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Kanvas makes the microbiome druggable—and the implications are massive

Kanvas looks amazing! They’re systematically deciphering microbiomes and developing clinical-stage interventions to improve patient outcomes in oncology and beyond. Very impressive! I’m also especially interested in their approach to maternal envi­ron­mental enteric dysfunction (EED), which apparently affects 150M people!


Ever since the genomics revolution revealed how reliant the human organism is on its microscopic microbial cohabitants, the microbiome has been medicine’s most elusive frontier, promising better health if only we could untangle the trillions of interactions that influence nearly every facet of our physiology. But until now, effective medicines that harness the microbiome have been rare. Because of the diversity of microbial species and the complexity of host-to-microbe interactions, as well as the lack of a reliable, easily manufactured drug modality (the package that delivers a medicine’s therapeutic effect), the microbiome has been hard to treat, despite its importance to functions like immune response. Microbiome science has disappointed patients, doctors, founders, and investors.

That’s why DCVC is so excited about the cascade of recent developments at Kanvas Biosciences, which is moving the field beyond descriptive profiling of the microbiome to translating comprehensive biochemical insights into clinically useful products. In the past few weeks, the Princeton-based spatial biology company has kicked off a Phase 1 clinical trial for its first drug candidate, secured significant new backing from the Gates Foundation (closing a $48 million Series A financing, bringing Kanvas’s total funding to $78 million), and bolstered its scientific leadership by adding one of the most respected names in bioengineering to its board.

Clinical milestone

The most significant milestone in Kanvas’s evolution is the dosing of the first patients in a Phase I clinical trial for KAN-4. This live biotherapeutic product (LBP), resembling an ordinary pill, treats the colitis that many cancer patients develop after receiving immune checkpoint inhibitors (ICIs), allowing them to remain on the life-saving therapy longer.

In Vivo RNA Delivery to Hematopoietic Stem and Progenitor Cells via Targeted Lipid NanoparticlesClick to copy article linkArticle link copied!

A nicely concise paper on antibody-linked lipid nanoparticles which target hematopoietic stem and progenitor cells in vivo, important yet tricky cell types to transduce for hematological gene therapy.


Ex vivo autologous hematopoietic stem cell (HSC) gene therapy has provided new therapies for the treatment of hematological disorders. However, these therapies have several limitations owing to the manufacturing complexities and toxicity resulting from required conditioning regimens. Here, we developed a c-kit (CD117) antibody-targeted lipid nanoparticle (LNP) that, following a single intravenous injection, can deliver RNA (both siRNA and mRNA) to HSCs in vivo in rodents. This targeted delivery system does not require stem cell harvest, culture, or mobilization of HSCs to facilitate delivery. We also show that delivery of Cre recombinase mRNA at a dose of 1 mg kg–1 can facilitate gene editing to almost all (∼90%) hematopoietic stem and progenitor cells (HSPCs) in vivo, and edited cells retain their stemness and functionality to generate high levels of edited mature immune cells.

Harmless viruses trap Salmonella on flexible polymer in portable microfluidic sensor

Researchers at Worcester Polytechnic Institute (WPI) have developed a solid polymer coated with harmless viruses to detect the bacteria Salmonella enterica (S. enterica), an advance that could lead to new ways of finding contamination in the food supply. The work is published in the journal ACS Applied Bio Materials.

The group, led by Yuxiang “Shawn” Liu, an associate professor in the Department of Mechanical and Materials Engineering, reports that the technology can rapidly capture and visualize foodborne bacterial contaminants in tiny fluid samples. With no need for incubation or complicated equipment in research centers, the technology has the potential to be used as a rapid biosensor in field applications and in areas with few resources.

“We have a solid surface that can be used anywhere in the food supply chain, from farm to fridge, to detect foodborne bacteria with minimum human intervention,” Liu says.

Humanity Will Change | Pantropy

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Imagine a civilization reaches something like a Type II level, advanced enough to move through interstellar space and keep large populations alive for generations. At that stage, the challenge is developing ships that can cross the void, and also making sure the people inside them can survive radiation, isolation, and extreme travel times. That could mean heavy genetic engineering before the journey begins, changing bone density, metabolism, resistance to disease, tolerance for low gravity, or even sensory systems and respiration. But when they finally arrive, they may still find that the planet is wrong for them, maybe the air is toxic, the gravity is crushing, the temperatures are extreme, or the native chemistry is incompatible with human biology.

At that point, they face two paths. One is terraforming, which means trying to remake an entire planet into something closer to Earth. That could involve thickening or thinning an atmosphere, warming a frozen world, cooling a hot one, importing water, altering soil chemistry, introducing engineered microbes, building orbital mirrors or shades, and managing the planet for centuries or even millennia. The scale of that project is absurdly expensive, not just in money but in energy, infrastructure, labor, time, and raw materials. You are not changing a city or even a continent, you are trying to rewrite a whole world.

The other option is pantropy. Instead of forcing the planet to become Earth-like, the colonists change themselves to fit the planet. They might alter their lungs to breathe a different atmospheric mix, redesign their skin to handle harsher radiation, reduce their size for lower resource use, strengthen their bodies for higher gravity, or even become something so biologically different that they no longer look fully human. That is the core idea of pantropy, adapting the colonists to the world rather than adapting the world to the colonists.

The term was coined by James Blish, and he used it in connection with the stories collected in The Seedling Stars, especially “Surface Tension.” which was first published in 1952 in Galaxy Science Fiction.

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When “Artificial Neurons” Can Talk Directly to the “Brain”

*** This content was analyzed and written by AI for informational purposes only.
*** Please consult a specialist for professional advice.

The world is entering an era where “technology” and “living organisms” merge into one. Most recently, in 2026, a research team from Northwestern University created a landmark breakthrough by developing “Printed Neurons.” These are not designed just to mimic biology—they can actually “transmit signals” to communicate with living brain cells!

Why is this a big deal?
Typically, the silicon-based computers we use today operate entirely differently from the human brain. Computers consume massive amounts of power and are rigid. In contrast, our brains use only about 20 watts (less than some lightbulbs) and are incredibly flexible.
Creating artificial neurons that “speak the same language as the brain” is the key to treating diseases that were once considered incurable.

Innovations in “Electronic Ink” and “3D Printing“
At the heart of this research lies a leap forward in materials science and engineering:
• Nanomaterials (MoS₂ and Graphene): Researchers used these materials to create a specialized “ink” for printing neural networks. These materials are unique for being both flexible and excellent conductors of electricity.
• Aerosol Jet Printing: This technology allows for nano-level precision printing on flexible plastic sheets, designed to contour perfectly to human tissue.
• Biomimicry: These artificial cells can generate electrical signals called “Spikes,” matching the rhythm and speed of actual biological neurons.

Proven! Successful Communication with a “Mouse Brain“
The research team tested the connection between these printed neurons and mouse brain tissue. The results showed that the mouse brain cells could receive and respond to signals from the artificial device as if they were from their own kind. This is vital evidence that humans can create devices that interface seamlessly with the nervous system.

The Age of Biohacking: Redefining Human Potential in the 21st Century

In a world where technology and biology converge at an accelerating pace, a new era of self-improvement is emerging — biohacking. This once-niche movement has transformed into a global phenomenon, attracting everyone from Silicon Valley executives to amateur enthusiasts. The promise? To optimize the human mind and body beyond natural limits using a blend of science, lifestyle adjustments, and cutting-edge technology.

But what exactly is biohacking? Is it the future of personal health and evolution, or a slippery slope into risky experimentation? In this article, we’ll delve deep into the world of biohacking — its origins, principles, popular techniques, controversies, and future potential. Whether you’re a skeptic, a curious observer, or a self-improvement junkie, the world of biohacking has something provocative for everyone.

Genetic Bottlenecks — How Few People Can Start a World? Or Restart One?

When disaster leaves only a handful, can a civilization restart? We explore genetic bottlenecks, colony failure, and the limits of survival.

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Watch my exclusive video Surviving a New Ice Age: https://nebula.tv/videos/isaacarthur–… out Practical Engineering: https://nebula.tv/practicalconstructi… 🛒 SFIA Merchandise: https://isaac-arthur-shop.fourthwall… 🌐 Visit our Website: http://www.isaacarthur.net ❤️ Support us on Patreon: / isaacarthur ⭐ Support us on Subscribestar: https://www.subscribestar.com/isaac-a… 👥 Facebook Group: / 1,583,992,725,237,264 📣 Reddit Community: / isaacarthur 🐦 Follow on Twitter / X: / isaac_a_arthur 💬 SFIA Discord Server: / discord Credits: Genetic Bottlenecks – How Few People Can Start a World? Or Restart One? Written, Produced & Narrated by: Isaac Arthur Select imagery/video supplied by Getty Images Chapters 0:00 Intro 10:56 Restoration 19:26 Practical Engineering.
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Credits:
Genetic Bottlenecks – How Few People Can Start a World? Or Restart One?
Written, Produced & Narrated by: Isaac Arthur.
Select imagery/video supplied by Getty Images.

Chapters.
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10:56 Restoration.
19:26 Practical Engineering

Brain motion is driven by mechanical coupling with the abdomen

UNIVERSITY PARK, Pa. — The brain is more mechanically connected to the body than previously appreciated, scientists reported today (April 27) in Nature Neuroscience. Through a study using mice and simulations, the team found a potential biological mechanism underlying why exercise is thought to benefit brain health: abdominal contractions compress blood vessels connected to the spinal cord and the brain, enabling the organ to gently move within the skull. This swaying facilitates the surrounding cerebrospinal fluid to flow over the brain, potentially washing away neural waste that could cause problems for brain function.

According to Patrick Drew, professor of engineering science and mechanics, of neurosurgery, of biology and of biomedical engineering at Penn State, the work builds on previous studies detailing how sleep and neuron loss can influence how and when cerebrospinal fluid flushes through the brain.

“Our research explains how just moving around might serve as an important physiological mechanism promoting brain health,” said Drew, corresponding author on the paper. “In this study, we found that when the abdominal muscles contract, they push blood from the abdomen into the spinal cord, just like in a hydraulic system, applying pressure to the brain and making it move. Simulations show that this gentle brain movement will drive fluid flow in and around the brain. It is thought the movement of fluid in the brain is important for removing waste and preventing neurodegenerative disorders. Our research shows that a little bit of motion is good, and it could be another reason why exercise is good for our brain health.”

Drew, who also holds the title of associate director of the Huck Institutes of the Life Sciences, explained how in a hydraulic system, a pump creates pressure that drives fluid flow. In this case, the pump is the abdominal contraction — which can be as light as the tensing prior to sitting up or taking a step. The contraction puts pressure on the vertebral venous plexus, a network of veins that connect the abdominal cavity to the spinal cavity, causing the brain to move.

Abstract: Nature Neuroscience Brain motion is driven by mechanical coupling with the abdomen.

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Genome pioneer Craig Venter dies: here’s how he transformed science

It’s very sad that Craig Venter passed away. One of a few people I’ve admired since middle school. Truly a life well lived.


Venter redrew the boundaries of biology — sequencing DNA at unprecedented speed, engineering synthetic life and charting ocean microbes.

Swine reporter model for preclinical evaluation and characterization of gene delivery vectors

Pigs which express tdTomato upon Cre or CRISPR editing of a genetic cassette inserted into their genome. (Pig analogue of Ai9 mice). This model system will aid translational preclinical studies for gene editing therapies.


A “turn-on” swine reporter model is developed to characterize local and systemic delivery of gene editors in vivo using viral or non-viral vectors. This adds the functionality of a reporter to preclinical gene delivery research in a large animal model that is more broadly accessible than nonhuman primates.

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