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Epistasis study uncovers genetic interactions linked to heart disease

Euan Ashley’s lab explores the intricate interactions of gene variants. Tiny “typos,” or genetic mutations, can sneak into segments of DNA. Many of these are harmless, but some can cause health problems. Two or more genes can team up and change the outcome of a physical or molecular trait. This phenomenon, known as epistasis, occurs through complex interactions between genes that are functionally related—such as those that support protein creation.

Identifying these group dynamics provides crucial clues to how genetic diseases manifest and should be treated. But they’re not easily detected and often fly under the radar.

To help root out these connections, Ashley, MB ChB, DPhil, professor of genetics and of biomedical data science, and a team of scientists, including co-corresponding author Bin Yu, Ph.D., a professor of statistics and of electrical engineering and computer sciences at the University of California, Berkeley, have developed computational techniques to identify and understand the hidden ways epistasis influences inherited diseases.

How can we better invest in people’s prosperity, health, skills and jobs? Davos 2026

‘People’, whether it’s for the benefit they bring to growth or the challenge they pose to the balance sheet, always feature on the Annual Meeting’s agenda.

This year, geopolitics dominated the headlines, but a quieter conversation about the investment in people persisted, reflecting a shared recognition that human well-being and human capital is the key to economic resilience.

Maternal microbiome compound may hold key to preventing liver disease

Children born to mothers who consume a high-fat, high-sugar diet during pregnancy and breastfeeding face a higher risk of developing fatty liver disease later in life.

New research from the University of Oklahoma suggests that risk may be reduced. A recent study has found that supplementing pregnant and lactating mice with a naturally occurring compound produced by healthy gut bacteria significantly lowered rates of fatty liver disease in their offspring as they aged.

The research is published in the journal eBioMedicine.

Securing the Neural Frontier: Cybersecurity and Privacy Risks in Brain-Computer Interfaces and Neurotechnology

Please see my LinkedIn article: “Securing the Neural Frontier.”

We are poised to witness one of the most significant technological advancements in human history: the direct interaction between human brains and machines. Brain-computer interfaces (BCIs), neurotechnology, and brain-inspired computing have already arrived and need to be secure.

Link.

‘HUGE BREAKTHROUGHS’: NVIDIA CEO reveals future of AI

NVIDIA CEO Jensen Huang discusses how artificial intelligence is advancing and handling competition with China on ‘Maria Bartiromo’s Wall Street.’ #fox #media #breakingnews #us #usa #new #news #breaking #foxbusiness #nvidia #ai #technology #tech #artificialintelligence #innovation #business #china #competition #jensenhuang #huang #ceo #economy #global #future.

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The Successor to CRISPR May Be Even More World Changing

When Feng Zhang was in his early 30s, he used a set of genes found in bacteria called CRISPR to pioneer a new kind of gene editing tool in human cells. Today, the MIT biochemist is studying a different set of microbial genes called TIGR. And they may be the key to developing CRISPR’s successor. For this SciShow Field Trips video, we traveled to Zhang’s lab to learn about what may be the next generation of gene editing.

High-risk EPN models present the immunotherapeutic target GD2 and are sensitive to GD2–CAR T cell therapy in vitro and in vivo

Research Letter: CAR T cells targeting the glycoprotein GD2 show potent antitumor efficacy in high-risk ependymoma models.

Antonio Carlos Tallon-Cobos & team establish a new ependymoma model for preclinical research and demonstrate a promising immunotherapeutic approach for this largely aggressive pediatric brain cancer.


1Princess Máxima Center for pediatric oncology, Utrecht, Netherlands.

2Hopp Children’s Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.

3Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Consortium (DKTK), Heidelberg, Germany.

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