Sci. Transl. Med. 18, eadt1211 (2026). DOI:10.1126/scitranslmed.adt1211
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SREBP-1 upregulates SOAT1 to promote tumor growth by preventing lipotoxicity
Zhong et al. demonstrate that SREBP-1 and SOAT1 are co-upregulated in GBM and NSCLC, coupling cholesterol acquisition and storage. They reveal that SREBP-1 transcriptionally activates SOAT1, enabling cancer cells to sustain cholesterol homeostasis, and that targeting SOAT1 disrupts this balance, leading to ROS accumulation, mitochondrial dysfunction, and tumor cell death.
A drug to cure jet lag?
Adapting to eastward travel, such as west-to-east transmeridian flights, or to night-shift work requires advancing the internal clock, a process that normally takes longer and is physiologically harder than delaying it.
Existing methods, such as light therapy or melatonin, are heavily constrained by timing and often yield inconsistent results.
Mic-628’s consistent phase-advance effect, regardless of when it is administered, represents a new pharmacological strategy for resetting the circadian clock.
The researchers discovered that Mic-628 selectively induces the mammalian clock gene Per1.
Mic-628 works by binding to the repressor protein CRY1, promoting the formation of a CLOCK–BMAL1–CRY1–Mic-628 complex that activates Per1 transcription through a “dual E-box” DNA element.
As a result, both the central clock in the brain’s suprachiasmatic nucleus (SCN) and peripheral clocks in tissues such as the lungs were advanced—in tandem and independent of dosing time.
In a simulated jet lag mouse model (6-hour light-dark phase advance), a single oral dose of Mic-628 shortened re-entrainment time from seven days to four.
Scientists confirm one-dimensional electron behavior in phosphorus chains
For the first time, researchers have shown that self-assembled phosphorus chains can host genuinely one-dimensional electron behavior. Using advanced imaging and spectroscopy techniques, they separated the signals from chains aligned in different directions to reveal their true nature. The findings suggest that squeezing the chains closer together could trigger a dramatic shift from semiconductor to metal. That means simply adjusting density could unlock entirely new electronic states.
Levi’s® Tests 3D Printing Technology
Over 50 years ago, the classic Levi’s® Trucker jacket was introduced. But we are not one to rest on past accomplishments.
Now, the brand is turning to futuristic modes of innovation in manufacturing, pioneering a new approach in denim design.
Fast Company joined Levi’s® Head of Global Product Innovation, Paul Dillinger, at the Autodesk Pier 9 Workshop in San Francisco to witness how Levi’s® has been experimenting with 3D printing, creating digital renderings of the denim jacket which is essentially a shell of what the “real” thing could look like.
Sebastien Bubeck — A Combinatorics Problem — IPAM at UCLA
Recorded 10 February 2026. Sebastien Bubeck of OpenAI presents “A Combinatorics Problem” at IPAM’s AI for Science Kickoff. Learn more online at: https://www.ipam.ucla.edu/programs/sp… AI for Science Kickoff 2026: This inaugural event brings together the pioneers who are defining how AI will accelerate scientific discovery — from Nobel and Fields Medal laureates to the leaders shaping AI innovation across academia, research labs, and industry. The event features keynote talks by leading AI Scientists and Mathematicians, as well as panel discussions focusing on perspectives on AI from three sides: Mathematics, Higher Education, and Industry. This event is organized jointly by IPAM, the UCLA Division of Physical Sciences, the SAIR Foundation and the World Leading Scientists Institute.
