Lifeboat Foundation

Scientists have discovered a new route to produce complex antibiotics exploiting gene editing to re-program pathways to future medicines urgently required to combat antimicrobial resistance, treat neglected diseases and tackle future pandemics.

Researchers from The University of Manchester have discovered a new way of manipulating key assembly line enzymes in bacteria which could pave the way for a new generation of antibiotic treatments.

New research published today in Nature Communications, describes how CRISPR-Cas9 gene editing can be used to create new nonribosomal peptide synthetase (NRPS) enzymes that deliver clinically important antibiotics. NRPS enzymes are prolific producers of natural antibiotics such as penicillin. However, up until now, manipulating these complex enzymes to produce new and more effective antibiotics has been a major challenge.

In this DNA factory, organism engineers are using robots and automation to build completely new forms of life.
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Ginkgo Bioworks, a Boston company specializing in “engineering custom organisms,” aims to reinvent manufacturing, agriculture, biodesign, and more.

Continue reading “This Synthetic DNA Factory Is Building New Forms of Life” »

Since artificial intelligence pioneer Marvin Minsky patented the principle of confocal microscopy in 1957, it has become the workhorse standard in life science laboratories worldwide, due to its superior contrast over traditional wide-field microscopy. Yet confocal microscopes aren’t perfect. They boost resolution by imaging just one, single, in-focus point at a time, so it can take quite a while to scan an entire, delicate biological sample, exposing it light dosages that can be toxic.

To push confocal imaging to an unprecedented level of performance, a collaboration at the Marine Biological Laboratory (MBL) has invented a “kitchen sink” confocal platform that borrows solutions from other high-powered imaging systems, adds a unifying thread of “Deep Learning” artificial intelligence algorithms, and successfully improves the confocal’s volumetric resolution by more than 10-fold while simultaneously reducing phototoxicity. Their report on the technology, called “Multiview Confocal Super-Resolution Microscopy,” is published online this week in Nature.

“Many labs have confocals, and if they can eke more performance out of them using these artificial intelligence algorithms, then they don’t have to invest in a whole new microscope. To me, that’s one of the best and most exciting reasons to adopt these AI methods,” said senior author and MBL Fellow Hari Shroff of the National Institute of Biomedical Imaging and Bioengineering.

https://youtube.com/watch?v=4siqZlP6XiE

Happy birthday, ISS.

The first components of the International Space Station (ISS) were launched on November 20, 1998, roughly 12 years after the first Soviet MIR-2 module was launched and a full 25 years after Skylab.

Continue reading “ISS Anniversary: Here’s How (And Why) Humans Have Lived in Space For Over Two Decades” »

Professor Norikazu Ichihashi and his colleagues at the University of Tokyo have successfully induced gene expression from a DNA, characteristic of all life, and evolution through continuous replication extracellularly using cell-free materials alone, such as nucleic acids and proteins for the first time.

The ability to proliferate and evolve is one of the defining characteristics of living organisms. However, no artificial materials with these characteristics have been created. In order to develop an artificial molecular system that can multiply and evolve, the information (genes) coded in DNA must be translated into RNA, proteins must be expressed, and the cycle of DNA replication with those proteins must continue over a long period in the system. To date, it has been impossible to create a reaction system in which the genes necessary for DNA replication are expressed while those genes simultaneously carry out their function.

The group succeeded in translating the genes into proteins and replicating the original circular DNA with the translated proteins by using a circular DNA carrying two genes necessary for DNA replication (artificial genomic DNA) and a cell-free transcription-translation system. Furthermore, they also successfully improved the DNA to evolve to a DNA with a 10-fold increase in replication efficiency by continuing this DNA replication cycle for about 60 days.

Continue reading “Novel artificial genomic DNA can replicate and evolve outside the cell” »

https://www.youtube.com/watch?v=wo4BlOeydmI

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Continue reading “Synthetic Biology, Artificial Microbes, and Bio-Organic Weapons” »

Dr. Yuval Noah Harari, macro-historian, Professor, best-selling author of “Sapiens” and “Homo Deus,” and one of the world’s most innovative and exciting thinkers, has a few hypotheses of his own on the future of humanity.

He examines what might happen to the world when old myths are coupled with new godlike technologies, such as artificial intelligence and genetic engineering.

Continue reading “Yuval Noah Harari on The Future of Humanity” »

CRISPR Gene editing therapy is used for the first time in living humans with amazing results.

— About ColdFusion –
ColdFusion is an Australian based online media company independently run by Dagogo Altraide since 2009. Topics cover anything in science, technology, history and business in a calm and relaxed environment.

Continue reading “BREAKTHROUGH: Scientists Reverse Blindness [CRISPR Technology]” »

Studying The Atoms Of Perception, Memory, Behavior and Consciousness — Dr. Christof Koch, Ph.D. — Chief Scientist, MindScope Program, Allen Institute.

Dr. Christof Koch, Ph.D. (https://alleninstitute.org/what-we-do/brain-science/about/te…stof-koch/) is Chief Scientist of the MindScope Program at the Allen Institute for Brain Science, originally funded by a donation of more than $500 million from Microsoft founder and philanthropist Paul G. Allen.

Continue reading “Dr. Christof Koch, Ph.D. — Chief Scientist, MindScope Program — Allen Institute for Brain Science” »