Heart failure with preserved ejection fraction (HFpEF) causes substantial morbidity and mortality and has few effective therapies. Its phenotype has changed over time, with morbid obesity and metabolic defects supplanting hypertension and cardiac hypertrophy. We reveal that cardiomyocytes from patients with severe obesity and HFpEF have very depressed contractile reserve, including reduced calcium-and length-stimulated tension, power, and myosin activation compared with less-obese HFpEF and nonfailing (NF) controls with or without obesity but similar to those with advanced HF and reduced ejection fraction. Myocyte defects correlate with body mass index and exercise hemodynamics in patients with HFpEF but not NF and appear reversible upon weight loss. Increased troponin I phosphorylation at threonine 181 occurs only in heart failure with obesity, contributing to sarcomere dysfunction.
Wu et al. present an ensemble pipeline, PhageHost, comprising a protein language model, TailSeek, for tail fiber detection from phage and prophage genomes and a deep learning model, HostBuster, that integrates tail fiber features with host information to predict the lytic potential of phage–K. pneumoniae pairs.
A groundbreaking new vaccine technology using artificial intelligence could offer immunity against entire families of viruses and protect against future mutations with a single injection.
Researchers say this could prevent future pandemics before they emerge, saving millions of lives and sparing countries from the necessity of lockdowns.
A “super-antigen” has been developed through AI machine learning that meticulously analyses past and current outbreaks to pinpoint the essential elements for the survival of viruses.
What happens when an economist starts designing a future society?
Thirteen years ago, I sat down with Robin Hanson for a second time. It became the most vigorous debate ever recorded.
I rarely disagree with a guest. With Robin, I disagreed more than I ever had.
Here is what unsettled me. His work on the Em Economy reads like social science. It uses the language of markets, incentives, and equilibrium. But underneath the economic reasoning sit choices that are not economic at all. Policies of social discrimination. The full privatization of law and punishment. Minds run a thousand times faster, and handed a thousand times more voting power. Emulations deleted when they cannot pay their storage fees.
These are not technical footnotes. They are ethical and political decisions wearing the costume of impartial analysis.
Adam Smith, the father of economics, was first a moral philosopher. He understood where the tools of his discipline stop being useful and start being dangerous.
Why do cells age—and why do we lose our energy and vitality as we get older? This question is one of the central challenges of modern biomedicine. The focus is particularly on mitochondria—tiny cellular organelles long known as the cell’s powerhouses but now understood as dynamic control centers that not only produce energy, but also coordinate cellular communication, adaptation, and many of the processes essential for life.
They supply us with the energy that our body needs for movement, growth, and repair processes. But as we age, these powerhouses begin to slow down. It has long been known that their function declines with age. But until now, the mechanisms driving this gradual decline have been poorly understood.
Focus on membrane lipids For a long time, it was assumed that genetic damage within the mitochondria themselves was primarily responsible. A study now published in Nature Communications by an international research team led by Dr. Maria Ermolaeva of the Leibniz Institute on Aging—Fritz Lipmann Institute (FLI) in Jena provides a surprising answer to this question: A key factor appears to be the imbalance in the structure of the mitochondrial network, which is caused by the absence of a major lipid in the membrane composition.
At the heart of quantum computing are qubits, which offer the promise of answering questions that defeat today’s machines, but are notoriously delicate and unstable.
Microsoft says the qubits on Majorana 2, its new chip, survive for an average of 20 seconds, rather than the milliseconds of Majorana 1.
That means the new chip is 1,000 times more reliable — an improvement in performance the tech giant compares to the difference between a phone that needs charging every day to one which needs charging every few years.
We’ve been looking for messages from the stars ever since Frank Drake pointed the Green Bank radio telescope at Tau Ceti and Epsilon Eridany 65 years ago. He saw nothing that couldn’t be explained by natural causes. Nor have the much more extensive SETI surveys conducted since. So, maybe there are no alien signals to see. Or maybe we need to update how we search for them. We have, after all, learned an awful lot since 1960—both about the galaxy and about observing the galaxy.
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Researchers in Japan have created some of the world’s smallest semiconducting nanotubes, structures 100,000 times thinner than a human hair. By growing molybdenum disulfide inside protective tubes of boron nitride, the researchers, including those from the University of Tokyo, produced highly uniform tubes just 1 nanometer wide, a scale at which it’s difficult to make stable nanotube structures. The work confirms decades-old theoretical predictions about how these ultrafine materials behave and could also provide a new route toward miniaturized electronic devices.
A few years ago, carbon nanotubes were attracting a lot of press attention. But there’s a new contender in the ring, and it offers some advantages over its carbon counterpart that could tempt engineers to design products around it.
