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Mitochondrial specialization and signaling shape neuronal function
How neuronal function is shaped by mitochondria.
Despite the established links between mitochondrial dysfunction and neuronal disorders, the specialization of mitochondria to support the specific demands of neurons has been less extensively explored.
Proper mitochondrial positioning influences an array of neuronal functions and processes, from neurodevelopment through synaptic transmission, due to the participation of mitochondria as local ATP suppliers, Ca2+ sinks, and sites of neurotransmitter synthesis.
In neurons, mitochondria are also crucial for local translation in axons and dendrites, to which they provide both local ATP and mRNA transport. In this way, mitochondria emerge as centers for neuronal plasticity sciencenewshighlights ScienceMission https://sciencemission.com/Mitochondrial-specialization
Neurons are specialized cells designed to process information and transmit it, often across long distances. In many neurons, the axonal volume far exceeds the somato-dendritic volume, creating a need for long-range transport and local polarization mechanisms. In addition, action potential firing and restoration of ionic gradients, as well as dynamic changes in synaptic plasticity, further increase the energetic demands of neurons. In this review, we highlight the roles mitochondria play in vertebrate neuronal biology and how mitochondrial functionality is tuned to support the unique demands of neurons. We cover the influence of mitochondrial positioning, ATP generation and Ca2+ buffering on neuronal function, and explore the role of mitochondria in neurotransmitter metabolism and local protein translation.
Simple patch can make medications safer and more effective
Vancomycin is the antibiotic doctors reach for when almost nothing else will work. It’s used in hospitals for serious drug-resistant infections, or for when an infection is spreading through the patient’s bloodstream, but it’s also notoriously tricky to dose: too little and it won’t knock out the infection, too much and the patient risks kidney damage or even death. Up to 40% of patients receiving vancomycin develop an acute kidney injury.
Right now, dosage levels are monitored by repeated blood tests, an invasive and time-consuming process that can’t always give clinicians the data they need in time. Hoping to solve this issue, UNSW and international researchers working alongside Australian diagnostics company Nutromics developed a minimally invasive patch that tracks the antibiotic in patients every five minutes.
The team has published the results of a clinical trial in Nature Biotechnology, and say its success demonstrates that the major scientific and safety challenges have been solved.
The Philosophy of Entropy: Order, Decay, and the Meaning of Equilibrium
Entropy is one of the most profound and misunderstood concepts in modern science — at once a physical quantity, a measure of uncertainty, and a metaphor for the passage of time itself. Entropy: The Order of Disorder explores this concept in its full philosophical and scientific depth, tracing its evolution from the thermodynamics of Clausius and Boltzmann to the cosmology of the expanding universe, the information theory of Shannon, and the paradoxes of quantum mechanics.
At the heart of this study lies a critical insight: entropy in its ideal form can exist only in a perfectly closed and isolated system — a condition that is impossible to realize, even for the universe itself. From this impossibility arises the central tension of modern thought: the laws that describe equilibrium govern a world that never rests.
Bridging physics, philosophy, and cosmology, this book examines entropy as a universal principle of transformation rather than decay. It situates the second law of thermodynamics within a broader intellectual landscape, connecting it to the philosophies of Heraclitus, Kant, Hegel, and Whitehead, and to contemporary discussions of information, complexity, and emergence.
Computer simulations reveal hurricane currents can knock down surface wave heights
Using advanced computer simulations, researchers from the University of Rhode Island’s Graduate School of Oceanography (GSO) have concluded how and why strong ocean currents modify surface waves. “Our primary finding is that hurricane-generated ocean currents can substantially reduce both the height and the dominant period of hurricane waves,” said Isaac Ginis, URI professor of oceanography. “The magnitude of wave reduction depends strongly on how accurately ocean currents are predicted. This highlights the importance of using fully coupled wave-ocean models when forecasting hurricane waves.”
Ginis conducted the research with URI Professor Tetsu Hara and Angelos Papandreou, who earned his Ph.D. in oceanography from URI in December 2025. Their results were published in a peer-reviewed article in the Journal of Physical Oceanography in January 2026.
According to Ginis, waves are most strongly reduced by currents on the front right of the storm, where winds, waves, and currents are typically strongest.
Encapsulated PbS quantum dots boost solar water splitting without sacrificial agents
A research team affiliated with UNIST has developed stable and efficient chalcogenide-based photoelectrodes, addressing a longstanding challenge of corrosion. This advancement paves the way for the commercial viability of solar-driven water splitting technology—producing hydrogen directly from sunlight without electrical input.
Jointly led by Professors Ji-Wook Jang and Sung-Yeon Jang from the School of Energy and Chemical Engineering, the team reported a highly durable, corrosion-resistant metal-encapsulated PbS quantum dot (PbS-QD) solar cell-based photoelectrode that delivers both high photocurrent and long-term operational stability for photoelectrochemical (PEC) water splitting without the need for sacrificial agents. The research is published in the journal Nature Communications.
PEC water splitting is a promising route for sustainable hydrogen production, where sunlight is used to drive the decomposition of water into hydrogen and oxygen within an electrolyte solution. The efficiency of this process depends heavily on the stability of the semiconductor material in the photoelectrode, which absorbs sunlight and facilitates the electrochemical reactions. Although chalcogenide-based sulfides, like PbS are highly valued for their excellent light absorption and charge transport properties, they are prone to oxidation and degradation when submerged in water, limiting their operational stability.
Enhanced Selenium Supplement Extends Lifespan and Delays Multi‐Organs Aging by Regulating the Sik1 Pathway Through Maintaining Calcium Homeostasis
In healthy aging strategies, nutritional supplements synergize with optimized dietary and lifestyle interventions by modulating aging-related molecular pathways.[ 8, 9 ] Notably, NMN exerts multi-organ anti-aging effects by elevating NAD+ levels to activate the SIRT1 pathway, thereby significantly enhancing mitochondrial function while reducing oxidative stress and DNA damage.[ 10 ] Similarly, curcumin delays aging and related diseases through pleiotropic mechanisms involving oxidative stress regulation, anti-inflammatory actions, telomere maintenance, and sirtuin protein modulation.[ 11 ] However, practical applications face significant challenges: bioactive compounds like resveratrol and curcumin suffer from limited bioavailability due to poor aqueous solubility and first-pass metabolism, while excessive supplementation of antioxidants such as vitamins C/E may disrupt reactive oxygen species (ROS) signaling homeostasis, potentially inducing cellular toxicity or even increasing hemorrhagic risk.[ 12-14 ] Future development of anti-aging supplements should focus on: 1) innovative formulation strategies to enhance bioavailability; 2) optimized dosing regimens to minimize toxicity; and 3) long-term clinical studies to validate efficacy.
Selenium, an essential trace element with diverse biological activities, plays a critical role in healthy aging.[ 15-17 ] ≈1 billion people worldwide are affected by selenium deficiency, which is closely linked to neurological disorders, cardiovascular abnormalities, malignancies, and immune dysfunction.[ 18-20 ] Substantial evidence supports the anti-aging effects of selenium through multiple mechanisms: 1) Selenomethionine (SeMet) effectively suppresses Fe2+/H2O2- or Aβ-induced free radical generation, demonstrating therapeutic potential for Alzheimer’s disease characterized by oxidative stress;[ 21 ] 2) Selenium supplementation elevates serum GPx3 levels, a selenoprotein predominantly localized in the basement membrane of renal proximal tubules, modulating mitochondrial quality control pathways to mitigate heavy metal-induced renal aging;[ 22 ] and 3) Our recent findings reveal that selenium supplementation significantly attenuates age-related muscle atrophy by preserving redox homeostasis and regulating muscle protein metabolism.[ 23 ] Recent clinical trials in patients with advanced non-small cell lung cancer (NSCLC) demonstrated that oral administration of selenium nanoparticles (SeNPs) as a dietary supplement (200 µg day−1) in combination with Bev+AP chemotherapy significantly enhanced therapeutic outcomes compared to chemotherapy alone. The SeNPs combination group showed remarkable tumor regression, with progression disease rates decreasing dramatically from 50% to 0% and partial response rates increasing to 83.3%, along with significantly improved objective response rate and disease control rate.[ 24 ] Importantly, this regimen maintained excellent safety profiles without triggering fluctuations in pro-inflammatory or immunosuppressive cytokines. These compelling findings not only establish SeNPs as a safe and effective adjuvant therapy for advanced NSCLC but also provide valuable clinical translation data for nano-selenium formulations in oncology. Despite selenium’s proven benefits in reducing oxidative damage, maintaining genomic stability, and delaying telomere shortening, its narrow therapeutic window, limited bioavailability, and specific mechanisms in multi-organ protection during natural aging require further investigation.
Nanodelivery carriers have emerged as a next-generation platform for gene and drug delivery, offering tunable physicochemical properties such as size, composition, and surface modifications.[ 25 ] Our team has developed organically-bridged mesoporous silica nanoparticles (MSNs) by incorporating functional diselenide bonds into the silica framework at the molecular level, addressing the critical challenge of poor biodegradability in conventional silica materials.[ 26 ] This nanocarrier exhibits unique dual redox-responsive properties, allowing for more precise maintenance of redox homeostasis compared to traditional antioxidants, aligning with the core goal of preserving organismal homeostasis in anti-aging research. Building on this breakthrough, a comprehensive research framework was established: first, this study constructed a natural aging mouse model with MSNs, disulfide-bridged MSNs (SMSNs), commercially available SeMet as controls and then compared the effects of diselenide-bridged MSNs (SeMSNs) on lifespan extension, frailty delay, and multi-organ anti-aging. Next, key pathways and targets were identified through multi-organ transcriptome sequencing, followed by in-depth mechanistic studies. Finally, clinical translation was integrated by analyzing the correlation between serum selenium levels and aging biomarkers in the elderly, and validating the clinical effects of SeMSNs using primary adipose precursor cells (APCs) models. This systematic approach provides a solid theoretical foundation and clinical evidence for the application of nano-selenium in anti-aging research.