Traumatic head injuries from collision and combat sports disrupt the blood-brain barrier and trigger inflammation for years after retirement, shows a new MRI and transcriptomic analysis of retired athletes.
Find out more in Science TranslationalMedicine.
Sci. Transl. Med. 18, eadu6037 (2026). DOI:10.1126/scitranslmed.adu6037
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The European Space Agency announced Thursday it has re-established communication with a spacecraft that is part of its Proba-3 mission, after losing contact with the satellite a month ago.
Proba-3, which launched on a two-year mission in 2024, uses two spacecraft flying in precise formation to simulate a solar eclipse more than 60,000 kilometers (37,000 miles) above Earth.
Scientists have used this delicate dance to get a rare glimpse of the sun’s little-known outer atmosphere, which is called the corona.
Nutrient stress in DNA damage.
The dynamic interplay between nutrient stress and DNA damage governs cellular survival through coordinated regulation of genomic integrity and metabolic adaptation. Nutrient deprivation, such as glucose or amino acid limitation, engages nutrient sensors, including AMPK and mTORC1, to rewire energy homeostasis while directly influencing DNA repair via regulating PARP1, BRCA1, and other core repair machinery.
DNA damage-activated kinases (ATM/ ATR) orchestrate metabolic reprogramming to fuel repair processes, enforcing context-dependent cell fate decisions via cell cycle arrest or apoptosis regulation.
Nutrient stress exacerbates genomic instability through depleting antioxidants, such as NADPH or glutathione (GSH), promoting oxidative DNA lesions that overwhelm repair capacity, while defective DNA repair conversely drives metabolic dysregulation in tumors.
In the future, more efficacious tumor therapeutic strategies propose combining targeted nutrient stress with DNA damage repair inhibitors to exploit synthetic lethality. However, clinical translation requires resolving key challenges including tumor heterogeneity in nutrient stress-response pathways and adaptive metabolic plasticity during therapy sciencenewshighlights ScienceMission https://sciencemission.com/nutrient-stress–and-DNA-damage
Cells are constantly exposed to various stresses, including nutrient deprivation and genotoxic stress, which dynamically interact with cellular sensing pathways to influence metabolism, gene expression, and homeostasis. The integration of nutrient-sensing mechanisms and DNA damage response pathways is critical in cancer progression. While individual processes are well-characterized, their cross-regulatory mechanisms are just beginning to emerge. Deciphering the interplay between nutrient stress and DNA damage is crucial for elucidating the mechanisms underlying cellular responses to stress and developing therapeutic strategies for various diseases, including cancer. This review highlights the relationship between nutrient stress and DNA damage, especially its underlying sensing pathway and cell fate determination.
Yuan et al. report a high-quality chromosome-scale genome of the hexaploid halophyte Sesuvium portulacastrum. Comparative genomics and transcriptomics provide insights into its salt-adaptation evolution and identify the key salt-tolerant gene SpHAK3, offering genetic resources for improving crop tolerance.
The researchers also discovered a tiny antibody, called a nanobody, which mimics NPC1 at the receptor-binding site and can slip past a protective cap on Marburg’s entry protein, bind to it and block its attachment to the receptor. In lab tests, this nanobody prevented Marburg virus from entering cells. ScienceMission sciencenewshighlights.
In a new study published in Nature the researchers found that the Marburg virus (MBV), one of the world’s deadliest pathogens with an average 73% fatality rate, is unusually efficient at getting inside human cells. They also showed that the virus’s entry protein contains structural features that explain this efficiency and point to a strategy for blocking infection.
The researchers designed a tightly controlled system that enables a fair comparison of the entry proteins of Marburg and its relative Ebola. The team further found that the two viruses share the same human receptor. The authors determined structures of MBV glycoprotein (GP) in three states: unbound; bound to its endosomal receptor NPC1; and complexed with a neutralizing nanobody.
Marburg’s entry protein binds this receptor in a distinct orientation and with higher affinity, then changes shape in ways that help the virus enter cells. The authors show that the glycan cap shields the receptor-binding site from NPC1 but only partially from the nanobody, enabling limited immune evasion. After glycan cap cleavage, NPC1 binds to MBV GP in a distinct orientation compared with EBOV GP, providing an additional anchor and enhancing receptor affinity. NPC1 engagement also induces substantial conformational changes in MBV GP, probably facilitating membrane fusion. Using this approach, they showed that Marburg’s entry protein can drive viral entry into human cells up to 300 times more efficiently than Ebola’s.
All right, let’s go.
Number 10. Methuselah’s Star.
In 2000, a team of astronomers led by Howard Bond at Penn State University pointed the Hubble Space Telescope at a faint star in the constellation Libra and made a discovery that should have been impossible. The star, designated HD 140,283 and later nicknamed Methuselah, appeared to be 14.5 billion years old. The universe itself is only 13.8 billion years old. A star older than the cosmos that contains it shouldn’t exist. Yet there it was, burning quietly just 190 light years from Earth, defying the most fundamental timeline in all of physics.
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What if gravity is not fundamental but emerges from quantum entanglement? In this episode, physicist Ted Jacobson reveals how Einstein’s equations can be derived from thermodynamic principles of the quantum vacuum, reshaping our understanding of space, time, and gravity itself.
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