A team of researchers at the Departments of Physical Chemistry and Organic Chemistry of the University of Malaga and The Biomimetic Dendrimers and Photonic Laboratory of the research institute IBIMA Plataforma BIONAND has achieved a breakthrough that combines materials science and biomedicine. They have developed a new family of fluorescent molecules with promising applications in the study of living cells and the medicine of the future. The study has just been published in Advanced Materials.
The team of researchers has created a new family of fluorescent molecules that glow in a surprising way. These types of molecules typically lose part of their intensity or change to more dull colors when dissolved in water or other biological media. However, these new molecules do just the opposite: They emit a higher fluorescence intensity because their coloration shifts to the blue region of the light spectrum.
This behavior, which scientists described as “counterintuitive,” is key because it means that dyes work better in aqueous media like the inside of a cell, something essential for biomedical applications. In other words, they do not turn off when they are needed most but rather maintain—and even enhance—their brightness in real conditions of use.