Basic properties of symmetric random matrices can explain the emergence of macroscopic patterns in neural networks, suggesting that initialization conditions of connected neural populations may confer computational advantages across the mouse brain.
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Orbital Data Centers: Power and Thermal Management for Scalable Architectures
Redwire’s latest whitepaper examines the challenges and opportunities associated with scaling orbital data centers (ODCs), with a focus on power generation and thermal management. ODCs could eventually surpass terrestrial data centers by leveraging abundant solar energy in space and avoiding Earth-based infrastructure limitations.
The whitepaper examines the scaling of power and thermal systems for ODCs within a single-spacecraft architecture and highlights how the future success of ODCs will depend on treating power and thermal management as primary architectural drivers from the earliest stages of design.
Drawing on decades of Redwire’s spaceflight heritage in deployable structures, high-power solar arrays, and thermal management systems, the in-depth study also highlights how existing flight-proven technologies can support practical and scalable orbital compute architectures.
Scientists just captured a mysterious quantum “dance” inside superconductors
Scientists just spotted a mysterious quantum “dance” that could rewrite superconductivity—and reshape future tech. For the first time, researchers have directly visualized the quantum behavior that drives superconductivity, a state in which paired electrons allow electricity to flow with zero resistance at very low temperatures.
But what they observed came as a surprise.
In a study published April 15 in Physical Review Letters, the team captured images of individual atoms forming pairs inside a specially prepared gas cooled to nearly absolute zero — the unreachable limit to how cold anything can get. This system, known as a Fermi gas, lets scientists replace electrons with atoms so they can study superconductivity in a highly controlled environment.
Scientists just discovered what coffee is really doing to your gut and brain
C Decaf even improved learning and memory, while caffeine boosted focus and reduced anxiety. Together, they show coffee works through multiple pathways beyond just caffeine.
Researchers at APC Microbiome Ireland, a leading research center at University College Cork, have taken a major step toward understanding how coffee benefits the body. For the first time, scientists have closely examined how coffee interacts with the gut-brain axis, the communication network that links the digestive system and the brain.
The findings, published in Nature Communications and supported by the Institute for Scientific Information on Coffee (ISIC), show that regularly drinking both caffeinated and decaffeinated coffee can shape the gut microbiome and influence mood and stress.
A Residual N-Terminal Peptide Enhances Signaling of Depalmitoylated Hedgehog to the Patched Receptor
During their biosynthesis, Sonic hedgehog (Shh) morphogens are covalently modified by cholesterol at the C-terminus and palmitate at the N-terminus. Although both lipids initially anchor Shh to the plasma membrane of producing cells, it later translocates to the extracellular compartment to direct developmental fates in cells expressing the Patched (Ptch) receptor. Possible release mechanisms for dually lipidated Hh/Shh into the extracellular compartment are currently under intense debate. In this paper, we describe the serum-dependent conversion of the dually lipidated cellular precursor into a soluble cholesteroylated variant (ShhC) during its release. Although ShhC is formed in a Dispatched- and Scube2-dependent manner, suggesting the physiological relevance of the protein, the depalmitoylation of ShhC during release is inconsistent with the previously postulated function of N-palmitate in Ptch receptor binding and signaling. Therefore, we analyzed the potency of ShhC to induce Ptch-controlled target cell transcription and differentiation in Hh-sensitive reporter cells and in the Drosophila eye. In both experimental systems, we found that ShhC was highly bioactive despite the absence of the N-palmitate. We also found that the artificial removal of N-terminal peptides longer than eight amino acids inactivated the depalmitoylated soluble proteins in vitro and in the developing Drosophila eye. These results demonstrate that N-depalmitoylated ShhC requires an N-peptide of a defined minimum length for its signaling function to Ptch.
Reversing Humanity’s #1 Killer
Heart disease still kills nearly 20 MILLION people every year worldwide — roughly 1 person every 1.5 seconds. — But what if medicine could move beyond simply slowing plaque buildup…and actually REMOVE toxic oxidized cholesterol from arteries? — Dr. Matthew “Oki” O’Connor, CEO and Co-Founder, Cyclarity Therapeutics.
In the time it will take you watch this episode, over 2,000 people around the world will die from diseases driven by arterial plaque. But what if we could actually remove the toxic cholesterol already trapped inside arteries?
Today we’re diving into one of the biggest unsolved problems in medicine and aging: how do you actually remove arterial plaque instead of merely slowing its progression?
Cardiovascular disease remains the world’s leading killer, despite decades of statins, anti-inflammatory drugs, and newer RNA-based therapies. Most existing treatments help manage cholesterol and reduce risk, but very few directly target the toxic debris already embedded inside plaques.
But what if we could literally extract some of the most dangerous oxidized cholesterol molecules from the body?
This tiny outer Solar System world has an atmosphere. It shouldn’t
Astronomers have spotted something surprising in the far outer Solar System—a faint, short-lived atmosphere clinging to a tiny icy world that shouldn’t be able to hold one at all. The object, called 2002XV93, is far smaller than Pluto, yet observations during a rare stellar alignment revealed its presence through a subtle dimming of starlight. Even more puzzling, calculations suggest this atmosphere should vanish within about 1,000 years unless it’s constantly being replenished.
A group of professional and amateur astronomers in Japan has uncovered evidence that a small, distant object in the outer Solar System is surrounded by a thin atmosphere. The finding is surprising because the object is far too small to hold onto gas for long, raising new questions about how and when this atmosphere formed. Future observations will be needed to better understand its composition and origin.
Far beyond Neptune’s orbit, thousands of icy bodies known as trans-Neptunian objects (TNOs) circle the Sun. Pluto is the most well-known example and is one of the few with a confirmed thin atmosphere. For most TNOs, however, the combination of extremely low temperatures and weak gravity makes it unlikely for them to retain any gases. As a result, scientists generally expect these distant objects to be airless.
