Lifeboat Foundation

Derrick Broze, Guest Waking Times

New scientific research is causing scientists to rethink what they believe about the static nature of genes. What do these discoveries mean for a species increasingly facing environmental and political calamity?

Ongoing discoveries regarding how environmental factors can affect life on the genetic level are causing many scientists and researchers to rethink the notion that the genetic makeup of an individual is static and unchanging. Most recently, a team of researchers with Tufts University has found evidence which suggests stress or mistreatment during childhood can lead to genetic changes which are passed down to the victim’s children and grandchildren. Larry Feig and his team have shown that inducing stress on mice can lead to genetic changes which are imprinted on the sperm. This same effect has been found in male humans as well.

Continue reading “What Does Epigenetics Mean for Humanity’s Awakening?” »

Canadian researchers have discovered a new and direct molecular mechanism to stop cancer cells from proliferating. In the prestigious journal Nature Cell Biology, scientists from Université de Montréal show that a disruption of a fine balance in the composition of ribosomes (huge molecules that translate the genetic code into proteins) results in a shutdown of cancer cell proliferation, triggering a process called senescence.

“Ribosomes are complex machines composed of both RNAs and proteins that make all the proteins necessary for cells to grow,” said UdeM biochemistry professor Gerardo Ferbeyre, the study’s senior author. Cancer cells grow and proliferate relentlessly and thus require a massive amount of ribosomes, he explained. Growing cells must coordinate the production of both ribosomal RNAs and ribosomal proteins in order to assemble them together in strict proportion to each other.

“We were surprised, however, to find that if the production of ribosomal RNA–protein proportions are driven out of balance in a cancer cell, proliferation can be shut down by in a very simple and direct manner,” said Ferbeyre.

Continue reading “Scientists discover a new mechanism that prevents the proliferation of cancer cells” »

https://wisechase.tv/the-bugs-that-reverse-damage/

https://www.youtube.com/watch?v=Nufc8vTsbBY

Life extension genetics.

Many factors contribute to exceptional longevity, with genetics playing a significant role. However, to date, genetic studies examining exceptional longevity have been inconclusive. This comprehensive review seeks to determine the genetic variants associated with exceptional longevity by undertaking meta-analyses.

Meta-analyses of genetic polymorphisms previously associated with exceptional longevity (85+) were undertaken. For each variant, meta-analyses were performed if there were data from at least three independent studies available, including two unpublished additional cohorts.

Continue reading “Review and meta-analysis of genetic polymorphisms associated with exceptional human longevity” »

“I believe gene therapy will become a mainstay in treating, and maybe curing, many of our most devastating and intractable illnesses,” said FDA commissioner Dr Scott Gottlieb after Luxturna’s approval.

As innovative gene and cell therapies continue to make the transition from the laboratory to the clinic, they are bringing with them the promise of truly personalised medicine. The last few years have seen the regulatory approval of the first gene therapies that take a patient’s own immune cells and genetically engineer them to target cancer cells more effectively.

These chimeric antigen receptor T-cell (CAR-T) therapies now represent a rapidly growing field, with Novartis’s Kymriah, the first CAR-T therapy approved by the US Food and Drug Administration (FDA) in August 2017 for the treatment of a rare blood cancer, seen as the tip of the iceberg for this treatment class’ potential. Approval of Kite Pharma’s Yescarta, a CAR-T treatment for certain forms of non-Hodgkin lymphoma, followed just a few months later.

Continue reading “Can the gene and cell therapy revolution scale up?” »

Monsanto’s agricultural biotechnology research and development operations that are going to Bayer are the largest in the world and include making genetically modified seeds for such crops as corn, soybeans and cotton. Corn represented almost 60 percent of Monsanto’s total seed and genomics business last year.

German conglomerate Bayer on Thursday closed its $63 billion merger with St. Louis-based agribusiness giant Monsanto and plans to drop the U.S. company’s name.

A being that can consciously alter its own DNA via technological intervention (i.e. cybernetic means) is what our Second Womb has been nurturing. We have used civilization to protect ourselves while we crack the code of our biological being. We started in the womb of the cave. Then moved on to the womb of the hut. Then the village, the city, and the state. All thew hile, we have been tinkering with our own DNA and the DNA of other species. To me, this is the real posthuman or transhuman — it is the creature that is actively editing its own biological blueprint through tech. This is what we’ve been doing since we started augmenting our bodies with clothing and animal skins. We’ve been modifying our ability to endure the slings and arrows of the cosmos.

What is human civilization? It is difficult to assert that other animals do not create their own civilizations — termites for instance meet some criteria for being categorized as cyborgs (building temperature-controlled mega structures). Animals communicate, express feelings, and have personalities. Octopi arrange furniture for would-be mates. Others engage in mating rituals. Some mourn the dead. Birds can solve simple math. Critters scheme, enterprise, forge bonds, and even produce art. What do we do that animals do not?

To our credit, we are the only animals that record, share, and develop history upon structures and materials outside of our bodies. We harness energy for massive projects. We farm, but again, so do leaf-cutter ants. But we create genetically novel vegetables and animals. We alter the global climate. Our enterprises are global, and given time and opportunity, our projects will eventually become exostellar. We do all this rather ferociously. Human history is a rather short explosion of civilization-building activities, and yet it might already have irrevocably altered the future of all life on this planet. No other creature has created a circumstance quite like that of human beings and our anthropocene project. For instance, unless we clean up the environment, the next few generations of plant and animal life are going to have be extremely resilient to radiation, Styrofoam, plastics, and other run-offs squeezed out from the human project. That is just a fact of life now on earth.

Continue reading “Human Civilization is our Second Womb for Birthing Transhumans” »

Maryam shanechi, university of southern california.

With recent technological advances, we can now record neural activity from the brain, and manipulate this activity with electrical or optogenetic stimulation in real time. These capabilities have brought the concept of brain-machine interfaces (BMI) closer to clinical viability than ever before. BMIs are systems that monitor and interact with the brain to restore lost function, treat neurological disorders, or enhance human performance.

Continue reading “The State of Brain-Machine Interfaces” »