Lifeboat Foundation

The topic for the December Journal Club will be the recently published paper – Fisetin is a senotherapeutic that extends health and lifespan. This commonly available supplement and a plant-based polyphenol appears to influence the aging process in mice by clearing senescent cells, one of the suggested reasons we age.

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Paper: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197652/

A recent study by Harvard Medical School scientists suggests that defective one-carbon metabolism and cellular respiration might contribute to age-related immunosenescence, the decline of immune function typically observed during aging [1].

Abstract

Researchers have discovered a link between the cellular recycling system known as autophagy and the behavior of microglial immune cells during aging.

We have discussed the polarization of macrophages in a number of previous articles, and it has become quite a hot topic among researchers in the last few years. Microglia are tissue-resident macrophages in the central nervous system, and, like other macrophages, they also have a certain polarization state that essentially determines their behavioral patterns and activities.

There are two main polarizations in macrophages that are of interest: M1 and M2. In simple terms, M1 macrophages aggressively intercept pathogens and are proinflammatory, as they use various cellular weapons against invading bacteria and viruses. In contrast, M2 macrophages are focused on reducing inflammation to facilitate tissue repair and healing.

Continue reading “Loss of Autophagy Linked to Changes in Microglia” »

Mice had more stamina, hair and improved organ function with the drug.

When we die, our energy is redistributed throughout the universe according to the law of conservation of energy. While this should not be confused with our consciousness living forever, our energy continuing after we’re gone could make death a less scary prospect.

For the most serious devotees, immortality-seeking is a full-time commitment to keeping abreast of the latest innovations—they speak of these “modalities” with the same reverence a Christian would of a blessing. A $250 billion industry of antiaging products and services is there for the collection—and many of their offerings are for sale at RAADfest.

Ivan Apers, center, surrounded by participants in the RAAD Challenge, a yearlong health and fitness regimen culminating at RAADfest. Members showed off their results with a choreographed workout set to music.

This story appears in VICE Magazine’s Burnout and Escapism Issue. Click HERE to subscribe.

Continue reading “Meet the People Trying to Live Long Enough to Live Forever” »

Researchers from the Rutgers New Jersey Medical School are attempting to defy and reverse the biological aging process by developing a therapeutic vaccine that would bolster the essential repair and regeneration processes of cells.

This is potentially important research since the current life expectancy at birth is around 78.8 years in the USA.

In the United States, about 46 million people are above the age of 65. This number is expected to double by 2060, therefore increasing age-related health issues, reports Census.org.

Continue reading “An Anti-Aging Vaccine?” »

There’s a positive correlation of assisted reproductive technologies with arterial hypertension. Epigenetics and hormone treatments with IVF are probable causes.

Assisted reproductive technologies (ART) have been shown to induce premature vascular aging in apparently healthy children. In mice, ART-induced premature vascular aging evolves into arterial hypertension. Given the young age of the human ART group, long-term sequelae of ART-induced alterations of the cardiovascular phenotype are unknown.

This study hypothesized that vascular alterations persist in adolescents and young adults conceived by ART and that arterial hypertension possibly represents the first detectable clinically relevant endpoint in this group.

Continue reading “Association of Assisted Reproductive Technologies With Arterial Hypertension During Adolescence” »

Whether we will ever find a way to overcome the physiological trade offs that hold back immortality, or whether we will really be able to replicate human consciousness in a computer are questions too difficult for us yet to answer. But are those leading the charge against death at least inspiring us to lead healthy lives, or are they simply rallying against an inevitable fate?

Long read: How nature is fighting our attempts to use biohacking to live forever.