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Scientists Put a Fruit Fly’s Brain in a Computer Simulation… What It Did Is Now Scaring Scientists

Scientists have achieved an incredible breakthrough by recreating the brain of a fruit fly inside a computer simulation. By mapping around 140,000 neurons and millions of connections, they built a digital brain that can sense its environment, process information, and even control a virtual body. In the simulation, the digital fly was able to search for food, respond to stimuli, and show behaviors that were not directly programmed by scientists. This discovery shows how powerful neural connections are in generating behavior. It also raises fascinating questions about the nature of intelligence, consciousness, and whether complex brains—including ours—could one day be simulated in computers.

sources

https://eon.systems/updates/embodied-brain-emulation.

Research Paper for more information.
https://marginalrevolution.com/margin

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#Neuroscience.
#ArtificialIntelligence.
#BrainSimulation.
#FruitFlyBrain.
#Connectome.
#FutureTech.
#ComputerSimulation.
#NeuralNetworks.
#ScienceDiscovery

Gut microbes unlock hormone signaling that regulates gut movement, study suggests

Millions of people worldwide are periodically or chronically affected by gut-related conditions, such as irritable bowel syndrome (IBS), gastroesophageal reflux disease (GERD) and gastroenteritis. Uncovering the physiological and biological processes that contribute to gut health could thus be highly valuable, as it might help devise more effective interventions to prevent and treat these ailments.

The transit of food, fluids and waste through the intestine is known to be coordinated by various interacting systems in the body, including gut wall muscles, neurons in the gastrointestinal tract and hormones. A growing body of research has also been exploring the crucial contribution of bacteria and other microorganisms residing in the digestive tract, which are collectively referred to as the gut microbiome.

Researchers at Boston Children’s Hospital, Harvard Medical School, the University of North Carolina at Chapel Hill and Laval University recently carried out a study aimed at better understanding how these gut microbes interact with specific sex hormones and nerve cells that control the movement of muscles in the intestines.

This specially-designed jacket pulls drinking water from thin air

Engineers at The University of Texas at Austin have developed a jacket that harvests drinking water directly from the air. The technology could benefit anyone who spends a lot of time in areas without easy access to drinking water, from hobbyist hikers, campers and runners to agricultural workers, emergency responders and soldiers. The advance in fabric technology comes alongside a new benchmark for atmospheric water harvesting.

“Water harvesting from air is usually imagined as a stationary device such as a box, a panel or a large sorbent bed,” said Guihua Yu, chair professor of the Cockrell School of Engineering’s Walker Department of Mechanical Engineering and Texas Materials Institute and one of the leaders of the new research appearing in Science Advances. “Here, we wanted to rethink the form of the technology. If the fabric itself can collect water from air, it opens a new direction for personal and portable water access.”

The textile incorporated into the jacket collects moisture and funnels it to detachable harvesting units. Those units are placed in a foldable collector piece and heated to produce water.

Resolving Feynman’s restaurant problem reveals optimal solutions and human strategies

They reconstructed Feynman’s “restaurant problem” and proved that his solution was mathematically optimal. The challenge belongs to a class of problems known as “explore versus exploit” decisions—a tradeoff that appears everywhere from choosing restaurants and dating partners to scientific research and artificial intelligence. Explore too much, and you waste opportunities enjoying known good options. Exploit too soon, and you might miss something even better.


Feynman’s restaurant problem is an instance of what is known as an optimal stopping problem (7, 8). As such, it falls in the same category as the famous secretary problem (9), in which an interviewer seeks to maximize the probability of hiring the best candidate for a position but can only evaluate those candidates relative to one another. This problem can be translated to the dining setting by assuming the goal is to maximize the probability of selecting the best restaurant over a series of meals. However, Feynman’s problem differs from the classic secretary problem in three ways: the distribution from which the restaurants are drawn is known, the diner is able to return to restaurants that they visited previously, and the goal is to maximize the total score across nights rather than the probability of identifying the single best option.

Feynman’s restaurant problem is also closely related to the finite-horizon multi-armed bandit problem (10, 11), in which a decision-maker is presented with a set of options that differ in their payoffs (such as different arms of a gambling machine) and seeks to maximize the total payoff received from trying those options a fixed number of times. Again, this could be translated to the dining context, treating the restaurants as the different options. The key difference here is that in the multiarmed bandit problem the payoffs are usually stochastic, with a distribution around the true value, while in Feynman’s problem the true value of a restaurant is directly observed. Like the multiarmed bandit problem, Feynman’s restaurant problem creates a tension between exploring new options and exploiting knowledge acquired so far, but does so without dealing with uncertain observations.

Optimal stopping problems often arise in everyday life, appearing not just in choosing what to eat, but in finding a home, deciding who to marry, selecting a parking spot, and knowing when to quit a job (12). Extensive literatures have explored how people solve variants of the secretary problem (13 17) and the multiarmed bandit problem (18 25). Feynman’s restaurant problem is a valuable addition to this canon: by removing uncertain observations, it makes it possible to study the explore–exploit tradeoff in a particularly pure manner, and the existence of closed-form expressions for the optimal policy facilitates its comparison to human behavior. In fact, previous behavioral experiments have used optimal stopping problems that are similar to (26 28) or variants on (29 and 30) Feynman’s restaurant problem (for a detailed breakdown see Discussion). Here, we make use of the optimal solutions we derived for multiple variants of this problem, together with an innovative experimental design that allows us to get an unusually clear picture of people’s behavior and to draw direct parallels between results in the psychological literature and the solution found by Feynman. As a consequence, we hope to not just re-solve the problem that Feynman first posed more than 40 y ago, but to resolve the question of how people perform such tasks.

Peak Protocol: Mountain Longevity Retreat

Science-first longevity retreat in Colorado.

Hey friends, we’re running a longevity retreat in the CO mountains this August!

Peak Protocol is a 4-day science-first retreat at SageStone Adventure Lodge in Granite, CO (August 6–9).

The idea is to bring together people who want to get serious about their health, put them in a gorgeous venue with longevity doctors and scientists, and give everyone a personalized longevity plan to leave with.

What’s included:

✅ Custom biomarker panel before you arrive.

RNA-guided transposon mechanics show use of figure-eight intermediate and direct-transfer route

IS110 transposons are a large, diverse family of bacterial insertion sequences (IS elements)—small, mobile DNA elements that can move from one genomic location to another. They have recently attracted broad interest due to the finding that some of these transposons use a bridge RNA (bRNA) to recognize both donor DNA and target DNA.

Upon this discovery, researchers hoped that bRNA-guided transposon systems could offer a genome-editing strategy distinct from classical CRISPR-Cas nucleases and thereby enable programmable DNA integration. However, it remained unclear how IS110 elements insert donor DNA into target sites and whether these elements rely on one or multiple reaction pathways.

Now, a new study led by Xue Chaoyou from the Tianjin Institute of Industrial Biotechnology of the Chinese Academy of Sciences, in collaboration with Lou Huiqiang at China Agricultural University and RAO Shuquan from the Chinese Academy of Medical Sciences, answers these questions by showing that RNA-guided IS110 transposons use two mechanistically distinct pathways to mobilize DNA.

Polis declares statewide drought emergency

Gov. Jared Polis on Thursday declared a statewide drought emergency, citing the record-low snowpack and prolonged warmer temperatures across Colorado.

He also activated the next phase of the state’s drought response plan. Polis had placed Colorado under Phase 2 in March.

“Today, I am issuing a statewide drought emergency to support Coloradans, our economy, farmers and ranchers, and outdoor enthusiasts in the face of one of the most severe droughts in Colorado’s recorded history. With every county in the state experiencing drought conditions, activating Phase 3 of our Drought Response Plan allows us to better coordinate agencies, prepare for worsening conditions, and support Colorado communities, agriculture, water users, and our environment,” he said in a statement. “State agencies will do their part to reduce water usage at state facilities and I encourage every Coloradan to use water wisely.”

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