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How Qing featherwork got its colors: New scans reveal multiple birds and hidden pigment layers

The kingfisher’s brilliant blue feathers were once used like paint to create works of art. The technique, known as tian-tsui, was popular during China’s Qing Dynasty. And because tian-tsui uses delicate feathers, previous scientists struggled to study them using traditional analytical techniques. So, researchers reporting in ACS Omega developed new methods of investigating these featherworks without harming them. The team found that multiple bird species and layered pigments provided a one-of-a-kind palette.

The shades of blue in kingfisher feathers are the result of a phenomenon called structural color. Rather than being created by pigment molecules, structural color is created by tiny, ordered structures in the feathers that interact with light to create the observed coloring—in this case, blue or purple. To gain insights into several featherwork pieces and the feathers that went into making them, Madeline Meier and colleagues combined different imaging and spectroscopy techniques that rely on the ways the feathers reflect and scatter light.

The team analyzed a decorative tian-tsui screen estimated to date from the late 18th to the early 19th century that features intricate scenes in a variety of colors. In one panel, analysis revealed that the blue feathers belonged to the common kingfisher, and the purple came from the black-capped kingfisher. The green feathers had different nanostructures than the blue feathers, leading the researchers to conclude that the green ones belonged to another bird entirely: the mallard duck.

How temperature changes light: New model could guide smarter LEDs, sensors and photonic devices

Technion researchers have developed, for the first time, a comprehensive physical model explaining how the properties of a radiating material, including absorption, emission, and quantum efficiency, affect the fundamental characteristics of the light it emits as a function of temperature. In essence, the emitted light changes its color, intensity, and randomness according to the material’s properties and its temperature. The discovery was published in Optica and opens new possibilities for designing advanced light sources, optical sensors, and thermally based photonic systems.

The research was led by M.Sc. student Tomer Bar-Lev and Prof. Carmel Rotschild from the Faculty of Mechanical Engineering and the Russell Berrie Nanotechnology Institute at the Technion. According to the researchers, the central phenomenon examined in this work is photoluminescence, a process in which a material emits light in response to incident illumination. In this phenomenon, light particles (photons) are absorbed by the material and re-emitted, forming the basis of many technologies, including LED lighting and optical sensors.

The Technion researchers demonstrated that the influence of fundamental physical laws formulated more than a century ago is far broader than previously thought.

Giving X-ray vision a sense of direction

Whether in tooth enamel or in nanomaterials made of silicon, the orientation of tiny internal structures often determines the properties of a material. A new X-ray method can even make this nano-order visible when the structures are actually too small to be imaged directly. The method was developed by an international team led by the Helmholtz Center Hereon, and it opens up new possibilities to investigate materials and biological structures. The research is published in the journal Light: Science & Applications.

In medical X-ray imaging, the picture is created by the varying attenuation of X-rays in the body. In order to examine materials or biological tissue in detail, experts use advanced techniques that provide additional information, such as dark-field imaging. This technique exploits the fact that X-rays are scattered, i.e., deflected, at internal interfaces and irregularities. “The scattering reveals a lot about internal structures that are not directly visible in the actual image,” explains Hereon researcher Sami Wirtensohn, first author of the study.

To make these fine structures visible, the dark field method blocks the direct X-ray beam. This allows the detector to capture only the radiation scattered inside the sample. Until now, this method has only been able to show that such structures exist, but not how they are spatially aligned.

Our Extropian Future, with Natasha Vita-More

Our extropian future: natasha vita-more on AI, nanotechnology, mind uploading, and the birth of transhumanism.

What happened to the future we dreamed about on the Extropian mailing list 30 years ago? Did we get the timelines wrong, or was the architecture of our thinking correct? In this compelling follow-up to the conversation with Max More, Giulio Prisco sits down with Natasha Vita-More—futurist, designer, and co-founder of the Extropian movement—to assess the state of \.

Spontaneous Emergence of Self-Replicating Molecules Containing Nucleobases and Amino Acids

The conditions that led to the formation of the first organisms and the ways that life originates from a lifeless chemical soup are poorly understood. The recent hypothesis of “RNA-peptide coevolution” suggests that the current close relationship between amino acids and nucleobases may well have extended to the origin of life. We now show how the interplay between these compound classes can give rise to new self-replicating molecules using a dynamic combinatorial approach. We report two strategies for the fabrication of chimeric amino acid/nucleobase self-replicating macrocycles capable of exponential growth. The first one relies on mixing nucleobase-and peptide-based building blocks, where the ligation of these two gives rise to highly specific chimeric ring structures. The second one starts from peptide nucleic acid (PNA) building blocks in which nucleobases are already linked to amino acids from the start. While previously reported nucleic acid-based self-replicating systems rely on presynthesis of (short) oligonucleotide sequences, self-replication in the present systems start from units containing only a single nucleobase. Self-replication is accompanied by self-assembly, spontaneously giving rise to an ordered one-dimensional arrangement of nucleobase nanostructures.

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Nanoparticles overcome drug-resistant cancer via sequential drug release and photothermal therapy

Cancer cells frequently develop the ability to expel anticancer drugs before they can work—a phenomenon called multidrug resistance (MDR)—which is one of the leading reasons why chemotherapy fails in patients. Research published in the Journal of Controlled Release addresses that problem with a fundamentally new strategy: instead of simply increasing drug doses or switching drugs, researchers engineered nanoparticles that first disable the cancer cell’s drug-expulsion mechanism, and only then release the anticancer drug.

By combining this sequential drug delivery approach with photothermal therapy (using near-infrared laser light to heat and destroy the tumor), complete tumor elimination and 100% survival in a mouse model of drug-resistant cancer were achieved, with no detectable toxicity to normal tissues.

This remarkable drug delivery system was developed by an international research team led by Professor Eijiro Miyako at Tohoku University, who is also a Visiting Professor at Japan Advanced Institute of Science and Technology, in collaboration with the group of Drs. Alberto Bianco and Cécilia Ménard-Moyon at the French National Center for Scientific Research (CNRS)/University of Strasbourg.

The “Nanobot” Singularity: Ray Kurzweil’s Terrifying Plan for 2030

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What if immortality and god-like intelligence were just a few years away?
Renowned futurist and former Google engineer Ray Kurzweil predicts that humanity is rapidly approaching a \.

In Vivo RNA Delivery to Hematopoietic Stem and Progenitor Cells via Targeted Lipid NanoparticlesClick to copy article linkArticle link copied!

A nicely concise paper on antibody-linked lipid nanoparticles which target hematopoietic stem and progenitor cells in vivo, important yet tricky cell types to transduce for hematological gene therapy.


Ex vivo autologous hematopoietic stem cell (HSC) gene therapy has provided new therapies for the treatment of hematological disorders. However, these therapies have several limitations owing to the manufacturing complexities and toxicity resulting from required conditioning regimens. Here, we developed a c-kit (CD117) antibody-targeted lipid nanoparticle (LNP) that, following a single intravenous injection, can deliver RNA (both siRNA and mRNA) to HSCs in vivo in rodents. This targeted delivery system does not require stem cell harvest, culture, or mobilization of HSCs to facilitate delivery. We also show that delivery of Cre recombinase mRNA at a dose of 1 mg kg–1 can facilitate gene editing to almost all (∼90%) hematopoietic stem and progenitor cells (HSPCs) in vivo, and edited cells retain their stemness and functionality to generate high levels of edited mature immune cells.

Scientists Uncover Hidden Property of Light That Twists Matter Sideways

The researchers confirmed this by designing experiments that removed angular momentum while preserving helicity. The sideways rotation still occurred, showing that helicity plays the key role.

This finding offers a deeper understanding of how light interacts with matter at extremely small scales. It also points to new ways of controlling nanoscale systems, with possible applications in light-driven nanomachines and advanced sensing technologies.

“This work represents a new measurement paradigm for nanoscale optomechanics,” says Tanaka. “Just as optical tweezers opened a new field in single-molecule biophysics, we hope this platform will unlock access to nanoscale mechanical phenomena that have so far remained beyond reach.”

Researchers combine five metals to build a better nanocrystal

A nanocrystal is an extraordinarily tiny piece of material—composed of anywhere from a few to a few thousand atoms—in which atoms are arranged in a precise, ordered structure. Think of it like taking a piece of gold and shrinking it down to the size of a few hundred atoms. It’s still gold, still crystalline, just almost incomprehensibly small.

Nanocrystals are in the transistors inside computers and smartphones, in smartphone displays and TV screens, in the gold-nanoparticle sensors that power COVID and pregnancy tests, and in the pipes of your car exhaust system, among countless other innovations.

Their small size gives them a dramatically higher ratio of surface area to volume, making them especially useful as catalysts—materials that speed up chemical reactions without being consumed in the process.

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