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Researchers praise ‘stunning’ results of new prostate cancer treatment

A new drug for advanced prostate cancer has shown promise in early trials experts have said, with the medication shrinking tumours in some patients.

Prostate cancer is the most common cancer among men in many countries, including the US and UK. About 1.5 million men are diagnosed worldwide each year.

The new drug has caused excitement as it is a type of treatment called immunotherapy. This approach uses the body’s own immune system to fight disease, and has already proved beneficial for some cancers. However, experts note it has not yet had the same impact on prostate cancer.

Targeting mitochondrial metabolism with combined metabolic activators

Combined metabolic activators to treat mitochondrial dysfunction.

Mitochondrial dysfunction is a common feature of many human diseases and is emerging as a therapeutic target.

Systems biology and multiomics approaches have revealed that deficits in glutathione and NAD+ metabolism, impaired fatty acid oxidation, and disrupted redox balance are key drivers of disease pathogenesis.

Combined metabolic activators (CMA) were developed to address these metabolic deficits through the complementary actions of serine, Nacetylcysteine, L-carnitine, and NAD+ precursors.

CMA have been shown to lower hepatic fat, reduce systemic inflammation, accelerate recovery from infection, and improve cognitive performance in clinical studies. sciencenewshighlights ScienceMission https://sciencemission.com/Targeting-mitochondrial-metabolism

Mitochondria play a central role in energy metabolism, redox balance, and cellular homeostasis, and their dysfunction has been implicated in the pathogenesis of complex human diseases. Advances in systems biology and omics technologies have elucidated the mechanisms underlying these conditions, including metabolic dysfunction, mitochondrial impairment, inflammation, and redox imbalance. Preclinical and early clinical studies of combined metabolic activators (CMA), a formulation of bioactive metabolites, have demonstrated improvements in mitochondrial function and systemic metabolic profiles across multiple diseases.

Continue reading “Targeting mitochondrial metabolism with combined metabolic activators” | >

3D imagery helps bring world’s ant diversity to life

For more than a decade, Evan Economo’s lab has been using micro-CT machines to scan insect specimens. The resulting X-ray images help researchers study the form and structure of insects—a subfield of entomology known as morphology—but the process is costly and time-consuming.

“One limitation is that you can get this rich 3D dataset, but it could take 10 hours to scan one specimen,” explained Economo, who chairs the University of Maryland’s Department of Entomology and holds the James B. Gahan and Margaret H. Gahan Professorship.

As a senior author of a paper published in the journal Nature Methods, Economo tested a high-tech workflow to speed up their efforts.

‘Superconducting dome’ hints at high-temperature superconductivity in thin nickelate films

Superconductivity is a quantum state of matter characterized by an electrical resistance of zero and the expulsion of magnetic fields at low temperatures below a critical point. Superconductors, materials in which this state occurs, have proved to be highly advantageous for the development of various technologies, including medical imaging devices, particle accelerators and quantum computers.

While superconductivity typically only occurs at extremely low temperatures, recent studies showed that in some materials it can arise at higher temperatures. These unconventional superconducting materials are referred to as high-temperature (high-Tc) superconductors.

Researchers at the National Laboratory of Solid-State Microstructures and Nanjing University recently gathered hints of high-Tc superconductivity in a thin film nickelate, a material that contains nickel and oxygen arranged in a thin layered crystal structure. Their paper, published in Physical Review Letters, maps the evolution of physical states in these materials under different conditions, unveiling a so-called “superconducting dome” in this phase diagram, which is associated with high-Tc superconductivity.

Hybrid ‘super foam’ uses 3D-printed struts to absorb up to 10 times more energy

Aerospace engineering and materials science researchers at Texas A&M University and the DEVCOM Army Research Laboratory have developed a “super foam” that can absorb up to 10 times more energy than conventional padding.

The composite, published and described in the journal of Composite Structures, combines an ordinary foam with 3D-printed injections of stretchy, plastic columns known as struts.

The result? An affordable, lightweight and ultra-durable hybrid foam poised to redefine the defense, automotive, aerospace and consumer industries.

Gravitational waves reveal hidden structure of galactic centers

A new study published in Nature Astronomy indicates that the dense, star-and dark-matter–rich environments around supermassive black hole binaries pack on the order of a million solar masses into each cubic parsec. The team used gravitational-wave data from pulsar timing arrays to probe galactic centers that are otherwise impossible to observe directly.

Pulsar timing arrays (PTAs) use precise measurements of timing residuals from millisecond pulsars to detect gravitational waves at nanohertz frequencies. These arrays revealed a stochastic gravitational-wave background, an incoherent hum from countless supermassive black hole binaries spiraling together across the universe.

However, the signal carries a twist. At the lowest frequencies, the spectrum appears to turn over, deviating from predictions for binaries evolving purely under gravitational-wave emission. That bend suggests that something in the environment, or highly eccentric orbits, is reshaping how these massive binaries lose energy and tighten over time.

Cheek cells may provide clues to schizophrenia risk

A simple cheek swab could one day provide a quick and noninvasive diagnostic test for schizophrenia. A new study published in Science Advances has identified higher levels of two biological markers in the cheek swabs of patients with schizophrenia compared with people who don’t have this mental health disorder. Schizophrenia is a long-term condition with a range of symptoms including hallucinations, delusions, muddled thoughts and loss of interest in everyday activities.

There is no single test for the illness, and diagnosis can be challenging because symptoms vary widely between people and typically relies on observing a patient’s behavior. It can, therefore, sometimes take months for a professional to make a diagnosis with any degree of certainty, as they have to rule out other possible causes. That is a lot of time for someone to wait without the right treatment if it is needed.

So researchers led by a team at Rutgers University in New Jersey decided to investigate whether molecular signatures in easy-to-collect buccal (cheek) cells could serve as reliable biomarkers.

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