Wang et al. report that Gn-specific mAbs from SFTS survivors exhibit broad and potent neutralization, with two providing complete protection in a lethal mouse model. This work maps the Gn antigenic landscape and establishes a deep mutational scanning platform coupled with structural validation for bunyavirus antibody discovery.
A team of scientists in Shanghai has developed a lab-grown biological pacemaker designed to mimic the heart’s natural rhythm control system. By working with human pluripotent stem cells, which can transform into many different types of tissue, the researchers created a three-dimensional sinoatrial node organoid capable of generating electrical impulses, the South China Morning Post reported.
To make the system more lifelike, the team linked the organoid to an artificial cardiac plexus, a network of nerves located near the base of the heart that helps regulate heartbeat activity. The achievement allowed researchers to recreate how the nervous system communicates with the heart, opening potential new paths for studying irregular heart rhythms and developing future treatments that could reduce reliance on electronic pacemakers.
The research, published in the journal Cell Stem Cell involved scientists from the Chinese Academy of Sciences and Fudan University. The team focused on the sinoatrial node, the tiny part of the heart responsible for controlling its rhythm. Although it plays a critical role in keeping the heart beating properly, the structure has been difficult for scientists to study because of its small size and hard-to-reach location inside the heart.
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Scientists used spider silk-inspired processing to turn corn protein into a strong biodegradable plastic alternative.
The South Island giant moa, a flightless bird that stood up to 12ft tall, last roamed New Zealand’s forests some 600 years ago. Yet the species may have taken a small, strange step back from extinction — thanks to an artificial egg made of silicone.
Colossal Biosciences, a Texan biotechnology firm, has developed a shell-less system it says is capable of supporting a bird embryo from early development through to the point of hatching.
So far the device has been used to produce baby chickens. The end goal, the company says, is to deploy a much larger version to resurrect the moa, whose eggs were about 80 times the volume of a farmyard hen’s.
Lunar Outpost has secured $30 million in Series B funding as the Colorado company tries to move from building individual lunar rovers to supplying the machines that could prepare the Moon for longer-term human use.
The money is meant to accelerate production of its robotics and mobility platforms. It also arrives as Lunar Outpost is promoting Pegasus, a smaller rover concept that Space.com reported the company hopes to deliver by the end of 2027 and launch to the Moon in 2028, on a timeline that broadly lines up with NASA’s current Artemis 4 schedule.
The real bet is not just exploration. It is that the Moon is becoming a worksite, and that whoever supplies the mobile robotic workforce may become more important than whoever sells the most dramatic single vehicle.
Almost 12 years ago, a 16-year-old girl named Stefanie wrote to me the night before her senior year of high school. She could not sleep. She was terrified of the Singularity. And she wanted to know what she could actually do about it.
I still get these messages. More of them than ever, in fact. The names change. The fear does not. If anything, in the age of frontier AI, autonomous agents, and accelerating capability, the desperation in young people’s voices has only deepened.
What struck me when I went back to read my reply was how little I wanted to change. The advice I gave Stefanie has, mostly, stood the test of time. So rather than rewrite it, I am simply reposting it. A few of the things I told her then, and would tell any anxious young person today:
Be unreasonable. The reasonable person adapts to the world. The unreasonable one persists in trying to adapt the world to herself. All progress depends on unreasonable people. Shaw was right.
Think in decades, not weeks. Life is a marathon, not a sprint. Persistence will be your best friend and your biggest enemy.
Prepare to fail. It took Edison thousands of attempts to make the light bulb. What matters is not how many times you fall, but how long you are willing to endure.