Dementia has many faces, and because of the wide range of ways in which it can develop and affect patients, it can be very challenging to treat. Now, however, using supercomputer analysis of big data, researchers from Japan were able to predict that a single protein is a key factor in the damage caused by two very common forms of dementia.
In a study published this month in Communications Biology, researchers from Tokyo Medical and Dental University (TMDU) have revealed that the protein HMGB1 is a key player in both frontotemporal lobar degeneration and Alzheimer disease, two of the most common causes of dementia.
Frontotemporal lobar degeneration can be caused by mutation of a variety of genes, which means that no one treatment will be right for all patients. However, there are some similarities between frontotemporal lobar degeneration and Alzheimer disease, which led the researchers at Tokyo Medical and Dental University (TMDU) to explore whether these two conditions cause damage to the brain in the same way.
Pandemic lockdown forces a new perspective on designs for futuristic AI-based computing devices.
Isaac Newton’s groundbreaking scientific productivity while isolated from the spread of bubonic plague is legendary. University of California San Diego physicists can now claim a stake in the annals of pandemic-driven science.
A team of UC San Diego researchers and colleagues at Purdue University have now simulated the foundation of new types of artificial intelligence computing devices that mimic brain functions, an achievement that resulted from the COVID-19 pandemic lockdown. By combining new supercomputing materials with specialized oxides, the researchers successfully demonstrated the backbone of networks of circuits and devices that mirror the connectivity of neurons and synapses in biologically based neural networks.
The next generation of computing and information processing lies in the intriguing world of quantum mechanics. Quantum computers are expected to be capable of solving large, extremely complex problems that are beyond the capacity of today’s most powerful supercomputers.
New research tools are needed to advance the field and fully develop quantum computers. Now Northwestern University researchers have developed and tested a theoretical tool for analyzing large superconducting circuits. These circuits use superconducting quantum bits, or qubits, the smallest units of a quantum computer, to store information.
Circuit size is important since protection from detrimental noise tends to come at the cost of increased circuit complexity. Currently there are few tools that tackle the modeling of large circuits, making the Northwestern method an important contribution to the research community.
No Man’s Sky
Researchers have created what they say is the largest computer simulation of the universe, and have made the data available for anyone to download for free.
An international team associated with the Center for Computational Astrophysics created the virtual universe using ATERUI II, the world’s most powerful astronomical supercomputer, according to a press release by the organization. Dubbed Uchuu (the Japanese word for “outer space”), the simulation contains a staggering 2.1 trillion particles spanning 9.6 billion virtual light-years. That’s big. Real big.
Isaac Newton’s groundbreaking scientific productivity while isolated from the spread of bubonic plague is legendary. University of California San Diego physicists can now claim a stake in the annals of pandemic-driven science.
A team of UC San Diego researchers and colleagues at Purdue University have now simulated the foundation of new types of artificial intelligence computing devices that mimic brain functions, an achievement that resulted from the COVID-19 pandemic lockdown. By combining new supercomputing materials with specialized oxides, the researchers successfully demonstrated the backbone of networks of circuits and devices that mirror the connectivity of neurons and synapses in biologically based neural networks.
The simulations are described in the Proceedings of the National Academy of Sciences (PNAS).
“Enormous clouds of gas are pulled into galaxies and used in the process of making stars,” said co-lead author Deanne Fisher, associate professor at the Centre for Astrophysics and Supercomputing at Swinburne University in Australia.
On its way in it is made of hydrogen and helium. By using a new piece of equipment called the Keck Cosmic Web Imager, we were able to confirm that stars made from this fresh gas eventually drive a huge amount of material back out of the system, mainly through supernovas.
But this stuff is no longer nice and clean – it contains lots of other elements, including oxygen, carbon, and iron.
“We are thinking about volumes in millions.”
“We are thinking about volumes in millions, not the thousands that people talk about with quantum computers based on superconducting,” said Marcus Doherty, chief science officer.
Quantum Brilliance delivered its first system to the Pawsey Supercomputing Centre in Australia earlier this year and is beginning to ship to other commercial customers.