Mosley et al. investigate the role of cytosolic DNA structure in activation of cGAS/STING by MSI colorectal cancers. They find MSI cytosolic DNA is enriched in G-quadruplexes, leading to more effective cGAS/STING activation. Micronuclei are less effective at activating cytotoxic T cells through cGAS/STING but increase IL-10 and Treg activation.
Marko et al. show that elevated insulin in obese mice suppresses adipocyte IRF4, which governs fat versus muscle preservation during 5:2 intermittent fasting (IF) with or without caloric restriction. During an acute fast in humans, obesity and elevated insulin promoted lean mass loss in males but not females.
https://doi.org/10.1172/jci.insight.
Robert A. Fenton & team show that a diet low in potassium causes bone loss in mice, effects that are attributable to altered calcium absorption by the kidney.
The figure shows deep learning instance segmentation model to identify kidney tubules and indicates low dietary K+ intake alters the abundance of the calcium-sensing receptor.
1Department of Biomedical Sciences, University of Veterinary Medicine, Vienna, Austria.
2Department of Biomedicine, Aarhus University, Aarhus, Denmark.
3Department of Medicine, Division of Nephrology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Project Hail Mary, a story by Andy Weir (author of The Martian), features some of the most creative speculative evolution scenarios in modern science fiction. With the release of the film adaptation starring Ryan Gosling, now seemed like a great time to explore the speculative biology of the aliens in this story: the Astrophage and the Eridians (Rockyâs species).
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Our goal is to make a full 20 minute long animated SCP short film, and have been preparing the groundwork for it for over two years now! Finally, we get to share this with the whole world, in the hopes to make this project a reality!
Based on the SCP wiki, licensed under CC BY-SA 4.
Sabine Hossenfelder, Ivette Fuentes and James Ladyman discuss the scaling laws of the universe and the fundamental nature of reality.
Is the universe one thing, or many things?
With a free trial, you can watch the full debate NOW at https://iai.tv/video/the-one-and-theâ⊠central question in ancient Greek philosophy was the problem of the One and the Many. It is a question that has echoed across Western culture and is still with us today. Should we see the world as a coherent whole or a multitude of separate parts? The puzzle is that we need both the whole and the parts, but an explanation of the relationship between them has proved problematic and perhaps unknowable. In contemporary physics, the parts are the teeming world of particle physics, and these should make up the cosmological world of the universe as a whole and the overall framework of Einsteinian space-time. But as yet we have not been able to combine the two coherently. Is looking at the universe from the small scale and the large always going to be incompatible? Does it mean a theory of everything is an illusion and the attempt to combine quantum mechanics and Einsteinâs general relativity a forlorn project? Or is the parallel with the ancient Greek puzzle accidental and the current challenge one that might be overcome? #quantumphysics #universe #philosophy #fundamentalunits #theoryofeverything Sabine Hossenfelder is a theoretical physicist and acclaimed science communicator, known for her sharp critiques of the scientific mainstream. She is also a best-selling author and YouTuber. Ivette Fuentes is a theoretical quantum physicist at the University of Southampton and Emmy Fellow at the University of Oxford. James Ladyman is a philosopher of science at the University of Bristol. He is best known for his book Every Thing Must Go, calling for a metaphysics grounded in physics and complexity science. Hosted by Jack Symes. 00:40 James Ladyman on the different notions of scale 02:39 Sabine Hossenfelder on energy in the universe 05:19 Ivette Fuentes on unifying quantum mechanics and general relativity 09:00 Is the universe âOneâ or âManyâ? 17:15 Particles are not fundamental The Institute of Art and Ideas features videos and articles from cutting edge thinkers discussing the ideas that are shaping the world, from metaphysics to string theory, technology to democracy, aesthetics to genetics. Subscribe today! https://iai.tv/subscribe?utm_source=Y⊠For debates and talks: https://iai.tv For articles: https://iai.tv/articles For courses: https://iai.tv/iai-academy/courses.
A central question in ancient Greek philosophy was the problem of the One and the Many. It is a question that has echoed across Western culture and is still with us today. Should we see the world as a coherent whole or a multitude of separate parts? The puzzle is that we need both the whole and the parts, but an explanation of the relationship between them has proved problematic and perhaps unknowable. In contemporary physics, the parts are the teeming world of particle physics, and these should make up the cosmological world of the universe as a whole and the overall framework of Einsteinian space-time. But as yet we have not been able to combine the two coherently.
Is looking at the universe from the small scale and the large always going to be incompatible? Does it mean a theory of everything is an illusion and the attempt to combine quantum mechanics and Einsteinâs general relativity a forlorn project? Or is the parallel with the ancient Greek puzzle accidental and the current challenge one that might be overcome?
#quantumphysics #universe #philosophy #fundamentalunits #theoryofeverything.