Lifeboat Foundation

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New extensive study shares recent discoveries and sheds light on the role of telomere length in human diseases and aging. Part 3 of 3.

Newly published research reports on the accuracy of telomere length as a biomarker of aging, and its role in maximum human lifespan.

New research reports on the accuracy of telomere length as a biomarker of aging, and its role in maximum human lifespan. Part 1 of 3.

Dr. West keynoted at the very first SENS conference, back in 2003 in Cambridge, and it’s a true delight…

In a new study, researchers propose that TIGIT is a marker of T cell senescence and exhaustion in the immune system. However, not only is TIGIT just a biomarker, it is also a potential therapeutic target; as the researcher team discovered, lowering levels of TIGIT resulted in the restoration of some lost function in T cell populations that were experiencing high levels of senescence and exhaustion.

In a new study, researchers propose that TIGIT is a marker of T cell senescence and exhaustion in the immune system[1]. However, not only is TIGIT just a biomarker, it is also a potential therapeutic target; as the researcher team discovered, lowering levels of TIGIT resulted in the restoration of some lost function in T cell populations that were experiencing high levels of senescence and exhaustion.

Aging is associated with immune dysfunction, especially T-cell defects, which result in increased susceptibility to various diseases. Previous studies showed that T cells from aged mice express multiple inhibitory receptors, providing evidence of the relationship between T-cell exhaustion and T-cell senescence. In this study, we showed that T-cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif (ITIM) domain (TIGIT), a novel co-inhibitory receptor, was upregulated in CD8 + T cells of elderly adults. Aged TIGIT + CD8 + T cells expressed high levels of other inhibitory receptors including PD-1 and exhibited features of exhaustion such as downregulation of the key costimulatory receptor CD28, representative intrinsic transcriptional regulation, low production of cytokines, and high susceptibility to apoptosis. Importantly, their functional defects associated with aging were reversed by TIGIT knockdown.

That wisdom from Ecclesiastes is the theme of five new novels, which, if they did not give me a taste of immortality, at least made me feel like the week would never end. The coincidence of their arrival is a little creepy, but it suggests the growing relevance of this subject for a generation reviewing itineraries to the undiscovered country with deep ambivalence. In shades of comedy and tragedy, realism and fantasy, these contemporary authors dig up a lot of old conceits and, like Dr. Frankenstein, zap them to life with mixed results.

The dark side of immortality: “How to Stop Time,” “Eternal,” “The Immortalists,” “Immortal Life” and “The Afterlives.”

As part of our ongoing series covering the hallmarks of aging, we are taking a look at deregulated nutrient sensing today and how these four pathways regulate metabolism and influence aging.

To understand studies on nutrient sensing in the context of aging, let’s introduce four key protein groups. In this post, we’ll explore the pathways they help control and how they affect aging. These key proteins are IGF-1, mTOR, sirtuins, and AMPK[2]. We call these proteins “nutrient sensing” because nutrient levels influence their activity[2].

Diagnosis, Advice, and Treatment: This article is intended for informational and educational purposes only and is not a substitute for professional medical advice. Anti-aging therapies are considered experimental and involve extra risks. The information provided in this article should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed physician should be consulted for the diagnosis and treatment of any and all medical conditions. Call 911 or the equivalent emergency hotline for all medical emergencies. As well, consult a licensed physician before your changing diet, supplement or exercise programs. Photos, External Links & Endorsements: This article is not intended to endorse companies, organizations or products. Links to external websites, depiction/mention of company names or brands, are intended only for illustration and do not constitute endorsements.