Signals originating in the brain make their way to gut nerve cells, leading to a release of inflammatory chemicals.
Mental stress has long been linked to flare-ups of gastrointestinal conditions such as irritable bowel syndrome (IBS).
A bacterium in the intestines of stressed mice interferes with cells that protect against pathogens.
A new study reported that SARS-CoV-2, the virus that causes COVID, can infect dopamine neurons in the brain and trigger senescence—when a cell loses the ability to grow and divide. The researchers from Weill Cornell Medicine, Memorial Sloan Kettering Cancer Center, and Columbia University Vagelos College of Physicians and Surgeons suggest that further research on this finding may shed light on the neurological symptoms associated with long COVID, such as brain fog, lethargy, and depression.
The findings, published in Cell Stem Cell on Jan. 17, show that dopamine neurons infected with SARS-CoV-2 stop working and send out chemical signals that cause inflammation. Normally, these neurons produce dopamine, a neurotransmitter that plays a role in feelings of pleasure, motivation, memory, sleep, and movement. Damage to these neurons is also connected to Parkinson’s disease.
“This project started out to investigate how various types of cells in different organs respond to SARS-CoV-2 infection. We tested lung cells, heart cells, pancreatic beta cells, but the senescence pathway is only activated in dopamine neurons,” said senior author Dr. Shuibing Chen, director of the Center for Genomic Health, the Kilts Family Professor Surgery and a member of the Hartman Institute for Therapeutic Organ Regeneration at Weill Cornell Medicine. “This was a completely unexpected result.”
MKUltra is not referenced explicitly on Stranger Things — the popular Netflix show — but the series seems to be inspired by the controversial CIA program. In the show, a government laboratory is conducting illegal experiments on a young girl and other persons, torturing them, and harnessing their special abilities for their own purposes. This is similar to the goals of the CIA human experimentation project, which was started 70 years ago.
Controversial and unethical experiments were conducted on human subjects by the Agency for the MKUltra project, including the use of mind control techniques and the administration of drugs such as LSD and other chemicals. Electroshock, hypnosis, sensory deprivation, verbal and sexual abuse, and other forms of torture were also part of the non-consensual experiments, which were created because the CIA was convinced that communists had discovered a way to control human minds. Its activities — which were hidden and classified before their files being destroyed after an investigation — remain a subject of concern and investigation to this day.
MKUltra was a CIA program involving the research and development of chemical and biological agents. According to official documents, it was “concerned with the research and development of chemical, biological and radiological materials capable of employment in clandestine operations to control human behavior.”
Steamy World Could Be a Sample of Water-Rich Planets Throughout Our Galaxy The search for life in space goes hand-in-hand with the search for water on planets around other stars. Water is one of the most common molecules in the universe, and all life on Earth requires it. Water functions as a solvent by dissolving substances and enabling key chemical reactions in animal, plant, and microbial cells. It is much better at this than other liquids.
Learn how deep learning is revolutionizing the study of explosive perchlorate salts, offering safer alternatives to traditional methods and advancing our understanding of molecular structures.
Use of deep learning in chemistry as researchers employ artificial intelligence to uncover the molecular mysteries behind explosive perchlorate salts.
Tunneling is a fundamental process in quantum mechanics, involving the ability of a wave packet to cross an energy barrier that would be impossible to overcome by classical means. At the atomic level, this tunneling phenomenon significantly influences molecular biology. It aids in speeding up enzyme reactions, causes spontaneous DNA mutations, and initiates the sequences of events that lead to the sense of smell.
Photoelectron tunneling is a key process in light-induced chemical reactions, charge and energy transfer, and radiation emission. The size of optoelectronic chips and other devices has been close to the sub-nanometer atomic scale, and the quantum tunneling effects between different channels would be significantly enhanced.
Insects have been shown to have the ability to detect different chemical agents. Here, the authors present a nanomaterial-assisted neuromodulation strategy to augment the chemosensory abilities of insects via photothermal effect and on-demand neurotransmitter release from cargo-loaded nanovehicles to augment natural sensory function.
Measuring the amount of precipitation that falls in a specific location is simple if that location has a device designed to accurately record and transmit precipitation data. In contrast, measuring the amount and type of precipitation that falls to Earth in every location is logistically quite difficult. Importantly, this information could provide a wealth of data for characterizing and predicting Earth’s water, energy and biogeochemical cycles.
Scientists from the China Meteorological Administration developed and launched a satellite created to measure Earth precipitation with radar while orbiting in space.
This is the first of two precipitation missions planned by the team to accurately measure the occurrence, type and intensity of any precipitation across the world, including over oceans and complex terrain. Specifically, the FY-3G satellite is designed to assess the 3-dimensional (3D) form of rainfall and other precipitation for weather systems at Earth’s middle and lower latitudes.
A University of Massachusetts Amherst team has made a major advance toward modeling and understanding how intrinsically disordered proteins (IDPs) undergo spontaneous phase separation, an important mechanism of subcellular organization that underlies numerous biological functions and human diseases.
IDPs play crucial roles in cancer, neurodegenerative disorders and infectious diseases. They make up about one-third of proteins that human bodies produce, and two-thirds of cancer-associated proteins contain large, disordered segments or domains. Identifying the hidden features crucial to the functioning and self-assembly of IDPs will help researchers understand what goes awry with these features when diseases occur.
In a paper published in the Journal of the American Chemical Society, senior author Jianhan Chen, professor of chemistry, describes a novel way to simulate phase separations mediated by IDPs, an important process that has been difficult to study and describe.
In chemistry, structure is everything. Compounds with the same chemical formula can have different properties depending on the arrangement of the molecules they’re made of. And compounds with a different chemical formula but a similar molecular arrangement can have similar properties.
Graphene and a form of boron nitride called hexagonal boron nitride fall into the latter group. Graphene is made up of carbon atoms. Boron nitride, BN, is composed of boron and nitrogen atoms. While their chemical formulas differ, they have a similar structure —so similar that many chemists call hexagonal boron nitride “white graphene.”
Carbon-based graphene has lots of useful properties. It’s thin but strong, and it conducts heat and electricity very well, making it ideal for use in electronics.
