Lifeboat Foundation

The potential for personalized cancer treatment is fueling the need to identify T cell responses against neoantigens and other cancer-specific epitopes for the success of immunotherapy. Continuous advancements of epitope discovery prediction technology is leading to precise identification of antigen-specific T cells, playing a central role in monitoring immune responses to infection and cancer immunotherapies. Hence, the understanding of major histocompatibility complex class (MHC) molecules and peptides interaction within the immune system is fundamental for developing treatments in diseases like cancer and the creation of innovative vaccines.

Fundamentally, in vivo interaction between processed antigen loaded on MHC molecules is important communication for the adaptive immune response to alert against foreign antigens or cancerous cells. MHC I and II molecules loaded with foreign antigens or cancerous fragments are of great interest to the activation of the adaptive immune response. In vivo, peptide exchange reactions are not required for presentation of antigens by MHC molecules because they bind degraded antigens during assembly in the ER. However, peptide exchange reactions play an important role in the assembly of MHC molecules in vitro. It becomes essential to consider the allelic variation and peptide binding when utilizing MHC molecules for T cell detection ex vivo. It has been shown that immunogenic peptides tend to interact with their restricting MHC molecule. Thus, having the capability to assess the binding affinity of an in vitro interaction between peptide and MHC I is highly valued.

Scientists at the University of Florida have pioneered a method for using semiconductor technology to manufacture processors that significantly enhance the efficiency of transmitting vast amounts of data across the globe. The innovation, featured on the current cover of the journal Nature Electronics, is poised to transform the landscape of wireless communication at a time when advances in AI are dramatically increasing demand.

Traditionally, wireless communication has relied on planar processors, which, while effective, are limited by their two-dimensional structure to operate within a limited portion of electromagnetic spectrum. The UF-designed approach leverages the power of semiconductor technology to propel wireless communication into a new dimension—quite literally.

Researchers have successfully transitioned from planar to three-dimensional processors, ushering in a new era of compactness and efficiency in data transmission.

Join us for an extraordinary livestream webinar, ‘Paving the Way for the Future: Learning from 4 Biostasis Cases and the Challenges and Advancements at Tomorrow Bio’ featuring esteemed speakers Dr. Emil Kendziorra and Dr. Irishikesh Santhosh from Tomorrow Biostasis GmbH. This pivotal session, scheduled for March 18th, 2024, at 7:00 PM, will delve into the latest advancements and real-world applications of biostasis, focusing on the detailed processes and outcomes associated with four distinct patient cases from 2023.

In this webinar, we will explore the intricate procedures and challenges encountered during the biostasis process, including stabilization in the face of cardiopulmonary arrest, the nuances of surgical and perfusion procedures, and the critical cooldown process for long-term storage. Our experts will unpack the innovative techniques employed, the utilization of cryoprotectant solutions, cooling techniques, and the diligent monitoring through CT scans, alongside the resolution of unforeseen technical challenges.

Continue reading “Biostasis Progress: Unveiling 4 Patient Cases from Tomorrow Bio” »

3D processors for wireless communications? Now great and discovered by DARPA!

A breakthrough in the creation of 3D processors using semiconductor technology could reshape the future of wireless communication.

Scientists have grown small but complex models of human organs from live fetus cells for the first time, giving experts new insight into our development and potential treatments for malformations while in the womb.

These organoids aren’t full replicas of organs, but they’re close enough to the real deal that they can be used to study disease and other aspects of human biology that are difficult to investigate in living people.

In a new study carried out by an international team of researchers, lung, kidney, and intestine organoids were grown from living stem cells in amniotic fluid. This fluid helps to protect the growing baby and feed it with nutrients, and is taken from the mother without harming her baby as part of regular pregnancy tests.

Gartner predicts, too, that by 2027 15% of EV companies founded since the last decade will be acquired or bankrupt. “This does not mean the EV sector is crumbling,” said Pedro Pacheco, vice president of research at Gartner. “It is simply entering a new phase where companies with the best products and services will win over the remaining.” Of course, at least 18 EV and battery startups that went public in recent years and attracted huge investments are now struggling for cash, with plenty going belly up, including Lordstown Motors and Proterra.

Still, new innovations will push BEV price down, Gartner states. “New OEM incumbents want to heavily redefine the status quo in automotive,” he added. “They brought new innovations that simplify production costs such as centralized vehicle architecture or the introduction of gigacastings that help reduce manufacturing cost and assembly time, which legacy automakers had no choice to adopt to survive.”

By 2027, next-gen BEVs will be cheaper to make than comparable ICE vehicles, with production costs dropping faster than battery costs. But there’s a rub: Repair costs will be more expensive, Gartner says. By 2027, it predicts that the average cost of an EV body and battery “serious accident repair” will increase by 30%.

AI isn’t nearly as popular with the global populace as its boosters would have you believe.

As Axios reports based on a new poll of 32,000 global respondents from the consultancy firm Edelman, public trust is already eroding less than 18 months into the so-called “AI revolution” that popped off with OpenAI’s release of ChatGPT in November 2022.

“Trust is the currency of the AI era, yet, as it stands, our innovation account is dangerously overdrawn,” Justin Westcott, the global technology chair for the firm, told Axios. “Companies must move beyond the mere mechanics of AI to address its true cost and value — the ‘why’ and ‘for whom.’”

We may be on the cusp of an era of astonishing innovation — the limits of which aren’t even clear yet.

The increasing demand for ever-faster information processing has ushered in a new era of research focused on high-speed electronics operating at frequencies nearing terahertz and petahertz regimes. While existing electronic devices predominantly function in the gigahertz range, the forefront of electronics is pushing towards millimeter waves, and the first prototypes of high-speed transistors, hybrid photonic platforms, and terahertz metadevices are starting to bridge the electronic and optical domains.

However, characterizing and diagnosing such devices pose a significant challenge due to the limitations of available diagnostic tools, particularly in terms of speed and spatial resolution. How shall one measure a breakthrough device if it’s the fastest and smallest of its kind?

In response to this challenge, a team of researchers from the University of Konstanz now proposes an innovative solution: They create femtosecond electron pulses in a transmission electron microscope, compress them with infrared laser light to merely 80 femtosecond duration, and synchronize them to the inner fields of a laser-triggered electronic transmission line with the help of a photoconductive switch. Then, using a pump-probe approach, the researchers directly sense the local electromagnetic fields in their electronic devices as a function of space and time.