Lifeboat Foundation

LEAF President Keith Comito on the channel TYT talking about healthy life extension! smile

If we can reach our third and final stretch goal and expand the scope of the experiment massively. Could NMN be a true anti-aging drug?

Sp S on S so S red S.

Continue reading “The last 15 hours of the NAD+ Mouse fundraiser and we are only $2431 away from the final goal” »

A thought experiment to see whether life extension might contribute to your happiness.

Today, we’re going to engage in a thought experiment. We’re going to imagine a world with some sort of antechamber to life in which you hang around as some sort of disembodied entity before you are born. (Some people actually believe in something like that, but we won’t go there; it’s just a thought experiment.)

The Choice to Be Born

Continue reading “Choosing Health Early On” »

http://www.undoing-aging.org/news/professor-richard-barker-t…nbrFm8JTxA

Richard is an internationally respected leader in healthcare and life sciences. He says: “I’m focused on accelerating precision medicine technologies to advance our healthy lifespan”.

Yesterday, we announced the successful completion of the NAD+ Mouse Project after a great fundraiser, but it seems we are not done yet. The research team at Harvard has announced a new stretch goal for the last two days of the campaign.

A new $75,000 goal is to be the final step, and to support that, Dr. David Sinclair is offering to fund match the next $5000 in donations to the project to help it reach this final goal. So, for the next two days, all donations are worth double.

The final goal will be to add even more comprehensive testing, such as end-of-life pathology (frequency and specificity of neoplasms/tumors/cancer) and MRI diagnostics (body composition, lean-to-fat ratio). This would really allow the researchers to maximize the useful data they collect during the study and help assess any changes to cancer risk, why each animal died, and what age-related diseases were affected by the drug.

The October 2018 Rejuvenation Roundup is out!

Longevity Month is behind us, and the holiday season lies ahead; to set the mood, what could be better than sitting down comfortably with your favorite hot drink and reading the latest updates from the world of rejuvenation? Let’s get started.

Eat This, Not That! –Bioquark Inc.

https://www.eatthis.com/tips-to-live-longer/

Good information 💜.

Dr. Antonei Csoka of Howard University discusses the concept of aging as meta-disease and about the hierarchy of some of the Hallmarks of Aging. He also discusses some of the philosophical and metaphysical underpinnings for the goal of overcoming age-related disease.

Continue reading “Dr. Antonei Csoka at Ending Age-Related Diseases 2018 — Aging as Meta-Disease” »

The October Journal Club will be focusing on a new study in worms where a combination of compounds acted in synergy to almost double lifespan.

SUMMARY There is growing interest in pharmacological interventions directly targeting the aging process. Pharmacological interventions against aging should be efficacious when started in adults and, ideally, repurpose existing drugs. We show that dramatic lifespan extension can be achieved by targeting multiple, evolutionarily conserved aging pathways and mechanisms using drug combinations. Using this approach in C. elegans, we were able to slow aging and significantly extend healthy lifespan. To identify the mechanism of these drug synergies, we applied transcriptomics and lipidomics analysis. We found that drug interactions involved the TGF-b pathway and recruited genes related with IGF signaling. daf-2, daf-7, and sbp-1 interact upstream of changes in lipid metabolism, resulting in increased monounsaturated fatty acid content and this is required for healthy lifespan extension. These data suggest that combinations of drugs targeting distinct subsets of the aging gene regulatory network can be leveraged to cause synergistic lifespan benefits.