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T cells secrete DNA to boost the immune system’s cancer-fighting ability

Activated immune cells secrete tiny capsules bearing DNA that can enter other immune and tumor cells to stimulate the body’s defense systems, according to a study led by investigators at Weill Cornell Medicine. The discovery extends the scientific understanding of the immune system, identifies a new strategy for boosting immunity against cancers and potentially offers a new tool for delivering genetic payloads to other cells.

Most animal cells secrete tiny capsules known as extracellular vesicles—nanoscale, membrane-bound particles—whose cargo can include proteins, snippets of DNA and other molecules. In the new study, published April 30 in Cancer Cell, the researchers discovered that vesicles secreted by activated T cells —major weapons of the immune system—carry DNA that enters immune cells and nearby tumor cells to enhance the immune response against the tumor. Preclinical experiments showed that this vesicle-associated DNA could be useful therapeutically, boosting T cell attacks against tumors that otherwise evoke little or no immune response.

“These findings reveal a natural mechanism for treating immunologically silent tumors and other diseases that stem from insufficient immune surveillance,” said study co-senior author Dr. David Lyden, the Stavros S. Niarchos Professor in Pediatric Cardiology and a member of the Gale and Ira Drukier Institute for Children’s Health and the Sandra and Edward Meyer Cancer Center at Weill Cornell Medicine.

Deciphering the Nanoscale Architecture of Presynaptic Actin Using a Micropatterned Presynapse-on-Glass Model

Prefrontal cortex encodes behavior states decoupled from motor execution.

By tracking the natural actions of freely moving rats, Välikangas et al. show that prefrontal cortex encodes abstract behavioral states rather than low-level physical aspects of movement. Prefrontal activity anticipates behaviors and operates on slow timescales, suggesting that it represents high-level goals rather than moment-to-moment motor output.

Rethinking robotics with physical intelligence

Today’s advances in robotics are often driven by breakthroughs in artificial intelligence, machine learning, and perception. But in complex and constrained environments, the limiting factor is often hardware, not software. Systems that rely on constant data processing, high-bandwidth communication, and centralized compute can face delays, power constraints, and vulnerabilities that limit performance or prevent mission success altogether.

DARPA is looking to tackle these challenges by embedding intelligence directly into the physical materials of robotic systems. A new Request for Information (RFI), calls on the research community to help define a new class of materials capable of intermixed sensing, adapting, and acting in real time without relying on continuous external computation or communication links.

While the RFI itself is exploratory, it is a first step toward a more immediate opportunity: an invite-only, in-person workshop planned for the summer 2026. Selected participants will have the chance to present their ideas, engage with DARPA, and inform future program directions.

Endocannabinoid modulation of a reciprocal fronto-coerulear connection in contextual discrimination

Locarno, Nava, Barsotti et al. define a fronto-coerulear anatomical-functional loop under endocannabinoid (eCB) negative feedback that regulates contextual discrimination. Prefrontal cortex (PFC) inputs drive locus coeruleus (LC) norepinephrine (NE) release to enhance cortical firing, while locally mobilized eCBs weaken PFC to LC synapses, constraining NE-dependent entrainment of PFC neuronal assemblies.

NO-independent inflammatory response by iNOS

The finding challenges a longstanding assumption in immunology: that iNOS controls immune cell behaviour primarily through nitric oxide production. The study shows that the physical shape of iNOS – stabilised by its cofactor, tetrahydrobiopterin (BH4) – is what drives the interaction with IRG1, independently of whether iNOS is producing nitric oxide at all.

The researchers used co-immunoprecipitation and mass spectrometry to confirm that iNOS is a direct binding partner of IRG1 in living cells, with computational modelling and molecular dynamics simulations used to predict and validate the structure of the interaction. Surface plasmon resonance confirmed that the binding is stable and high-affinity in both mouse and human models, and that it does not occur with the related protein eNOS – pointing to a specific, evolutionarily conserved function.

In cells lacking iNOS, IRG1 produced more than 15 times more itaconate compared with normal cells following immune stimulation. Critically, iNOS mutants unable to produce nitric oxide still suppressed IRG1 – what mattered was whether iNOS could adopt the correct shape, determined by BH4 binding. Disrupting that binding abolished the effect entirely.

The work also showed that in the absence of iNOS, IRG1 associated with a different set of partner proteins involved in glycolysis and cell metabolism – suggesting iNOS effectively sequesters IRG1 away from those roles, with wider consequences for how immune cells manage energy during inflammation.

A protein long understood to drive inflammation by producing nitric oxide has a second, previously unknown role – it physically binds to another key protein inside cells to directly modulate the immune response. The discovery, published in Nature Metabolism, could open new routes to treating conditions such as cardiovascular disease, arthritis, Crohn’s and other inflammatory diseases.

When the immune system detects infection or injury, it triggers inflammation to fight back. That response is essential, but it must be carefully controlled. If it runs too hard for too long, it causes the tissue damage that underlies many chronic diseases. Understanding the molecular switches that regulate inflammation – and finding new ways to target them – is one of the biggest challenges in modern medicine.

Continue reading “NO-independent inflammatory response by iNOS” | >

Epilepsy ‘brain blips’ can be predicted a full second early with neuron-level probes

Epilepsy is best known for seizures, but many people with the condition also experience much more frequent and subtler disruptions. These brief bursts of abnormal brain activity, called interictal epileptiform discharges (IEDs), can happen thousands of times a day, interfering with attention, memory, language, and sleep.

Scientists at UC San Francisco have discovered that these “brain blips” are not random events, as had been believed. Rather, they unfold in a predictable pattern that can be detected a full second before they occur — raising new possibilities to ward them off altogether.

The researchers used a high-resolution technology recently adapted for humans that can record the activity of individual neurons. They tracked more than 1,000 neurons in four patients undergoing surgery for epilepsy.

XXP instrument back online, marking a key milestone in high-energy upgrade to SLAC’s X-ray laser

XPP, the X-ray Pump Probe instrument at the Linac Coherent Light Source (LCLS), is back online and welcoming researchers after a complete rebuild. The overhaul has readied XPP for the significant increase in X-ray output expected from the ongoing high-energy upgrade to LCLS at the Department of Energy’s SLAC National Accelerator Laboratory. LCLS is a pioneering X-ray free-electron laser facility used by scientists around the world to capture ultrafast snapshots of natural processes.

“Completing the XPP rebuild on-time and on-budget is a key milestone for the high-energy upgrade effort, and we’re thrilled that the instrument is back to supporting researchers from around the world,” said John Hogan, project director for the LCLS high-energy upgrade. “This was a huge team effort, involving partners across SLAC’s engineering, science and project teams.”

Since its 2010 debut, XPP has enabled groundbreaking research across materials science—from quantum information storage to material dynamics across timescales—as well as studies in chemistry, physics and bioscience. Researchers have leveraged XPP to pioneer X-ray optics technologies, including cavity-based X-ray oscillators that are shaping future X-ray free-electron laser facilities.

Sudden quantum jolts may not break adiabatic behavior after all

In thermodynamics, an “adiabatic process” is a system change that transfers no heat in or out of the system. Any and all energy change in that system are therefore accomplished by doing work on the system, work being action that moves matter over a distance. (An example is a bicycle tire pump or lifting a box from the floor.)

The “adiabatic theorem” says that if you change a system slowly enough, it will remain in the same energy state. For example, if you walk slowly enough holding a full cup of coffee, the coffee will not spill—the coffee system has time to relax back to its steady state—but if you make a quick and sudden change while holding the coffee cup, some coffee will spill over the cup’s edge.

There is a similar theorem in quantum mechanics—a quantum system that is changed (perturbed) slowly enough will remain in its existing quantum state (often its ground state), while a sudden change, such as a photon impinging upon an atom, changes its energy state.

Twisting water reveals hidden order across four molecular layers at air-water interface

Researchers from the Department of Physical Chemistry at the Fritz Haber Institute and Freie Universität Berlin have revealed the arrangement of water molecules at the interface between liquid water and air. Their findings help to better understand interfacial chemistry, which is largely determined by the specific arrangement of the water molecules. Published in Science Advances, the study shows that one parameter in particular—one that has been neglected until now—is of fundamental importance: the water twist.

Water is arguably the most important molecule on Earth. Interfaces of water play a critical role in numerous processes within physiology, at the ocean surface, and in the atmosphere. In these processes, it is primarily the incredibly thin region of water directly at the boundary that governs their behavior.

Crucially, the sheer presence of the interface perturbs the molecular structure of water, generating preferential orientations and an altered hydrogen-bond network, which give rise to profoundly different properties of water in that region. While these unique structures are at the heart of many interfacial phenomena, characterizing them is monumentally difficult.

A new way to understand the evolution of spacetime dynamics

The concept of spacetime, first described in Einstein’s theory of general relativity, has since been widely studied by many physicists worldwide. Spacetime is described mathematically as a four-dimensional (4D) continuum in which physical events occur, which merges three-dimensional (3D) space, with one-dimensional (1D) time.

This 4D continuum is known to continuously evolve following complex and intricate patterns that are governed by Einstein’s field equations; mathematical equations that describe how matter and energy shape spacetime. While various past theoretical studies explored the evolution of spacetime, identifying patterns that persist during its evolution has proved challenging so far.

Researchers at Adolfo Ibáñez University in Chile and Columbia University set out to explore the evolution of spacetime using ideas rooted in nonlinear electrodynamics, an area of physics that studies the behavior of electric and magnetic fields in complex materials.

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