Cornell scientists have discovered a potentially transformative approach to manufacturing one of the world’s most widely used chemicals—hydrogen peroxide—using nothing more than sunlight, water and air. The research is published in the journal Nature Communications.

“Currently, hydrogen peroxide is made through the anthraquinone process, which relies on fossil fuels, produces chemical waste and requires transport of concentrated peroxide—all of which have safety and environmental concerns,” said Alireza Abbaspourrad, associate professor of Food Chemistry and Ingredient Technology in the Department of Food Science in the College of Agriculture and Life Sciences, and corresponding author of the research.

Hydrogen peroxide is ubiquitous in both industrial and consumer settings: It bleaches paper, treats wastewater, disinfects wounds and household surfaces, and plays a key role in electronics manufacturing. Global production runs into the millions of tons each year. Yet today’s process depends almost entirely on a complex method involving hazardous intermediates and large-scale central chemical plants.

Scientists at EPFL have created a scalable 3D organoid model that captures key features of early limb development, revealing how a specialized signaling center shapes both cell identity and tissue organization.

During early development, the embryo builds the body’s organs by exchanging chemical signals between different cell types. When developing limbs, a thin band of skin cells at the limb’s surface, called the “apical ectodermal ridge” (AER), sends signals that guide the underlying population as it grows and forms bone, cartilage, and connective tissue.

The AER is hard to study because it forms only briefly in the embryo and secretes several types of signaling molecules at once. Studying these interactions in embryos is difficult, so scientists often turn to organoids, tiny lab-grown organs that offer researchers a controlled way to study how cells behave and interact as tissues form.