Lifeboat Foundation

An interesting paper that uses ALA to shore up telomerase activity, loss of telomeres inhibition of P53 expression and mitochondrial dysfunction in one go. They use ALA (alpha lipoic acid) to induce PGC-1α in this case though PGC1-alpha seems to be a potential target for intervention as I understand that ALA is difficult to deliver to cells. In this case this involves the vascular system and atherosclerosis.

http://www.cell.com/cell-reports/abstract/S2211-1247(15)00825-6

Short telomeres and Mitochondrial dysfunction are increasingly implicated as being closely linked as this 2012 Dephino paper demonstrates in the aging heart:

Continue reading “PGC-1α Modulates Telomere Function and DNA Damage in Protecting against Aging-Related Chronic Diseases” »

LISTENING, the award-winning debut feature from visionary director Khalil Sullins, is a psychological thriller about penniless grad students who invent mind-reading technology that destroys their lives. David, Ryan, and Jordan hope the telepathy invention will solve all their problems, but the bleeding-edge technology opens a Pandora’s box of new dangers, as the team discovers that when they open their minds, there is nowhere to hide their thoughts. Secrets and betrayals surface, and the technology is stolen by a covert government agency with a hidden agenda. With no one left to trust, David is forced against his friends in a life-or-death battle over not only the privacy of the human mind, but the future of free will itself.

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“Now in its 8th annual cycle with the strongest applicant pool yet, including the most diverse pool of program entrants to date creating change in 136 countries, The Fuller Challenge remains the only award specifically working to identify and catalyze individuals and teams employing a whole systems approach to problem solving.”

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Most cancer-busting strategies focus on removing cancerous cells. While this approach has proved extremely effective on many patients, most treatments have unpleasant side effects and there are many strains which prove extremely challenging to remove. An alternative model to this is to alter instead of remove — fixing cancerous behaviour by ‘reprogramming’ cells that go rogue; essentially swiss finishing school for cellular miscreants. A study published in Nature Cell Biology now provides hope that this tactic could in fact work in many cancers.

Researchers from Mayo Clinic’s Florida campus have found that adhesion proteins, which act like a glue sticking cells together, actually interact with a cell’s ‘microprocessor’. This processor creates molecules called miRNAs, which regulate multiple genes and essentially activate or de-activate different behavioural programs (like commands in computer programming). When healthy cells bump into a neighbour and begin to glue together, these adhesion proteins normally influence both cells — tuning down growth pathways. In cancer, the lab found this adhesion is perturbed; de-regulating miRNA production and enabling rampant growth. When scientists corrected these miRNA levels, the growth was arrested.

Continue reading “Can We Reprogram Cancer Cells Back To Normal?” »

A new story on transhumanism from Tech Insider which is Business Insider’s new tech site:

This presidential candidate wants you to live forever.

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Research and development in human–robot trust is the cutting edge of artificial intelligence, but faith in machines can often be misplaced.

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A little know startup in Seattle could do for metal what 3D printing is doing for other materials like plastic.

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Matter that drops into a black hole is gone forever, right? Not so, declares Stephen Hawking.

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Our brains didn’t evolve to deal with understanding exponential growth, it’s freaking terrifying.

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