Lifeboat Foundation

A research team led by Dr. Cai at the Albert Einstein college of medicine have shown that stem cells in the hypothalamus influence how fast we age. The new research, shown in mice, may lead to approaches that delay or even prevent age-related diseases[1].

Unfortunately like 70% of scientific research, this publication is behind a paywall, so those wishing to read will have to use the usual channels to obtain the publication. We discuss why paywalls are an unacceptable barrier to progress here in our interview with Sci-Hub.

Imagine a world in which you’re 90 years old and nowhere near middle-aged. An app on your phone has hacked your DNA code, so you know exactly when to go to the doctor to receive gene therapy to prevent all the diseases you don’t yet have. A microchip in your skin sends out a signal if you’re at risk of developing a wrinkle — so you step out of the sun and hotfoot it to your dermatologist. Every evening you sync your brain-mapping device with The Cloud, so even if you were caught up in a fatal accident you’d still be able to cheat death — every detail of your life would simply be downloaded to one of the perfect silicon versions you’d had made of yourself, ensuring you last until at least your 1,000th birthday.

This may sound like science fiction but it could be your fate — provided you can afford it. If current research develops into medicine, in the London of the future the super-rich won’t simply be able to buy the best things in life, they’ll be able to buy life itself by transforming themselves into a bio-engineered super-race, capable of living, if not forever, then for vastly longer than the current UK life expectancy of 81 years.

The science of turning back the clock has never been more advanced. In Boston, a drug capable of reversing half a lifetime of ageing in mice is about to be tested on humans in a medical trial monitored by NASA. NMN is a compound found naturally in broccoli which boosts levels of NAD, a protein involved in energy production that depletes as we get older. Professor David Sinclair, who headed up the initial research at Australia’s University of New South Wales, doses himself with 500mg daily, and claims that he has already become more youthful. According to blood tests analysing the state of the 48-year-old’s cells, prior to taking the pills Sinclair was in the same physical shape as a 57-year-old, but now he’s ‘31.4’.

Continue reading “Why the super-rich are ploughing billions into the booming ‘immortality industry’” »

Scientists at Albert Einstein College of Medicine have found that stem cells in the brain’s hypothalamus govern how fast aging occurs in the body. The finding, made in mice, could lead to new strategies for warding off age-related diseases and extending lifespan. The paper was published online today in Nature.

The hypothalamus was known to regulate important processes including growth, development, reproduction and metabolism. In a 2013 Nature paper, Einstein researchers made the surprising finding that the hypothalamus also regulates aging throughout the body. Now, the scientists have pinpointed the cells in the hypothalamus that control aging: a tiny population of adult neural stem cells, which were known to be responsible for forming new brain neurons.

“Our research shows that the number of hypothalamic neural stem cells naturally declines over the life of the animal, and this decline accelerates aging,” says senior author Dongsheng Cai, M.D., Ph.D., (professor of molecular pharmacology at Einstein. “But we also found that the effects of this loss are not irreversible. By replenishing these stem cells or the molecules they produce, it’s possible to slow and even reverse various aspects of aging throughout the body.”

What if there was one thing that you could do today to delay or improve the natural aging process in your body and mind?

At Emerge we are constantly seeking collaboration with the best minds in the world for helpful and practical advice on how to stay physically, mentally and financially healthy. Today we explore the concept of what it would be like to totally reimagine aging.

We’ve spent weeks rounding-up the top experts from around the world in various aging (also referred to as senescence) fields and asked them one question for our highly health conscious audience:

Continue reading “Top Aging Experts Reveal the Best Habit for How to Stay Young” »

Gene editing aims to make precise changes to the target DNA whilst avoiding altering other parts of the DNA. The objective of this is to remove undesirable genetic traits and introduce desirable changes in both plants and animals. For example, it could be used to make crops more drought resistant, prevent or cure inherited genetic disorders or even treat age-related diseases.

As some of you may recall, back in May a study was published which claimed that the groundbreaking gene editing technique CRISPR caused thousands of off target and potentially dangerous mutations[1]. The authors of the paper called for regulators to investigate the safety of the technique, a move that could potentially set back research years if not decades.

This publication has been widely blasted by the research community due to serious questions about the study design being raised. One of the problems with this original paper was that it involved only three mice, this is an extremely poor number to make the kind of conclusions the paper did. There have been calls for the paper to be withdrawn and critical responses to the study.

When British billionaire Jim Mellon wants to map out an investment strategy, he likes to write a book first. Out of that process came his most recent work — Juvenescence: Investing in the Age of Longevity. Now he and some close associates with some of the best connections in biotech are using the book as inspiration to launch a new company — also named Juvenescence — with plans to make a big splash in anti-aging research.

We would like to know what you would like to see being offered as donation rewards in future campaigns? What would you like to see as a reward for a $25, $50, $100 or even $1000 donation let us know your thoughts by adding ideas to the poll below.

There is a persistent view that life extension advocacy is something that does not require any investments and can be done in your spare time. Fundraising for overheads is like an elephant in the room: it is hard not to notice it is there, but people try to avoid talking about it.

The truth is, it all depends on how ambitious the goal of that advocacy is. Without a doubt, talking to friends about the promise of rejuvenation technologies or reposting research news on your Facebook feed is useful and it can be done for free.

But what if the goal is more ambitious – to change local legislation to make it more longevity-friendly, to convert decisionmakers of the state grant system to allocate more money to rejuvenation research, or to reach out to wealthy individuals able to fund more studies? These activities require money. In this article we will help you become more familiar with the notion of advocacy and the expenditures behind it.

The immune system plays a key role in tissue regeneration and the various types of immune cells such as macrophages, can help or hinder that repair process.

Inflammation is part of the immune response but with aging that immune response becomes deregulated and the inflammation becomes excessive. Excessive levels of inflammation generally speaking inhibit tissue regeneration and when that inflammation is continual, as it often is in aging, this leads to a breakdown in the ability to heal injuries.

As well as a deregulated and dysfunctional immune system aging also sees rising numbers of senescent cells accumulate which also cause inflammation. The immune system fails as we age and stops clearing away these cells leading to a downward spiral of inflammation and increasingly poor tissue repair.