Lifeboat Foundation

Populations of indigenous people in southern Africa carry a gene that causes lighter skin, and scientists have now identified the rapid evolution of this gene in recent human history.

The gene that causes lighter skin pigmentation, SLC24A5, was introduced from eastern African to southern African populations just 2,000 years ago. Strong positive selection caused this gene to rise in frequency among some KhoeSan populations.

UC Davis anthropologist Brenna Henn and colleagues have shown that a gene for lighter skin spread rapidly among people in southern Africa in the last 2,000 years.

Continue reading “Rapid genetic evolution linked to lighter skin pigmentation in a southern African population” »

D esigner therapies are treatments tailored to a specific disease, and nowhere is the need greater for new therapies than in a group of nervous system disorders, known as “neurodegenerative diseases.”

Many of these diseases are common and well-known, such as Alzheimer’s or Parkinson’s disease. However, some are very rare, genetic disorders that are the consequence of a defective gene. In all these diseases, a mutant protein that misfolds causes the degeneration and death of neurons. One effective therapeutic strategy is to prevent the rogue protein from ever being made.

Spinocerebellar ataxia type 7 (SCA7) is one such disease in which nerves in different parts of the brain, including the eye, degenerate, which leads to blindness and difficulty walking, speaking, and balancing. SCA7 is dominantly inherited — which means that you just need one bad copy of the mutation to cause disease. The disease occurs when a short section of DNA that encodes ataxin-7 gene is erroneously repeated — like a word in a book printed two or three times. In this case, three chemical units of the DNA sequence — C-A-G — are repeated over and over.

Continue reading “Scientists May Have Halted Blindness Caused by This Rare Genetic Disease” »

Continue reading “Regenerage — SMX Radio — The Net of Regenerative Medicine — Bioquark” »

And, so far, they’re just fine. America needs a sober debate about the pros and cons of Crispr instead of a paranoid ban on the technology.

Imagine one drug that can target and kill malignant cells for some patients with many types of cancer. A new drug called Vitrakvi (larotrectinib), now approved by the U.S. Food and Drug Administration, shows promise of doing just that for both adults and children with a variety of sometimes rare cancers that share one specific genetic mutation.

The mutation, called a TRK fusion, occurs when one of three NTRK genes becomes mistakenly connected to an unrelated gene and ignites uncontrolled growth. By solely targeting this mutation, the drug is designed to turn off growth signaling with a minimum of other toxicities.

According to the drug manufacturer, Loxo Oncology, this specific mutation can occur in a small subset of various adult and pediatric solid tumors ranging from cancers of the appendix, bile ducts, breast, lung, pancreas and thyroid to melanoma, GIST and various sarcomas.

Continue reading “FDA Approves Drug That Targets Key Genetic Driver of Cancer” »

Neoliberalism slows down evolution! Just kidding…or am I? 🧐😁🤣🙈.

Like other organisms, bacteria constantly have to fight to survive in hostile living conditions. Together with colleagues in Finland, researchers at the Max Planck Institute for Evolutionary Biology in Plön have discovered that bacteria adapt to their environment more slowly and less efficiently as soon as they are exposed to two stress factors rather than one. This is due to mutations in different genes. The slower rate of evolution led to smaller population sizes. This means that evolution can take divergent paths if an organism is exposed to several stress factors.

Bacteria rarely live alone; they are usually part of a community of species that is exposed to various stress factors. They can often react to these factors by adapting to new environmental conditions with astonishing speed. Antibiotics that enter soil and water via waste water and accumulate there in low concentrations can trigger the evolution of resistance in bacteria – even though these concentrations are so low that they inhibit bacterial growth only slightly or not at all. However, bacteria do not only have to fight antibiotics; they also have to deal with predators. This is why they often grow in large colonies that cannot be consumed by predatory organisms.

Continue reading “Double the stress slows down evolution” »

Continue reading “Bioquark — Electroceuticals — Real Bodies” »

https://paper.li/e-1437691924#/&h=AT3mdHzXuCejMgVQDYy6JiVw58…e-BeRlnE2g

“Our world is changing so fast… this year we have sessions on artificial intelligence, genetics and what the future holds for our planet. There is a new term now — cli-fi. We have a beautiful session on cli-fi, on what would happen if bees disappear.

”I feel at this moment in our country it is very very important to give impetus to empirical thinking,” the author of ”Paro: Dreams of Passion” said.

Continue reading “12th Jaipur Literature Festival: AI, cli-fi, genetics sessions on line-up” »