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Category: chemistry

What’s inside a masterpiece? Laser scans and AI map paint layers molecule by molecule

Paintings are far more than dabs of oil on canvas. They are complex works of art composed of multiple layers, from primer and glues to the pigments and protective varnishes applied by the artists. Being able to see into these layers and map their chemical makeup is essential for art historians and conservators. A new technique developed by an international team of scientists can now probe paint layers in far greater molecular detail than before.

As they describe in a paper published in the journal Science Advances, the researchers combined a technique called MALDI-MSI (matrix-assisted laser desorption/ionization mass spectrometry imaging) with an AI named MSIpredictART to help identify the specific pigments and binders present in each layer of a painting.

Current approaches looking at the internal structure of a painting have to run several different tests on tiny samples. MALDI-MSI reduces the need for multiple separate techniques by using a high-resolution laser scan to map both the pigments and the binder or glue that holds them together.

Hygroscopic salts pull lithium from mining waste using only moisture from air

The world cannot have enough of the third element on the periodic table. From smartphones and laptops to state-of-the-art EVs, all are powered by lithium batteries. The demand for metal is only going to rise, and projected values suggest nearly a triple increase in demand by 2030. The traditional process of lithium mining is both water and energy-hungry. One such step is the dissolution of lithium salts from other competing minerals during the separation process.

In a study published in Nature Communications, researchers present a clever way to harness the deliquescence of lithium chloride hydrate (LHT)—a unique ability to naturally pull moisture from the air to dissolve itself—to extract and concentrate lithium from mining waste while leaving behind unwanted minerals.

The method achieved up to 97% lithium recovery with an increase in the lithium purity by 1,500 times, producing a liquid concentrate with lithium levels reaching 97,000 parts per million, which was more than twice as concentrated as the standard solutions used in battery processing.

AI Designed Peptides Could Cure… EVERYTHING. LigandForge Is Here

LigandForge generates 150,000 peptide drug candidates in 3 minutes — a million times faster than existing methods, unlocking a tsunami of possible treatments.

A man with no medical background used ChatGPT, AlphaFold, and Grok to design a custom mRNA cancer vaccine for his dying dog — and her biggest tumor shrank 75%.

Meanwhile, scientists discovered a single protein that literally spreads aging through your bloodstream. These stories are each incredible on their own. But the big story is the implications for curing aging.

In this deep dive, I break down how these three breakthroughs fit together, what peptides and mRNA vaccines actually are (and how they’re different), and why this moment might be the most important inflection point in the history of drug design.

The age of custom AI cures isn’t coming. It’s here.

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Breaking recalcitrant lignin bonds with electricity for conversion into value-added chemicals: An e-biorefinery

A research team led by Professor Jaehoon Kim at Sungkyunkwan University and Dr. Dong Ki Lee at the Korea Institute of Science and Technology (KIST) has developed a highly efficient catalytic process that electrochemically converts lignin, a key component of woody biomass, into value-added aromatic compounds and cyclohexene-based compounds.

The study demonstrates that the recalcitrant ether bonds in lignin can be selectively cleaved under relatively mild conditions without the use of external hydrogen gas, while simultaneously upgrading lignin into useful chemical precursors.

The research results were published in Applied Catalysis B: Environment and Energy.

Understanding protein motion could greatly aid new drug design

For many people, “protein” is the key element of a food order. However, beyond the preferred choice of meats or plant-based alternatives, proteins encompass a large class of complex biomolecules whose chemical structure is encoded in our genes. Proteins have critical functions in living cells; they help repair and build body tissues, drive metabolic reactions, maintain pH and fluid balance, and keep our immune systems strong.

To perform their important functions, many proteins have a dynamic molecular structure capable of adopting multiple conformations. For a long time, scientists have suspected that proteins don’t change shape at random. Instead, they seem to move according to deep, slow rhythms—like a building that sways gently in the wind rather than shaking violently.

Those slow rhythms guide how a protein bends, twists, and shifts between its different forms. If one could understand those rhythms, one might be able to predict—and even hurry along—the protein’s movements.

Space launches are changing the chemistry of Earth’s atmosphere, studies warn. Here’s what can be done

Look up on a clear night and you’ll see the streaks of our new space age. What you don’t see is the growing fallout for the atmosphere that keeps us alive.

A wave of satellite launches and reentries is changing the chemistry and physics of the middle and upper atmosphere.

Studies warn of ozone depletion, stratospheric heating and new metal aerosols from burning spacecraft. The pace is accelerating fast and unless we redesign how we use and retire satellites, we risk swapping one environmental problem (congestion in Earth orbit from too many spacecraft) for another (an atmosphere seeded with rocket soot and satellite ash).

From engineered fungal molecules to drug leads, chem-bio hybrid synthesis enables antiparasitic drug discovery

Amebiasis is a parasitic disease caused by the microscopic protozoan Entamoeba histolytica. Infection occurs through the ingestion of cysts from contaminated water or food. Worldwide, approximately 50 million symptomatic cases are estimated annually, mainly in tropical and subtropical regions.

Fumagillin, a fungal natural product, has been studied for decades as a potential antiparasitic drug, but its more potent relative, ovalicin, was never developed. Now, a study published in the Journal of the American Chemical Society reveals why: although ovalicin is highly active against amebiasis, liver enzymes rapidly break it down in the body. Researchers used a chem-bio hybrid approach to turn that insight into metabolically stable drug candidates that worked in animal models of amebiasis, including liver infection with abscess formation.

The research team, led by scientists from the Graduate School of Bioagricultural Sciences at Nagoya University, identified the liver cytochrome P450 enzymes responsible for ovalicin breakdown, with CYP 2B1 and CYP 2C6 emerging as the main drivers. Blocking these enzymes with a chemical inhibitor significantly prolonged ovalicin survival, providing strong evidence that rapid liver metabolism limits its effectiveness.

Simulated microgravity alters sperm navigation, fertilization and embryo development in mammals

Simulated microgravity reveals species-specific effects on sperm navigation, fertilization, and early embryo development, highlighting compensatory mechanisms and chemical cues critical for reproduction in future space missions.

Organocatalytic strategy provides a metal-free route to antiviral candidates

A research team led by Prof. Sun Jianwei has achieved an advancement in organic synthesis and medicinal chemistry by developing an air-stable chiral phosphine-catalyzed enantioselective approach to synthesize enantioenriched S(IV)-stereogenic vinyl sulfinamides—an under-explored class of organosulfur compounds with promising antiviral activity.

The importance of chiral-at-sulfur compounds in drug discovery and organic synthesis is indisputable. More than a quarter of top-selling small molecule pharmaceuticals contain sulfur atoms, and chiral sulfinamides bearing S(IV) chirality are key building blocks for medicinal chemistry, asymmetric synthesis auxiliaries, and catalytic ligands. However, current methods to access enantioenriched sulfinamides rely on transition metal catalysis with organometallic nucleophiles, and efficient organocatalytic strategies have long remained unexplored, creating a critical gap in synthetic chemistry for this valuable chemical space.

To address this challenge, Prof. Sun’s team published a study in Nature Chemistry detailing the design and synthesis of a novel C₂-symmetric chiral phosphine catalyst—QianPhos—derived from the SPHENOL chiral skeleton. This custom catalyst exhibits extraordinary air stability and structural rigidity, which enables highly chemo-, enantio-, and diastereoselective C−S bond formation via a [3+2] annulation between Morita–Baylis–Hillman (MBH) esters and sulfinylamines.

Webb and Hubble share the most comprehensive view of Saturn to date

NASA’s James Webb Space Telescope and Hubble Space Telescope have teamed up to capture new views of Saturn, revealing the planet in strikingly different ways. Observing in complementary wavelengths of light, the two space observatories provide scientists with a richer, more layered understanding of the gas giant’s atmosphere.

Both sense sunlight reflected from Saturn’s banded clouds and hazes, but where Hubble reveals subtle color variations across the planet, Webb’s infrared view senses clouds and chemicals at many different depths in the atmosphere, from the deep clouds to the tenuous upper atmosphere.

Together, scientists can effectively “slice” through Saturn’s atmosphere at multiple altitudes, like peeling back the layers of an onion. Each telescope tells a different part of Saturn’s story, and the observations together help researchers understand how Saturn’s atmosphere works as a connected three-dimensional system. Both complement previous observations done by NASA’s Cassini orbiter during its time studying the Saturnian system from 1997 to 2017.

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