Lifeboat Foundation

Some time ago, we discussed the matter of beauty in the context of life extension; in particular, we tried to dispel the belief that the motivation behind life extension might be simply vanity. The article argued that there is nothing wrong with wanting to preserve youthful looks and attempted to explain the evolutionary reasons for our perception of beauty, but it did not discuss a perhaps even more important fact: aesthetics are not the main problem of elderly looks. The main problem, as it always is with age-related decay, is a decline in health and functionality.

What do elderly people look like?

If I ask you to imagine an old person, you’re likely to imagine somebody with grey hair, slack, wrinkled skin, and weak and flaccid muscles. While these features may vary from person to person, this is an accurate enough description of anyone past the age of 70, and it generally gets worse and worse as aging progresses. Exercise might help improve your physical condition, and perhaps a good facial cream might make you look slightly younger than your chronological age, but, after a certain point, the signs of age-related decay are unmistakable and irreversible.

Today, we have a guest article from Dr. Marion Tible, a scientist, and author over at the aging research-focused blog Long Long Life. What follows is an introduction to the senescent cell-clearing therapies known as senolytics, these therapies are poised to enter human trials and if successful could revolutionize how we treat age-related diseases.

What are senolytics?

Discovered in 2015 by a team from Mayo Clinic and the Scripps Research Institute in the United States, senolytics are a growing trend in the anti-aging community. They are very promising drugs in the fight against cellular senescence, a hallmark of aging.

Accelerating rejuvenation therapies to repair the damage of aging. Berlin, March, 15 — 17.

During the recent Undoing Aging conference in Berlin, we worked with Anna Dobryukha from Komsomolskaya Pravda, one of the largest Russian publishing houses. We collaborated on a series of interviews, including this one with Dr. Jonathan Clark from the Babraham Institute.

The Undoing Aging conference, a collaboration between the SENS Research Foundation and Michael Greve’s Forever Healthy Foundation, took place on March 15–17 in Berlin, and it saw many researchers, advocates, investors, and other important members of the longevity community gather together to learn about the latest progress in rejuvenation biotechnology.

LEAF arranged a travel grant for Anna Dobryukha, one of the best Russian journalists writing about aging, longevity, and rejuvenation research, to join us, so it made sense to collaborate with her on the most interesting interviews. Anna works for Komsomolskaya Pravda, one of the largest Russian publishing houses, which has a newspaper, a radio station, and a website with over 40 million readers.

Continue reading “Undoing Aging with Dr. Jonathan Clark” »

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“Old age isn’t a battle,” she says, quoting Philip Roth, “old age is a massacre.” In the past few years, she has given up on screenings and scans. Not that she is lazy or suicidal. But at 76, she considers herself old enough to die. All the self-help books aimed at her age group tell her otherwise; they talk of “active ageing”, “productive ageing”, “anti-ageing”, even “reverse-ageing”, with a long life promised to anyone who makes an effort, regardless of factors such as genetics or poverty. But to her, ageing is “an accumulation of disabilities”, which no amount of physical activity or rigorous self-denial can prevent. If she has symptoms, she’ll have them investigated. But when a doctor tells her there could be an undetected problem of some kind, she won’t play along.

A great iconoclast has written a polemic about ageing that sends up New Age platitudes and is full of scepticism of the wellness industry.

Blake Morrison

Continue reading “Natural Causes” »

Peripheral Elevation of a #Klotho Fragment Enhances Brain Function and Resilience in Young, Aging, and α-Synuclein Transgenic Mice.

Klotho is a longevity factor associated with cognitive enhancement when genetically and widely overexpressed over the lifetime of mice. Leon et al. show that peripheral delivery of a klotho fragment, αKL-F, acutely enhances cognition and neural resilience in young, aging, and disease model mice, establishing its therapeutic relevance and dissecting its underlying mechanisms.

Happy birthday to dr. aubrey de grey bigsmile

How many biologists does it take to make nontrivial progress on an unsolved mathematical problem for the first time in nearly 70 years? The answer is one, at least if the biologist is Dr. Aubrey de Grey, the pioneer of the repair approach to aging.

Yes, you read that right. Today, in occasion of Dr. de Grey’s birthday, we’ve decided to take a short break from biology and rejuvenation to tell our readers about the recent scientific achievement of one of the world’s most famous biogerontologists—unexpectedly, but pleasantly so, in the field of mathematics.

Continue reading “Happy birthday Aubrey de Grey” »

https://theglowingskinseries.com/day-15/