An intriguing paper by Lin et al. where cells were engineered to express a signaling pathway that transcribes a gene of interest upon generation of reactive oxygen species (ROS) by CBCFO nanoparticles in response to applied electromagnetic fields. When implanted in a mouse model of diabetes, nanoparticle-treated genetically engineered cells produced insulin and decreased blood glucose levels in the mice after electromagnetic field application.
Wireless magnetic control of gene expression in mammalian cells has been developed based on intracellular nanointerface and ROS-mediated signalling. The approach allows remotely tunable insulin release and regulates blood glucose in diabetic mice.









