Lifeboat Foundation

Everyone has BRCA1 and BRCA2 genes, but mutations in these genes—which can be inherited—increase the risk of breast and ovarian cancer.

The study found that the immune cells in breast tissue of healthy women carrying BRCA1 or BRCA2 gene mutations show signs of malfunction known as exhaustion. This suggests that the immune cells can’t clear out damaged breast cells, which can eventually develop into breast cancer.

This is the first time that exhausted immune cells have been reported in non-cancerous breast tissues at such scale—normally these cells are only found in late-stage tumors. The results raise the possibility of using existing immunotherapy drugs as early intervention to prevent breast cancer developing, in carriers of BRCA1 and BRCA2 gene mutations.

Biotech startup eGenesis developed a gene-edited kidney that was successfully transplanted into a living patient last week. Its CEO says the company is just getting started.

The gene-editing technique CRISPR disabled HIV that lay dormant in immune cells in a lab experiment, raising hopes for an eventual cure.

By Clare Wilson

Groundbreaking research has led to the creation of threofuranosyl nucleic acid (TNA), offering enhanced stability and therapeutic potential, with applications in drug delivery and diagnostics.

The DNA carries the genetic information of all living organisms and consists of only four different building blocks, the nucleotides. Nucleotides are composed of three distinctive parts: a sugar molecule, a phosphate group, and one of the four nucleobases adenine, thymine, guanine, and cytosine. The nucleotides are lined up millions of times and form the DNA double helix, similar to a spiral staircase.

Breakthrough in Nucleic Acid Research.

Natural killer (NK) cells target infected and oncogenic cells, but are difficult to work with in vitro. Discover novel approaches to producing genetically modified NK cells for cell therapy.

Researchers at Trinity College Dublin have recovered remarkably preserved microbiomes from two teeth dating back 4,000 years, found in an Irish limestone cave. Genetic analyses of these microbiomes reveal major changes in the oral microenvironment from the Bronze Age to today. The teeth both belonged to the same male individual and also provided a snapshot of his oral health.

A new study has revealed that the size of human brains is getting larger, which means increased brain reserve and decreased chances of developing dementia. The researchers at UC Davis Health reached the conclusion by comparing the size of the brains of people born in the 1930s with those of people born in the 1970s. They noticed that the latter had 6.6 per cent larger brains. The study was published in JAMA Neurology.

“The decade someone is born appears to impact brain size and potentially long-term brain health,” said Charles DeCarli, first author of the study.

He further adds that genetics may also play a major role in determining the size of the brain. “Genetics plays a major role in determining brain size, but our findings indicate external influences — such as health, social, cultural and educational factors — may also play a role,” he said.

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In a recent study published in the journal Nature Aging, researchers assessed the added predictive value of integrating polygenic risk scores (PRSs) and gut microbiome scores with conventional risk factors for common diseases in a long-term cohort study.

Analysis: Integration of polygenic and gut metagenomic risk prediction for common diseases. Image Credit: remotevfx.com / Shutterstock.

Continue reading “Multiomic approach boosts disease prediction accuracy beyond traditional methods” »

To what extent are exceptional human achievements influenced by genetic factors? This question, dating back to the early days of human genetics, seems to be easier to address today as modern molecular methods make it possible to analyze DNA of individuals throughout history. But how reliable are the answers in this day and age?