Engineered microorganisms are widely used in industrial biotechnology and biopharmaceutical applications, including the production of biofuels, sustainable chemicals, and therapeutic compounds. However, concerns remain regarding the unintended environmental release and uncontrolled proliferation of genetically engineered microbes. For this reason, biocontainment technologies, which are designed to prevent microorganisms from surviving outside controlled environments, have become increasingly important in both academia and industry.
Conventional biocontainment strategies have relied on auxotrophy-based approaches, toxin–antitoxin systems, or DNA cleavage-based technologies such as CRISPR-Cas9. However, these methods often suffer from environmental dependency, genetic instability, and the risk of unintended mutations and cellular stress caused by DNA double-strand breaks.
In particular, DNA cleavage-based systems may compromise genomic stability and allow certain mutant cells to escape survival control. In addition, CRISPR interference (CRISPRi)-based systems are inherently reversible, posing challenges for achieving complete and permanent control of cell viability.
The conditions that led to the formation of the first organisms and the ways that life originates from a lifeless chemical soup are poorly understood. The recent hypothesis of “RNA-peptide coevolution” suggests that the current close relationship between amino acids and nucleobases may well have extended to the origin of life. We now show how the interplay between these compound classes can give rise to new self-replicating molecules using a dynamic combinatorial approach. We report two strategies for the fabrication of chimeric amino acid/nucleobase self-replicating macrocycles capable of exponential growth. The first one relies on mixing nucleobase-and peptide-based building blocks, where the ligation of these two gives rise to highly specific chimeric ring structures. The second one starts from peptide nucleic acid (PNA) building blocks in which nucleobases are already linked to amino acids from the start. While previously reported nucleic acid-based self-replicating systems rely on presynthesis of (short) oligonucleotide sequences, self-replication in the present systems start from units containing only a single nucleobase. Self-replication is accompanied by self-assembly, spontaneously giving rise to an ordered one-dimensional arrangement of nucleobase nanostructures.
A single-atom platinum catalyst lights ammonia at 200 °C and keeps it burning steadily at 1,100 °C with low NOx, generating high-grade, carbon-free heat for steel, cement and chemicals.
Kanvas looks amazing! They’re systematically deciphering microbiomes and developing clinical-stage interventions to improve patient outcomes in oncology and beyond. Very impressive! I’m also especially interested in their approach to maternal environmental enteric dysfunction (EED), which apparently affects 150M people!
Ever since the genomics revolution revealed how reliant the human organism is on its microscopic microbial cohabitants, the microbiome has been medicine’s most elusive frontier, promising better health if only we could untangle the trillions of interactions that influence nearly every facet of our physiology. But until now, effective medicines that harness the microbiome have been rare. Because of the diversity of microbial species and the complexity of host-to-microbe interactions, as well as the lack of a reliable, easily manufactured drug modality (the package that delivers a medicine’s therapeutic effect), the microbiome has been hard to treat, despite its importance to functions like immune response. Microbiome science has disappointed patients, doctors, founders, and investors.
That’s why DCVC is so excited about the cascade of recent developments at Kanvas Biosciences, which is moving the field beyond descriptive profiling of the microbiome to translating comprehensive biochemical insights into clinically useful products. In the past few weeks, the Princeton-based spatial biology company has kicked off a Phase 1 clinical trial for its first drug candidate, secured significant new backing from the Gates Foundation (closing a $48 million Series A financing, bringing Kanvas’s total funding to $78 million), and bolstered its scientific leadership by adding one of the most respected names in bioengineering to its board.
Clinical milestone
The most significant milestone in Kanvas’s evolution is the dosing of the first patients in a Phase I clinical trial for KAN-4. This live biotherapeutic product (LBP), resembling an ordinary pill, treats the colitis that many cancer patients develop after receiving immune checkpoint inhibitors (ICIs), allowing them to remain on the life-saving therapy longer.
A joint research team from Nitto Boseki Co., Ltd. (Nittobo) and Tohoku University has revealed that polyionic liquids (PILs) can achieve high carbon dioxide (CO₂) adsorption when their counter anions are exchanged. This discovery provides a critical new design guideline for the development of high-performance CO2 recovery devices and gas separation membranes.
The research was led by Associate Professor Kouki Oka of the Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, with the results published online in Reaction Chemistry & Engineering.
PILs are known for their strong ability to attract CO₂ and for their stability as solid materials. However, conventional anion exchange methods struggle to remove inorganic salts, which are by-products of the manufacturing process. These impurities make it difficult to accurately evaluate the materials’ true performance.
A nanocrystal is an extraordinarily tiny piece of material—composed of anywhere from a few to a few thousand atoms—in which atoms are arranged in a precise, ordered structure. Think of it like taking a piece of gold and shrinking it down to the size of a few hundred atoms. It’s still gold, still crystalline, just almost incomprehensibly small.
Nanocrystals are in the transistors inside computers and smartphones, in smartphone displays and TV screens, in the gold-nanoparticle sensors that power COVID and pregnancy tests, and in the pipes of your car exhaust system, among countless other innovations.
Their small size gives them a dramatically higher ratio of surface area to volume, making them especially useful as catalysts—materials that speed up chemical reactions without being consumed in the process.
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Imagine a civilization reaches something like a Type II level, advanced enough to move through interstellar space and keep large populations alive for generations. At that stage, the challenge is developing ships that can cross the void, and also making sure the people inside them can survive radiation, isolation, and extreme travel times. That could mean heavy genetic engineering before the journey begins, changing bone density, metabolism, resistance to disease, tolerance for low gravity, or even sensory systems and respiration. But when they finally arrive, they may still find that the planet is wrong for them, maybe the air is toxic, the gravity is crushing, the temperatures are extreme, or the native chemistry is incompatible with human biology.
At that point, they face two paths. One is terraforming, which means trying to remake an entire planet into something closer to Earth. That could involve thickening or thinning an atmosphere, warming a frozen world, cooling a hot one, importing water, altering soil chemistry, introducing engineered microbes, building orbital mirrors or shades, and managing the planet for centuries or even millennia. The scale of that project is absurdly expensive, not just in money but in energy, infrastructure, labor, time, and raw materials. You are not changing a city or even a continent, you are trying to rewrite a whole world.
The other option is pantropy. Instead of forcing the planet to become Earth-like, the colonists change themselves to fit the planet. They might alter their lungs to breathe a different atmospheric mix, redesign their skin to handle harsher radiation, reduce their size for lower resource use, strengthen their bodies for higher gravity, or even become something so biologically different that they no longer look fully human. That is the core idea of pantropy, adapting the colonists to the world rather than adapting the world to the colonists.
The term was coined by James Blish, and he used it in connection with the stories collected in The Seedling Stars, especially “Surface Tension.” which was first published in 1952 in Galaxy Science Fiction.
Neurodegenerative disorders entail a progressive loss of neurons in cerebral and peripheral tissues, coupled with the aggregation of proteins exhibiting altered physicochemical properties. Crucial to these conditions is the gradual degradation of the central nervous system, manifesting as impairments in mobility, aberrant behaviors, and cognitive deficits. Mechanisms such as proteotoxic stress, neuroinflammation, oxidative stress, and programmed cell death contribute to the ongoing dysfunction and demise of neurons. Presently, neurodegenerative diseases lack definitive cures, and available therapies primarily offer palliative relief. The integration of nanotechnology into medical practices has significantly augmented both treatment efficacy and diagnostic capabilities.
Researchers from the National University of Singapore (NUS) and collaborators have developed a predictive design strategy for creating graphene-like molecules with multiple interacting spins and enhanced resilience to magnetic perturbations, opening new avenues for molecular-scale quantum information technologies and next-generation spintronics.
The research team was led by Professor Lu Jiong from the NUS Department of Chemistry and the NUS Institute for Functional Intelligent Materials, together with Professor Wu Jishan from the NUS Department of Chemistry, and international collaborators, including key contributor Professor Pavel Jelínek from the Czech Academy of Sciences in Prague.
Magnetic nanographenes, which are molecules composed of fused benzene rings, are of growing interest for quantum technologies because they can host unpaired electrons, or spins, that may be used to store and process information. Unlike conventional magnetic materials based on metal atoms, these carbon-based systems offer chemical versatility and long spin coherence times. However, engineering a single molecule that contains multiple strongly coupled spins in a stable and controlled manner remains a major challenge.
Chemists and computer scientists tapped AI to find new disinfectants to combat the growing threat of dangerous “superbugs.”
The Journal of Chemical Information and Modeling published their computational-experimental framework for developing quaternary ammonium compounds, or QACs, to kill bacteria.
The method yielded 11 new QACs that show activity against antimicrobial-resistant bacteria.
