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Researchers identify new blood markers that may detect early pancreatic cancer

NIH-funded, four-marker panel could one day help catch one of deadliest cancers at more treatable stages.

National Institutes of Health (NIH)-supported investigators have developed a blood test to find pancreatic ductal adenocarcinoma, one of the deadliest forms of cancer. The new test could improve survival rates from pancreatic cancer, which tends to be diagnosed at late stages when therapy is less likely to be effective. The findings were published in Clinical Cancer Research.

Overall, only about 1 in 10 pancreatic cancer patients survive more than five years from diagnosis. However, experts expect that when the cancer is found and treated at an earlier stage, survival would improve. While finding the cancer early is key, there are no current screening methods to do so.

Flavanols Break the Rules of Nutrition: Scientists Uncover the Surprising Way They Boost the Brain

The health benefits of dietary flavanols appear to come from their ability to trigger responses in the brain and the body’s stress systems. That slightly dry, tightening feeling some foods leave in the mouth is known as astringency, and it comes from naturally occurring plant compounds called pol

Using rare sugars to address alcoholism

While investigating the FGF21-oxytocin-dopamine system, a mechanism that regulates sugar appetite, a team of researchers at Kyoto University noticed reports suggesting that the protein FGF21 may regulate alcohol ingestion.

The team’s original aim had been to address sugar appetite in lifestyle-related diseases, but since alcohol is a fermented product of sugar, they speculated that perhaps the body contains a system that recognizes both alcohol and sugar as the same entity.

Alcohol consumption and intervention challenges Excessive alcohol consumption is a major global health issue, and effective countermeasures for prevention and treatment are limited. Patients with alcohol dependence generally have a low adherence to pharmaceuticals, and many avoid drug treatment because it deprives them of the pleasure of drinking.

A new flexible AI chip for smart wearables is thinner than a human hair

The promise of smart wearables is often talked up, and while there have been some impressive innovations, we are still not seeing their full potential. Among the things holding them back is that the chips that operate them are stiff, brittle, and power-hungry. To overcome these problems, researchers from Tsinghua University and Peking University in China have developed FLEXI, a new family of flexible chips. They are thinner than a human hair, flexible enough to be folded thousands of times, and incorporate AI.

A flexible solution

In a paper published in the journal Nature, the team details the design of their chip and how it can handle complex AI tasks, such as processing data from body sensors to identify health indicators, such as irregular heartbeats, in real time.

New Study Reveals How Nanoplastics Make Bacteria More Dangerous

Nanoplastics already raise fears because people can ingest them directly. Now scientists say these tiny particles can create a different kind of danger when they end up in water: they can help bacteria become tougher and harder to remove.

A study in Water Research led by Virginia Tech’s Jingqiu Liao, working with international collaborators, found that nanoplastics can influence how environmental microbes behave in ways that may indirectly affect human health. The concern is not just what the particles might do in the body, but what they might encourage in the water systems people rely on every day.

“It is very important to better understand the adverse effects of the nanoplastics on human health, and not just in humans but also in the environment, which indirectly influences human health,” said Liao, assistant professor of civil and environmental engineering. “The nanoplastics can make the antimicrobial-resistant pathogens better survive, which could be harmful to the environment and would have public health implications.”

Game-Changing Blood Pressure Drug Works for Patients Not Controlled by Standard Treatments

Blood pressure is one of the most common health problems worldwide, yet it remains difficult to control for many patients even with daily medication. New research from the United Kingdom suggests a different approach could help. Scientists report that a treatment given just twice a year may offer sustained blood pressure reductions for people whose hypertension has proven hard to manage.

The findings come from a large international clinical trial published in JAMA and led by researchers at Queen Mary University of London. The study focused on a long-acting injectable therapy designed to work alongside existing blood pressure medications rather than replace them.

Neuralink’s Brain Chip: How It Works and What It Means

Elon Musk recently announced that Neuralink, his company aiming to revolutionize brain-computer interfaces (BCIs), has successfully implanted a brain chip in a human for the first time. The implantation of the device, called “the Link,” represents a leap forward in the realm of BCIs, which record and decode brain activity, that may allow for new innovations in health care, communication, and cognitive abilities.

Though limited information on the technology is available and Neuralink’s claims have not been independently verified, here’s a look at the Link, its functionality, and the potential implications of this groundbreaking innovation.

Prenatal exposure to air pollution associated with lower cognitive performance in early childhood

The prenatal period is a critical window for brain development, yet few studies have examined the impact of air pollution exposure during pregnancy on child cognition. A new study led by the Barcelona Institute for Global Health (ISGlobal), in collaboration with the University of Barcelona (UB), shows that prenatal exposure to pollution is associated with lower cognitive performance in newborns.

These findings highlight the importance of reducing air pollution exposure, especially during pregnancy, to protect neurodevelopment.

The study, published in Environmental Pollution, included data from 168 mother-child pairs participating in the BiSC (Barcelona Life Study Cohort) project, conducted in Barcelona between 2018 and 2023.

Brewing possibilities: Using caffeine to edit gene expression

What if a cup of coffee could help treat cancer? Researchers at the Texas A&M Health Institute of Biosciences and Technology believe it’s possible. By combining caffeine with the use of CRISPR—a gene-editing tool known as clustered regularly interspaced short palindromic repeats—scientists are unlocking new treatments for long-term diseases, like cancer and diabetes, using a strategy known as chemogenetics.

The work is published in the journal Chemical Science.

Yubin Zhou, professor and director of the Center for Translational Cancer Research at the Institute of Biosciences and Technology, specializes in utilizing groundbreaking tools and technology to study medicine at the cellular, epigenetic and genetic levels. Throughout his career and over 180 publications, he has sought answers to medical questions by using highly advanced tools like CRISPR and chemogenetic control systems.

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