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A series of clinical trials have tested an experimental treatment for Parkinson’s disease that uses a novel approach: administering the drug straight into the brain via implanted ports. The leading researchers believe this may be a “breakthrough” therapeutic strategy for neurological conditions.

Newly trialed therapy could launch a fresh chapter in the treatment of Parkinson’s disease.

In a new series of studies that culminated with an open-label trial (where participants were aware of what treatment they would receive), scientists have begun testing the effectiveness of a new treatment — and method of delivery — for Parkinson’s disease.

“The future belongs to those who prepare for it today.”–Malcolm X “Be open-minded, but not so open-minded that your brains fall out.”–Groucho Marx In our …

It’s good to see a growing response to the materialist superstition about the mind and the brain from the neuroscience and philosophy community. Materialist theories of the mind are philosophically indefensible and scientifically discredited. Dualism is necessary to account for the immaterial nature of the intellect, for the metaphysical simplicity of the mind, and for free will. Of the varieties of dualism, I believe that Thomistic dualism offers the most satisfactory framework for neuroscience.

Continue reading “An Oxford Neuroscientist Explains Mind vs. Brain” »

Gut microbiome affect metabolic and neural diseases through alterations in epigenetic expressions by DNA methylation and miRNA modulations.

Unlike Neuralink, Synchron’s stent-like neural implant is a brain-computer interface that’s inserted through the jugular vein.

For the “big data” revolution to continue, we need to radically rethink our hard drives. Thanks to evolution, we already have a clue.

Our bodies are jam-packed with data, tightly compacted inside microscopic structures within every cell. Take DNA: with just four letters we’re able to generate every single molecular process that keeps us running. That sort of combinatorial complexity is still unheard of in silicon-based data storage in computer chips.

Add this to the fact that DNA can be dehydrated and kept intact for eons—500,000 years and counting—and it’s no surprise that scientists have been exploiting its properties to encode information. To famed synthetic biologist Dr. George Church, looking to biology is a no-brainer: even the simple bacteria E. Coli has a data storage density of 10¹⁹ bits per cubic centimeter. Translation? Just a single cube of DNA measuring one meter each side can meet all of the world’s current data storage needs.

Schizophrenia is a severe mental health condition that causes significant disability, and affects 1 in 100 people. Patients with schizophrenia commonly experience negative symptoms, which include lack of motivation, social isolation and inability to experience pleasurable feeling. The current antipsychotics minimally improve these negative symptoms, and there are no currently licensed treatments. In addition, it is estimated that total service costs for schizophrenia in England alone will be £6.5 billion by 2026. In view of this, there is considerable interest in identifying potential treatment targets for these symptoms. However, the nature of the changes in brain chemistry that contribute to these negative symptoms is unknown.

Mu-opioid receptors (MOR) are found in a region of the brain called the striatum and they play a crucial role in how we experience pleasure and reward. Our bodies naturally produce opioid molecules that include endorphins; which are hormones secreted by the brain that are known to help relieve pain or stress and boost happiness. MORs are receptors that bind these naturally produced endogenous opioid molecules, and stimulation of the MOR system starts a signalling cascade that causes an increase in motivation to seek reward and increase food palatability amongst many other effects. Interestingly, MORs were found to be reduced in the striatum post-mortem in schizophrenia. So, it was unclear whether the availability of these receptors was increased when individuals were alive, or whether reduced MORs was related to the negative symptoms of schizophrenia.

The latest brain scan research from the Psychiatric Imaging group at the MRC LMS published on 3 October in Nature Communications has reported how the MOR system contributes to the negative symptoms displayed in schizophrenia patients. For the first time, this research study showed how MOR levels are significantly reduced in the striatum region of the brain. Thus, a lack of MOR system stimulation in the brain contributes to these negative feelings that schizophrenia patients can experience.

One of the most astonishing revelations might be that information equals reality. In other words, the basis for our material reality is actually immaterial information. Pattern and flow of information is what defines our experiential reality.

Everything boils down to the binary code of Nature. This is a basic tenet of Digital Physics which is the science of information. Nature computes. Deep down we are information technology. We run on genetic, neural and societal codes. Our DNA-based biology is clearly code-theoretic. We are alphabetic all the way down. We communicate intersubjectively mind-to-mind via language-structured exchange of information.

A recent study shows that human speech is transmitted at about 39 bits a sec. Idealist philosopher Terence McKenna used to say that “The world is made of language and if you know the words the world is made of you can make of it whatever you wish.”