Lifeboat Foundation

Mitochondria are the energy suppliers of our body cells. These tiny cell components have their own genetic material, which triggers an inflammatory response when released into the interior of the cell. The reasons for the release are not yet known, but some cardiac and neurodegenerative diseases as well as the aging process are linked to the mitochondrial genome. Researchers at the Max Planck Institute for Biology of Aging and the CECAD Cluster of Excellence in Aging research have investigated the reasons for the release of mitochondrial genetic material and found a direct link to cellular metabolism: when the cell’s DNA building blocks are in short supply, mitochondria release their genetic material and trigger inflammation. The researchers hope to find new therapeutic approaches by influencing this metabolic pathway.

Our body needs energy—for every metabolic process, every movement and for breathing. This energy is produced in tiny components of our body cells, the so-called mitochondria. Unlike other cell components, mitochondria have their own genetic material, mitochondrial DNA. However, in certain situations, mitochondria release their DNA into the interior of the cell, causing a reaction from the cell’s own immune system and being associated with various diseases as well as the aging process. The reasons for the release of mitochondrial DNA are not yet known.

“After hopefully demonstrating efficacy through the pilot study, Conboy says that plans are underway for a 200–300 person, placebo-controlled Phase 3 trial to prove the use of the plasma dilution as a technology that innovatively treats co-morbidities of aging.”

This could be the first bridge.

UC Berkeley’s Irina Conboy talks parabiosis, plasma dilution, and why young blood may not hold the all answers.

Cryopreservation, or the long-term storage of biomaterials at ultralow temperatures, has been used across cell types and species. However, until now, the practical cryopreservation of the fruit fly (Drosophila melanogaster)—which is crucial to genetics research and critical to scientific breakthroughs benefiting human health—has not been available.

“To keep alive the ever-increasing number of fruit flies with unique genotypes that aid in these breakthroughs, some 160000 different flies, laboratories and stock centers engage in the costly and frequent transfer of adults to fresh food, risking contamination and genetic drift,” said Li Zhan, a postdoctoral associate with the University of Minnesota College of Science and Engineering and the Center for Advanced Technologies for the Preservation of Biological Systems (ATP-Bio).

In new research published in Nature Communications, a University of Minnesota team has developed a first-of-its-kind method that cryopreserves fruit fly embryos so they can be successfully recovered and developed into adult insects. This method optimizes embryo permeabilization and age, cryoprotectant agent composition, different phases of nitrogen (liquid vs. slush), and post-cryopreservation embryo culture methods.

All brains shrink with age, and the dominant view has been that more education slows the rate of shrinking. However, the evidence has been inconclusive because studies have not been able to track the rate of change over time. Until now.

Measured brain shrinkage over time

A team of researchers measured brain aging by measuring the volume of the cortical mantle and hippocampus regions of the brain, in MRI scans from more than 2000 participants in the Lifebrain and UK biobanks. These areas of the brain are prone to shrinkage over time, as a natural part of aging. Participants’ brains were scanned up to three times over an 11 year period, in what is known as a ‘longitudinal’ study.

CEO of Turn. Bio at 3:40 talking about getting product to market in a few years rather than a decade.

#ERA #sebastiano #turnbio #krammer #stanford #healthspan #aging #longevity.
Ms. Anja Krammer, CEO of Turn Biotechnologies talks about the initial targets for ERA, the time line for clinical trials and FDA approval.
Turn Bio was co-founded by Dr. Vittorio Sebastiano to develop and market the Epigenetic Reprogramming of Aging technology that came out of his lab in Stanford University.
Ms. Krammer is a veteran of F500 healthcare and technology companies and co-founder of three Silicon Valley start ups. She is an entrepreneur who has built biotech, pharmaceutical and consumer businesses by assembling high-performance, results-driven teams and a counsellor to multiple enterprises, who has served on boards of public and private companies, industry organizations and foundation.

Continue reading “Clinical Trial Target & Timeline for Aging Diseases | Ms. Anja Krammer” »

Mice fed every other day in another study lived, on average, 12% longer than mice fed every day, largely due to the delay of cancerous diseases.

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According to the International Food Information Council’s 2020 Food and Health Survey, you most likely know someone who is practicing intermittent fasting. The survey of 1000 adult Americans found that one in ten were putting down the fork during specified periods of time, making it America’s most popular “diet.”

Continue reading “Intermittent Fasting for Longevity: The Science Behind the Hype” »

The only thing bad about Star Trek was they made the Borg evil.

Emerging technologies have unprecedented potential to solve some of the world’s most pressing issues. Among the most powerful — and controversial — is the gene-editing tech, CRISPR-Cas9, which will improve agricultural yields, cure genetic disorders, and eradicate infectious diseases like malaria. But CRISPR and other disruptive technologies, like brain-machine interfaces and artificial intelligence, also pose complex philosophical and ethical questions. Perhaps no one is better acquainted with these questions than Peter Diamandis, founder of the XPRIZE Foundation and co-founder of Singularity University and Human Longevity Inc. In this session, Peter will give a state of the union on the near future and explore the profound ethical implications we will face in the ongoing technological revolution.

Continue reading “CRISPR, AI & Brain-Machine Interface: The Future Is Faster Than You Think, Peter Diamandis” »

The most interesting part is a longevity escape velocity answer starting at 12:19 and going to 16:30.

Join Aubrey de Grey, Ph.D., Sergey Young, and Sourav Sinha as they talk about how our understanding of aging has developed in the last two decades. They will discuss:

Continue reading “SERGEY YOUNG — AMA #8: ‘Aging as an Engineering Problem’ with Aubrey de Grey” »

Fasting is one of those subjects that is widely talked about, in limited circles. Those who have looked cannot but be intrigued and impressed by the claims and results, whilst those who have not, think it borders on madness, and must be bad for you because…well, FOOD!!

So, for those who want a refresher on the science, through to those who have questions they have always been embarrassed to ask, and onwards to all those you want to send this link to, in an attempt to open their eyes…I did a quick guide to what we know, what are just finding out and at the end, the top questions that get asked on the topic.

Continue reading “Fasting Questions And Answers” »