HOMA calculator: https://www.omnicalculator.com/health/homa-ir.
Papers referenced in the video:
Growth hormone-releasing hormone disruption extends lifespan and regulates response to caloric restriction in mice.
https://pubmed.ncbi.nlm.nih.gov/24175087/
Continue reading “Insulin Sensitivity Is A Hallmark Of Longevity” »
https://youtube.com/watch?v=mWWDMV2W7QM
Experts predict that we’ll be able to live up to 20% longer over the next 100 years. Here’s how humans are trying to live forever. Andrea Schmitz and Benji Jones Apr 3, 2019, 12:00 PM @ These potential treatments for aging could unlock cures to a range of age-related illnesses, from cancer to heart disease – Charlotte Hu Aug 20, 2018, 1:21 PM @ Animals that defy the rules of aging — like naked mole rats — could help scientists unravel the secrets to longevity – Charlotte Hu Aug 15, 2018, 2:54 PM @ Everything you thought you knew about aging is wrong – Erin Brodwin Apr 27, 2016, 12:13 PM *© 2021 Insider Inc. @ Other very important information, images, YouTube Videos (Ray Kurzweil – Physical Immortality – 3 de jan. de 2017 & Ray Kurzweil + Disruptive Technologies and Dangerous Ideas – 5 de dez. de 2017), websites, social networks and links.
Hello everybody! In this episode, we interview Felix Werth, a trully hero of the rejuvenation field: in 2015 he created a party in Germany to defend more investments in our field, and his party is contesting the general elections in the country on September 26th 2021! However, he needs our help right now, since his party has until July 19th to collect enough signatures to participate in 14 German states covering 98% of the country’s population. So be sure to check the interview and the party’s website (https://parteifuergesundheitsforschung.de) to see how you can help.
In this episode of ImmortaliCast, Nicolas and Nina talk to Felix Werth, the founder and leader of the German Party for Health Research, a party with a single issue: 10% of the government budget should be spent on research for the development of treatments of age-related diseases. The party will contest the German general elections of September 26th 2021.
Continue reading “Felix Werth: The rejuvenation field in the ballot in Germany” »
We may have progressed beyond drinking mercury to try to prolong life. Instead, by a British government estimate, we have what may be called the ‘immortality industrial research complex’ – using genomics, artificial intelligence and other advanced sciences, and supported worldwide by governments, big business, academics and billionaires – that’s worth US$110 billion today and US$610 billion by 2025.
We are living longer than at any time in human history. And while the search is on for increased longevity if not immortality, new research suggests biological constraints will ultimately determine when you die.
This product came out months ago with some shocking numbers as to effect. But those effects were in mice tests. 10–20% increase in lifespan and 55% increase in healthspan. It is AKG, Rejuvant, it’s a product you can buy now. There will be a part 2 of this interview so I hope to hear about human data.
Here we present an interview with Tom Weldon the founder and CEO of Ponce de Leon Health, which makes Rejuvant a Calcium AKG based supplement. In this video Tom talks through the process and reasons for selecting CaAKG. He also talks about some of the other results that they found in their tests, especially with respect to mixing different supplements and their combined effects.
Continue reading “CaAKG — The Science Behind Rejuvant | Tom Weldon Interview Series Part I” »
There are Sirt6 activators on the market, but since we are not seeing any major news about results I would question their value.
SPONSOR: Longevity. Technology — https://www.longevity.technology/?utm_source=SSS&utm_medium=…aign=Sirt6
Continue reading “The longevity sirtuin – what you need to know about SIRT6” »
The population on Earth is increasingly growing and people are expected to live longer in the future. Thus, better and more reliable therapies to treat human diseases such as Alzheimer’s and cardiovascular diseases are crucial. To cope with the challenge of ensuring healthy aging, a group of international scientists investigated the potential of biosynthesising several polyamines and polyamines analogs with already known functionalities in treating and preventing age-related diseases.
One of the most interesting molecules to study was spermidine, which is a natural product already present in people’s blood and an inducer of autophagy that is an essential cellular process for clearing damaged proteins, e.g., misfolded proteins in brain cells that can cause Alzheimer’s. When people get older the level of spermidine in the blood decrease and dietary supplements, or certain food products are needed to maintain a stable and high level of spermidine in the blood. However, those products are difficult to produce with traditional chemistry due to their structural complexity and extraction of natural resources is neither a commercially viable nor a sustainable approach.
Therefore, the researchers instead decided to open their biochemical toolbox and use classical metabolic engineering strategies to engineer the yeast metabolism to produce polyamines and polyamines analogs.
Research conducted by Qiang et al has discovered a link between a protein in red blood cells and age-related decline in cognitive performance. Published in the open access journal PLOS Biology on 17th June 2021, the study shows that depleting mouse blood of the protein ADORA2B leads to faster declines in memory, delays in auditory processing, and increased inflammation in the brain.
As life expectancies around the world increase, so are the number of people who will experience age-related cognitive decline. Because the amount of oxygen in the blood also declines with age, the team hypothesized that aging in the brain might be naturally held at bay by adenosine receptor A2B (ADORA2B), a protein on the membrane of red blood cells which is known to help release oxygen from the blood cells so it can be used by the body. To test this idea, they created mice that lacked ADORA2B in their blood and compared behavioral and physiological measures with control mice.
The team found that as the mice got older, the hallmarks of cognitive decline—poor memory, hearing deficits, and inflammatory responses in the brain—were all greater in the mice lacking ADORA2B than in the control mice. Additionally, after experiencing a period of oxygen deprivation, the behavioral and physiological effects on young mice without ADORA2B were much greater than those on normal young mice.
A new study led by University of Maryland and UCLA researchers found that DNA from tissue samples can be used to accurately predict the age of bats in the wild. The study also showed age-related changes to the DNA of long-lived species are different from those in short-lived species, especially in regions of the genome near genes associated with cancer and immunity. This work provides new insight into causes of age-related declines.
This is the first research paper to show that animals in the wild can be accurately aged using an epigenetic clock, which predicts age based on specific changes to DNA. This work provides a new tool for biologists studying animals in the wild. In addition, the results provide insight into possible mechanisms behind the exceptional longevity of many bat species. The study appears in the March 12, 2021, issue of the journal Nature Communications.
“We hoped that these epigenetic changes would be predictive of age,” said Gerald Wilkinson, a professor of biology at UMD and co-lead author of the paper. “But now we have the data to show that instead of having to follow animals over their lifetime to be sure of their age, you can just go out and take a tiny sample of an individual in the wild and be able to know its age, which allows us to ask all kinds of questions we couldn’t before.”
