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Category: chemistry

Novel ‘XFELO’ laser system produces razor-sharp X-ray light

A team of engineers and scientists has shown for the first time that a hard-X-ray cavity can provide net X-ray gain, with X-ray pulses being circulated between crystal mirrors and amplified in the process, much like happens with an optical laser. The result of the proof-of-concept at European XFEL is a particularly coherent, laser-like light of a quality that is unprecedented in the hard X-ray spectrum.

Lasing inside a cavity had been challenging to achieve with short-wavelength X-rays for a variety of reasons, including—on a basic level—that the nature of the light makes it difficult to reflect the beam at large angles. The “XFELO” (short for: X-Ray Free-Electron Laser Oscillator) technique opens new perspectives for scientific investigations, from ultrafast chemical reactions to detailed analyses of the smallest biological structures. The research is published in the journal Nature.

New ABF crystal delivers high-performance vacuum ultraviolet nonlinear optical conversion

Vacuum ultraviolet (VUV, 100–200 nm) light sources are indispensable for advanced spectroscopy, quantum research, and semiconductor lithography. Although second harmonic generation (SHG) using nonlinear optical (NLO) crystals is one of the simplest and most efficient methods for generating VUV light, the scarcity of suitable NLO crystals has long been a bottleneck.

To address this problem, a research team led by Prof. Pan Shilie at the Xinjiang Technical Institute of Physics and Chemistry of the Chinese Academy of Sciences (CAS) has developed the fluorooxoborate crystal NH4B4O6F (ABF)—offering an effective solution to the practical challenges of VUV NLO materials. The team’s findings were recently published in Nature.

The team’s key achievement is the development of centimeter-scale, high-quality ABF crystal growth and advanced anisotropic crystal processing technologies. Notably, ABF uniquely integrates a set of conflicting yet critical properties required for VUV NLO materials—excellent VUV transparency, a strong NLO coefficient, and substantial birefringence for VUV phase-matching—while fulfilling stringent practical criteria: large crystal size for fabricating devices with specific phase-matching angles, stable physical/chemical properties, a high laser-induced damage threshold, and suitable processability. This breakthrough resolves the long-standing field challenge where no prior crystal has met all these criteria simultaneously.

Establishing design principles for achieving ultralow thermal conductivity via controlled chemical disorder

A major challenge in thermal-management and thermal-insulation technologies, across multiple industries, is the lack of materials that simultaneously offer low thermal conductivity, mechanical robustness, and scalable fabrication routes.

Discovering materials that exhibit completely insulating thermal behavior—or, conversely, extraordinarily high thermal conductivity—has long been a dream for researchers in materials physics. Traditionally, amorphous materials are known to possess very low thermal conductivity.

This naturally leads to an important question: Can a crystalline material be engineered to achieve thermal conductivity close to that of an amorphous solid? Such a material would preserve the structural stability of a crystal while achieving exceptionally low thermal conductivity.

Brewing possibilities: Using caffeine to edit gene expression

What if a cup of coffee could help treat cancer? Researchers at the Texas A&M Health Institute of Biosciences and Technology believe it’s possible. By combining caffeine with the use of CRISPR—a gene-editing tool known as clustered regularly interspaced short palindromic repeats—scientists are unlocking new treatments for long-term diseases, like cancer and diabetes, using a strategy known as chemogenetics.

The work is published in the journal Chemical Science.

Yubin Zhou, professor and director of the Center for Translational Cancer Research at the Institute of Biosciences and Technology, specializes in utilizing groundbreaking tools and technology to study medicine at the cellular, epigenetic and genetic levels. Throughout his career and over 180 publications, he has sought answers to medical questions by using highly advanced tools like CRISPR and chemogenetic control systems.

Highly stable Cu₄₅ superatom could transform carbon recycling

After years of trying, scientists have finally created a stable superatom of copper, a long-sought-after chemical breakthrough that could revolutionize how we deal with carbon emissions.

Copper is a cheap and common metal, and because of its ability to bind carbon atoms together (C-C coupling), scientists have wanted to use it to turn carbon dioxide into products like ethylene for plastics and fuels. However, it corrodes or falls apart almost immediately when exposed to air or harsh industrial conditions.

A superatom is a cluster of atoms that behaves like a single atom, but with greater stability. In this new study published in the Journal of the American Chemical Society, scientists from Tsinghua University in Beijing built a nanocluster made from 45 copper atoms (Cu45).

Lieutenant Colonel Erin Maurer — Surviving The Unthinkable: NATO’s Frontline CBRN Defense

Surviving the unthinkable: nato’s frontline CBRN defense — lieutenant colonel erin maurer, CBRN defense lead, J3 force protection directorate, allied joint force command brunssum, NATO.

Lieutenant Colonel Erin Maurer is the CBRN Defense Lead, J3 Force Protection Directorate, at NATO Joint Force Command Brunssum, The Netherlands (https://jfcbs.nato.int/), a position she has held since July 2024.

LTC Maurer enlisted in the United States Army Reserves in 2004, and upon graduating from Penn State University in 2008, commissioned as a Second Lieutenant through the Reserve Officers Training Corps (ROTC), branched Chemical Corps. Her assignments have included:

Brigade chemical officer, company executive officer, and forward operating base operations officer, for 4th infantry brigade combat team, 3rd infantry division, fort stewart, georgia;

Headquarters Company Commander, Support Battalion, 1st Special Warfare Training Group (Airborne);

Continue reading “Lieutenant Colonel Erin Maurer — Surviving The Unthinkable: NATO’s Frontline CBRN Defense” | >

Novel nanomaterial uses oxidative stress to kill cancer cells

Scientists at Oregon State University have developed a new nanomaterial that triggers a pair of chemical reactions inside cancer cells, killing the cells via oxidative stress while leaving healthy tissues alone. The study led by Oleh and Olena Taratula and Chao Wang of the OSU College of Pharmacy appears in Advanced Functional Materials.

The findings advance the field of chemodynamic therapy (CDT), an emerging treatment approach based on the distinctive biochemical environment found in cancer cells. Compared to healthy tissues, malignant tumors are more acidic and have elevated concentrations of hydrogen peroxide, the scientists explain.

Conventional CDT works by using the tumor microenvironment to trigger the chemical production of hydroxyl radicals—molecules, made up of oxygen and hydrogen—with an unpaired electron. These reactive oxygen species are able to damage cells through oxidation by stealing electrons from molecules like lipids, proteins, and DNA.

‘Goldilocks size’ rhodium clusters advance reusable heterogeneous catalysts for hydroformylation

Recent research has demonstrated that a rhodium (Rh) cluster of an optimal, intermediate size—neither too small nor too large—exhibits the highest catalytic activity in hydroformylation reactions. Similar to the concept of finding the “just right” balance, the study identifies this so-called “Goldilocks size” as crucial for maximizing catalyst efficiency. The study is published in the journal ACS Catalysis and was featured as the cover story.

Led by Professor Kwangjin An from the School of Energy and Chemical Engineering at UNIST, in collaboration with Professor Jeong Woo Han from Seoul National University, the research demonstrates that when Rh exists as a cluster —comprising about 10 atoms—it outperforms both single-atom and nanoparticle forms in reaction speed and activity.

Hydroformylation is a vital industrial process used for producing raw materials for plastics, detergents, and other chemicals. Currently, many Rh catalysts are homogeneous—dissolved in liquids—which complicates separation and recycling. This challenge has driven efforts to develop solid, heterogeneous Rh catalysts that are easier to recover and reuse.

Synthetic ‘muscle’ with microfluidic blood vessels shows promise for soft robotics

Researchers are continuing to make progress on developing a new synthetic material that behaves like biological muscle, an advancement that could provide a path to soft robotics, prosthetic devices and advanced human-machine interfaces. Their research, recently published in Advanced Functional Materials, demonstrates a hydrogel-based actuator system that combines movement, control and fuel delivery in a single integrated platform.

Biological muscle is one of nature’s marvels, said Stephen Morin, associate professor of chemistry at the University of Nebraska–Lincoln. It can generate impressive force, move quickly and adapt to many different tasks. It is also remarkable in its flexibility in terms of energy use and can draw on sugars, fats and other chemical stores, converting them into usable energy exactly when and where they are needed to make muscles move.

A synthetic version of muscle is one of the Holy Grails of material science.

Raman sensors with push-pull alkyne tags amplify weak signals to track cell chemistry

Seeing chemistry unfold inside living cells is one of the biggest challenges of modern bioimaging. Raman microscopy offers a powerful way to meet this challenge by reading the unique vibrational signatures of molecules. However, cells are extraordinarily complex environments filled with thousands of biomolecules.

To make specific molecules stand out, researchers often attach small chemical probes, such as alkyne tags, that produce signals in a so-called cell-silent spectral window where native cellular components do not scatter light. This allows Raman microscopes to selectively detect the tagged molecules against an otherwise crowded molecular background. Despite this advantage, the widespread adoption of Raman microscopy in biology has been limited by one fundamental problem: Raman signals are extremely weak.

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