undergraduate students from the University of Hamburg built a cavity detector to search for axions—among the most promising candidates for dark matter—and set new experimental limits on their properties.

The result was achieved with relatively limited resources, showing that even small-scale experiments can make a meaningful contribution to one of the most open challenges in modern physics.

‘Dancing jets’ from black hole reveal an immense power equivalent to 10,000 suns

New Curtin University-led research has used a radio telescope that spans Earth to snap images that measure the immense power of jets from black holes, confirming scientists’ theories of how black holes help shape the structure of the universe.

In a paper published in Nature Astronomy, researchers found the power of the jets in Cygnus X-1—a system comprised of the first confirmed black hole and a supergiant star—was equivalent to the power output of 10,000 suns.

To record the measurement, researchers used an array of linked-up telescopes separated by large distances to observe the black hole jets being buffeted by the winds of the star as the black hole moved around its orbit—much like how strong winds on Earth can push around water in a fountain.

Iron plus UV light turns alcohol into hydrogen with catalyst-like efficiency

Publishing in Communications Chemistry, researchers from Kyushu University have discovered a simple method of generating hydrogen gas by mixing methanol, sodium hydroxide, and iron ions, then irradiating the solution with UV light.

Furthermore, the catalytic activity of the reaction is comparable to that of some previously reported systems that use organometallic and heterogeneous catalysts. The team also demonstrated that the method could generate hydrogen gas from other alcohols and biomass-derived materials, such as glucose and cellulose.

From microchip circuits to the medicine you take when you fall ill, everything in our lives requires catalysts. Naturally, research and development of catalysts are not only lucrative but essential to maintaining our modern lifestyle.

Metal Ion-Mediated Regulation of Cell Fate: A Novel Strategy for Synergy with Radiotherapy and Immunotherapy

Metal ions are indispensable for living organisms, participating in essential physiological processes. However, their dysregulated accumulation can trigger cell death and metal overload. The recent discovery of novel regulated cell death modalities, such as cuproptosis and ferroptosis, has significantly advanced the understanding of metal ions in cell fate and immune regulation. This review systematically elucidates the molecular mechanisms underlying metal ion-induced cell death, encompassing oxidative stress, mitochondrial dysfunction, DNA damage, and epigenetic modifications. It further classifies and discusses the hallmarks of various programmed and non-programmed cell death pathways, emphasizing the pivotal role of metal ions in anti-tumor immunity.

Activities Like Reading May Reduce Alzheimer’s Risk by 38%

Intellectually engaging and stimulating activities like reading, writing, and learning new languages are linked to a lower risk of Alzheimer’s disease and mild cognitive impairment in later life. The corresponding study was published in Neurology.

“Our study looked at cognitive enrichment from childhood to later life, focusing on activities and resources that stimulate the mind. Our findings suggest that cognitive health in later life is strongly influenced by lifelong exposure to intellectually stimulating environments,” said study author, Andrea Zammit, PhD, of Rush University Medical Center in Chicago, in a press release.

For the study, the researchers analyzed data from 1939 adults with an average age of 80 years old who were dementia-free at the start of the study. They were followed for around eight years.

AI turns plain-language prompts into lab-ready recipes for novel materials

Advances in artificial intelligence promise to help chemical engineers discover complex new materials. These materials could be used for reactions such as turning carbon dioxide into fuel, but technical barriers have limited catalysis adoption so far. Researchers at the University of Rochester are now harnessing the benefits of large language models (LLMs) similar to ChatGPT, Claude, or Gemini to empower more researchers to use AI to discover new materials and accelerate experiment workflows.

In a study published in ACS Central Science, a team led by Marc Porosoff, an associate professor in the Department of Chemical and Sustainability Engineering, and Andrew White, visiting associate professor and the cofounder and chief technology officer of Edison Scientific, describes an AI based–method they developed that allows users to input natural language prompts about the materials they want to create and suggest optimal procedures for experiments to produce them. As the users run the experiments, they input the results back into the AI model and continue iterating until they reach their goal.

“We’re able to leverage the pre-trained knowledge of large language models and well-established statistical methods for materials discovery to help us as researchers navigate large experimental design spaces more efficiently,” says Porosoff.

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