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DeepMind has released a catalog of 71 million possible variants that can cause diseases.

Genetic mutations are changes to our DNA sequence. This happens when cells make copies of themselves during cell division. Mutation is the ultimate source of human genetic variation and has evolutionary and disease genetics implications. A mutation affecting our genes might give birth to a genetic disorder. But just because you have a mutation doesn’t mean it will be a genetic disorder.

That is why researchers at DeepMind, the artificial intelligence arm of Google, have announced that they have trained a machine learning model called AlphaMissense to classify which DNA variations in our genomes are likely to cause disease.

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There is powerful science behind how our beliefs inform our genetic expression. It’s not our genes alone that dictate our health outcomes, rather it’s the biology of belief that determines our destiny.

Continue reading “How Our GENES Listen To Our Beliefs: Heal The Body & Prevent Disease | Dr. Bruce Lipton” »

Fresh from solving the protein structure challenge, Google’s deep-learning outfit is moving on to the human genome.

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Scientists established an epigenetic mouse model for glioma, providing insight into how epigenetics can initiate cancer.

Studying genes in families with a propensity for certain diseases has led to many critical advances in medicine, including the discovery of statins in family members who suffered heart attacks at an early age.

Now, a team of researchers at Case Western Reserve University has identified an inherited mutation in a gene linked to a highly lethal cancer called esophageal adenocarcinoma (EAC).

“With this discovery, we will be able to identify early those at a high risk of developing EAC in their lifetime, and accordingly tailor screening, lifestyle and treatment strategies to prevent cancer development,” said Kishore Guda, an associate professor at the Case Western Reserve School of Medicine and member of the Case Comprehensive Cancer Center.

New research indicates that butterflies and moths share “blocks” of DNA

DNA, or deoxyribonucleic acid, is a molecule composed of two long strands of nucleotides that coil around each other to form a double helix. It is the hereditary material in humans and almost all other organisms that carries genetic instructions for development, functioning, growth, and reproduction. Nearly every cell in a person’s body has the same DNA. Most DNA is located in the cell nucleus (where it is called nuclear DNA), but a small amount of DNA can also be found in the mitochondria (where it is called mitochondrial DNA or mtDNA).

New research provides insight about the bedrock scientific principle that mitochondrial DNA -; the distinct genetic code embedded in the organelle that serves as the powerplant of every cell in the body -; is exclusively passed down by the mother.

The study, a collaboration among Oregon Health & Science University and other institutions, published today in the journal Nature Genetics.

Scientists have long recognized the fact that mitochondrial DNA, or mtDNA, comes exclusively from egg cells in humans, meaning only the mother contributes the genetic code carried by thousands of mitochondria necessary for energy production in every cell in the body.

CRISPR-based genome editing has the potential to treat many human genetic diseases, but achieving stable, efficient and safe in vivo delivery remains a challenge. This Review assesses current delivery systems for genome editors—focusing on adeno-associated viruses and lipid nanoparticles—and highlights data from recent clinical trials. Emerging delivery systems and ongoing challenges in the field are discussed.