How stepping outside with your pan turns meal prep into a health upgrade
Category: health – Page 14
New digital cognitive test for diagnosing Alzheimer’s disease
“The unique aspect of our BioCog test is that unlike other digital tests, it has been evaluated in a primary care population, i.e. patients seeking treatment at a health centre because they are experiencing cognitive problems, such as memory problems. Combining the results of the digital test and the blood test increases the accuracy of diagnosing Alzheimer’s disease. The purpose of the test is to make things easier for primary care doctors,” says one of the authors.
The digital test is done by the patient individually on a tablet computer. The test measures:
Alzheimer’s disease is the most common cause of dementia. As new disease-modifying treatments for Alzheimer’s disease are now becoming available, both early and accurate diagnosis in a resource-efficient assessment process are becoming increasingly important, as not everyone responds to the new drugs. Seeking medical care for cognitive impairment is not necessarily the result of Alzheimer’s disease – it can for example be caused by depression, fatigue or other dementias.
“Primary care does not have the resources, time or specialist knowledge to investigate possible Alzheimer’s disease in the same way as specialised memory clinics. And this is where a digital cognitive test can make the biggest difference,” says the senior author.
Unlike pen-and-paper tests, which are generally used to assess cognitive impairment, digital tests provide a more detailed picture. More aspects and new variables that could not previously be measured as easily are included.
Galaxies Reveal Hidden Maps of Dark Matter in the Early Universe
Researchers uncover a key protein and a promising strategy to prevent bone damage from steroids.
The rheumatology and orthopedic researchers discovered that a protein called Basigin, which gets activated in stem cells when people take steroids, is a key reason why bones weaken and blood vessels in bone tissue become abnormal. By blocking Basigin, they were able to protect and even restore bone health in mice, suggesting a promising new treatment path.
Their findings were published in Nature Communications.
This Popular Diet Seems to Reduce Gum Disease, Scientists Say
There’s something rather special about the Mediterranean diet: already associated with a lower risk of Alzheimer’s disease, early death, poor mental health, and more besides, a new study links the diet to better gum health too.
The study, carried out by researchers from King’s College London and the University of Catania in Italy, involved 195 participants with an average age of 49, who were given a health check-up and quizzed on their dietary habits.
Those participants who stuck more closely to the plant-rich Mediterranean diet were less likely to have gum disease, the data showed – especially those who didn’t eat much red meat.
Childhood stress strongly linked to chronic disease in adulthood, researchers report
Research published by Duke University researchers has found a strong link between higher stress in children and adverse health conditions for them later in life. Appearing in the journal Proceedings of the National Academy of Sciences, the study used measurable metrics of health over time to create a more quantitative view of how stress early in life affects health.
“We’ve had an idea for a long time, since the ’80s at least, that when children have adversity in their lives, it affects how their bodies work, not just psychologically, but also physiologically. It gets underneath the skin, and it becomes embodied in the way your body handles stress,” said co-author Herman Pontzer, Duke professor of evolutionary anthropology and global health.
Researchers focused on allostatic load (AL), which refers to the wear and tear on the body because of chronic stress. The researchers “tested associations between childhood AL and adult cardiometabolic health,” relying on biomarkers that included antibodies of C-reactive protein, which is a marker of inflammation in the body; and the Epstein-Barr virus, which is common and highly contagious; body mass index; and blood pressure.
Rising Cognitive Disability as a Public Health Concern Among US Adults
From 2013 to 2023, rates of cognitive disability nearly doubled among U.S. adults under 40.
Cognitive disability includes self-reported serious difficulty concentrating, remembering, or making decisions.
Rates are highest among people with chronic diseases or lower household incomes.
Background and Objectives.
Unlocking the immune system’s instruction manual: How T follicular helper cells mount a flexible response
Scientists have uncovered how a key type of immune cell adapts its behavior depending on the type of infection, paving the way for better vaccines and advancing research into immune-related diseases.
In their study published in Nature Immunology, a WEHI-led research team has revealed how T follicular helper (Tfh) cells tailor their instructions to the immune system depending on the pathogen they encounter.
The findings shed light on the molecular “instruction manual” that guides antibody production and long-term immunity, offering new tools to improve vaccine design and develop targeted therapies for immune-related conditions and other major health challenges, including cancer.
Home high-intensity aerobic training outperforms balance training for cerebellar ataxias
Columbia University Medical Center-led research reports that home high-intensity aerobic training improved ataxia symptoms, fatigue, and aerobic fitness more than dose-matched home balance training in individuals with cerebellar ataxias.
Cerebellar ataxias are a group of different disorders marked by progressive loss of coordination that leads to disability. About 150,000 people in the US live with these conditions, with mean annual health care costs above $18,000 per person. Ongoing trials are searching for treatments that slow disease progression and improve functional abilities. Clinical practice guidelines advise balance training for cerebellar ataxia.
Previous work in ataxia has centered on balance-focused programs that can improve Scale for the Assessment and Rating of Ataxia (SARA) scores by 1.0 to 2.8 points when exercises are sufficiently challenging, a range that meets or exceeds the minimal clinically significant difference of 1.0 point.
Novel gene therapy for hereditary hearing loss developed at Tel Aviv University
Scientists from the Gray Faculty of Medical & Health Sciences at Tel Aviv University introduced an innovative gene therapy method to treat impairments in hearing and balance caused by inner ear dysfunction. According to the researchers, “This treatment constitutes an improvement over existing strategies, demonstrating enhanced efficiency and holds promise for treating a wide range of mutations that cause hearing loss.”
The study was led by Prof. Karen Avraham, Dean of the Gray Faculty of Medical & Health Sciences, and Roni Hahn, a PhD student from the Department of Human Molecular Genetics and Biochemistry. The study was conducted in collaboration with Prof. Jeffrey Holt and Dr. Gwenaëlle Géléoc from Boston Children’s Hospital and Harvard Medical School and was supported by the US-Israel Binational Science Foundation (BSF), the National Institutes of Health/NIDCD and the Israel Science Foundation Breakthrough Research Program. The study was featured on the cover of the journal EMBO Molecular Medicine.
Prof. Avraham explains: “The inner ear consists of two highly coordinated systems: the auditory system, which detects, processes, and transmits sound signals to the brain, and the vestibular system, which enables spatial orientation and balance. A wide range of genetic variants in DNA can affect the function of these systems, leading to sensorineural hearing loss and balance problems. Indeed, hearing loss is the most common sensory impairment worldwide, with over half of congenital cases caused by genetic factors. In this study, we aimed to investigate an effective gene therapy for these cases using an approach that has not been applied in this context before.”
Drinking any amount of alcohol likely increases dementia risk
Drinking any amount of alcohol likely increases the risk of dementia, suggests the largest combined observational and genetic study to date, published in BMJ Evidence-Based Medicine.
Even light drinking—generally thought to be protective, based on observational studies—is unlikely to lower the risk, which rises in tandem with the quantity of alcohol consumed, the research indicates.
Current thinking suggests that there might be an “optimal dose” of alcohol for brain health, but most of these studies have focused on older people and/or didn’t differentiate between former and lifelong non-drinkers, complicating efforts to infer causality, note the researchers.