A research team led by UAB researcher David Reverter has discovered the molecular mechanism that describes in detail the process regulating cell division in bacteria, based on the binding of the MraZ protein to the dcw gene cluster. The research has been published in Nature Communications.
Cell division is a central process in all living organisms and requires the coordinated action of many proteins and other regulatory elements. In most bacteria, this process is encoded in a gene cluster called the dcw operon, which groups all the genes that produce the proteins necessary to carry out cell division and bacterial wall formation.
These sets of genes are activated by proteins that act as transcription factors: they bind to the promoter region of the gene, the DNA sequence that indicates the point to start transcription, just before the first codon (the basic unit of gene information) that codes for the beginning of the protein sequence. One of these transcription factors is MraZ, the first gene of the dcw operon in all bacteria. When activated, the necessary proteins (encoded within the genes of the operon) are produced so that the bacteria can divide. It is, therefore, the transcription factor that controls the activity of the operon responsible for cell division in most bacteria.