Lifeboat Foundation

Great news! The AgeMeter campaign (https://www.lifespan.io/agemeter) has been extended by 2 weeks; partly because the project lead Elliott Small has been called in by FEMA to help with Hurricane Harvey. We are also happy to announce 2 sources of matching funds to help carry this important project to victory)!

Please check the campaign updates or our post for all the details: http://www.leafscience.org/fighting-aging-and-hurricane-harvey/

Using the power of artificial intelligence and machine learning the project is developing a free to use application to help speed up research and reduce animal suffering.

For more info and to find out how you can help please visit:

https://www.lifespan.io/campaigns/mouseage-photographic-aging-clock-in-mice/

Dr. Aubrey de Grey gives his opinion on this, and explains how people can help support research at the SENS Research Foundation.

This video is presented by LEAF. Please support our work by becoming a “Lifespan Hero”: http://lifespan.io/hero

Panel: Dr. Alexandra Stolzing, Dr. Aubrey de Grey, Dr. Oliver Medvedik, Elena Milova, Keith Comito, Steve Hill and Alen Akhabaev.

If there was a poster child of aging diseases, it would be Alzheimer’s disease. The brains of people suffering from Alzheimer’s disease have deposits of amyloids resulting from the loss of proteostasis. Alzheimer’s disease is accompanied by the presence of amyloid beta protein and tau protein as well as large numbers of activated pro-inflammatory immune cells.

The debate about which is primary has raged for many years in the research world, and it is still not clear how these three elements combine to cause disease progression. A new study has attempted to untangle the mystery and suggests the order is beta amyloid, inflammation, then tau, and this study identifies new targets for therapies[1].

Fantastic momentum so far on the MouseAge campaign, which raised over 10% of its goal on the first day! To learn more about how we are speeding up research and helping reduce animal suffering vist the campaign page:

https://www.lifespan.io/campaigns/mouseage-photographic-aging-clock-in-mice

A big thanks to Elena Milova, Thomas Klauset Aurdal, Jim Mellon (Juvenescence), James Joyce, Emanuele Ascani, Louie Helm, Martin Kleman, William DeVore, John D Gauchat, Peter Svensson, Poly Mamoshina, Felix Weimer, Reason (Fight Aging), Gennady Stolyarov (US Transhumanist Party). Alexey Strygin, Aleksandr Popov, Lars Christensen, Matthew Clarke and our Anonymous donors!

Continue reading “Great going everyone” »

This will be the first visual biomarker for aging in mice, and will help validate potential anti-aging interventions. For more info please visit:

https://www.lifespan.io/campaigns/mouseage-photographic-aging-clock-in-mice/

The old saying “use it or lose it” very much applies to reducing the impact that aging has on the mind and body. Of all the things we can do right now to help stay healthy as we grow older, exercise is probably the most useful.

Supplements have questionable results in humans, and none can really be described as geroprotective due to the lack of data. However, lifestyle and diet are very important in how we age, and caloric restriction has shown some interesting benefits in multiple species, including humans.

However, of all these things, exercise is probably the most important, and staying active can greatly influence our trajectory towards frailty in old age. Many people do not get the exercise they need as they age and, as a result, this can influence how well they age. Certainly, some level of age-related frailty may be a case of neglect and not exercising enough[1].

I’m excited to see Mark O’Connell’s book “To Be a Machine” (about # transhumanism ) get shortlisted for the Royal Society Science Book Prize, one the biggest science book prizes in the world. The final chapter of “To Be a Machine” is about my Immortality Bus journey and presidential campaign (a version of that chapter appeared in The New York Times Magazine after Mark rode with me on the bus). The book also has a wikipedia page now. Winner to be announced on September 19. https://en.m.wikipedia.org/wiki/To_Be_a_Machine

Immensely wealthy and powerful men like Peter Thiel and Elon Musk want to live forever. But at what cost?