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Category: chemistry

Insulin on edge: Study identifies stress-triggered gene behind diabetes

Researchers from Osaka Metropolitan University have identified a gene that, when activated by metabolic stress, damages pancreatic β-cells—the cells responsible for insulin production and blood sugar control—pushing them toward dysfunction. The findings highlight a promising new target for early intervention in type 2 diabetes. The study is published in the Journal of Biological Chemistry.

While many factors can contribute to type 2 diabetes, lifestyle, especially diet, plays a major role in its onset. Genetics matter, but poor eating habits can greatly increase the risk of developing what is now often called a “silent epidemic.”

“Type 2 diabetes occurs when pancreatic β-cells, which secrete insulin to regulate , become impaired due to prolonged stress caused by poor dietary habits, a condition known as ,” said Naoki Harada, an associate professor at Osaka Metropolitan University’s Graduate School of Agriculture and lead author of this study.

Surprising versatility of boron nitride nanotubes displayed in fusion of art and science

In an elegant fusion of art and science, researchers at Rice University have achieved a major milestone in nanomaterials engineering by uncovering how boron nitride nanotubes (BNNTs)—touted for their strength, thermal stability and insulating properties—can be coaxed into forming ordered liquid crystalline phases in water. Their work, published in Langmuir, was so visually striking it graced the journal’s cover.

That vibrant image, however, represents more than just the beauty of science at the nanoscale. It captures the essence of a new, scalable method to align BNNTs in using a common bile-salt surfactant—sodium deoxycholate (SDC)—opening the door to next-generation materials for aerospace, electronics and beyond.

“This work is very interesting from the fundamental point of view because it shows that BNNTs can be used as model systems to study novel nanorod liquid crystals,” said Matteo Pasquali, the A.J. Hartsook Professor of Chemical and Biomolecular Engineering, professor of chemistry, materials science and nanoengineering and corresponding author on the study.

High explosives in slow motion: Freezing molecules in place shows chemical reactions

Safe and effective high explosives are critical to Lawrence Livermore National Laboratory’s (LLNL) mission of stockpile stewardship. It is relatively simple to study the composition of such material before a detonation or examine the soot-like remnants afterward. But the chemistry in between, which dictates much of the detonation process, evades experimental interrogation as it passes by in a few nanoseconds or less.

In a study published in the Proceedings of the National Academy of Sciences, researchers from SLAC National Accelerator Laboratory and LLNL triggered a slow decomposition of a high explosive and measured the effects on the molecules within it. The work provides the proof of concept for a process that could be extended to examine ultra-fast dynamic chemistry during detonations and illuminates intermediate structures that have never been experimentally seen before.

At the Stanford Synchrotron Radiation Lightsource, the team used X-rays to both trigger the involved in decomposition and measure the results.

Two-step system makes plastic from carbon dioxide, water and electricity

What if a machine could suck up carbon dioxide from the atmosphere, run it through a series of chemical reactions, and essentially spit out industrially useful plastic?

“I think that is something that we, as a society, would be interested in. After all, in addition to being a , carbon dioxide is an abundant and inexpensive feedstock,” says Theo Agapie, Ph.D., the John Stauffer Professor of Chemistry and the executive officer for chemistry at Caltech. “With our new work, we have taken a significant step in that direction.”

Reporting in the journal Angewandte Chemie International Edition, Agapie and a team of Caltech chemists have developed a system that uses electricity from sustainable sources to carry out the chemical conversion of carbon dioxide (CO2) into molecules, such as ethylene and , that are useful for making more complex compounds.

Turning captured carbon into natural gas could provide cost-competitive energy storage

Solar and wind energy are highly variable, dependent on the day, weather and location of the facilities. At times, they can generate more electricity than is needed, but they can also fall short when demand is at its peak. Unfortunately, any extra energy created by these sources is often wasted, as there are few methods that adequately store it long-term. To improve energy security in the United States, the nation requires both sources of energy and novel ways to store and distribute it.

In a new study, published in Cell Reports Sustainability, researchers from Lawrence Livermore National Laboratory (LLNL) have explored how a reactive capture and conversion (RCC) process could be used to produce synthetic renewable natural gas—a chemical form of long-duration energy storage.

“Rather than sourcing carbon from below-ground, RCC enables the use of above-ground carbon as a resource,” said LLNL scientist and lead author Alvina Aui. “Synthetic renewable natural gas, when used as an energy-storage option, can reduce grid instability caused by the intermittency of energy sources like wind and solar.”

Elemental discovery: Researchers find new oxidation state for rare earth element

A longstanding mystery of the periodic table involves a group of unique elements called lanthanides. Also known as rare earth elements, or REEs, these silvery-white metals are challenging to isolate, given their very similar chemical and physical properties. This similarity makes it difficult to distinguish REEs from one another during extraction and purification processes.

Detailed imaging of key receptors suggests new avenue for repairing brain function

For the first time, scientists using cryo-electron microscopy have discovered the structure and shape of key receptors connecting neurons in the brain’s cerebellum, which is located behind the brainstem and plays a critical role in functions such as coordinating movement, balance and cognition.

The research, published in Nature, provides new insight that could lead to the development of therapies to repair these structures when they are disrupted either by injury or affecting —sitting, standing, walking, running, and jumping—learning and memory.

The study, by scientists at Oregon Health & Science University, reveals the organization of a specific type of glutamate receptor—a that conveys signals between neurons and is considered the primary excitatory neurotransmitter in the brain—bound together with proteins clustered on synapses, or junctions, between neurons in the cerebellum.

Synthetic ‘killswitch’ uncovers hidden world of cellular condensates

Researchers at the Max Planck Institute for Molecular Genetics have developed a novel synthetic micropeptide termed the “killswitch” to selectively immobilize proteins within cellular condensates, unveiling crucial connections between condensate microenvironments and their biological functions.

Biomolecular condensates are specialized regions inside cells, existing without membranes, where critical biochemical reactions occur. Their importance in health and disease is well established, including roles in cancer progression and viral infection.

Methods to precisely probe and manipulate condensates in living cells remain limited. Existing strategies lack specificity, either dissolving condensates indiscriminately or requiring artificial protein overexpression, which obscures the natural behavior of native cellular proteins.

Engineers turn toxic ancient tomb fungus into anti-cancer drug

Penn-led researchers have turned a deadly fungus into a potent cancer-fighting compound. After isolating a new class of molecules from Aspergillus flavus, a toxic crop fungus linked to deaths in the excavations of ancient tombs, the researchers modified the chemicals and tested them against leukemia cells. The result? A promising cancer-killing compound that rivals FDA-approved drugs and opens up new frontiers in the discovery of more fungal medicines.

“Fungi gave us penicillin,” says Sherry Gao, Presidential Penn Compact Associate Professor in Chemical and Biomolecular Engineering (CBE) and in Bioengineering (BE) and senior author of a new paper in Nature Chemical Biology on the findings. “These results show that many more medicines derived from natural products remain to be found.”

Advanced algorithm to study catalysts on material surfaces could lead to better batteries

A new algorithm opens the door for using artificial intelligence and machine learning to study the interactions that happen on the surface of materials.

Scientists and engineers study the that happen on the surface of materials to develop more energy efficient batteries, capacitors, and other devices. But accurately simulating these fundamental interactions requires immense computing power to fully capture the geometrical and chemical intricacies involved, and current methods are just scratching the surface.

“Currently it’s prohibitive and there’s no supercomputer in the world that can do an analysis like that,” says Siddharth Deshpande, an assistant professor in the University of Rochester’s Department of Chemical Engineering. “We need clever ways to manage that large data set, use intuition to understand the most important interactions on the surface, and apply data-driven methods to reduce the sample space.”