Lifeboat Foundation

Researchers at UC Davis are the first to report how a specific type of brain cells, known as oligodendrocyte-lineage cells, transfer cell material to neurons in the mouse brain. Their work provides evidence of a coordinated nuclear interaction between these cells and neurons. The study was published today in the Journal of Experimental Medicine.

“This novel concept of material transfer to neurons opens new possibilities for understanding brain maturation and finding treatments for neurological conditions, such as Alzheimer’s disease, cerebral palsy, Parkinson’s and Huntington’s disease,” said corresponding author Olga Chechneva is an assistant project scientist at UC Davis Department of Biochemistry and Molecular Medicine and independent principal investigator in the Institute for Pediatric Regenerative Medicine at Shriners Children’s Northern California.

Oligodendrocyte-lineage cells, also called oligodendroglia, are a type of glial cells found in the central nervous system. From birth onward, these glial cells arise to support neural circuit maturation. They are mostly known for their role in myelination—the formation of the insulating myelin sheath around nerve axons.

Senescent cells are those that have stopped dividing but haven’t read the “time to die” memo. Instead, they hang around, accumulating in the body and fueling chronic inflammation – sometimes called inflammaging – which in turn, contributes to conditions such cardiovascular diseases, chronic kidney disease, type 2 diabetes, cancer, sarcopenia and degenerative disorders.

Longevity. Technology: In mice, eliminating senescent cells from aging tissues can restore tissue balance and lead to an increased healthy lifespan. Now a team led by investigators at Massachusetts General Hospital (MGH), a founding member of Mass General Brigham (MGB), has found that the immune response to a virus that is ubiquitously present in human tissues can detect and eliminate senescent cells in the skin [1].

For the study, which is published in Cell, the scientists analyzed young and old human skin samples to learn more about the clearance of senescent cells in human tissue.

What did scientists think about aging in 1931? That’s right. 1931. because that is the year the first biological textbook was published “The Science of Life”. I managed to get my hands on the first edition of this textbook. This was my face when i first received it. As you can see i was quite excited. And this textbook is made up of separate books. I bought book i last year and i read it. Having enjoyed it and discovered that it was part of this massive ensemble piece — well, i’ve read the first “book” — there are, if my roman numerals are correct, 9 books in total. And in this first book, penned “The Living Body”, the authors, most famously, H.G.Wells, Sir Julian Huxley and G.P.Wells, H.G’s son discusses the body as a machine and that.

“For the present it is enough to remember that all animals (including men) are combustion engines of an intricate and curious kind, which live by oxidising their food”

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Pushing The Boundaries Of Research To Build A Synthetic Kidney — Dr. Andrew McMahon, Ph.D. & Lewis Kleinberg, University Kidney Research Organization (UKRO)

The University Kidney Research Organization (UKRO — https://ukrocharity.org/) is a Los Angeles-based nonprofit charity, co-founded prominent entertainment attorney Kenneth Kleinberg, inspired by his personal journey with kidney disease, focused on supporting medical research and education related to the causes, treatment, and eradication of all forms of kidney disease.

Continue reading “Dr Andrew McMahon & Lewis Kleinberg — Pushing The Boundaries Of Research To Build A Synthetic Kidney” »

‘This doesn’t mean I have become immortal,’ he says. ‘However…’

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*Not a low-calorie food.

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That plateau is called “mortality compression”—where the age of death remains relatively fixed. It’s been a consistent phenomenon for folks born up until the 1900s. But according to the study, “mortality postponement”—where the maximum age at death is on the rise—seems to be more common in those born between 1910 and 1950. This means the oldest people born in that timeframe have a solid chance at stretching their years beyond 120.

“As these cohorts attain advanced ages in coming decades, longevity records may increase significantly,” McCarthy says in the news release. “Our results confirm prior work suggesting that if there is a maximum limit to the human lifespan, we are not yet approaching it.”

Smoothing the speed bumps in an important cellular pathway seems to be implicated in ageing.

Taken in pill form, the drug would eliminate cells in the human body that are responsible for advancing the ageing process – potentially doubling our lifespan. But is this desirable?