Lifeboat Foundation

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“Our world is changing so fast… this year we have sessions on artificial intelligence, genetics and what the future holds for our planet. There is a new term now — cli-fi. We have a beautiful session on cli-fi, on what would happen if bees disappear.

”I feel at this moment in our country it is very very important to give impetus to empirical thinking,” the author of ”Paro: Dreams of Passion” said.

Continue reading “12th Jaipur Literature Festival: AI, cli-fi, genetics sessions on line-up” »

A team of doctors in Brazil have announced a medical first that could someday help countless women unable to have children because of a damaged or absent uterus. In a case report published Tuesday in the Lancet, they claim to have successfully helped a woman give birth using a transplanted uterus from a deceased donor.

According to the report, the team performed the operation on an unnamed 32-year-old woman in a Brazilian hospital in September 2016. The woman had been born with a rare genetic condition that left her without a uterus, known as Mayer-Rokitansky-Küster-Hauser syndrome, but she was otherwise healthy. The donor was a 45-year-old woman who had suddenly died of stroke; she had had three successful pregnancies delivered vaginally in the past.

• The FDA on Monday approved a new cancer treatment in an unconventional way: not by tumor type, but rather by the genetic mutation the drug targets.
• The drug, Vitrakvi, was developed by Loxo Oncology in partnership with pharma giant Bayer.
• It’s only the second time the FDA has approved a cancer drug’s use based on a certain mutation rather than a particular tumor type.

The Food and Drug Administration on Monday took an unconventional approach to approving a new cancer drug.

The drug, Vitrakvi, was developed by Loxo Oncology. It’s the company’s first drug to get approved.

A blood test can detect cancer within just 10 minutes, scientists have found, raising hopes that hard-to-spot diseases could be picked up early when treatment is most effective.

Currently doctors use symptoms and a raft of tests and biopsies to determine if cancer is present which can sometimes take months.

The new method from the University of Queensland looks for differences in the genetic code of cancerous and healthy cells.

Continue reading “Blood test to detect cancer within just 10 minutes developed by scientists” »

Analyst Salveen Richter and colleagues laid it out:

The potential to deliver “one shot cures” is one of the most attractive aspects of gene therapy, genetically engineered cell therapy, and gene editing. However, such treatments offer a very different outlook with regard to recurring revenue versus chronic therapies… While this proposition carries tremendous value for patients and society, it could represent a challenge for genome medicine developers looking for sustained cash flow.

For a real-world example, they pointed to Gilead Sciences, which markets treatments for hepatitis C that have cure rates exceeding 90 percent. In 2015, the company’s hepatitis C treatment sales peaked at $12.5 billion. But as more people were cured and there were fewer infected individuals to spread the disease, sales began to languish. Goldman Sachs analysts estimate that the treatments will bring in less than $4 billion this year.

Continue reading “‘Is curing patients a sustainable business model?’ Goldman Sachs analysts ask” »

The Pentagon is also looking at living camouflage, self-healing paint, and a variety of other applications of engineered organisms, but the basic science remains a challenge.

How do you detect submarines in an expanse as large as the ocean? The U.S. military hopes that common marine microorganisms might be genetically engineered into living tripwires to signal the passage of enemy subs, underwater vessels, or even divers.

It’s one of many potential military applications for so-called engineered organisms, a field that promises living camouflage that reacts to its surroundings to better avoid detection, new drugs and medicines to help deployed forces survive in harsh conditions, and more. But the research is in its very early stages, military officials said.

Continue reading “The US Military Is Genetically Engineering New Life Forms To Detect Enemy Subs” »

Last week Chinese researchers rocked the world with reports that twin babies whose genes the scientists’ edited prior to birth had been born, the product of secret experiments that are being widely decried as unethical. Even as that story plays out, it is true that CRISPR gene editing is already being used in humans, in ways that illustrate just how unethical this recent use was.

“Patients’ parents have been emailing me a lot,” says Hye Young Lee, a researcher at the University of Texas San Antonio whose work looks at alternative delivery methods for CRISPR. Lee says she normally gets a few emails a month from the parents of the patients she works with, but that the number of emails went up recently—in relation, she suspects, to the news of the CRISPR babies, which is creating the illusion that CRISPR and other gene editing techniques are ready for extensive use in humans.

The scientific community’s current consensus is that they’re far from being at that stage—and it’s impossible to know now when or if they will be. But gene editing is being used in adult humans, to early trials to treat genetic diseases. In terms of gene editing for adults, “I know that there are things going on,” Lee says, but it’s nothing like this week’s news. Although her own work is at least a few years away from being ready for human testing, there are some cautiously progressing trials at drug companies using CRISPR in adult humans who have diseases that are the result on mutations in a single gene.

I just love it when the reductionists are wrong…again. I can not help myself. bigsmile

University of Nebraska-Lincoln researchers have found revolutionary evidence that an evolutionary phenomenon at work in complex organisms is at play in their single-celled counterparts, too.

Species most often evolve through DNA mutations inherited by successive generations. A few decades ago, researchers began discovering that multicellular species can also evolve through epigenetics: traits originating from the inheritance of cellular proteins that control access to an organism’s DNA, rather than genetic changes.

Continue reading “Evolution sans mutation discovered in single-celled archaea” »

NANJING — Chinese researchers have developed a new evaluating model using medical imaging to help painlessly evaluate tumor progression in patients.

Doctors usually use the biological characteristics of tumors to observe the progress and response to treatment, such as if there are gene mutations or malignant features. Previous studies have shown that identifying the biological characteristics may contribute to better treatment and may increase survival rates.

Traditional methods to get tumor tissue include surgery and puncture, which are invasive, painful and costly.

Continue reading “Researchers develop painless method to evaluate tumor progression” »