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Chickens Hatch From World’s First Artificial Eggs

On May 19, Dallas-based Colossal Biosciences, which last year made headlines when it effectively de-extincted the dire wolf, announced that it had hatched a flock of 26 live chicks from fully artificial eggs. The technology behind the breakthrough can be later applied to bring back the dodo and New Zealand’s giant, flightless moa—both on Colossal’s de-extinction ‘to do’ list…

…Designing an artificial shell is not easy because a natural shell is deceptively complex. Made principally of calcium carbonate arranged in a crystalline structure, a typical egg shell is no more than 0.4 mm thick, and covered with up to 17,000 tiny pores to allow for gas exchange with the ambient atmosphere—carbon dioxide out, and oxygen in. There are, too, a pair of slick inner membranes in the egg that perform another critical function, protecting the growing chick from invading bacteria. But those membranes have to be exceedingly thin…

…The egg Colossal invented was very different. The inner membranes were made of vanishingly thin silicon using a proprietary technology that Colossal is planning to patent. The shell itself was only about two-thirds of a shell—a titanium structure that resembles nothing so much as a soft-boiled-egg cup with its top missing, albeit with hundreds of hexagonal pores to allow for gas exchange. Once a few dozen of the titanium eggs were manufactured, Colossal gathered fertilized chicken eggs from an avian farm the company owns and operates and transported them to the lab. There, the scientists gently opened the top of the egg and transferred the yolk and the white and the tiny embryo onto the titanium egg cup and covered the cup with a transparent lid. The embryos were about three days past fertilization when they were transferred, meaning that they had 18 days remaining in their three-week incubation cycle.

‘We place the egg into an incubator that controls the environment,’ says Lambert. ‘We then collect visual images at periodic milestones to understand how development is progressing.’ When the incubation period was done, the chicks began ‘pipping,’ using their beaks to break through the membrane just the way an ordinary chick breaks through its shell. Eventually, the 26 chicks were moved to the same Texas farm from which their eggs were collected, where they can live out their five to 10 year lifespan.

The breakthrough could help bring giant birds back from extinction.

Say Goodbye to the Generative AI Buffet Line

Remember the early days of AI when a single monthly fee seemed like the ultimate golden ticket? It felt like having a limitless digital brain at our fingertips—until the dreaded usage limit pop-up appeared right in the middle of a critical project. Suddenly, that all-access pass felt more like a restrictive tether, leaving many of us frustrated by hidden caps and invisible throttles just when we needed peak performance the most.

It turns out, we were looking at AI pricing all wrong. Instead of a standard software subscription, artificial intelligence is much more like a utility—a highly measurable resource that actually makes more sense on a pay-as-you-go basis. Imagine a single, centralized workspace where you can seamlessly switch between the biggest powerhouse models on the market for your heavy-duty coding or reasoning, and then route simple summaries to lightning-fast, budget-friendly models.

No more juggling five different logins, and no more getting cut off; just total transparency and control over exactly what you spend.

We are finally entering an era where users hold the reins, and the chaotic days of unpredictable quotas are fading fast. I just published a new piece diving deep into how this shift toward unified, ledger-based AI platforms is completely changing the game for creators, developers, and everyday users alike.

Check out the full article at the link below to explore how this new approach works and why it is exactly the upgrade we have all been waiting for!

Remember late 2022 and early 2023? In tech years, it feels like a lifetime ago. That was when generative AI first exploded onto the scene, and the pricing was brilliantly, beautifully simple. You signed up for a basic flat subscription—usually around $20 a month—and you had the magic of the universe at your fingertips. If you were an enterprise team, maybe you stepped up to a specialized tier. But overall, the premise was the same.

Continue reading “Say Goodbye to the Generative AI Buffet Line” | >

Biodegradable sensors attached to plants detect pesticides in 3 minutes

Researchers at the São Carlos Institute of Physics at the University of São Paulo (IFSC-USP) in Brazil, led by Paulo Augusto Raymundo-Pereira, have created biodegradable, “wearable” sensors for plants to monitor their health, including the presence of pesticides. The sensors are made from carbon ink and are screen-printed onto transparent cellulose acetate bioplastics.

The study was published in Biosensors and Bioelectronics: X. The World Economic Forum selected wearable sensor engineering as one of the top ten emerging technologies of 2023 for its potential to improve plant health and increase agricultural productivity.

However, most wearable devices today are made from nonrenewable plastic polymers derived from petroleum and have poor adhesion to uneven, wavy, and curved surfaces.

Tailored drinks could provide space nutrition

Researchers have developed customizable omega-3 nanoemulsion drinks to protect astronauts’ bones and muscles from space radiation. [ https://www.labroots.com/trending/space/30563/tailored-drink…utrition-2](https://www.labroots.com/trending/space/30563/tailored-drink…utrition-2)

How could customizable drinks help provide astronauts on future, long-term space missions with the proper levels of nutrition? This is what a recent study published in ACS Food Science & Technology hopes to address as a team of researchers investigated novel methods for improving future astronaut diets. This study has the potential to help scientists, mission planners, and astronauts develop improved dietary plans, specifically as space mission durations are aimed to increase in the coming years.

For the study, the researchers introduced beverage nanoemulsion drinks, with emulsion drinks being a common drink that typically consists of a blended mixture of two normally non-mixable substances like an oily substance and watery substance with microscopic droplets within the liquid since they don’t full mix together. In this case, the researchers propose nanoemulsion drinks with even smaller droplets and consist of water and Omega-3 fatty acids (fish oil), which provide bone and muscle protection against space radiation.

In the end, the researchers found that customizable drinks with a variety of sweetness levels and flavors are the best options. Going forward, the researchers aspire to test the tastiness of the beverages under microgravity conditions, as they note the drinks taste like typical flat sodas after carbonation loss.

Bioengineers condense protein engineering and testing to a single day

Proteins are critical to life—and to industry. There are countless proteins that could be engineered to treat and even cure serious diseases and cellular dysfunctions. Industrial applications are similarly promising, with proteins increasingly used as enzymes in food manufacturing and in consumer detergents.

While AI can help suggest improvements, each novel protein must still be created in the real world and tested for performance. It is a labor-intensive process that involves constructing the DNA instructions for each protein in yeast or bacteria and growing individual clones for protein production and testing. This can take many days for a single protein of interest and even longer if the protein needs to be tested in mammalian cells, a process that requires retrieving DNA from microbes for transfer to the mammalian cells.

In a new paper, Michael Z. Lin, a professor of neurobiology and of bioengineering in the schools of Engineering and Medicine, and graduate students, Yan Wu in bioengineering and Pengli Wang in chemical engineering, say they have condensed the time-intensive protein building and testing process to just 24 hours.

A fresh approach to peppermint: 250 new variants could boost flavor and fight disease

The genomics of peppermint are not as fresh as their flavor but scientists from the University of California, Davis, have found a way to breathe new genetic variation into the species. The findings, published in the Proceedings of the National Academy of Sciences, could help the mint industry develop new varieties of peppermint and provide a roadmap for improving clonal crops more generally.

Similar to strawberries, potatoes and many fruit trees, peppermint plants (Mentha × piperita) are reproduced asexually by a process called clonal propagation. In the case of peppermint, this means that their genomes have remained unaltered for more than 200 years. This lack of genetic variation leaves them susceptible to disease and means that properties such as yield and flavor have remained stagnant.

UC Davis plant biologists used radiation to induce mutations in the leading peppermint clone grown in the United States, resulting in more than 250 new and genetically distinct variants. Altogether, they introduced 1,406 large genetic mutations, which can now be used to identify key genes for breeding or selecting new and superior peppermint varieties.

A neuropeptide regulates cell non-autonomous protein homeostasis

FLP-17’s role in stress resistance aligns with its established functions. FLP-17 belongs to an evolutionarily conserved class, FMRF-amide/RF-amide neuropeptides, that plays important roles in energy balance and reproduction across phyla.34,35 In C. elegans, FLP-17 is secreted from a pair of sensory neurons (BAG) in response to low oxygen and high carbon dioxide, which can be caused by unfavorable food conditions or pathogens.36,37 FLP-17 then acts through specific neurons to inhibit egg laying and initiate an aversion behavior until the animal has reached more favorable conditions.30,36 Interestingly, unfavorable food conditions and pathogens also threaten organismal protein homeostasis.33,38 Therefore, we speculate that FLP-17 evolved to simultaneously protect the animal from proteotoxic stress while facilitating a behavioral program to help the animal navigate to more favorable conditions.

To coordinate adaptive behavioral and metabolic responses, FLP-17 primarily signals through the GPCR EGL-6 in specific neurons.30,31 Therefore, we tested whether EGL-6 also mediates FLP-17’s role in UPRER activation and found that FLP-17-induced activation of the UPRER and ER stress resistance is partially dependent on EGL-6. Egl-6 expression is predominantly neuronal, evidenced by transcriptional reporters and single-cell RNA-seq datasets.30,39 However, low levels of egl-6 expression were detected in intestine-specific translation of ribosome-affinity purification, which may better reflect protein levels.40 This suggests that FLP-17 may signal either through an intermediate cell type (such as a neuron) or directly to the intestine to activate UPRER.30,39 Furthermore, the partial dependence, combined with persistent stress gene activation in egl-6 (lof) backgrounds (Figure 5 E), indicates that additional unidentified receptors and mechanisms likely contribute to FLP-17 phenotypes.

Although FLP-17 was sufficient to activate the UPRER, it was not required for cell non-autonomous activation of the UPRER by glial:: xbp-1s, as flp-17 null mutants did not suppress glial:: xbp-1s phenotypes. This likely reflects neuropeptide network redundancy. Supporting this hypothesis, flp-17 (lof)) resulted in modest upregulation of stress response genes (Figure S3G) and a slight increase in hsp-4p::GFP in the glial:: xbp-1s animals (Figure 2D), suggesting compensatory activation of stress signaling pathways when FLP-17 is absent. This compensation could occur through multiple mechanisms. First, glial:: xbp-1s may induce multiple neuropeptides that provide functionally redundant UPRER activation. While no other candidate from our neuropeptidomics screen was individually sufficient to induce UPRER, we cannot exclude compensation by peptides not detected in our analysis, such as insulin-like peptides.

How Intestinal Aging Encourages Harmful Bacteria

In Aging Cell, researchers have elucidated the relationship between intestinal aging and age-related changes to the gut microbiome.

Two interdependent biologies

The human gut works through the interaction of two entirely different sets of cells. The first is the body’s actual cells, including the intestinal barrier between the gut and the rest of the body, various types of ordinary immune cells, and Peyer’s patches with follicle-associated epithelium (FAE) areas that contain microfold cells (M cells), which perform crucial immunoregulatory tasks [1]. The second is the gut microbiome, the various types of bacteria that help us digest food.

Scientists Say This Simple Supplement May Actually Reverse Heart Disease

Scientists in Japan say a common supplement may actually help “unclog” certain diseased heart arteries from the inside out.

A simple food supplement sold in Japan may have helped reverse a dangerous form of heart disease that often resists standard treatment, according to researchers at Osaka University. The findings, originally published in the European Heart Journal, continue to attract attention because they describe something rarely seen in cardiology: clogged heart arteries becoming noticeably clearer after a nutritional intervention rather than conventional cholesterol lowering alone.

Scientists target a hidden form of heart disease.

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