Lifeboat Foundation

One of the biggest challenges in treating brain cancer has been getting drugs to cross the blood-brain barrier and attack tumours where they’re needed.

But scientists say they’ve now developed a truly soluble liquid aspirin that can make its way into the brain, and, in the lab at least, kill cancerous glioblastoma cells without harming healthy brain tissue.

The research hasn’t been published in a peer-reviewed journal as yet, so we need to take it with a big pinch of salt for now. But scientists from the Brain Tumour Research Centre at the University of Portsmouth in the UK just presented it at the Brain Tumours 2016 conference in Poland.

Continue reading “Scientists say they’ve developed aspirin that crosses the blood-brain barrier” »

3D printing has has a presence in the medical industry since the 1980s for modelling body parts that are otherwise untouchable without invasive surgery, but research into the potential of this technology is bringing clinicians closer to getting a good look up close at the real thing. Instead of scans, what about injecting a camera no bigger than a grain of salt into your patient?

A group of German researchers have been working on a complex lens system that is small enough to fit inside a syringe, and applications aren’t just limited to the medical industry. They have the potential to also be used in many products which need parts to be as small and light as possible, such as drones and smart phones.

Continue reading “Tiny 3D Printed Cameras with Enormous Potential” »

Two interconnected brain areas — the hippocampus and the entorhinal cortex — help us to know where we are and to remember it later. By studying these brain areas, researchers at Baylor College of Medicine, Rice University, The University of Texas MD Anderson Cancer Center and the National Cancer Institute have uncovered new information about how dysfunction of this circuit may contribute to memory loss in Alzheimer’s disease. Their results appear in Cell Reports.

“We created a new mouse model in which we showed that spatial memory decays when the entorhinal cortex is not functioning properly,” said co-corresponding author Dr. Joanna Jankowsky, associate professor of neuroscience at Baylor. “I think of the entorhinal area as a funnel. It takes information from other sensory cortices — the parts of the brain responsible for vision, hearing, smell, touch, and taste — and funnels it into the hippocampus. The hippocampus then binds this disparate information into a cohesive memory that can be reactivated in full by recalling only one part. But the hippocampus also plays a role in spatial navigation by telling us where we are in the world. These two functions converge in the same cells, and our study set out to examine this duality.”

The new mouse model was genetically engineered to carry a particular surface receptor on the cells of the entorhinal cortex. When this receptor was activated by administering the drug ivermectin to the mice, the cells of the entorhinal cortex silenced their activity. They stopped funnelling information to the hippocampus. This system allowed the scientists to turn off the entorhinal cortex, and to determine how this affected hippocampal function.

A drink containing liquid aspirin could extend the lives of thousands of brain cancer patients, according to breakthrough research.

British experts have found that the simple drug can cross the ‘blood-brain barrier’ — a hurdle which has so far stopped cancer drugs attacking brain tumours.

Scientists will today announce the results of early tests which show liquid aspirin is ten times more effective than any existing chemotherapy at killing brain cancer cells.

Continue reading “How liquid aspirin could help fight brain cancer: Special version of the drug found to be ten times more effective at killing cancer cells than chemotherapy” »

With a radio specifically designed to communicate through tissue, Professors David Blaauw (http://web.eecs.umich.edu/faculty/blaauw/) and David Wentzloff (http://web.eecs.umich.edu/~wentzlof/) from the University of Michigan’s Electrical and Computer Engineering Department (https://www.eecs.umich.edu/ece/) are adding another level to a computer platform small enough to fit inside a medical grade syringe.

With this enabling technology, real time information can be applied to devices monitoring heart fibrillation as well as glucose monitoring for diabetics.

Continue reading “Injectable Computers” »

Different species of animals either live a very long time or do not die of old age. Some cases are the tortoise & lobster species that live to be over 130 years old naturally and don’t usually die unless they get sick or are killed.

After we grow up our cells ultimately stop self-replicating. A researcher named Leonard Hayflick figured out that each of our cells divide around 50 times and then they stop. Once all of our cells stop duplicating we start to deteriorate and then ultimately die. This finding showed that we are in fact programmed to die biologically.

Its painful to bear views that make many think I’m an imbicile and dislike me. So please, if anybody has a rational argument why any of this is wrong, I beg to be enlightened. I’ve set up a diagram for the purpose that will support you to add your criticism exactly where it is pertinent. https://tssciencecollaboration.com/graphtree/Are%20Vaccines%20Safe/406/4083

(1) The National Academy’s Reviews Of Vaccine Safety
The Institute of Medicine of the National Academies has provided several multi-hundred page surveys studying the safety of vaccines, but rather than reassuring, these itemize some iatrogenic conditions being caused, and pronounce the scientific literature inadequate to say whether most others are. The 2011 Institute of Medicine (IOM) Review[1] looked at 146 vaccine-condition pairs for causality, reporting:

• 14 for which the evidence is said to convincingly support causality, the vaccine is causing the condition.
• 4 where the evidence is said to favor acceptance.
• 5 where the evidence is said to favor rejection, including MMR causing autism.
• 123 where the evidence is said insufficient to evaluate.

The 2003 IOM Review on multiple vaccines said[2]:
“The committee was unable to address the concern that repeated exposure of a susceptible child to multiple immunizations over the developmental period may also produce atypical or non-specific immune or nervous system injury that could lead to severe disability or death (Fisher, 2001). There are no epidemiological studies that address this.”
and:
“the committee concludes that the epidemiological and clinical evidence is inadequate to accept or reject a causal relationship between multiple immunization and an increased risk of allergic disease, particularly asthma.”

• None of the IOM Safety Reviews[1][2][3][4] addressed the aluminum (for example whether the aluminum is causing autism), or mentioned contaminants, or discussed animal models although they had concluded as just quoted there is generally no epidemiological or clinical data worth preferring.

(2) The Aluminum.
Alum was added to vaccines back in the 1920’s, with no test of parenteral toxicity until recently[5], because it prods the immature immune system out of its normal operating range.[6] Maybe they figured aluminum is common in the environment, but injection bypasses half a dozen evolved sequential filters that normally keep it out of circulatory flow during development. Vaccines put hundreds of times as much aluminum into infants’ blood as they would otherwise get, and in an unnatural form that is hard for the body to remove.[7][8 (cfsec 4.2)][9]. The published empirical results indicate its highly toxic.

Continue reading “The Top Ten Reasons I Believe Vaccine Safety Is an Epic Mass Delusion” »

It is good to see production costs v. value add return comparisons with drugs as part of an ongoing drive to create drugs cheaper and making them cheaper to patients. However, lets do not sacrifice quality (especially in areas like cancer, MS, etc.) for costs of development/ cost savings. Value of life is priceless.

Defining the value of a drug in relation to its cost and benefit is an emerging theme in cancer care but remains untested.

A new UK study has identified a gene signature that predicts poor survival from ovarian cancer. The study also identified genes which help the cancer develop resistance to chemotherapy — offering a new route to help tackle the disease.

The study, published in the International Journal of Cancer, examined the role of HOX genes in ovarian cancer resistance and whether a drug known as HXR9 which targets HOX, could help prevent the resistance from developing.

The HOX gene family enables the remarkably rapid cell division seen in growing embryos. Most of these genes are switched off in adults, but previous research has shown that in several cancers, including ovarian cancer, HOX genes are switched back on, helping the cancer cells to proliferate and survive.