Lifeboat Foundation

Mitochondria — the structures within cells mostly known for converting nutrients into usable energy — may play a larger and more direct role in the aging process than previously thought, according to USC Leonard Davis School of Gerontology Assistant Professor David Lee.

In addition to powering cells, mitochondria serve important roles in coordinating metabolism, Lee said. And evidence has shown that mitochondria — which have their own smaller genome separate from the larger collection of genes in a cell’s nucleus — lose function and accrue DNA damage during the aging process, reflecting a role in aging.

In trying to determine how the mitochondria are involved in aging, many researchers have studied the signals sent from the nucleus to the mitochondria and how they change with age. However, Lee theorizes that communication between the cell’s powerhouse and its control center may be taking place in both directions, with signaling molecules originally coded in the mitochondrial DNA regulating the nucleus and causing changes that affect key cellular factors of aging, such as metabolism.

Scientists have struggled for millennia to understand human consciousness — the awareness of one’s existence. Despite advances in neuroscience, we still don’t really know where it comes from, and how it arises.

But researchers think they might have finally figured out its physical origins, after pinpointing a network of three specific regions in the brain that appear to be crucial to consciousness.

It’s a pretty huge deal for our understanding of what it means to be human, and it could also help researchers find new treatments for patients in vegetative states.

Continue reading “Harvard Scientists Think They’ve Pinpointed the Physical Source of Consciousness” »

If you were to compare yourself to a neutron star, you probably wouldn’t find very many things in common. After all, neutron stars – celestial bodies with super strong magnetic fields – are made from collapsed star cores, lie light-years away from Earth, and don’t even watch Netflix.

But, according to new research, we share at least one similarity: the geometry of the matter that makes us.

Researchers have found that the ‘crust’ (or outer layers) of a neutron star has the same shape as our cellular membranes. This could mean that, despite being fundamentally different, both humans and neutron stars are constrained by the same geometry.

Continue reading “Scientists Have Found a Bizarre Similarity Between Human Cells and Neutron Stars” »

Hey folks, great news! The Patrons Challenge is going really well and we have already passed the halfway mark for new Patrons which is superb. Thanks to Reason and Josh Triplett who are doubling all new pledges made this year. So if you are interested in being a Patron this is a great time to join us.

Our Winter fundraiser has also reached almost 25k and is going great guns. The more we can raise the more research we can do and as this year has shown, some truly great results are starting to arrive for the SENS approach to treating age-related diseases.

Our guest for this show is Aubrey de Grey, Ph.D., and he refuses to accept aging as something we can not change. Aubrey is a Biomedical Gerontologist and Chief Scientific Officer of The SENS Research Foundation. I talk more about his background and the SENS Foundation in the interview. Aubrey has put forth a model for aging based on seven types of damage that occur as a product of aging. We discuss this model and the techniques the possibly address each category of damage. This interview is longer than the other thus far but it had me gripped the entire time so enjoy!

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Continue reading “Aubrey de Grey on living to 150 or beyond using biotechnology” »

They could someday help millions get their voices back.

Transplanted embryonic neurons can properly connect into the developed visual cortex of adult mice and improve the animals’ sensitivities to visual cues over time, scientists reported today (October 26) in Nature. By demonstrating that added neurons can become fully functional in circuits that normally do not rewire in adulthood, the team’s results suggest that the brain may be more plastic than previously thought.

“Calorie restriction has been known to extend lifespan for a long time.” said Dr. Kennedy. “The DNA damage response is linked to aging as well. LOS1 may be connecting these different processes.”

A number of the age-extending genes the team identified are also found in C. elegans roundworms, indicating these mechanisms are conserved in higher organisms. In fact, many of the anti-aging pathways associated with yeast genes are maintained all the way to humans.

The research produced another positive result: exposing emerging scientists to advanced lab techniques, many for the first time.

SRF Summer Scholars Program opens December 1st!

The SRF Summer Scholars Program offers undergraduate students the opportunity to conduct biomedical research to combat diseases of aging, such as cancer, Alzheimer’s, and Parkinson’s Disease. Under the guidance of a scientific mentor, each Summer Scholar is responsible for his or her own research project in such areas as genetic engineering and stem cell research. The Summer Scholars Program emphasizes development of both laboratory and communication skills to develop well-rounded future scientists, healthcare professionals, and policy makers. Students participating in the program will hone their writing skills via periodic reports, which are designed to emulate text scientists commonly must produce. At the end of the summer, students will have the opportunity to put all of their newly developed communication skills into practice at a student symposium.

Continue reading “2017 SRF Summer Scholars Program” »