Lifeboat Foundation

The fourth Lifespan.io campaign and CellAge are using synthetic biology to create an accurate aging biomarker for senescent cells and a new therapy for precision targeting of those problem cells. Senescent cells are one of the processes of aging and this could change the way we age.

Lifespan.io is proud to present our fourth rejuvenation biotechnology project!

Continue reading “CellAge: Targeting Senescent Cells With Synthetic Biology” »

In Brief

• By observing the transparent cells of roundworms, researchers have uncovered a link between lifespan and the natural cellular process of RNA splicing.
• This research could lead to new breakthroughs in anti-aging treatments that would allow humans to indefinitely keep ourselves healthy, stalling death for as long as possible.

Though aging seems like one of the most natural things, an affair common to all living creatures, the process is actually poorly understood by scientists. A new study detailed in Nature aims to shed light on the phenomenon as a research team led by the Harvard T.H. Chan School of Public Health has uncovered a relationship between lifespan and RNA splicing, a core function of cells that allows a single gene to produce a variety of proteins.

The researchers already knew that mutations in RNA splicing could lead to disease, but they wanted to find out if the act of splicing itself had an impact on the aging process. To find out, they designed experimental setups using the roundworm Caenorhabditis elegans, which show visible signs of aging during their short three-week lifespan.

Continue reading “A New Aging Discovery Could Allow Humans to Extend Their Lifespan” »

Hemophilia is a devastating genetic condition—without the ability to form blood clots, those who have it risk bleeding to death from even the slightest cut.

Infertile women have been offered new hope after scientists found that a common cancer drug triggers the development of new eggs, an outcome which was previously thought to be impossible.

In a discovery hailed as “astonishing”, researchers at the University of Edinburgh proved it is possible to reverse the clock and coax the ovaries back into a pre-pubescent state where they begin to produce new eggs.

Women are born with all their eggs, which is why conceiving becomes harder with age, because the eggs grow old, become damaged and eventually run out entirely.

Continue reading “Infertility breakthrough as cancer drug sparks growth of new eggs in ‘astonishing’ discovery” »

The full antiaging rejuvenation toolkit of the next few decades will consist of a range of different treatments, each targeting a different type of molecular damage in cells and tissues. Fightaging predicts the likely order of arrival of some of these therapies, based on what is presently going on in research, funding, and for-profit development.

1) Clearance of Senescent Cells

Everon Biosciences, Oisin Biotechnologies, SIWA Therapeutics, and UNITY Biotechnology are all forging ahead with various different approaches to the selective destruction of senescent cells. No doubt many groups within established Big Pharma entities are also taking a stab at this, more quietly, and with less press attention. UNITY Biotechnology has raised more than $100 million to date, demonstrating that there is broad enthusiasm for this approach to the treatment of aging and age-related disease.

Continue reading “Fight Aging predicts the sequence of arrival for meaningful antiaging therapies” »

A brand new type of HIV vaccine will move onto phase II clinical trials in 2017, after phase I trials showed that it was safe to use in humans.

The potential new vaccine will be tested on 600 people in North America, to see how well it can prevent them from getting the virus.

Before we get too excited, the phase I trials were only set up to show that the vaccine was tolerated well by the human body — they didn’t demonstrate if it actually works as a preventative treatment.

Continue reading “A First-of-Its-Kind HIV Vaccine Will Move to Phase II Trials in 2017” »

Scientists hoping to get a glimpse of molecules that control brain activity have devised a new probe that allows them to image these molecules without using any chemical or radioactive labels.

Currently the gold standard approach to imaging molecules in the brain is to tag them with radioactive probes. However, these probes offer low resolution and they can’t easily be used to watch dynamic events, says Alan Jasanoff, an MIT professor of biological engineering.

Jasanoff and his colleagues have developed new sensors consisting of proteins designed to detect a particular target, which causes them to dilate blood vessels in the immediate area. This produces a change in blood flow that can be imaged with magnetic resonance imaging (MRI) or other imaging techniques.

Continue reading “A radiation-free approach to imaging molecules in the brain” »

Great.

Research published in Acta Neuropathologica, identified alterations in a protein known as ATRX in human brain tumours; researchers might also be able to target microRNAs directly, altering their levels to make cancer cells less likely to form tumours.

A recent study suggests that two recently discovered genetic differences between brain cancer cells and normal tissue cells could offer clues to tumour behaviour and potential new targets for therapy.

Continue reading “Research sets new target for brain cancer therapy” »

A huge discovery has just been made about Parkinson’s disease that scientists may have been looking for answers in the wrong place all along. Scientists have found that there is a strong correlation between symptoms of Parkinson’s and bacteria in the gut, not the brain, based on examinations of mice.

Parkinson’s disease is the second most common debilitating brain disorder in the world after Alzheimer’s. It is a neurodegenerative disease that involves a type of protein that builds up around brain cells and then causes the patient to lose motor function. Naturally, scientists had been looking at the brain for answers in dealing with it, but a new study finds that perhaps the answer was in the gut bacteria all along, according to an Axial Biotherapeutics statement.

The finding could lead to a new generation of probiotics that are far more sophisticated than typical brands currently available to the public.

Continue reading “Massive Parkinson’s discovery could change everything” »