Lifeboat Foundation

Biotech start-up Pretzel Therapeutics launched Monday with $72.5 million in Series A financing to develop novel, mitochondria-based therapies for rare genetic disorders and diseases of aging.

Pretzel plans to target mitochondrial diseases, a highly heterogenous group of conditions caused by DNA mutations in the mitochondria or the nucleus. These disorders are very rare, afflicting around one in 5,000 people.

Pretzel CEO Jay Parrish told BioSpace the funding “should enable us to get close to the clinic if not into the clinic with one or more programs.”

Hugo Cox.

At the end of a winding dirt track off Bear Creek Road, a few miles from Los Gatos in California’s Santa Cruz mountains is the home of Aubrey de Grey, the 53-year-old English research scientist from whom the claim originates. It looks exactly like the place you would expect a mad professor to live.

Summary: Determining the structure of vitronectin, a protein implicated in age-related macular degeneration and some neurodegenerative disorders, and using pressure to alter the protein shape may help in the development of new treatments for AMD.

Source: Sanford Burnham Prebys.

Research led by Sanford Burnham Prebys professor Francesca Marassi, Ph.D., is helping to reveal the molecular secrets of macular degeneration, which causes almost 90% of all age-related vision loss.

Japan is investing a lot into Longevity Research in hopes of keeping us young forever. And recently, they managed to bring about a new kind of vaccine which…

Senescent macrophages are in fact also found to express senescence-related markers p16(Ink4a) and β-galactosidase (β-gal), and promote inflammation in diseased tissues [25, 26]. Our previous work has indicated increased cellular senescence in dystrophic muscles of mdx/utr(−/−) mice [3], however, whether or not macrophages in particular develop cellular senescence and promote senescence associated phenotypes was still unknown. To this end, here we further examined mdx/utr(−/−) mice and solved these puzzles.

Immune cells in the skeletal muscle are activated during muscle injury and promote the process of muscle regeneration by coordinating with muscle stem cells. However, studies with severely diseased muscles further demonstrate that immune cells can become dominantly activated and is inductive of increased fatty infiltration and fibrosis formation, while at the same time potently repress the proliferation and function of muscle stem cells [27]. Our current results in severely dystrophic muscle reveal a similar situation of interaction between macrophages and MPCs, showing that the function of MPCs is repressed by the senescent macrophages. As senescent cells accumulate in the aged or diseased tissues, it can exert profound effects on the growth and function of normal cells by releasing SASPs [9, 10].

Axolotls Can Regenerate Their Own Brains: New research maps out the different cell types hoping to pave the way to regenerative medicine!

O.o!!!

According to recent research, the protein CHIP can control the insulin receptor more effectively while acting alone than when in a paired state. In cellular stress situations, CHIP often appears as a homodimer – an association of two identical proteins – and mainly functions to destroy misfolded and defective proteins. CHIP thus cleanses the cell. In order to do this, CHIP works with helper proteins to bind a chain of the small protein ubiquitin to misfolded proteins.

As a result, the cell detects and gets rid of defective proteins. Furthermore, CHIP controls insulin receptor signal transduction. CHIP binds to the receptor and degrades it, preventing the activation of life-extending gene products.

Continue reading “Scientists Discover a Molecular Switch That Controls Life Expectancy” »

Are you looking for the most recent Artificial Intelligence Trends? Artificial intelligence will have advanced far enough to become the most revolutionary technology ever devised by man. Artificial intelligence (AI) is progressing at an alarming rate. At the moment, new technical applications and systems are being employed to imitate, extend, and expand human intelligence.

Curious to know more? stay connected for that as we dive deeper!

Continue reading “BREAKTHROUGH! The Gap between the Human Brain and Ai is closed!” »

Article originally published on LINKtoLEADERS under the Portuguese title “Sem saber ler nem escrever!”

In the 80s, “with no knowledge, only intuition”, I discovered the world of computing. I believed computers could do everything, as if it were an electronic God. But when I asked the TIMEX Sinclair 1000 to draw the planet Saturn — I am fascinated by this planet, maybe because it has rings —, I only glimpse a strange message on the black and white TV:

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Continue reading “No knowledge, only intuition!” »