Lifeboat Foundation: Safeguarding Humanity
Toggle light / dark theme

Blog

Get the latest international news and world events from around the world.

Log in for authorized contributors

New Study Links Altered Cellular States to Brain Structure

Researchers at the Icahn School of Medicine at Mount Sinai have characterized how cellular senescence—a biological process in which aging cells change how they function—is associated with human brain structure in both development and late life. The study, published January 22 in Cell, provides new insight into how molecular signatures of cellular senescence that are present during development and aging mirror those associated with brain volume and cortical organization.

Understanding brain structure is a central challenge in neuroscience. Although brain structure changes throughout life and is linked to both aging and neurodegenerative conditions such as Parkinson’s and Alzheimer’s diseases, the underlying molecular processes involved—including cellular senescence—are not defined. Cellular senescence is commonly defined as a state characterized by permanent cell cycle arrest in the absence of cell death, in which cells have altered function. While cellular senescence has been implicated in aging and disease, its role in shaping human brain structure—both during development and aging—has remained unclear.

“This is the first study to directly link senescence-related molecular networks in living human brain tissue to measurable differences in brain structure within the same individuals,” said Noam Beckmann, PhD, Director of Data Sciences and founding member for the Mount Sinai Clinical Intelligence Center, Assistant Professor of Artificial Intelligence and Human Health, and co-senior author of the paper. “By identifying molecular pathways that are engaged in both brain structure development and aging, our work highlights senescence as a fundamental biological feature of brain aging and neurodegenerative disease and helps prioritize targets for future experimental research aimed at protecting brain health.”

Researchers unlocked a new shortcut to quantum materials

Scientists are learning how to temporarily reshape materials by nudging their internal quantum rhythms instead of blasting them with extreme lasers. By harnessing excitons, short-lived energy pairs that naturally form inside semiconductors, researchers can alter how electrons behave using far less energy than before. This approach achieves powerful quantum effects without damaging the material, overcoming a major barrier that has limited progress for years.

Not just a pain in the bone

In a new Science study, researchers report an unexpected role for sensory nerves in bone healing, providing insights into communication between the nervous system and the cells responsible for bone repair.

Learn more in a new Science Perspective.

Growth factors secreted by sensory nerves promote fracture healing.

Vicki Rosen and Francesca Gori Authors Info & Affiliations

Science

Vol 391, Issue 6781

Continue reading “Not just a pain in the bone” | >

Dried blood spot biomarker test for the detection of Alzheimer’s disease

The researchers tested a new method for detecting Alzheimer’s disease using a few drops of blood obtained from the fingertip and then dried on a card. This process was used to find proteins linked to Alzheimer’s disease and other brain changes in the 337 participants.

The study found that levels of p-tau217 in finger-prick samples closely matched results from standard blood tests and were able to identify Alzheimer’s disease-related changes in spinal fluid with an accuracy of 86 per cent. Two other markers, glial fibrillary acidic protein (GFAP) and neurofilament light (NfL), were also successfully measured and showed strong agreement with traditional tests.

While not ready for clinical use, this breakthrough addresses critical barriers in Alzheimer’s research by enabling remote participation in studies, clinical trial recruitment and monitoring, broader population sampling for epidemiological research, and inclusion of underrepresented communities and regions with limited healthcare infrastructure.

The findings suggest that this simple technique could make large-scale studies and remote testing possible, including for people with Down syndrome, who face a higher risk of Alzheimer’s disease and for other underserved populations. ScienceMission sciencenewshighlights.

A groundbreaking international study has demonstrated that Alzheimer’s disease biomarkers can be accurately detected using simple finger-prick blood samples that can be collected at home and mailed to laboratories without refrigeration or prior processing.

The research published in Nature Medicine. It represents the first large-scale validation of this accessible testing approach that removes geographic barriers and opens brain disease research to global populations without requiring specialised healthcare infrastructure.

Continue reading “Dried blood spot biomarker test for the detection of Alzheimer’s disease” | >

Cellular senescence linked to brain structure changes across lifespan

Researchers at the Icahn School of Medicine at Mount Sinai have characterized how cellular senescence—a biological process in which aging cells change how they function—is associated with human brain structure in both development and late life.

The study, published in Cell, provides new insight into how molecular signatures of cellular senescence that are present during development and aging mirror those associated with brain volume and cortical organization.

Understanding brain structure is a central challenge in neuroscience. Although brain structure changes throughout life and is linked to both aging and neurodegenerative conditions such as Parkinson’s and Alzheimer’s diseases, the underlying molecular processes involved—including cellular senescence—are not defined.

Abstract: Infiltration of T cell acute lymphoblastic leukemia (ALL) into the meninges worsens prognosis

Ksenia Matlawska-Wasowska & team show T-cell leukemia exploits an inflammatory pathway to invade the brain’s protective layers, revealing a potential target for therapies aimed at preventing disease progression:

The image features GFP⁺ T-ALL leukemic infiltrates within whole-mount murine meningeal tissue. Credit: Wojciech Ornatowski.

1Department of Cell Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, Alabama, USA.

2Department of Pediatrics, University of New Mexico, Albuquerque, New Mexico, USA.

3Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, USA.

Why Jupiter and Saturn Have Different Polar Vortices

“Our study shows that, depending on the interior properties and the softness of the bottom of the vortex, this will influence the kind of fluid pattern you observe at the surface,” said Dr. Wanying Kang.

What processes are responsible for shaping Jupiter and Saturn’s polar weather? This is what a recent study published in the Proceedings of the National Academy of Sciences hopes to address as a team of scientists from the Massachusetts Institute of Technology (MIT) investigated how the polar vortex structures on Jupiter and Saturn could provide key insight into the interiors of both planets. This study has the potential to help scientists better understand the complex processes on gas giant planets, which could serve as analogs for gas giant exoplanets.

For the study, the researchers used a series of computer models to simulate how the vortex patterns on Jupiter and Saturn are produced. The motivation for this study comes from several years of spacecraft images and observations that clearly show both planets exhibiting very different polar vortex patterns. Until now, researchers have been stumped regarding the processes responsible for two different patterns on each planet. In the end, the researchers discovered that the planet’s interior composition is responsible for the polar vortex patterns. For example, Jupiter’s interior is comprised of light materials, resulting in a large area of smaller vortices. In contrast, Saturn’s interior is comprised of denser materials, resulting in one large vortex.

A Double Helium Tail Wraps Around WASP-121b

“We were incredibly surprised to see how long the helium escape lasted,” said Dr. Romain Allart.

What effects can an exoplanet orbiting close to its star have on the former’s atmosphere? This is what a recent study published in Nature Communications hopes to address as a team of scientists investigated a unique atmospheric phenomenon of an ultra-hot Jupiter, the latter of which are exoplanets that orbit extremely close to their stars, and the intense heat causes their atmospheres to slowly strip away. This study has the potential to help scientists better understand the formation and evolution of ultra-hot Jupiters and their solar systems, and where we could search for life beyond Earth.

For the study, the researchers analyzed data obtained by NASA’s James Webb Space Telescope (JWST) for the ultra-hot Jupiter WASP-121b, which is located approximately 880 light-years from Earth and orbits its F-type star in only 1.3 days. For context, F-type stars are larger and hotter than our Sun—which is a G-type star—and the closest planet to our Sun—Mercury—orbits our Sun in 88 days. What makes WASP-121b intriguing is not only is its helium atmosphere is slowly being stripped away, also called atmospheric escape, but the data revealed that this has resulted in two helium tails wrapping around WASP-121b while circling approximately 60 percent of the exoplanet’s orbit.

/* */