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A Single Molecule May Explain How Blood Flow in The Brain Triggers Dementia

Reduced blood flow to the brain is thought to be a key factor in many forms of dementia, including Alzheimer’s, and scientists have just identified a new mechanism regulating this flow, which may also help explain how it goes wrong.

A fat molecule helps maintain the system’s balance, researchers at the University of Vermont discovered, and in mouse models of Alzheimer’s disease, disruption of this balance led to problems.

Fixing the imbalance restored more normal blood flow, offering a hopeful new target for understanding and treating dementia-related brain changes.

Presenting data from the largest integrated thyroid cancer single-cell sequencing atlas

Here, Vivian L. Weiss & team highlight stromal tumor-dynamics occurring across the spatial evolution of thyroid cancer from indolent to lethal disease, identifying a prognostic invasive cell subtype:

The figure shows two distinct patterns associated with anaplastic thyroid carcinoma.

6The Francis Crick Institute, London, United Kingdom.

7Institute of Interdisciplinary Research (IRIBHM), Universite Libre de Bruxelles, Brussels, Belgium.

8Department of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, Washington, USA.

Organ cross-talk: molecular mechanisms, biological functions, and therapeutic interventions for diseases

3. Pathology as Network Dysregulation.

In recent years, a transformative view of physiology has emerged: the body operates not as isolated organs, but as an integrated communication network in which signals flow bidirectionally between the brain, the immune system, the gut, and peripheral organs. This comprehensive review synthesizes current mechanistic insights into this “organ cross-talk” and frames them within systems biology and neuroscience.

At its core, organ cross-talk encompasses neural, endocrine, metabolic, and immune signaling between organs that coordinate homeostasis and orchestrate responses to stress and disease. From a neuroscience vantage point, three themes stand out:

1. The Brain as a Communication Hub.

2. Peripheral Feedback to the CNS.

Continue reading “Organ cross-talk: molecular mechanisms, biological functions, and therapeutic interventions for diseases” | >

First Dawn of Universe Simulation: EWOG

From Dark till First Dawn of Universe Simulation: EWOG Quantum Gravity Theory.

🚀From Dark till First Dawn of Universe Simulation: Why EWOG is promising to the Cosmic Race! 🌌 https://lnkd.in/gFBNsKtq Ever wonder how the James Webb Space Telescope (JWST) keeps finding massive, mature galaxies that “shouldn’t exist” yet? Standard cosmology (ΛCDM) is struggling to explain this without extreme fine-tuning. But Entanglement-Weighted Operator Gravity (EWOG) provides a first-principles answer. 🧩 The “Quantum Turbo” Effect In the dense early universe, high quantum entanglement between matter and geometry temporarily boosted gravity’s strength. The Core Idea: Gravity isn’t a constant; it’s an operator weighted by entanglement (Ŵ). * Curvature from Commutators: R̂ᵤᵥ = [∇̂ᵤ, ∇̂ᵥ] * The Boosted Coupling: G_eff(a, k) = G_N [1 + α₀(1 — e⁻ᵐʳ)ℱ] This “turbo boost” allowed gas to collapse into stars 150,000 years earlier than standard models predict.

Agenus Closes Strategic Immunotherapeutic Collaboration with Zydus Lifesciences

As part of the collaboration, Agenus has granted Zydus exclusive rights to develop and commercialize BOT and BAL in India and Sri Lanka, with Agenus eligible to receive royalties on net sales in those territories.

“Closing this collaboration with Zydus strengthens our balance sheet and, critically, secures dedicated U.S. manufacturing capacity at a pivotal moment for Agenus,” continued Armen. “With these foundations in place, our focus in 2026 is disciplined execution—advancing our Phase III program, broadening paid patient access through authorized pathways, and progressing toward regulatory submission supported by one of the most substantial clinical datasets generated in [microsatellite stable] MSS colorectal cancer.”

Following the closing, the Emeryville and Berkeley, CA, biologics manufacturing facilities will be transferred to Zydus and housed under a newly formed subsidiary named Zylidac Bio. Agenus has secured committed manufacturing capacity at these U.S. sites to support BOT+BAL supply needs for its clinical trials, global access programs, and future commercialization.

AI model detects prediabetes using ECG data without need for blood tests

DiaCardia, a novel artificial intelligence model that can accurately identify individuals with prediabetes using either 12-lead or single-lead electrocardiogram (ECG) data, has been developed. This breakthrough holds promise for future home-based prediabetes screening using consumer wearable devices, without requiring invasive blood tests.

Type 2 diabetes occurs when the human body either cannot make enough insulin or does not use insulin well, resulting in high blood glucose levels. This condition is a growing global health burden that can reduce the quality of life and life expectancy.

Before type 2 diabetes develops, many people go through a prolonged stage called prediabetes, where blood glucose levels are above normal but not high enough to be diagnosed as diabetes. Prediabetes is an important window wherein lifestyle changes can reduce the progression to diabetes.

Archaeologists Have Discovered an Ancient “Factory” That Could “Reshape What We Thought We Knew” About Roman Britain

A major ancient Roman industrial site on the River Wear may be one of the most important archaeological discoveries of the last hundred years, experts say.

Situated in northern England, the Roman site has yielded more than 800 whetstones on the riverbanks, with the expectation that hundreds or even thousands more may remain buried and await discovery. Durham University’s Department of Archaeology oversaw the work, which potentially could reframe our past understanding of Roman activity in the area.

Roman Whetstones

Liraglutide in Acute Minor Ischemic Stroke or High-Risk Transient Ischemic Attack With Type 2 Diabetes: The LAMP Randomized Clinical Trial

Liraglutide addition for Chinese patients with type 2 diabetes and minor AIS or high-risk TIA reduced 90-day stroke recurrence and improved functional outcomes.

Question Do glucagon-like peptide–1 receptor agonists (liraglutide) reduce stroke recurrence in patients with type 2 diabetes who have minor acute ischemic stroke or high-risk transient ischemic attack?

Findings In this randomized clinical trial of 636 participants with type 2 diabetes, 25 patients (7.9%) who were randomly assigned to receive standard therapy plus liraglutide and 44 (13.8%) of those who received standard therapy had recurrent stroke at 90 days.

Meaning The results of this randomized clinical trial suggest that, compared with standard therapy, liraglutide might reduce recurrent stroke in patients with type 2 diabetes who had minor acute ischemic stroke or high-risk transient ischemic attack.

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