This systematic review examines structural, functional, neurochemical, and plasticity brain changes associated with social determinants of health in individuals with, or at risk for, schizophrenia-spectrum psychotic conditions.
Category: chemistry
Gene tied to energy production in brain could lead to new treatment for cognitive disorders
Researchers in the Jacobs School of Medicine and Biomedical Sciences at the University at Buffalo have discovered a connection between a specific gene and healthy brain function. “The hope is that this discovery could eventually lead to expanded treatment for psychiatric and neurological disorders such as schizophrenia, bipolar disorder and autism,” explains Mikhail V. Pletnikov, MD, Ph.D., professor and chair of the Department of Physiology and Biophysics, the senior author of the study with Kateryna (Kate) Murlanova, Ph.D., the first lead author and a research scientist in the department.
They discovered that the NPAS3 gene expressed in astrocytes—the cells that help with brain chemistry—regulates the energy production required to support thinking and memory. NPAS3 is a transcription factor, which means it directs how certain genes work and influences how cells function. Their findings are published in Science Advances.
“Previous studies have linked NPAS3 to conditions involving cognitive problems, such as schizophrenia, but scientists didn’t know exactly how it might be involved,” Pletnikov says.
Brain enzyme caught doing something unexpected—it builds polysialic acid on itself
A chance discovery at Nagoya University in Japan has shown that a well-known brain enzyme has a hidden ability: It builds a sugar chain on itself, becomes secreted from the cell and deactivates, then switches on outside the cell once the chain is removed. The finding, published in the Journal of Biological Chemistry, overturns a decades-old assumption about how polysialic acid, a sugar chain critical for brain development and function, is produced and shows a new way an enzyme can regulate its own activity.
The human brain is covered in sugar chains, or glycans, molecular structures that coat cells and regulate how they communicate. One of the most important is polysialic acid, a long chain found mainly in the brain.
Polysialic acid keeps brain cells from adhering too tightly to each other and binds to growth factors and neurotrophins to regulate the presentation of their receptors. Through this, it plays a key role in learning, memory and neural development. Importantly, these sugar chains change rapidly in response to brain activity. The ability to restore them quickly is thought to be essential for normal brain function.
Diamond-based particle detector captures one-picosecond electron bursts for high-rate beam diagnostics
Physicists at UC Santa Cruz and other institutes across California and New Mexico have developed a detection system that will allow next-generation particle accelerators to better reveal fundamental biological and chemical processes, as well as advance critical areas such as materials science and energy research.
The Advanced Accelerator Diagnostics Collaboration, a group of two University of California campuses and three U.S. national laboratories, came together to solve a growing need for high-rate beam diagnostics. These accelerators will now jump from 120 pulses a second to 1 million pulses a second, straining current beam diagnostic systems. The results are now published in the journal Physical Review Accelerators and Beams.
“It really highlights the power of collaboration between universities and national laboratories,” said Bruce Schumm, the Long Family Professor of Experimental Physics. “If you took away Lawrence Berkeley Lab, if you took away Los Alamos, if you took away UC Davis, any of those, the whole thing would have fallen apart.”
How to train your magnet: Excitons as a new knob for magnetic control
Scientists can learn a lot about a quantum material by watching how it responds to light. In magnetic semiconductors, one especially useful messenger is the exciton: a pairing of a negatively charged electron and the positively charged “hole” it leaves behind. Until now, excitons in magnetic materials have mostly been used as reporters. They could reveal how spins were arranged or how magnetic waves moved through a material. But Cornell researchers have shown that excitons can do more than observe magnetism. They can actively steer it.
In the paper “Excitonic Spin Torque in a Magnetic Semiconductor,” published June 15 in Nature Materials, Youn Jue (Eunice) Bae, assistant professor of chemistry and chemical biology in the College of Arts and Sciences, and colleagues report that excitons created by light can exert a spin torque in the two-dimensional magnetic semiconductor chromium sulfide bromide, or CrSBr. The finding establishes excitons as a new way to control magnetic motion with light.
“Excitons have been very useful for watching what spins are doing in magnetic materials,” Bae said. “What we show here is that excitons can also act back on the spins. They are not just spectators; they can help drive the magnetic motion.”
Origin-of-life simulations + Algorithmic-chemistry for AGI
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Reversible chirality switching in MoS₂ generates spin currents without magnets
A newly developed method allows researchers to dynamically switch chirality—a particular lack of mirror symmetry—to generate spin currents in semiconductors, researchers from Science Tokyo report. Their approach relies on the reversible insertion and removal of small chiral molecules from the interlayer gaps of a layered, nonchiral semiconductor material using electrochemistry.
The findings could pave the way for the development of novel chiral spintronic materials and technologies that do not rely on magnets or magnetic fields.
New plasma trick could unlock smaller, more powerful computer chips
Under carefully controlled conditions, particles within a plasma can strike the surface of a TMD material and knock atoms loose. The challenge is achieving enough energy to remove sulfur atoms from the top layer without harming the molybdenum layer beneath. Because the difference between success and damage is so small, developing a reliable process has proven difficult.
Using computer simulations, researchers found that treating molybdenum disulfide with oxygen or fluorine before plasma exposure can make the process much more controlled. Their findings were published in the Journal of Physical Chemistry Letters.
Intermolecular collisions may explain why organic radical fluids become unusually magnetic
Certain substances can become magnetic when exposed to an external magnetic field. Magnetic susceptibility measures how easily a material can be magnetized. Materials known as organic radicals have been noted to possess anomalously large magnetic susceptibility. However, researchers have been unable to explain this phenomenon using conventional theories.
Now, researchers at the University of Osaka have developed a theoretical framework to explain this anomalous magnetic susceptibility. This discovery was recently published in the Journal of Physical Chemistry Letters.
Bacteria reveal ‘glue’ protein that fastens antibiotic-resistant outer membrane to cell wall
Researchers at the University of Notre Dame and collaborators have discovered a key process in how the outer membrane of gram-negative bacteria attaches to the cell wall, advancing the understanding of how these bacteria frequently develop resistance to antibiotics.
The research, published in the Journal of the American Chemical Society, was carried out in the laboratory of Shahriar Mobashery, Navari Professor of Life Sciences in the Department of Chemistry and Biochemistry, with structural aspects of the study performed by Juan A. Hermoso of the Institute of Physical Chemistry “Blas Cabrera” in Madrid, Spain. The researchers discovered that the protein PA2854 performs the reaction that keeps the outside layers, or envelope, of gram-negative bacteria connected to each other.
Mobashery and collaborators studied the process in Pseudomonas aeruginosa (P. aeruginosa), a ubiquitous antibiotic-resistant bacterium commonly affecting people with cystic fibrosis. P. aeruginosa, like other gram-negative bacteria including E. coli, Klebsiella pneumoniae and Salmonella, is shielded by a three-layer biological envelope that prevents many antibiotics from penetrating and damaging the bacteria. Gram-positive bacteria do not have an outer membrane and are generally more susceptible to antibiotics.