A study in mice and nematodes has investigated a potential new therapeutic approach that could help people with the genetic variant that predisposes them to Alzheimer’s disease.
Japanese startup PorMedTec says it’s have cloned three piglets with the express purpose of having their organs be viable for transplantation to humans, without being rejected by the immune system.
The company imported gene-edited cells from a US biotech startup called eGenesis and used them to create genetically modified embryos, the Japan Times reports, which were then implanted into the uterus of a pig.
“The realization of xenotransplantation has been long awaited in Japan for several years, but it remained in the basic research stage because pigs that could withstand clinical application were still under development,” the company said in a statement.
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Plant leaves come in many different shapes, sizes and complexities. Some leaves are large and smooth, while others are smaller and serrated. Some leaves grow in single pieces while others form multiple leaflets. These variations in leaf structure play a crucial role in how plants adapt—and survive—in different environments.
“Plant morphology is diverse in nature,” said Zhongchi Liu, a professor emerita in the University of Maryland’s Department of Cell Biology and Molecular Genetics. “Morphological differences contribute to plant survival, including how well plants can regulate their temperatures and how efficiently they can transport water from their roots to the rest of their bodies.
Understanding the mechanisms responsible for diverse leaf forms will lead to a better understanding of how plants can survive challenging conditions.
Two RNA-editing therapies for genetic diseases have recently gained approval for clinical trials, raising hopes for safer treatments.
Near-gapless and haplotype-resolved genome assemblies of the dwarfing ‘M9’ and semi-vigorous ‘MM106’ rootstocks and a major apple cultivar ‘Fuji’ provide insights into the genetic basis of rootstock-induced dwarfing traits.
To construct a pan-genome that encompasses the full range of genetic diversity in B. ole racea, we analyzed the resequencing data of 704 globally distributed B. ole racea accessions covering all different morphotypes and their wild relatives (Supplementary Tables 1 and 2). We identified 3,792,290 SNPs and 528,850 InDels in these accessions using cabbage JZS as reference genome22. A phylogenetic tree was then constructed using SNPs, which classified the 704 accessions into the following three main groups: wild B. ole racea and kales, arrested inflorescence lineage (AIL) and leafy head lineage (LHL; Fig. 1a and Supplementary Note 2). The phylogenetic relationship revealed in our study was generally consistent with those reported previously4,5,24,25. Based on the phylogeny and morphotype diversity, we selected 22 representative accessions for de novo genome assembly (Table 1).
We assembled genome sequences of the 22 accessions by integrating long-reads (PacBio or Nanopore sequencing), optical mapping molecules (BioNano) or high-throughput chromosome conformation capture data (Hi-C) and Illumina short-reads (Methods; Supplementary Note 2 and Supplementary Tables 3–7). The total genome size of these assemblies ranged from 539.87 to 584.16 Mb with an average contig N50 of 19.18 Mb (Table 1). An average of 98% contig sequences were anchored to the nine pseudochromosomes of B. ole racea. The completeness of these genome assemblies was assessed using benchmarking universal single-copy orthologs (BUSCO), with an average of 98.70% complete score in these genomes (Supplementary Table 8).
To minimize artifacts that could arise from different gene prediction approaches, we predicted gene models of both the 22 newly assembled genomes and the five reported high-quality genomes5,21,22,23 using the same annotation pipeline (Methods). Using an integrated strategy combining ab initio, homology-based and transcriptome-assisted prediction, we obtained a range of 50,346 to 55,003 protein-coding genes with a mean BUSCO value of 97.9% in these genomes (Table 1). After gene prediction, a phylogenetic tree constructed based on single-copy orthologous genes clustered the 27 genomes into three groups, similar to the results observed in the population (Fig. 1a and b).
The cultivation of triploid genetics could be the game changer for the cannabis industry, as it promises to deliver higher THC levels, larger yields, faster growth, and seedless flowers.
The application of triploids is not a new concept in agriculture. Consuming seedless fruit generally enhances the eating experience for most people.
Consider bananas, for instance. Bananas lack seeds because the parent banana tree is triploid, even though pollination normally occurs.
Diagnosing schizophrenia as early as possible helps minimize the toll the neurological disorder takes on the body and the mind. Unfortunately the condition’s signs can be difficult to spot in the early stages.
That’s why researchers led by a team from the Indiana University School of Medicine have developed a test which offers a relatively simple and reliable way to check for current schizophrenia severity and future risk.
“Psychosis usually manifests in young adulthood – a prime period of life,” says neuroscientist Alexander Niculescu from the Indiana University School of Medicine. “Stress and drugs, including marijuana, are precipitating factors on a background of genetic vulnerability.”
Transposable elements are mobile genetic elements that can relocate within the genome and disrupt the normal function of genes, but are at the same time a source of evolutionary diversity. The lab of Tugce Aktas at the Max Planck Institute for Molecular Genetics has identified a novel pathway that keeps the activity of transposons in somatic cells in check after they have been transcribed.
Their findings have now been published in Nature. The work is a collaboration with the labs of Zachary D. Smith at the Yale Stem Cell Center, U.S., and Franz-Josef Müller from the Universitätsklinikum Schleswig-Holstein, Germany.
Over the course of evolution, the genomes of many organisms have become cluttered with ancient genetic remnants from evolution or parts of retroviruses that inserted their genetic code millions of years ago. Nearly half of the human genome consists of these transposable elements, or transposons.
