Lifeboat Foundation

Metabolism and total energy expenditure change throughout our lives, and now a new study documents a series of distinct, related changes in unprecedented detail. The data – drawn from a large cohort of humans spanning from birth to old age – shed new light on human development and aging and could help shape targeted nutrition and health strategies across the human lifespan.

The complex machine that is the human body requires a substantial amount of energy to fuel day-to-day physical activity and sustain life. However, while energy use is central to understanding many aspects of human health and physiology, including daily nutritional requirements and metabolic investment in myriad activities, very little is known about total energy expenditure in humans or how it varies over the human lifespan.

Most large-scale surveys of human energy expenditure have focused on basal expenditure, which only accounts for roughly half of total expenditure. And, while doubly labeled water (DLW) studies can provide a measure of total energy expenditure in free-living individuals, they, too, are often limited in sample size and diversity.

Bill Andrews gives us the simplest definition of aging as well as what he thinks to be accomplished to really admit aging has been cured.

This is an excerpt of a presentation he made last year at the NHIMA. See the description of the video for details.

Continue reading “Bill Andrews on age reversal and the Betty White Test (videoclip con S/T en Español)” »

The search for a fountain of youth has obsessed humankind for millennia, but a new wave of research is showing that the secret may have been running through our veins all along.

Dr. Jennifer Garrison, PhD (http://garrisonlab.com/) is Assistant Professor, Buck Institute for Research on Aging, Founder & Faculty Director, Global Consortium for Reproductive Longevity & Equality (https://www.buckinstitute.org/gcrle/), Assistant Professor in Residence, Cellular and Molecular Pharmacology, UCSF and Adjunct Assistant Professor of Gerontology, USC Leonard Davis School of Gerontology.

Dr. Garrison’s lab is interested in understanding how neuropeptides (a large class of signaling molecules which are secreted from neurons and transmit messages within the brain and across the nervous system) regulate changes in normal and aging animals as well in understanding how they control behavior at both the cell biological and neural circuit level.

Continue reading “Dr Jennifer Garrison, PhD — Global Consortium for Reproductive Longevity & Equality — Buck Institute” »

We interviewed four longevity experts (including several Lifeboat Foundation board members) to learn how they think about their diets. I was particularly struck by how different they all were (except almost all of them fasted)!

Food.

In all our research into longevity so far, from quantifying how we sleep to exploring the science behind whether human life extension is possible, nutrition has remained the most controversial and confusing subject that we’ve covered. For example, when we surveyed 101 of our readers on their longevity diet, we got 101 very different answers. There is little consensus on what the perfect life extension diet should look like.

In case this hasn’t been posted here yet.

Ageing is inevitable, but what if everything we’ve come to believe about ageing is wrong and we’re able to choose our lifespans? What if ageing is a disease?

Continue reading “Do we finally have control over ageing? | Prof David Sinclair” »

A DNA robot that can walk across biological cell membranes is the first one that can control living cells’ behaviour. The researchers who made the robot hope that it could improve cell-based precision medicine.

A team led by Hong-Hui Wang and Zhou Nie from Hunan University, China, has created a synthetic molecular robot that walks along the outer membrane of biological cells. The robot, powered by an enzyme’s catalytic activity, traverses across receptors that act as stepping stones on the cell surface. With each step, the robot activates a signal pathway that regulates cell migration. Driven by the robot’s movement, the cells can reach speeds of 24 μm/hour.

The researchers write that the DNA robot offers, for the first time, an opportunity to accurately and predictably control the nanoscale operations that power a live cell. They suggest that similar molecular machines that guide cell behaviours could play a role in cell-based therapies and regenerative medicine.

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Levine’s Biological age calculator is embedded as an Excel file in this link:
https://michaellustgarten.com/2019/09/09/quantifying-biological-age/

Continue reading “Attempting To Further Reduce Biological Age: hs-CRP” »

All things must die, according to the poet Alfred Lord Tennyson, but that could be about to change.

A growing number of tech billionaires have decided they want to use their enormous wealth to try to help humans “cheat death.”

Amazon’s Jeff Bezos, Alphabet’s Larry Page, Oracle’s Larry Ellison and Palantir’s Peter Thiel are just a few of the super-rich who have taken a keen interest in the fast-emerging field of longevity, according to interviews, books and media reports.