Lifeboat Foundation

Glucosepane is one of the most significant mechanisms of aging and yet very few people are working on it!

As we age skin and blood vessels lose their elasticity. People care too much about the skin and too little about the blood vessels, but that is always the way of it. Appearance first and substance later, if at all. Yet you can live inside an aged skin; beyond the raised risk of skin cancer its damaged state arguably only makes life less pleasant, and the present state of medical science can ensure that the numerous age-related dermatological dysfunctions can be kept to a state of minor inconvenience. Loss of blood vessel elasticity, on the other hand, will steadily destroy your health and then kill you. Arterial stiffening causes remodeling of the cardiovascular system and hypertension. The biological systems that regulate blood pressure become dysfunctional as blood vessels depart from ideal youthful behavior, creating a downward spiral of increasing blood pressure and reactions to that increase. Small blood vessels fail under the strain in ever larger numbers, damaging surrounding tissue. In the brain this damage contributes to age-related cognitive decline by creating countless tiny, unnoticed strokes. Ultimately this process leads to dementia. More important parts of the cardiovascular system are likely to fail first, however, perhaps causing a stroke, or a heart attack, or the slower decline of congestive heart failure.

From what is known today, it is reasonable to propose that the two main culprits driving loss of tissue elasticity are sugary cross-links generated as a byproduct of the normal operation of cellular metabolism and growing numbers of senescent cells. Elasticity is a property of the extracellular matrix, an intricate structure of collagens and other proteins created by cells. Different arrangements of these molecules produce very different structures, ranging from load-bearing tissues such as bone and cartilage to elastic tissues such as skin and blood vessel walls. Disrupting the arrangement and interaction of molecules in the extracellular matrix also disrupts its properties. Persistent cross-links achieve this by linking proteins together and restricting their normal range of motion. Senescent cells, on the other hand, secrete a range of proteins capable of breaking down or remodeling portions of the surrounding extracellular matrix, and altering the behavior of nearby cells for the worse.

Continue reading “Scores of Labs Should be Gearing Up to Work on Glucosepane Cross-Link Breakers, But Are They?” »

Vivid holographic images and text can now be produced by means of an ordinary inkjet printer. This new method, developed by a team of scientists from ITMO University in Saint Petersburg, is expected to significantly reduce the cost and time needed to create the so-called rainbow holograms, commonly used for security purposes — to protect valuable items, such as credit cards and paper currency, from piracy and falsification. The results of the study were published 17 November in the scientific journal Advanced Functional Materials.

The team, led by Alexander Vinogradov, senior research associate at the International Laboratory of Solution Chemistry of Advanced Materials and Technologies (SCAMT) in ITMO University, developed colorless ink made of nanocrystalline titania, which can be loaded into an inkjet printer and then deposited on special microembossed paper, resulting in unique patterned images. The ink makes it possible to print custom holographic images on transparent film in a matter of minutes, instead of days as with the use of conventional methods.

Rainbow holograms are widely used to fight against the forgery of credit cards, money, documents and certain manufactured products that call for a high level of protection. Even though the technology of obtaining holographic images was already developed in the 1960s, there still exist numerous technical difficulties that impede its further spread and integration into polygraphic industry.

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https://www.youtube.com/watch?v=Q9Ec7AvnufQ

Ray Kurzweil: https://en.wikipedia.org/wiki/Ray_Kurzweil#Health_and_aging

Raymond “Ray” Kurzweil is an American author, computer scientist, inventor and futurist. Aside from futurology, he is involved in fields such as optical character recognition (OCR), text-to-speech synthesis, speech recognition technology, and electronic keyboard instruments. He has written books on health, artificial intelligence (AI), transhumanism, the technological singularity, and futurism. Kurzweil is a public advocate for the futurist and transhumanist movements, and gives public talks to share his optimistic outlook on life extension technologies and the future of nanotechnology, robotics, and biotechnology.

Continue reading “Ray Kurzweil — The Future of Medicine” »

The world of superconductivity is in uproar. Last year, Mikhail Eremets and a couple of pals from the Max Planck Institute for Chemistry in Mainz, Germany, made the extraordinary claim that they had seen hydrogen sulphide superconducting at −70 °C. That’s some 20 degrees hotter than any other material—a huge increase over the current record.

Eremets and co have worked hard to conjure up the final pieces of conclusive evidence. A few weeks ago, their paper was finally published in the peer reviewed journal Nature, giving it the rubber stamp of respectability that mainstream physics requires. Suddenly, superconductivity is back in the headlines.

Today, Antonio Bianconi and Thomas Jarlborg at the Rome International Center for Materials Science Superstripes in Italy provide a review of this exciting field. These guys give an overview of Eremet and co’s discovery and a treatment of the theoretical work that attempts to explain it.

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A new lithium-air battery created by researchers at the University of Cambridge points the way to the ultimate battery packs of the future, its makers say. With a very high energy density, more than 90 percent efficiency and the capability for more than 2,000 recharge cycles, the new test battery could prove an important stepping stone in the development of this essential technology.

If you’re getting tired of announcements about breakthroughs in battery technology, that’s understandable: as they’re so essential to modern life, many teams of scientists are busy working on the problem around the clock, but it’s an incredibly complex area of chemistry. Any new battery has to improve on what we already have, be safe to use in consumer gadgets, and be commercially viable enough to be affordable for manufacturers.

Those are difficult targets to hit, and that’s why many ‘miracle’ batteries have since fallen by the wayside – once the initial lab work is done, proving concepts and scaling up production is very difficult to get right. The potential rewards are huge though, not just for smartphones but for electric cars and solar power, where batteries are essential for storing energy to use when the sun isn’t shining.

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A Nobel prize winning scientist who shared the 2008 prize for medicine for his role in establishing the link between HIV and AIDS has stirred up a good deal of both interest and skepticism with his latest experimental results, which more or less show that DNA can teleport itself to distant cells via electromagnetic signals. If his results prove correct, they would shake up the foundations upon which modern chemistry rests. But plenty of Montagnier’s peers are far from convinced.

The full details of Montagnier’s experiments are not yet known, as his paper has not yet been accepted for publication. But he and his research partners have made a summary of his findings available. Essentially, they took two test tubes – one containing a fragment of DNA about 100 bases long, another containing pure water – and isolated them in a chamber that muted the earth’s natural electromagnetic field to keep it from muddying the results. The test tubes were housed within a copper coil emanating a weak electromagnetic field.

Several hours later, the contents of both test tubes were put through polymerase chain reactions to identify any remnants of DNA – a process that subjected the contents to enzymes that would make copies of any DNA fragments they found. According to Montagnier, the DNA was recovered from both tubes even though the second should have only contained water.

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Liquid water exists on the surface of Mars during the planet’s warmer seasons, according to new research published in Nature Geosciences . This revelation comes from new spectral data gathered by NASA’s Mars Reconnaissance Orbiter (MRO), a spacecraft that studies the planet from orbit. The orbiter analyzed the chemistry of weird dark streaks that have been known to appear and disappear seasonally on the Martian surface. The analysis confirms that these streaks are formed by briny — or salty — water flowing downhill on Mars.

NASA has advertised these findings as the solution to a major Mars mystery: does the Red Planet truly have liquid water on its surface? Researchers have known that water exists in ice form on Mars, but it’s never been confirmed if water can remain in a liquid state. The space agency is claiming that we now have that answer.

This isn’t the first study to suggest liquid water is present in some form on Mars. Scientists have theorized for years that Mars was once home to a large ocean more than 4 billion years ago. And recent findings from the Mars Curiosity rover suggest that liquid water exists just underneath the Martian surface. The discovery of water on Mars has almost become a joke among planetary scientists. Alfred McEwen, a planetary geologist at Planetary Image Research Laboratory who also worked on this research, wrote in Scientific American that the studies have become extremely commonplace: “Congratulations — you’ve discovered water on Mars for the 1,000th time!” he joked.

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A new type of battery could provide better storage for renewable energy than Tesla’s Powerwall. Here’s how it works.

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Researchers from the Institute of General Physics of the Russian Academy of Sciences, the Institute of Bioorganic Chemistry of the Russian Academy of Sciences and MIPT have made an important step towards creating medical nanorobots. They discovered a way of enabling nano- and microparticles to produce logical calculations using a variety of biochemical reactions.

Details of their research project are given in the journal Nature Nanotechnology. It is the first experimental publication by an exclusively Russian team in one of the most cited scientific magazines in many years.

The paper draws on the idea of computing using biomolecules. In electronic circuits, for instance, logical connectives use current or voltage (if there is voltage, the result is 1, if there is none, it’s 0). In biochemical systems, the result can a given substance.

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