One-minute-long excerpt of the intervention of Professor David Sinclair during an event organized by the SALT Fund, that took place in October.
In this excerpt, Professor Sinclair talks about the work done in his Lab at Harvard University on partial cellular reprogramming and rejuvenation.
Innovation At The Intersection Of Cancer & Aging, Via Digital Health & Behavioral Sciences — Dr. Corinne Leach, Ph.D. American Cancer Society
Dr. Corinne Leach, PhD, MPH, MS, is a gerontologist, digital health strategist, and behavioral scientist, who serves as the Senior Principal Scientist, Behavioral Research, at the American Cancer Society (https://www.cancer.org/).
Becoming Immortal through Mind Uploading sounds like something that’ll only be possible around the 2100’s. But amazingly, a group of scientists at Nectome are working on giving us the ability to live forever inside of a computer simulation by the end of this decade for around 10000$.
Ray Kurzweil, director of engineering at Google, has long predicted that people will be able to upload their entire brains to computers and become digitally immortal by 2045. Kurzweil made this claim for many years, e.g. during his speech in 2013 at the Global Futures 2045 International Congress in New York, which claims to subscribe to a similar set of beliefs. Mind uploading has also been advocated by a number of researchers in neuroscience and artificial intelligence, such as the late Marvin Minsky.
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Aging affects everybody, so it’s easy to understand why so much scientific attention is focused on studying it. Scientists in Canada now claim to have found that telomeres play a different role in cellular aging than previously thought.
One of the main points of interest in anti-aging biology are what’s known as telomeres. These are sections of “junk” DNA that form caps on the ends of chromosomes, protecting important genetic information from damage when a cell divides. But a piece of the telomere is eroded away with each cell division, and when it gets too short the cell stops dividing entirely, entering a dormant state known as senescence. The build-up of these senescent cells contributes to a range of symptoms we associate with aging, such as frailty and age-related diseases.
The implication of this model is that telomeres take on a pre-emptive protection role – they signal to cells to stop dividing as soon as one telomere wears out. But there is evidence to suggest that cell division can continue with as many as five dysfunctional telomeres.
Cryogenically frozen dead people are held preserved in a clinic at Scottsdale, Arizona in the hope that maybe someday science would be advanced enough to bring them back to life. This unique cryonics clinic is run by Alcor Life Extension Foundation, and surprisingly, many people, including some famous personalities like PayPal co-founder Peter Theil, are actually spending hundreds of thousands of dollars to have their bodies preserved here after death.
The idea of waking up in the future sounds like a great plot for a sci-fi movie or a novel but through cryonics 0 organizations like Alcor are trying to do the same in reality. Max Moore, a futurist and the former CEO of Alcor, believes that people can be rescued from death. “Our view is that when we call someone dead it’s a bit of an arbitrary line. In fact they are in need of a rescue,” he said in an interview. What’s perhaps more surprising is that Alcor is not the only cryonics clinic preserving dead bodies for revival in the future.
Discussing The Future Of “Seno-Therapeutic” Development — Dr. Judith Campisi, PhD, Professor of Biogerontology, Buck Institute for Research on Aging.
Dr. Judith Campisi, PhD (https://www.buckinstitute.org/lab/campisi-lab/) is a biochemist, cell biologist, and Professor of Biogerontology at the Buck Institute for Research on Aging.
Shokrollah Elahi led a new study showing that short-lived white blood cells called neutrophils play a role in impaired T cell functions and counts in people with HIV, as well as the chronic inflammation that is common with the virus. (Photo: Najmeh Bozorgmehr)
In a groundbreaking study of people living with HIV, University of Alberta researchers found that elusive white blood cells called neutrophils play a role in impaired T cell functions and counts, as well as the associated chronic inflammation that is common with the virus.
Neutrophils are a foundational part of the body’s immune system and the most abundant type of white blood cell, making up about 60 to 80 per cent of circulating immune cells in the blood. However, unlike other types of white blood cells, neutrophils are extremely short-lived and cannot be frozen and thawed like other immune cells, making them extremely difficult to examine, said study lead Shokrollah Elahi.
In a study published in Nucleic Acids Research, the team of cancer researcher Francis Rodier, an Université de Montréal professor, shows for the first time that cellular senescence, which occurs when aging cells stop dividing, is caused by irreversible damage to the genome rather than simply by telomere erosion.
This discovery goes against the scientific model most widely adopted in the last 15 years, which is based on one principle: telomeres, caps located at the ends of chromosomes whose purpose is to protect genetic information, erode with each cell division. When they get too short, they tell the cell to stop dividing, thus preventing damage to its DNA. Made dormant, the cell enters senescence.
For this model to be valid, the inactivation of a single telomere should be sufficient to activate the senescence program. Rodier’s laboratory and many others had already observed that several dysfunctional telomeres were necessary.
A futuristic Pill will soon have the ability to fix any issue with the Human body, cure any disease and even make you live longer. This advancement in Biology is made possible with the help of Artificial Intelligence in the form of Google’s Alphafold 2.0 which solved Protein Folding and created a huge medical database of all proteins for all scientists and researchers to use for free.
Protein folding is the physical process by which a protein chain is translated to its native three-dimensional structure, typically a “folded” conformation by which the protein becomes biologically functional. People like David Sinclair are using it to increase longevity and create future medicine and pills to give human actual superpowers.
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