Lifeboat Foundation

I would like to share a story. A story about sadness, depression, anger, and frustration. But most of all this is my personal story about triumphing over the death sentence of #cancer. I hope this story will give others who went through and are going through hope for the future.

My story started about 4 years ago on a cold winter day. Up until this point my life seemed invincible. That all changed. At the time I was working at the plasma center and we were preparing for an audit by the FDA. Before an audit we would have the floors waxed and make the center look as nice as possible. A few co-workers and I stayed late to help move the donor beds. I knew I had been feeling pain in my neck/shoulder area for a few weeks so I really didn’t want to. I figured it must have been from repetitive motions at work. I decided to just ignore it and help anyways: this decision changed my life dramatically.

As my coworker and I lifted a donor bed I felt a sharp pain in my neck. I could barely move my arm as it was so excruciating. I couldn’t lift my arm to my chest. I shyly let my manager know that I hurt myself. My manager had me go to Concentra #Health since I was going to be covered under worker’s compensation there. It was there I met Dr. Kreiger, one of the doctors who helped save my life.

Continue reading “My Journey With Cancer and the Hope for the Future” »

One of the #brain’s mysteries is how exactly it reorganizes new #information as you learn new tasks. The standard to date was to test how neurons learned new behavior one #neuron at a time. Carnegie Mellon University and the University of Pittsburgh decided to try a different approach. They looked at the population of neurons to see how they worked together while #learning a new behavior. Studying the intracortical population activity in the primary motor cortex of rhesus macaques during short-term learning in a brain–computer interface (BCI) task, they were able to study the reorganization of population during learning. Their new research indicates that when the brain learns a new activity that it is less flexible than previously thought. The researchers were able to draw strong hypothesis about neural reorganization during learning by using BCI. Through the use of BCI the mapping between #neural activity and learning is completely known.

“In this experimental paradigm, we’re able to track all of the neurons that can lead to behavioral improvements and look at how they all change simultaneously,” says Steve Chase, an associate professor of biomedical engineering at Carnegie Mellon and the Center for the Neural Basis of #Cognition. “When we do that, what we see is a really constrained set of changes that happen, and it leads to this suboptimal improvement of performance. And so, that implies that there are limits that constrain how flexible your brain is, at least on these short time scales.”

It is often challenging to learn new tasks quickly that require a high level of proficiency. Neural plasticity is even more constrained than previously thought as results of this research indicate.

Continue reading “The Limits of Neuroplasticity in the Brian” »

Utilizing induced pluripotent stem cells for regenerative medicine.

The #heart is the first organ to develop in the womb and the first cause of concern for many parents.

For expecting mothers, the excitement of pregnancy is often offset by anxiety over medication they require. Parents and doctors often have to consider the mother’s health as well as the potential risk regarding how medication could affect their baby. The U.S. Food and Drug Administration requires certain drugs to be labeled with pregnancy exposure and risk. Some drugs are labeled to show that testing on animals has failed to demonstrate a risk but there are no adequate and well-controlled studies of pregnant women.

Continue reading “Team develops 3D tissue model of a developing human heart” »

Scientists at the UNC School of Medicine and NC State have created an injectable gel-like scaffold that can hold combination #chemo-immunotherapeutic drugs and deliver them locally to tumors in a sequential manner. The results in animal models so far suggest this approach could one day ramp up therapeutic benefits for patients bearing tumors or after removal of the primary tumors.

The research, published in Science Translational Medicine, focused on two specific types of melanoma and breast #cancer, but this approach could work in other tissue types. Also, the research showed that this localized delivery of combination therapy significantly inhibited the recurrence of cancer after the primary tumor was surgically removed.

“We’ve created a simple method to use #chemotherapy while leveraging the biology of the #tumor and our natural defense against foreign invaders to beat back tumor development with limited side effects,” said senior author Zhen Gu, PhD, associate professor in the joint UNC/NCSU Biomedical Engineering Department. “We have a lot more work to do before human clinical trials, but we think this approach holds great promise.”

Continue reading “New therapeutic gel shows promise against cancerous tumors!” »

An article I wrote:

Study based upon human skeletal muscle aging, mutagenesis, and the role of #satellite cells

“A more comprehensive understanding of the interplay of stem cell–intrinsic and extrinsic factors will set the stage for improving cell therapies capable of restoring tissue homeostasis and enhancing muscle repair in the aged.”

Continue reading “Human Skeletal Muscle Aging and Mutagenesis” »

Enzymes play an important role in cognitive function. Enzymes are biological catalysts. They’re responsible for accelerating chemical reactions.

What role do enzymes play in #aging and cognitive function?

According to new research in laboratory mice by UC San Francisco scientists have discovered that loss of an #enzyme that modifies gene activity to promote brain regeneration may be partly responsible for age-related cognitive decline. When age related cognitive decline starts is still debatable, however the effects of age related cognitive decline are well known.