Lifeboat Foundation

An interview with SENS research Dr. Haroldo Silva and his work with ALT Cancer.

As you might have noticed, the SENS Research Foundation is presently asking for your support in a crowdfunding campaign that aims to close in on a universal therapy capable of effectively treating all types of cancer, one based on blocking telomere lengthening. As is often the case, the SENS network is here using philanthropic donations to pick up necessary work that hasn’t been taken on by the rest of the community, so as to unblock progress. The scientist who will lead the work is Haroldo Silva; he has been focused on this particular branch of cancer research for some years now, and below you’ll find a short interview that covers some of his thoughts on the field and on this effort in particular.

I should emphasize that this SENS initiative is an important component in efforts to completely change the way in which the research community approaches the treatment of cancer. The cancer research community suffers from a high level strategy problem: the majority of treatments are only applicable to a small number of cancer types, out of the hundreds of known types, and the majority of new technology platforms under development will be just as expensive to adapt to a different type of cancer as to build in the first place. A much more efficient approach is needed, as there are only so many researchers and only so much funding in the world. As Silva describes below, blocking telomere lengthening is the most efficient of possible better approaches: all cancers must lengthen their telomeres in order to grow, and abuse a small number of target mechanisms in order to do so.

Continue reading “Crowdfunding Progress Towards a Universal Therapy for All Cancers: an Interview with SENS Research Foundation Scientist Haroldo Silva” »

If human beings are ever to colonise other planets – which might become necessary for the survival of the species, given how far we have degraded this one – they will almost certainly have to use generation ships: spaceships that will support not just those who set out on them, but also their descendants. The vast distances between Earth and the nearest habitable planets, combined with the fact that we are unlikely ever to invent a way of travelling that exceeds the speed of light, ensures that many generations will be born, raised and die on board such a ship before it arrives at its destination.

A generation ship would have to be a whole society in microcosm, with hospitals and schools, living quarters and perhaps entertainment districts, a security force, maybe even a judiciary. It would need to be able to provide food for its crew, and that might require agriculture or aquaculture, perhaps even domestic animals (which might also be needed for the colonisation effort). Its design therefore presents a major challenge: not just to engineers but also to social scientists. How should the crew be selected and the environment structured to minimise interpersonal conflict? What size of population is optimal for it to remain committed to the single overarching project of colonising a new planet without too much of a risk of self-destructive boredom or excessive narrowing of the gene pool? Does mental health require that a quasi-natural environment be recreated within the ship (with trees, grass and perhaps undomesticated birds and small animals)?

As well as the technological and social challenges confronting the designers of such ships, there are fascinating philosophical and ethical issues that arise. The issue I want to focus on concerns the ethics of a project that locks the next generation into a form of living, the inauguration of which they had no say over, and that ensures their options are extremely limited.

Continue reading “Would it be immoral to send out a generation starship?” »

Verily and GlaxoSmithKline have partnered to form Galvani Bioelectronics, a new company which will focus on the research, development, and commercialization of bioelectronics. One of the first projects will be to develop a precision device that can fix type 2 diabetes.

Verily, formerly known as Google Life Sciences, is partnering with GlaxoSmithKline (GSK) to develop bioelectronic medicines that can “harness electrical signals in the body to treat chronic disease.”

The collaboration marries GSK’s pharmaceutical expertise with Verily’s prowess in developing tiny low power electronics. The unification will result in a new company called Galvani Bioelectronics, after Italian scientist Luigi Aloisio Galvani who was an early pioneer of bioelectricity.

Continue reading “Google is Developing ‘Bioelectronic Medicines’ to Try And Cure Chronic Illnesses” »

Is the “perfect human” a realistic goal? Well, a new scientific process promises to tweak selected bits of your DNA.

A universal cancer vaccine is on the horizon after scientists discovered how to rewire immune cells to fight any type of disease.

The potential new therapy involves injecting tiny particles of genetic code into the body which travel to the immune cells and teach them to recognise specific cancers.

Although scientists have shown previously that is it is possible to engineer immune cells outside the body so they can spot cancer it is the first time it has happened inside cells.

Continue reading “Universal cancer vaccine on horizon after genetic breakthrough” »

Fighter pilots and brain surgeons have a lot in common. With limited time and a high degree of risk, they must zero in on a dangerous target with the intent to destroy, making sure to minimise any collateral damage.

Perhaps no one understands that relationship better than Alon Geri and Moty Avisar, veterans of the Israeli Air Force and co-founders of Surgical Theatre, an Ohio-based company that brings state-of-the-art virtual reality to brain surgeons.

Physicians in thick black goggles can step inside a patient’s skull, explore the malformed region, craft a strategy for entry, elimination, and exit, and even do dry runs of the surgery itself. When it comes time to make the first incision, there are fewer surprises.

Continue reading “A team of ex-fighter pilots have invented a new way for surgeons look inside brains” »

https://youtube.com/watch?v=LTTX2408n3o

Technology is amazing and can be used to help so many. When I position technology; I do so in showing how it helps folks to combat devastating diseases, live life fully even if they became paralyzed at some point in their life and with technology they can walk again, etc. I caution folks to ensure that when we introduce technology that we explain our message well to the broader masses; or risk not be adopted.

We have to do a better job in explaining how AI, BMI, etc. will help the population. When we present things like BMI, Cell Circuitry, etc. we must market how folks used the technology to combat a disease, a disability, or be able to live a more fuller life, etc. I keep seeing either no message or the wrong message being presented to the masses. Instead of waiting for the technology being available; we must take consumers on a journey of possibilities that they can have with tech.

Continue reading “Religion plays a role in attitudes toward human enhancement technologies” »

Southern US is having a bad summer. Zika in FL and Brain eating amoebas in SC.

CHARLESTON COUNTY, S.C. — A patient in South Carolina has tested positive for Naegleria fowleri, the so-called “brain-eating amoeba,” The Centers for Disease Control confirmed in a statement.

Health officials think the patient may have been exposed during a July 24 swim at Martin’s Landing in the Edisto River, which runs through the southeast portion of the state through the Ernest F. Hollings Ace Basin National Wildlife park.

Continue reading “South Carolina patient has rare ‘brain-eating’ amoeba, CDC confirms” »

The findings showed that the shrinking of the hippocampus — brain region associated with learning and memory — actually precedes the onset of a change in behaviour — namely the loss of memory. “Until now, no one knew the evolution of these changes. Does the hippocampus shrink before or after memory loss? Or do the two happen handin- hand,” said Sumantra Chattarji, Professor at National Centre for Biological Sciences in Bengaluru, Karnataka, in a statement.

Using rats as a model system which reacts to stress much as humans do, the team studied how the brain changes in structure during stress. The results showed that when under stress, rats develop anxiety-related behaviours and their ability to form memories are affected. In the study, rats were subjected to stress for two hours every day over 10 days. The brains were examined with MRI scans on several days over the course of the study, and their ability to form memories were assessed repeatedly.

After just three days of stress, the hippocampus of every stressed rat had shrunk. “Normally structural changes are seen in the brain after a long time — say 10 to 20 days. Three days doesn’t even count as chronic stress,” Chattarji added. Five days after stress exposure, the rats’ hippocampus-based ability to make memories was tested again. The stressed rats were found to perform almost as well as unstressed rats, the researchers said. “Volume loss and shrinkage has happened, yet spatial memory is still holding up,” Chattarji said.

Continue reading “Brain scan during stress may predict memory loss” »