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Inside voice: what can our thoughts reveal about the nature of consciousness?

What was I thinking? This is not as easy or straightforward a question as I would have thought. As soon as you try to record and categorise the contents of your consciousness – the sense impressions, feelings, words, images, daydreams, mind-wanderings, ruminations, deliberations, observations, opinions, intuitions and occasional insights – you encounter far more questions than answers, and more than a few surprises. I’d always assumed that my stream of consciousness consisted mainly of an interior monologue, maybe sometimes a dialogue, but was surely composed of words; I’m a writer, after all. But it turns out that a lot of my so-called thoughts – a flattering term for these gossamer traces of mental activity – are preverbal, often showing up as images, sensations, or concepts, with words trailing behind as a kind of afterthought, belated attempts to translate these elusive wisps of meaning into something more substantial and shareable.

I discovered this because I’ve been going around with a beeper wired to an earpiece that sends a sudden sharp note into my left ear at random times of the day. This is my cue to recall and jot down whatever was going on in my head immediately before I registered the beep. The idea is to capture a snapshot of the contents of consciousness at a specific moment in time by dipping a ladle into the onrushing stream.

Sounds simple, but what the ladle scoops up is harder to describe than you might expect. Yes, these are my own thoughts, and who should know more about them than me, their thinker? Yet I’m finding that what we know about our own thinking is considerably less than we think.

The beeper exercise is part of a psychology experiment I volunteered to take part in. Descriptive experience sampling is a research method developed by Russell T Hurlburt, a social psychologist at the University of Nevada, Las Vegas; he has been using it for 50 years – which is to say, his entire career. To give you some perspective, beepers didn’t exist 50 years ago. Hurlburt, trained as an engineer, had to design and build his own unit, on which he holds a patent. It looks like an old-timey pocket radio: grey plastic, with one of those corrugated dials you rotate with your thumb to turn the thing on and boost the volume; the earpiece is flesh-toned, as that term was understood in 1973. For half a century now, Hurlburt has been scrupulously collecting reports of people’s inner experiences at random moments – and just as scrupulously resisting the urge to draw premature conclusions. A die-hard empiricist, he is as devoted to data as he is allergic to theories.


Scientists and philosophers studying the mind have discovered how little we know about our inner experiences.

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Cytoplasmic flow induced by a rotating wire in living cells: magnetic rotational spectroscopy and finite element simulations

How can scientists measure viscosity inside a living cell, whose entire volume is just a few picolitres? Using computer simulations, researchers evaluated magnetic rotational spectroscopy, a technique that spins microscopic magnetic wires to probe the cytoplasm. The study shows that the motion generated by the wire is extremely localized, affecting less than one percent of the cell, so the measurement does not harm the cell. The results also confirm that, under standard conditions, magnetic rotational spectroscopy accurately captures the cytoplasmic viscosity. These findings validate magnetic rotational spectroscopy as a precise and minimally invasive technique for quantifying the mechanical properties of living cells.

Read the article in Interface.


Abstract. Recent studies have highlighted intracellular viscosity as a key biomechanical property with potential as a biomarker for cancer cell metastasis.

Rejuvenating neurons restores learning and memory in mice

A research team asked whether rejuvenating these engram neurons could recover memory after decline has already begun? In a study published in Neuron, the team reports that “partial reprogramming” of engram neurons restores memory performance in multiple mouse settings. The approach uses a short, controlled pulse of three genes, Oct4, Sox2 and Klf4 referred together as “OSK”

Previous studies have shown that carefully timed expression of these factors can reset several aging-related features in cells. Here, the team targeted OSK specifically at the engram neurons that are active during learning, rather than broadly across the entire brain.

Working on mice, the researchers used gene therapy vectors (adeno-associated viruses) delivered by precise brain injections. They combined two elements: a system that adds a fluorescent tag to neurons that are activated by learning, and a switch that briefly turns OSK on during a defined time window.

The team used their approach in brain areas known to support different kinds of memory: the dentate gyrus of the hippocampus, which is important for learning and recent recall, and the medial prefrontal cortex, which contributes to remote recall two weeks later.

In aged mice, briefly activating OSK in learning-related hippocampal engram neurons restored memory, essentially bringing performance back to levels seen in young controls. When the same approach was applied to prefrontal cortex engrams, it also recovered remote memories formed weeks earlier.

The reprogrammed engram neurons also showed signs of improved health. They maintained their neuronal identity and displayed molecular features associated with a younger state, including changes in nuclear structure linked to aging.

The team then tested mouse models of Alzheimer’s disease. In a spatial-learning task, the mice showed inefficient navigation and impaired memory strategies. Reprogramming dentate gyrus engrams improved learning strategies during training, while targeting prefrontal engrams restored long-term spatial memory.

Abstract: Stressing the details in the link between chronic stress and liver cancer…

Here, Xuetian Yue discover chronic stress promotes aminopeptidase N expression to increase glutathione synthesis and inhibit ferroptosis in models of liver cancer.


1Department of Cellular Biology, School of Basic Medical Sciences;

2Key Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, School of Basic Medical Sciences; and.

3Key Laboratory for Experimental Teratology of the Ministry of Education, Department of Histology and Embryology, School of Basic Medical Sciences, Cheeloo Medical College, Shandong University, Jinan, China.

Abstract: Opening the gates to the blood brain barrier (BBB) in a high-grade glioma model

Amy B. Heimberger find therapeutic benefit in adding the STING agonist 8,803 to radiation in preclinical models of glioma. The combination reprogramed the glioma tumor microenvironment, and 8,803 induced the opening of the blood-brain barrier.


3Department of Radiology.

4Department of Neurology, and.

5Department of Radiation Oncology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.

Tumour–brain crosstalk restrains cancer immunity via a sensory–sympathetic axis

Tumor–brain crosstalk worsens lung cancer.

It is not clear how the brain senses and responds to tumors in peripheral organs, although tumors are innervated by different branches of the peripheral nervous system and increased tumor innervation is associated with poor cancer outcomes.

Authors in this study identify an immuno-suppressive tumor microenvironment established by a tumor–brain axis that promotes oncogenesis.

The researchers demonstrate that lung adenocarcinoma induces innervation and functional engagement of vagal sensory neurons. Mechanistically, the vagal sensory nerves transmit signals from lung tumors to brainstem nuclei, driving elevated sympathetic efferent activity in the tumor microenvironment. This, in turn, suppresses β2 adrenergic signalling in alveolar macrophage and anti-tumor immunity.

Disruption of this sensory-to-sympathetic pathway significantly inhibited lung tumor growth by enhancing immune responses against cancer. sciencenewshighlights sciencemissionn https://sciencemission.com/Tumour%E2%80%93brain-crosstalk


Mouse models demonstrate that vagal sensory neurons transmit signals from lung adenocarcinoma to the brain, increasing sympathetic efferent activity in the tumour microenvironment and thereby creating a immunologically permissive environment for tumour growth.

Researchers pioneer next-generation AI semiconductors with ‘thermal constraining’ technique

A research team led by Professor Taesung Kim from the School of Mechanical Engineering at Sungkyunkwan University has developed a technology that precisely controls the internal structure of semiconductors using heat, much like stamping out “bungeoppang” (fish-shaped pastry) in a mold. The team report that this approach improves the performance of next-generation artificial intelligence (AI) hardware. With this technology, complex AI computations can be processed more quickly using significantly less electricity than before. The findings are published in the journal ACS Nano.

Most computers and smartphones we use today operate based on the “von Neumann architecture.” This structure is similar to having a desk (the processor) and a bookshelf (the memory) placed far apart.

Each time you study, you have to go back and forth to get a book, which takes time and effort. To solve this problem, a method called “in-memory computing” has been proposed, in which computation is carried out directly inside the memory. The key component that enables this approach is the “ferroelectric transistor,” which is the focus of this study.

Feedback neurons based on perovskite memristor with nickel single-atom engineered reduced graphene oxide cathode

Scientists have long looked to the human brain as the ultimate blueprint for computing, seeking to build “neuromorphic” systems that process information with the same efficiency and flexibility as our own neurons. However, replicating the brain’s complex ability to both excite and inhibit signals—essentially “talking” and “listening” simultaneously—has proven difficult with standard hardware.

The problem? Perovskites are often too chaotic. Tiny charged particles called ions tend to zip around inside the material too quickly, making the device’s behavior hard to control. Additionally, the “bottlenecks” (barriers) where the electricity enters the device often cause lopsided performance, preventing the smooth, bidirectional communication required for advanced brain-like tasks.


Li et al. report feedback neurons based on perovskite memristors with a nickel single-atom modified reduced graphene oxide cathode. The device successfully implements an unsupervised learning network with over 50% clustering accuracy and cooperative learning for solving NP-hard combinatorial optimisation problem.

Nobel Prize in Physics 1903

The Nobel Prize in Physics 1903 was divided, one half awarded to Antoine Henri Becquerel “in recognition of the extraordinary services he has rendered by his discovery of spontaneous radioactivity”, the other half jointly to Pierre Curie and Marie Curie, née Skłodowska “in recognition of the extraordinary services they have rendered by their joint researches on the radiation phenomena discovered by Professor Henri Becquerel”

How dietary restriction rewires immunity to protect against infection

To understand the complex interactions involved in an immune response during scarcity, the team put mice on a 50% restricted-calorie diet and then exposed the animals to bacteria that infect the gut. The mice that were fed a standard diet experienced a metabolic crash— their blood glucose levels and body weight plummeted.

The researchers had expected this would happen to all the animals because mounting an immune response can consume up to 30% of the entire body’s fuel reserves. But in the calorie-restricted mice, the immune system appeared to be functioning perfectly well without using much glucose.

To unravel this enigma, the researchers inventoried the immune cells of the infected animals and discovered that T cells, which normally target invading microbes, were depleted in the calorie-restricted mice. Instead, short-lived neutrophils, which serve as the body’s first responders to infection, were ramped up to twice the normal amount and had measurably enhanced pathogen-killing abilities. The cells seemed to be operating in energy-saving mode, consuming much less glucose than neutrophils from well-fed animals.

The researchers are breaking new ground by outlining how a sudden fall in food intake triggers glucocorticoid levels to rise, resulting in two major shifts. First, the body repositions certain immune cells—especially naïve T cells—into the bone marrow, which becomes a kind of “safe house” for when the cells are needed. Second, during an infection, glucocorticoids tilt the immune response away from energy-intensive T cells toward neutrophils, abundant cells that act as immediate, short-lived defenders.

Beyond clearing a current infection, glucocorticoids prepare the immune system for repeat encounters with infectious agents. While the hormones direct killer T cells to stand down and neutrophils to step up, they also ensure memory T cells are preserved for future confrontations.


When food is scarce, stress hormones direct the immune system to operate in “low power” mode to preserve immune function while conserving energy, according to researchers. This reconfiguration is crucial to combating infections amid food insecurity.

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