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Archive for the ‘genetics’ category: Page 364

Jun 23, 2019

Japanese sign up for DNA matchmaking as country faces demographic crisis

Posted by in categories: biotech/medical, genetics

The scene resembles a typical blind speed-dating event: 13 women and 13 men, seated on either side of a bamboo screen in an upmarket Tokyo restaurant, are chatting in pairs on a strictly timed three-minute rotation.

But the doctor hovering on the fringes and the scientific documents held in the participant’s hands, however, offer a hint that this is no ordinary dating event: for everyone attending has undergone a DNA test in a bid to find their best romantic match.

Welcome to the world of DNA matchmaking. Forget hobbies, professions, ages or nose sizes: one critical new criteria for finding the perfect partner was recently added to Japan’s fast-paced dating world, with the launch of a new service that promises to find love based on genetic compatibility.

Jun 22, 2019

A Russian Biologist Wants To Create More Gene-Edited Babies

Posted by in categories: biotech/medical, genetics, health

Russian Biologist Seeks To Edit Genes Of Human Embryos With CRISPR : Shots — Health News A Moscow scientist claims he has a safe way of editing genes in human embryos — a method that could protect resulting babies from being infected with HIV. Approval of the experiment seems unlikely.

Jun 22, 2019

Automatic Quantum Computer Programming: A Genetic Programming Approach

Posted by in categories: computing, genetics, quantum physics

Provides an introduction to quantum computing for non-physicists, as well as an introduction to genetic programming for non-computer-scientists. The book explores several ways in which genetic programming can support automatic quantum computer programming and presents detailed descriptions of specific techniques, along with several examples of their human-competitive performance on specific problems. Source code for the author’s QGAME quantum computer simulator is included as an appendix, and pointers to additional online resources furnish the reader with an array of tools for automatic quantum computer programming.

Jun 21, 2019

Gensight Biologics Releases Data, CFO Responds to LEAF Inquiry

Posted by in categories: biotech/medical, genetics, life extension

Gensight Biologics, a company researching – among other things – the movement of mitochondrial genetic information to the nucleus to treat hereditary genetic diseases (a strategy that could also have an impact on aging according to the SENS Research Foundation), has recently released data for its latest trial of GS010, a therapy against the blindness-causing genetic disease LHON.


Note: Patrick Deane holds shares in Gensight Biologics (EPA: SIGHT).

Jun 21, 2019

Neanderthal and unknown human ancestor DNA found in the “dark heart” of chromosomes

Posted by in categories: biotech/medical, genetics

Genes get shuffled and re-dealt with every new generation, meaning many are relatively recent. But while exploring the “dark heart” of the human genome, geneticists have now found some of the most ancient pieces of DNA, inherited from Neanderthals and an as-yet-unknown human relative, which may be affecting our sense of smell to this day.

Jun 19, 2019

How common gut bacteria trigger a lethal autoimmune disease

Posted by in categories: biotech/medical, genetics

What causes the immune system, designed to protect us, to turn on the body and attack healthy cells? Common bacteria that reside in the human gut may be partly to blame, say Yale researchers, who studied the origins of a serious autoimmune disease that frequently affects young women.

For their study, the research team focused on cells from patients with antiphospholipid syndrome, an disorder that raises the risk of blood clots. This chronic condition can lead to lung clots, strokes, heart attacks, and in pregnant women, miscarriages or still births.

Using patient immune cells and antibodies, as well as animal models of the disease, the investigators did several experiments to explore the phenomenon. They found that a , Roseburia intestinalis, can trigger the disease in individuals who have a genetic predisposition. In those patients, the immune system’s defender T and B cells react to a blood protein involved in clotting, and also to the bacteria, in certain found in the bacteria. Over time, this ongoing “cross-reactive” response leads to tissue damage and chronic disease.

Jun 19, 2019

Using CRISPR to resurrect the woolly mammoth

Posted by in categories: biotech/medical, existential risks, genetics

De-extinction, bringing extinct species back from the dead, is now on the table thanks to the revolutionary gene-editing technology CRISPR.

Jun 19, 2019

Michio Kaku: Genetic and digital immortality are within reach

Posted by in categories: genetics, life extension

https://youtu.be/STisIGbJIAI via @michiokaku

Jun 18, 2019

New DNA-Scanning Software Can ID You in Minutes

Posted by in categories: biotech/medical, genetics

But could hackers abscond with your genetic information?

Jun 18, 2019

Sensitive scanning technology for low frequency nuclear point mutations in human genomic DNA

Posted by in categories: biotech/medical, genetics

Knowledge of the kinds and numbers of nuclear point mutations in human tissues is essential to the understanding of the mutation mechanisms underlying genetic diseases. However, nuclear point mutant fractions in normal humans are so low that few methods exist to measure them. We have now developed a means to scan for point mutations in 100 bp nuclear single copy sequences at mutant fractions as low as 10–6.Beginning with about 10 human cells we first enrich for the desired nuclear sequence 10 000-fold from the genomic DNA by sequence-specific hybridization coupled with a biotin–streptavidin capture system. We next enrich for rare mutant sequences 100-fold against the wild-type sequence by wide bore constant denaturant capillary electrophoresis (CDCE). The mutant-enriched sample is subsequently amplified by high fidelity PCR using fluorescein-labeled primers. Amplified mutant sequences are further enriched via two rounds of CDCE coupled with high fidelity PCR. Individual mutants, seen as distinct peaks on CDCE, are then isolated and sequenced. We have tested this approach by measuring N-methyl–N ′-nitro–N-nitrosoguanidine (MNNG)-induced point mutations in a 121 bp sequence of the adenomatous polyposis coli gene (APC) in human lymphoblastoid MT1 cells. Twelve different MNNG-induced GC→AT transitions were reproducibly observed in MNNG-treated cells at mutant fractions between 2 × 10–6 and 9 × 10–6. The sensitivity of this approach was limited by the fidelity of Pfu DNA polymerase, which created 14 different GC→TA transversions at a mutant fraction equivalent to ~10–6 in the original samples. The approach described herein should be general for all DNA sequences suitable for CDCE analysis. Its sensitivity and capacity would permit detection of stem cell mutations in tissue sectors consisting of ~10 cells.