Lifeboat Foundation

Summary: The epigenetic clocks of those who indulged in unhealthy behaviors as teens were 1.7 to 3.3 years older than individuals who reported more healthy lifestyles as teens.

Source: eLife.

Biological aging results from damage to cells and tissues in the body that accumulates over time. The results of the study could lead to new ways of identifying young people at risk of developing unhealthy habits that are associated with accelerated biological aging and suggest interventions to prevent poor health outcomes later on.

Scientists at the University of Pittsburgh School of Medicine have discovered the missing puzzle piece in the mystery of how melanoma tumors control their mortality.

In a paper published in Science this week, Jonathan Alder, Ph.D. and his team describe how they discovered the perfect combination of genetic alterations that tumors use to promote explosive growth and prevent their own demise, a development that could change the way oncologists understand and treat melanoma.

“We did something that was, in essence, obvious based on previous basic research and connected back to something that is happening in patients,” said Alder, assistant professor in the Division of Pulmonary, Allergy and Critical Care Medicine at Pitt’s School of Medicine.

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Today, Deep Longevity, a company will launch its new software as a service (SaaS) antiaging platform, SenoClock. The culmination of years of biogerontological research, SenoClock will host all of Deep Longevity’s patented aging clocks that may be used in clinical practice and other healthcare-adjacent industries.

Aging clocks available on the platform will allow its users to receive comprehensive and actionable pace of aging reports based on various data types, such as blood tests, psychological surveys, gut flora composition and more.

Longevity. Technology: Hospitals and clinics are mostly reactive when it comes to treatment, a practice that is partly due to infrastructure and partly due to human nature. However, as we discussed in our interview with Sir John Bell earlier this week, prevention must be the new paradigm and its one that better serves individuals, healthcare systems and populations as a whole. Deep Longevity’s new product SenoClock unlocks a preventive, longevity-focused mode of healthcare; a new SaaS platform, SenoClock offers physicians a single portal in which to track the aging rate of their patients, enabling them to generate personalised health plans.

A team of researchers at Umeå University has discovered that an enzyme in human cells has probably evolved from an ancient single-celled organism. The enzyme’s unique properties mean that it could be used as a building block in the design of new enzymes, for example in processing wood raw materials. The discoveries are presented in Science Advances.

Life on Earth is divided into three groups of organisms: bacteria, archaea and eukaryotes, with humans belonging to the last group, the eukaryotes. One theory is that we evolved from archaea, which in turn may have evolved from bacteria.

Now, a team of researchers from the Department of Chemistry at Umeå University has discovered clear traces of an archaea (odinarchaeota) in an enzyme found in the nucleus of human cells. The human enzyme is called AK6 and has a variety of functions, such as energy metabolism, genome stabilization and programmed cell death.

In a study recently published in the journal Nature Biomedical Engineering, researchers from Kanazawa University use a method called “lasso-grafting” to design therapeutics with enhanced longevity and brain penetration.

Cell growth and repair are stimulated by biomolecules known as cytokines and growth factors. Unfortunately, delivering adequate concentrations of these molecules to the brain for treating neurological conditions like Alzheimer’s disease is challenging as they are either cleared out of the blood very quickly or do not penetrate neural tissue effectively.

A research team led by Kunio Matsumoto and Katsuya Sakai at Kanazawa University in collaboration with Junichi Takagi, Osaka University and Hiroaki Suga, the University of Tokyo has now used a technique called “lasso-grafting” to design molecules that replicate growth factors with longer retention in the body and brain penetration.

This time I come to talk about a new concept in this Age of Artificial Intelligence and the already insipid world of Social Networks. Initially, quite a few years ago, I named it “Counterpart” (long before the TV series “Counterpart” and “Black Mirror”, or even the movie “Transcendence”).

It was the essence of the ETER9 Project that was taking shape in my head.

Over the years and also with the evolution of technologies — and of the human being himself —, the concept “Counterpart” has been getting better and, with each passing day, it makes more sense!

Imagine a purely digital receptacle with the basics inside, like that Intermediate Software (BIOS⁽¹⁾) that computers have between the Hardware and the Operating System. That receptacle waits for you. One way or another, it waits patiently for you, as if waiting for a Soul to come alive in the ether of digital existence.

Continue reading “Digital Doubles and Second Selves” »

In laboratory mice, pituitary dwarfism caused by genetic reduction or elimination of the activity of growth hormone (GH) significantly extends lifespan. The effects of congenital pituitary dwarfism on human longevity are not well documented. To analyse the effects of untreated pituitary dwarfism on human lifespan, the longevity of a diverse group of widely known little people, the 124 adults who played “Munchkins” in the 1939 movie The Wizard of Oz was investigated. Survival of “Munchkin” actors with those of controls defined as cast members of The Wizard of Oz and those of other contemporary Academy Award winning Hollywood movies was compared. According to the Kaplan–Meier survival curves, survival of female and male “Munchkin” actors was shorter than cast controls and Hollywood controls of respective sexes.

Michael Rae (Science Writer for SENS Research Foundation) asks Dr. Amit Sharma questions about his ApoptoSENS area of research.

This video is part of our End of Year Campaign 2022.

Continue reading “Ask Me Anything about ApoptoSENS — with Dr. Amit Sharma and Michael Rae” »