Lifeboat Foundation

As we age, our muscles and other tissues break down in much the same way as degenerative diseases progress. What we learn from studying degenerative diseases such as muscular dystrophy could help researchers develop new interventions to fight common age-related ailments and chronic illnesses.

With help from NIA, biotechnology company Juvena Therapeutics has begun unlocking the secrets of proteins for regenerative medicine. Juvena scientists are using a form of muscular dystrophy — myotonic dystrophy type 1 (DM-1) — as a model to sift through proteins that are produced by the body’s stem cells. These cells have the potential to become any type of cell in the body, from liver tissue to skin cells. The goal is to find proteins that encourage tissue growth and repair, ultimately designing new drugs to prevent and treat degenerative diseases like DM-1. As part of this process, Juvena hopes to learn more about how to reduce the effects of aging on muscles and other tissues, too.

A new biotech trying to establish itself can feel isolated from the larger scientific community. For example, Juvena is unable to submit findings for publication before taking care of intellectual property protections. But NIH’s peer-review process offered confidential, scientifically rigorous feedback to fill that critical gap, and the NIA Small Business Programs staff offered helpful advice.

Continue reading “Funded Small Business Spotlight: Juvena Therapeutics Unlocking the Secrets of Tissue Regeneration” »

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Continue reading “Albumin, CRP, and Creatinine: Better Markers Of Longevity Than Lipoproteins And Glycemic Status” »

A fortnightly meetup for the Transhumanism movement in Sydney to discuss the latest developments in emerging technology and product roadmap.

Insights into healing and aging were discovered by National Institutes of Health researchers and their collaborators, who studied how a tiny sea creature regenerates an entire new body from only its mouth. The researchers sequenced RNA from Hydractinia symbiolongicarpus, a small, tube-shaped animal that lives on the shells of hermit crabs. Just as the Hydractinia were beginning to regenerate new bodies, the researchers detected a molecular signature associated with the biological process of aging, also known as senescence. According to the study published in Cell Reports, Hydractinia demonstrates that the fundamental biological processes of healing and aging are intertwined, providing new perspective on how aging evolved.

https://www.nih.gov/news-events/news-releases/scientists-dis…a-creature

Continue reading “Scientists discover clues to aging and healing from a squishy sea creature” »

Discovering And Developing Medicines To Keep You Biologically Young — Dr. Marco Quarta, Ph.D. — Co-Founder and CEO, Rubedo Life Sciences; CEO, Phaedon Institute.

Dr. Marco Quarta, Ph.D. is Co-Founder and CEO of Rubedo Life Sciences (https://www.rubedolife.com/), a biopharmaceutical company developing a broad portfolio of innovative therapies engineered to target cells which drive chronic age-related diseases. The company’s proprietary ALEMBIC™ drug discovery platform has engineered novel first-in-class small molecules designed to selectively target senescent cells, which play a key role in the progression of pulmonary, dermatological, oncological, neurodegenerative, fibrotic and other chronic disorders.

Continue reading “Dr. Marco Quarta, Ph.D. — Co-Founder and CEO — Rubedo Life Sciences; CEO, The Phaedon Institute” »

This November, researchers, clinicians, and investors will descend on Miami, Florida for the annual Wonderland conference. This year, the world’s leading psychedelics conference is expanding its focus to include longevity for the first time, welcoming top speakers from across the field, from Bryan Johnson to Aubrey de Grey.

Through a series of keynotes, round table and panel discussions, and town hall open mic sessions, the event aims to explore the increasingly linked topics of psychedelic medicine, mental health, and longevity medicine.

Longevity. Technology: Every month it seems, more and more research is highlighting the connection between mental health and longevity – from accelerated biological aging to reduced life expectancy. With psychedelics simultaneously demonstrating compelling results in the treatment of mental conditions, from depression to PTSD, the synergies between longevity and psychedelic medicine are clear. We caught up with leading longevity physician Dr Halland Chen to tap into his views on recent developments in longevity medicine and its links with the psychedelic world.

Tumor metabolism is mandatory for the proper adaptation of malignant cells to the microenvironment and the acquisition of crucial cellular skills supporting the systemic spread of cancer. Throughout this journey, the contribution of the gut microbiota to the bioavailability of nutrients supporting the bioenergetic and biosynthetic requirements of malignant cells is an issue. This review will focus on the role of cysteine as a coin that mediates the metabolic crosstalk between microbiota and cancer. The key points enclose the way cysteine can be made available by the microbiota, by degradation of more complex compounds or by de novo synthesis, in order to contribute to the enrichment of the colonic microenvironment as well to the increase of cysteine systemic bioavailability. In addition, the main metabolic pathways in cancer that rely on cysteine as a source of energy and biomass will be pointed out and how the interspecific relationship with the microbiota and its dynamics related to aging may be relevant points to explore, contributing to a better understanding of cancer biology.

In the human organism, several interspecific relationships are constantly in operation, which are established between the different species that make up the microbiota and the human cells of the various organs where it resides. These interspecific relationships are mainly symbiotic in which both partners benefit. This is the case in health, but in disease, there are still some doubts about the role of the microbiota in the pathophysiology, namely, in the context of cancer, at both the organ and systemic levels. Currently, new clues have been proposed, and several studies have been developed to determine the influence of microbiota in cancer initiation, progression, and therapy, as it is extensively reviewed (1– 7).

Metabolic adaptation in cancer is undoubtedly an essential requirement for the establishment, growth, and spread of a malignant neoplasm. Cellular plasticity is crucial for the adaptation of the tumor cell to the microenvironment of the organ where carcinogenesis occurs and to the emergence of stress conditions, such as drug exposure. Recent studies prove that cysteine metabolic circuits are a relevant component of the metabolic network, sustaining biosynthesis and bioenergetics and allowing chemoresistance (as reviewed in 8 – 10). This review intends to confront some of the most recent findings in the field of cysteine metabolism in cancer and the role of the intestinal microbiota in the dynamic balance of the control of cysteine bioavailability and its putative impact on the progression of oncological disease.

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There is powerful science behind how our beliefs inform our genetic expression. It’s not our genes alone that dictate our health outcomes, rather it’s the biology of belief that determines our destiny.

Continue reading “How Our GENES Listen To Our Beliefs: Heal The Body & Prevent Disease | Dr. Bruce Lipton” »

Microglial cells are the maintenance workers of the central nervous system (CNS), protecting against pathogens and pruning damaged neurons to help the brain maintain homeostasis. Considered immune cells, microglia work to protect the brain from before it is fully formed through its lifetime, but they aren’t infallible. The cells can be primed early on to respond in certain ways, making the microglia’s clean-up efforts less efficient. As other cells age, they can complicate microglial function, making them less effective.

But the underlying mechanism of how microglial cells age and how their aging directly affects the brain is poorly understood—meaning that attempts to prevent or treat brain dysfunction may not be as effective as they could be, according to a multi-institutional collaboration led by Bo Peng and Yanxia Rao, both professors at Fudan University.

The team investigated how microglial cells change as they age in both male and female mice across their lifespans, finding what the researchers called “unexpected sex differences.” They also established a model to study aged microglial cells in a non-aged brain, revealing that aged-like microglia contribute to cognitive decline even in young mice. The researchers published their findings in Nature Aging.